Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Michaelsen KF et al. | Food sources and intake of n-6 and n-3 fatty acids in low-income countries with emphasis on infants, young children (6-24 months), and pregnant and lactating women. | 2011 | Matern Child Nutr | pmid:21366872 |
Briend A et al. | Fatty acid status in early life in low-income countries--overview of the situation, policy and research priorities. | 2011 | Matern Child Nutr | pmid:21366873 |
Saha SS and Ghosh M | Antioxidant effect of vegetable oils containing conjugated linolenic acid isomers against induced tissue lipid peroxidation and inflammation in rat model. | 2011 | Chem. Biol. Interact. | pmid:21382362 |
Singh KK et al. | Flaxseed: a potential source of food, feed and fiber. | 2011 | Crit Rev Food Sci Nutr | pmid:21390942 |
Parra-Cabrera S et al. | Dietary intakes of polyunsaturated fatty acids among pregnant Mexican women. | 2011 | Matern Child Nutr | pmid:21410881 |
Gopinath B et al. | Consumption of polyunsaturated fatty acids, fish, and nuts and risk of inflammatory disease mortality. | 2011 | Am. J. Clin. Nutr. | pmid:21411616 |
Poudyal H et al. | Lipid redistribution by α-linolenic acid-rich chia seed inhibits stearoyl-CoA desaturase-1 and induces cardiac and hepatic protection in diet-induced obese rats. | 2012 | J. Nutr. Biochem. | pmid:21429727 |
Salem N and Kuratko CN | Lack of evidence for increased α-linolenic acid metabolism in vegetarians. | 2011 | Am. J. Clin. Nutr. | pmid:21430120 |
Berasategi I et al. | "High in omega-3 fatty acids" bologna-type sausages stabilized with an aqueous-ethanol extract of Melissa officinalis. | 2011 | Meat Sci. | pmid:21439735 |
Barros R et al. | Dietary intake of α-linolenic acid and low ratio of n-6:n-3 PUFA are associated with decreased exhaled NO and improved asthma control. | 2011 | Br. J. Nutr. | pmid:21443816 |
He L et al. | Preparation of SiO2/(PMMA/Fe3O4) nanoparticles using linolenic acid as crosslink agent for nucleic acid detection using chemiluminescent method. | 2011 | J Nanosci Nanotechnol | pmid:21449377 |
Milberg P et al. | Antiarrhythmic effects of free polyunsaturated fatty acids in an experimental model of LQT2 and LQT3 due to suppression of early afterdepolarizations and reduction of spatial and temporal dispersion of repolarization. | 2011 | Heart Rhythm | pmid:21459164 |
de Goede J et al. | Alpha-linolenic acid intake and 10-year incidence of coronary heart disease and stroke in 20,000 middle-aged men and women in the Netherlands. | 2011 | PLoS ONE | pmid:21464993 |
Moltó-Puigmartà C et al. | Additional data from our study on fatty acids variations during lactation: correlations between n-3 and n-6 PUFAs in human colostrum, transitional, and mature milk. | 2011 | Clin Nutr | pmid:21470725 |
Lucas M et al. | Dietary intake of n-3 and n-6 fatty acids and the risk of clinical depression in women: a 10-y prospective follow-up study. | 2011 | Am. J. Clin. Nutr. | pmid:21471279 |
Carrillo C et al. | Oleic acid versus linoleic and α-linolenic acid. different effects on Ca2+ signaling in rat thymocytes. | 2011 | Cell. Physiol. Biochem. | pmid:21471726 |
López-López I et al. | Effect of cooking on the chemical composition of low-salt, low-fat Wakame/olive oil added beef patties with special reference to fatty acid content. | 2011 | Meat Sci. | pmid:21497025 |
Farina EK et al. | Dietary intakes of arachidonic acid and alpha-linolenic acid are associated with reduced risk of hip fracture in older adults. | 2011 | J. Nutr. | pmid:21508210 |
Diwakar BT et al. | Modulatory effect of α-linolenic acid-rich garden cress (Lepidium sativum L.) seed oil on inflammatory mediators in adult albino rats. | 2011 | Br. J. Nutr. | pmid:21521541 |
Márquez-Castillo A and Vidal-Quintanar RL | Improvements in the shelf life of commercial corn dry masa flour (CMF) by reducing lipid oxidation. | 2011 | J. Food Sci. | pmid:21535741 |
Nudda A et al. | Documentation of fatty acid profiles in lamb meat and lamb-based infant foods. | 2011 | J. Food Sci. | pmid:21535766 |
Li M et al. | Isolation of a novel C18-Δ9 polyunsaturated fatty acid specific elongase gene from DHA-producing Isochrysis galbana H29 and its use for the reconstitution of the alternative Δ8 pathway in Saccharomyces cerevisiae. | 2011 | Biotechnol. Lett. | pmid:21538137 |
Gorissen L et al. | Conjugated linoleic acid and conjugated linolenic acid production by bifidobacteria. | 2011 | Commun. Agric. Appl. Biol. Sci. | pmid:21539185 |
Ash MM et al. | Unrefined and refined black raspberry seed oils significantly lower triglycerides and moderately affect cholesterol metabolism in male Syrian hamsters. | 2011 | J Med Food | pmid:21548801 |
Labayen I et al. | Associations of birth weight with serum long chain polyunsaturated fatty acids in adolescents; the HELENA study. | 2011 | Atherosclerosis | pmid:21550607 |
Holy EW et al. | Dietary α-linolenic acid inhibits arterial thrombus formation, tissue factor expression, and platelet activation. | 2011 | Arterioscler. Thromb. Vasc. Biol. | pmid:21571683 |
Kasuli EG | Are alternative supplements effective treatment for diabetes mellitus? | 2011 | Nutr Clin Pract | pmid:21586420 |
Zhang Y et al. | α-Linolenic acid prevents endoplasmic reticulum stress-mediated apoptosis of stearic acid lipotoxicity on primary rat hepatocytes. | 2011 | Lipids Health Dis | pmid:21592363 |
Dumont J et al. | FADS1 genetic variability interacts with dietary α-linolenic acid intake to affect serum non-HDL-cholesterol concentrations in European adolescents. | 2011 | J. Nutr. | pmid:21593353 |
Djoussé L et al. | Plasma omega-3 fatty acids and incident diabetes in older adults. | 2011 | Am. J. Clin. Nutr. | pmid:21593500 |
Belin RJ et al. | Fish intake and the risk of incident heart failure: the Women's Health Initiative. | 2011 | Circ Heart Fail | pmid:21610249 |
Leyva DR et al. | The effect of dietary flaxseed on improving symptoms of cardiovascular disease in patients with peripheral artery disease: rationale and design of the FLAX-PAD randomized controlled trial. | 2011 | Contemp Clin Trials | pmid:21616170 |
Qiu L et al. | Coenzyme Q10 production by Sphingomonas sp. ZUTE03 with novel precursors isolated from tobacco waste in a two-phase conversion system. | 2011 | J. Microbiol. Biotechnol. | pmid:21617346 |
Park MH et al. | Effects of roasting conditions on the physicochemical properties and volatile distribution in perilla oils (Perilla frutescens var. japonica). | 2011 | J. Food Sci. | pmid:21623788 |
Banik M et al. | Transcript profiling and gene characterization of three fatty acid desaturase genes in high, moderate, and low linolenic acid genotypes of flax (Linum usitatissimum L.) and their role in linolenic acid accumulation. | 2011 | Genome | pmid:21627464 |
Letona AZ et al. | CLA-enriched diet containing t10,c12-CLA alters bile acid homeostasis and increases the risk of cholelithiasis in mice. | 2011 | J. Nutr. | pmid:21628634 |
Nassu RT et al. | The effects of feeding flaxseed to beef cows given forage based diets on fatty acids of longissimus thoracis muscle and backfat. | 2011 | Meat Sci. | pmid:21645974 |
Alessandri JM et al. | Influence of gender on DHA synthesis: the response of rat liver to low dietary α-linolenic acid evidences higher ω3 ∆4-desaturation index in females. | 2012 | Eur J Nutr | pmid:21647669 |
Ding BJ et al. | Terminal fatty-acyl-CoA desaturase involved in sex pheromone biosynthesis in the winter moth (Operophtera brumata). | 2011 | Insect Biochem. Mol. Biol. | pmid:21651981 |
Gao F et al. | Liver conversion of docosahexaenoic and arachidonic acids from their 18-carbon precursors in rats on a DHA-free but α-LNA-containing n-3 PUFA adequate diet. | 2011 Jul-Aug | Biochim. Biophys. Acta | pmid:21651989 |
Lee YJ and Jenkins TC | Biohydrogenation of linolenic acid to stearic acid by the rumen microbial population yields multiple intermediate conjugated diene isomers. | 2011 | J. Nutr. | pmid:21653571 |
Kowalska A et al. | Impact of diets with different proportions of linseed and sunflower oils on the growth, liver histology, immunological and chemical blood parameters, and proximate composition of pikeperch Sander lucioperca (L.). | 2012 | Fish Physiol. Biochem. | pmid:21656178 |
Zhang J et al. | Alpha-linolenic acid increases cholesterol efflux in macrophage-derived foam cells by decreasing stearoyl CoA desaturase 1 expression: evidence for a farnesoid-X-receptor mechanism of action. | 2012 | J. Nutr. Biochem. | pmid:21658928 |
West SG et al. | Effects of diets high in walnuts and flax oil on hemodynamic responses to stress and vascular endothelial function. | 2010 | J Am Coll Nutr | pmid:21677123 |
Anadon A et al. | A 4-week repeated oral dose toxicity study of dairy fat naturally enriched in vaccenic, rumenic and α-linolenic acids in rats. | 2011 | J. Agric. Food Chem. | pmid:21678997 |
Cuello S et al. | Comparative study of antioxidant and anti-inflammatory activities and genotoxicity of alcoholic and aqueous extracts of four Fabiana species that grow in mountainous area of Argentina. | 2011 | J Ethnopharmacol | pmid:21693175 |
Gorissen L et al. | Linoleate isomerase activity occurs in lactic acid bacteria strains and is affected by pH and temperature. | 2011 | J. Appl. Microbiol. | pmid:21699633 |
Rapoport SI et al. | Docosahexaenoic acid (DHA) incorporation into the brain from plasma, as an in vivo biomarker of brain DHA metabolism and neurotransmission. | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21704722 |
Svensson J et al. | Postprandial lipid responses to an alpha-linolenic acid-rich oil, olive oil and butter in women: a randomized crossover trial. | 2011 | Lipids Health Dis | pmid:21711508 |
Xie N et al. | α-Linolenic acid intake attenuates myocardial ischemia/reperfusion injury through anti-inflammatory and anti-oxidative stress effects in diabetic but not normal rats. | 2011 | Arch. Med. Res. | pmid:21722811 |
Kim Y and Ilich JZ | Implications of dietary α-linolenic acid in bone health. | 2011 Nov-Dec | Nutrition | pmid:21726979 |
Feskens EJ | The prevention of type 2 diabetes: should we recommend vegetable oils instead of fatty fish? | 2011 | Am. J. Clin. Nutr. | pmid:21733879 |
Sakurai K et al. | Dietary Perilla seed oil supplement increases plasma omega-3 polyunsaturated fatty acids and ameliorates immunoglobulin A nephropathy in high immunoglobulin A strain of ddY mice. | 2011 | Nephron Exp. Nephrol. | pmid:21734409 |
Myhrstad MC et al. | Effect of the fat composition of a single high-fat meal on inflammatory markers in healthy young women. | 2011 | Br. J. Nutr. | pmid:21736782 |
Brinkman MT et al. | Intake of α-linolenic acid and other fatty acids in relation to the risk of bladder cancer: results from the New Hampshire case-control study. | 2011 | Br. J. Nutr. | pmid:21736846 |
Arshad A et al. | Potential applications of fish oils rich in n-3 fatty acids in the palliative treatment of advanced pancreatic cancer. | 2011 | Br. J. Nutr. | pmid:21745426 |
Poudyal H et al. | Omega-3 fatty acids and metabolic syndrome: effects and emerging mechanisms of action. | 2011 | Prog. Lipid Res. | pmid:21762726 |
Trimarco B et al. | [The Alpha Omega study]. | 2011 Jul-Aug | G Ital Cardiol (Rome) | pmid:21779112 |
Angulo J et al. | Nutritional evaluation of fruit and vegetable waste as feedstuff for diets of lactating Holstein cows. | 2012 | J. Environ. Manage. | pmid:21784573 |
Zhang Y et al. | Effect of α-linolenic acid on endoplasmic reticulum stress-mediated apoptosis of palmitic acid lipotoxicity in primary rat hepatocytes. | 2011 | Lipids Health Dis | pmid:21787405 |
Dhobale MV et al. | Reduced levels of placental long chain polyunsaturated fatty acids in preterm deliveries. | 2011 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21816593 |
Jungheim ES et al. | Elevated serum α-linolenic acid levels are associated with decreased chance of pregnancy after in vitro fertilization. | 2011 | Fertil. Steril. | pmid:21840520 |
O'Neill CM et al. | Two high linolenic mutants of Arabidopsis thaliana contain megabase-scale genome duplications encompassing the FAD3 locus. | 2011 | Plant J. | pmid:21848868 |
Arsenault D et al. | Chronic dietary intake of α-linolenic acid does not replicate the effects of DHA on passive properties of entorhinal cortex neurons. | 2012 | Br. J. Nutr. | pmid:21851757 |
Vedtofte MS et al. | Dietary α-linolenic acid, linoleic acid, and n-3 long-chain PUFA and risk of ischemic heart disease. | 2011 | Am. J. Clin. Nutr. | pmid:21865326 |
Legrand P et al. | Update of French nutritional recommendations for fatty acids. | 2011 | World Rev Nutr Diet | pmid:21865827 |
Miyazawa D et al. | Biochemical responses to dietary α-linolenic acid restriction proceed differently among brain regions in mice. | 2011 | Biomed. Res. | pmid:21878731 |
Mazaki-Tovi M et al. | Effect of omega-3 fatty acids on serum concentrations of adipokines in healthy cats. | 2011 | Am. J. Vet. Res. | pmid:21879986 |
Guesnet P et al. | α-Linolenate reduces the dietary requirement for linoleate in the growing rat. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21880475 |
Kim HW et al. | Regulation of rat brain polyunsaturated fatty acid (PUFA) metabolism during graded dietary n-3 PUFA deprivation. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21880477 |
de Batlle J et al. | Association between Ω3 and Ω6 fatty acid intakes and serum inflammatory markers in COPD. | 2012 | J. Nutr. Biochem. | pmid:21889886 |
Degen C et al. | Metabolic and growth inhibitory effects of conjugated fatty acids in the cell line HT-29 with special regard to the conversion of t11,t13-CLA. | 2011 | Biochim. Biophys. Acta | pmid:21889998 |
Shchepinov MS et al. | Isotopic reinforcement of essential polyunsaturated fatty acids diminishes nigrostriatal degeneration in a mouse model of Parkinson's disease. | 2011 | Toxicol. Lett. | pmid:21906664 |
Zhang W et al. | Crystal structure of FAS thioesterase domain with polyunsaturated fatty acyl adduct and inhibition by dihomo-gamma-linolenic acid. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21908709 |
Bocianowski J et al. | Determination of fatty acid composition in seed oil of rapeseed (Brassica napus L.) by mutated alleles of the FAD3 desaturase genes. | 2012 | J. Appl. Genet. | pmid:21912934 |
Strandvik B | The omega-6/omega-3 ratio is of importance! | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21945460 |
Bassett CM et al. | The α-linolenic acid content of flaxseed can prevent the atherogenic effects of dietary trans fat. | 2011 | Am. J. Physiol. Heart Circ. Physiol. | pmid:21963840 |
Niculescu MD et al. | Maternal α-linolenic acid availability during gestation and lactation alters the postnatal hippocampal development in the mouse offspring. | 2011 | Int. J. Dev. Neurosci. | pmid:21964326 |
Mottram AR et al. | Fatty acids antagonize bupivacaine-induced I(Na) blockade. | 2011 | Clin Toxicol (Phila) | pmid:21970771 |
Demchenko K et al. | Analysis of the subcellular localisation of lipoxygenase in legume and actinorhizal nodules. | 2012 | Plant Biol (Stuttg) | pmid:21973171 |
Miranda J et al. | cis-9,trans-11,cis-15 and cis-9,trans-13,cis-15 CLNA mixture activates PPARα in HEK293 and reduces triacylglycerols in 3T3-L1 cells. | 2011 | Lipids | pmid:21984112 |
Jackson MD et al. | Associations of whole-blood fatty acids and dietary intakes with prostate cancer in Jamaica. | 2012 | Cancer Causes Control | pmid:21984307 |
Qi J et al. | The chloroplast-localized phospholipases D α4 and α5 regulate herbivore-induced direct and indirect defenses in rice. | 2011 | Plant Physiol. | pmid:21984727 |
Beaulieu A et al. | Leptin reverts pro-apoptotic and antiproliferative effects of α-linolenic acids in BCR-ABL positive leukemic cells: involvement of PI3K pathway. | 2011 | PLoS ONE | pmid:21991326 |
Agnihotri G et al. | Structure-activity relationships in toll-like receptor 2-agonists leading to simplified monoacyl lipopeptides. | 2011 | J. Med. Chem. | pmid:22007676 |
Sauerwald UC et al. | Effect of different levels of docosahexaenoic acid supply on fatty acid status and linoleic and α-linolenic acid conversion in preterm infants. | 2012 | J. Pediatr. Gastroenterol. Nutr. | pmid:22008957 |
Thomas T et al. | The effect of a 1-year multiple micronutrient or n-3 fatty acid fortified food intervention on morbidity in Indian school children. | 2012 | Eur J Clin Nutr | pmid:22009072 |
Lebold KM et al. | Vitamin E deficiency decreases long-chain PUFA in zebrafish (Danio rerio). | 2011 | J. Nutr. | pmid:22013196 |
Gibson R and Makrides M | α-Linolenate reduces the dietary requirement for linoleate in the growing rat. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22019216 |
Giltay EJ et al. | Effects of n-3 fatty acids on depressive symptoms and dispositional optimism after myocardial infarction. | 2011 | Am. J. Clin. Nutr. | pmid:22030221 |
McCullough RS et al. | The alpha linolenic acid content of flaxseed is associated with an induction of adipose leptin expression. | 2011 | Lipids | pmid:22031167 |
Dewell A et al. | Low- and high-dose plant and marine (n-3) fatty acids do not affect plasma inflammatory markers in adults with metabolic syndrome. | 2011 | J. Nutr. | pmid:22031659 |
Hofacer R et al. | Omega-3 fatty acid deficiency increases stearoyl-CoA desaturase expression and activity indices in rat liver: positive association with non-fasting plasma triglyceride levels. | 2012 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22047910 |
Jernerén F et al. | Linolenate 9R-dioxygenase and allene oxide synthase activities of Lasiodiplodia theobromae. | 2012 | Lipids | pmid:22048860 |
Gong J et al. | Genetic variation in stearoyl-CoA desaturase 1 is associated with metabolic syndrome prevalence in Costa Rican adults. | 2011 | J. Nutr. | pmid:22049297 |
Kuhns EH et al. | A lepidopteran aminoacylase (L-ACY-1) in Heliothis virescens (Lepidoptera: Noctuidae) gut lumen hydrolyzes fatty acid-amino acid conjugates, elicitors of plant defense. | 2012 | Insect Biochem. Mol. Biol. | pmid:22056272 |
Nwaru BI et al. | Maternal intake of fatty acids during pregnancy and allergies in the offspring. | 2012 | Br. J. Nutr. | pmid:22067943 |
Decsi T and Kennedy K | Sex-specific differences in essential fatty acid metabolism. | 2011 | Am. J. Clin. Nutr. | pmid:22089435 |
Mráz J and Pickova J | Factors influencing fatty acid composition of common carp (Cyprinus carpio) muscle. | 2011 | Neuro Endocrinol. Lett. | pmid:22101873 |
Kapich AN et al. | Comparative evaluation of manganese peroxidase- and Mn(III)-initiated peroxidation of C18 unsaturated fatty acids by different methods. | 2011 | Enzyme Microb. Technol. | pmid:22112267 |