Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Why not flaxseed oil? There's no mercury to worry about, and it does contain omega-3 fats...but not the best kind. | 2006 | Harv Health Lett | pmid:17152637 | |
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I take ground flaxseed to help control my cholesterol. But I read that the alpha-linoleic acid (ALA) in flax increases the risk of prostate cancer. Is this true? Does the risk differ between ground flaxseed and concentrated flaxseed oil in capsules? | 2006 | Johns Hopkins Med Lett Health After 50 | pmid:16548073 | |
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Burdge GC | Metabolism of alpha-linolenic acid in humans. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16828546 |
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Vanden Heuvel JP et al. | Differential activation of nuclear receptors by perfluorinated fatty acid analogs and natural fatty acids: a comparison of human, mouse, and rat peroxisome proliferator-activated receptor-alpha, -beta, and -gamma, liver X receptor-beta, and retinoid X receptor-alpha. | 2006 | Toxicol. Sci. | pmid:16731579 |
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Veltri BC et al. | Adipose fatty acid composition and rate of incorporation of alpha-linolenic acid differ between normal and lipoprotein lipase-deficient cats. | 2006 | J. Nutr. | pmid:17116707 |
Cunnane SC et al. | Suckling rats actively recycle carbon from alpha-linolenate into newly synthesized lipids even during extreme dietary deficiency of n-3 polyunsaturates. | 2006 | Pediatr. Res. | pmid:16326997 |
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Maillard V et al. | Dietary beta-carotene inhibits mammary carcinogenesis in rats depending on dietary alpha-linolenic acid content. | 2006 | Br. J. Nutr. | pmid:16869986 |
Moore CS et al. | Oily fish reduces plasma triacylglycerols: a primary prevention study in overweight men and women. | 2006 | Nutrition | pmid:17027436 |
Zhang HT et al. | [Functional expression of an omega-3 fatty acid desaturase gene from Glycine max in Saccharomyces cerevisiae]. | 2006 | Sheng Wu Gong Cheng Xue Bao | pmid:16572837 |
Sebei K et al. | Evolution of phosphoenolpyruvate carboxylase activity and lipid content during seed maturation of two spring rapeseed cultivars (Brassica napus L.). | 2006 | C. R. Biol. | pmid:16945838 |
Xiang M et al. | Diet and gene expression: delta-5 and delta-6 desaturases in healthy Chinese and European subjects. | 2006 | Ann. Nutr. Metab. | pmid:16988497 |
Wendland E et al. | Effect of alpha linolenic acid on cardiovascular risk markers: a systematic review. | 2006 | Heart | pmid:15890766 |
Yasui Y et al. | Troglitazone and 9cis,11trans,13trans-conjugated linolenic acid: comparison of their antiproliferative and apoptosis-inducing effects on different colon cancer cell lines. | 2006 | Chemotherapy | pmid:16899971 |
Murayama SY et al. | Construction and functional analysis of fatty acid desaturase gene disruptants in Candida albicans. | 2006 | Microbiology (Reading, Engl.) | pmid:16622072 |
Chuang CY et al. | Fractionation and identification of 9c, 11t, 13t-conjugated linolenic acid as an activator of PPARalpha in bitter gourd (Momordica charantia L.). | 2006 | J. Biomed. Sci. | pmid:16955349 |
Sanders TA et al. | Effect of varying the ratio of n-6 to n-3 fatty acids by increasing the dietary intake of alpha-linolenic acid, eicosapentaenoic and docosahexaenoic acid, or both on fibrinogen and clotting factors VII and XII in persons aged 45-70 y: the OPTILIP study. | 2006 | Am. J. Clin. Nutr. | pmid:16960164 |
Sawada Y et al. | Absolute configuration of volicitin from the regurgitant of lepidopteran caterpillars and biological activity of volicitin-related compounds. | 2006 | Biosci. Biotechnol. Biochem. | pmid:16960380 |
Ambrose DJ et al. | Lower pregnancy losses in lactating dairy cows fed a diet enriched in alpha-linolenic acid. | 2006 | J. Dairy Sci. | pmid:16840624 |
Arterburn LM et al. | Distribution, interconversion, and dose response of n-3 fatty acids in humans. | 2006 | Am. J. Clin. Nutr. | pmid:16841856 |
Breslow JL | n-3 fatty acids and cardiovascular disease. | 2006 | Am. J. Clin. Nutr. | pmid:16841857 |
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Tsuzuki T et al. | Conjugated linolenic acid is slowly absorbed in rat intestine, but quickly converted to conjugated linoleic acid. | 2006 | J. Nutr. | pmid:16857834 |
Levant B et al. | Diet (n-3) polyunsaturated fatty acid content and parity interact to alter maternal rat brain phospholipid fatty acid composition. | 2006 | J. Nutr. | pmid:16857847 |
Djoussé L et al. | Dietary linolenic acid and fasting glucose and insulin: the National Heart, Lung, and Blood Institute Family Heart Study. | 2006 | Obesity (Silver Spring) | pmid:16571856 |
Ramaprasad TR et al. | Spray-dried milk supplemented with alpha-linolenic acid or eicosapentaenoic acid and docosahexaenoic acid decreases HMG Co A reductase activity and increases biliary secretion of lipids in rats. | 2006 | Steroids | pmid:16499938 |
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Sánchez-Hernández C et al. | Reduced levels of volatile emissions in jasmonate-deficient spr2 tomato mutants favour oviposition by insect herbivores. | 2006 | Plant Cell Environ. | pmid:17080606 |
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Alessandri C et al. | Alpha-linolenic acid-rich wheat germ oil decreases oxidative stress and CD40 ligand in patients with mild hypercholesterolemia. | 2006 | Arterioscler. Thromb. Vasc. Biol. | pmid:17053175 |
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Bavelaar FJ et al. | Plasma lipids and fatty acid composition in parrots in relation to the intake of alpha-linolenic acid from two feed mixtures. | 2005 | J Anim Physiol Anim Nutr (Berl) | pmid:16138866 |
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