alpha-linolenic acid
Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
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Introduction
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with alpha-linolenic acid?
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
PubChem Associated disorders and diseases
What pathways are associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with alpha-linolenic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with alpha-linolenic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with alpha-linolenic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Reinders I et al. | Association of serum n-3 polyunsaturated fatty acids with C-reactive protein in men. | 2012 | Eur J Clin Nutr | pmid:22113248 |
| Järvinen R et al. | Associations of dietary polyunsaturated fatty acids with bone mineral density in elderly women. | 2012 | Eur J Clin Nutr | pmid:22113249 |
| Nandi S et al. | Effect of prostaglandin producing modulators on in vitro growth of buffalo uterine epithelial cells. | 2012 | Theriogenology | pmid:22115808 |
| Mitra K et al. | Studies of reaction variables for lipase-catalyzed production of alpha-linolenic acid enriched structured lipid and oxidative stability with antioxidants. | 2012 | J. Food Sci. | pmid:22122200 |
| Couëdelo L et al. | The fraction of α-linolenic acid present in the sn-2 position of structured triacylglycerols decreases in lymph chylomicrons and plasma triacylglycerols during the course of lipid absorption in rats. | 2012 | J. Nutr. | pmid:22131546 |
| Poudel-Tandukar K et al. | Relationship of serum fatty acid composition and desaturase activity to C-reactive protein in Japanese men and women. | 2012 | Atherosclerosis | pmid:22153152 |
| Hennessy AA et al. | The production of conjugated α-linolenic, γ-linolenic and stearidonic acids by strains of bifidobacteria and propionibacteria. | 2012 | Lipids | pmid:22160449 |
| Gupta R and Prabhune AA | Structural determination and chemical esterification of the sophorolipids produced by Candida bombicola grown on glucose and α-linolenic acid. | 2012 | Biotechnol. Lett. | pmid:22167634 |
| Padilla MN et al. | Molecular cloning, functional characterization and transcriptional regulation of a 9-lipoxygenase gene from olive. | 2012 | Phytochemistry | pmid:22169502 |
| Levitan EB et al. | α-Linolenic acid, linoleic acid and heart failure in women. | 2012 | Br. J. Nutr. | pmid:22172525 |
| Baars T et al. | Experimental improvement of cow milk fatty acid composition in organic winter diets. | 2012 | J. Sci. Food Agric. | pmid:22173628 |
| Zheng MM et al. | Immobilization of Candida rugosa lipase on hydrophobic/strong cation-exchange functional silica particles for biocatalytic synthesis of phytosterol esters. | 2012 | Bioresour. Technol. | pmid:22209442 |
| Chiu CC et al. | Associations between n-3 PUFA concentrations and cognitive function after recovery from late-life depression. | 2012 | Am. J. Clin. Nutr. | pmid:22218153 |
| Antruejo A et al. | Omega-3 enriched egg production: the effect of α -linolenic ω -3 fatty acid sources on laying hen performance and yolk lipid content and fatty acid composition. | 2011 | Br. Poult. Sci. | pmid:22221241 |
| Regensburger J et al. | Fatty acids and vitamins generate singlet oxygen under UVB irradiation. | 2012 | Exp. Dermatol. | pmid:22229443 |
| Tyagi A et al. | Attenuation of colonic inflammation by partial replacement of dietary linoleic acid with α-linolenic acid in a rat model of inflammatory bowel disease. | 2012 | Br. J. Nutr. | pmid:22243775 |
| Fekete K and Decsi T | Long-chain polyunsaturated fatty acids in inborn errors of metabolism. | 2010 | Nutrients | pmid:22254065 |
| Bradbury J | Docosahexaenoic acid (DHA): an ancient nutrient for the modern human brain. | 2011 | Nutrients | pmid:22254110 |
| Pirat C et al. | Targeting peroxisome proliferator-activated receptors (PPARs): development of modulators. | 2012 | J. Med. Chem. | pmid:22260081 |
| Aliani M et al. | Effect of flax addition on the flavor profile and acceptability of bagels. | 2012 | J. Food Sci. | pmid:22260132 |
| Huang T et al. | Effect of n-3 polyunsaturated fatty acid on gene expression of the critical enzymes involved in homocysteine metabolism. | 2012 | Nutr J | pmid:22260268 |
| Raatz SK et al. | Total dietary fat and fatty acid content modifies plasma phospholipid fatty acids, desaturase activity indices, and urinary prostaglandin E in women. | 2012 | Nutr Res | pmid:22260857 |
| Ibrahim A et al. | Dietary α-linolenic acid-rich formula reduces adhesion molecules in rats with experimental colitis. | 2012 | Nutrition | pmid:22261574 |
| Pal M and Ghosh M | Studies on comparative efficacy of α-linolenic acid and α-eleostearic acid on prevention of organic mercury-induced oxidative stress in kidney and liver of rat. | 2012 | Food Chem. Toxicol. | pmid:22269903 |
| Georgiadi A et al. | Detailed transcriptomics analysis of the effect of dietary fatty acids on gene expression in the heart. | 2012 | Physiol. Genomics | pmid:22274564 |
| He ML et al. | Feeding flaxseed in grass hay and barley silage diets to beef cows increases alpha-linolenic acid and its biohydrogenation intermediates in subcutaneous fat. | 2012 | J. Anim. Sci. | pmid:22274861 |
| Longvah T et al. | Eri silkworm: a source of edible oil with a high content of α-linolenic acid and of significant nutritional value. | 2012 | J. Sci. Food Agric. | pmid:22290445 |
| Sun T et al. | Meat fatty acid and cholesterol level of free-range broilers fed on grasshoppers on alpine rangeland in the Tibetan Plateau. | 2012 | J. Sci. Food Agric. | pmid:22318921 |
| Deckelbaum RJ and Torrejon C | The omega-3 fatty acid nutritional landscape: health benefits and sources. | 2012 | J. Nutr. | pmid:22323763 |
| Larsen MK et al. | Fatty acid, tocopherol and carotenoid content in herbage and milk affected by sward composition and season of grazing. | 2012 | J. Sci. Food Agric. | pmid:22337263 |
| Vyncke KE et al. | Dietary fatty acid intake, its food sources and determinants in European adolescents: the HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) Study. | 2012 | Br. J. Nutr. | pmid:22370331 |
| Park HG et al. | Production of a conjugated fatty acid by Bifidobacterium breve LMC520 from α-linolenic acid: conjugated linolenic acid (CLnA). | 2012 | J. Agric. Food Chem. | pmid:22372442 |
| Liu HL et al. | Identification and evaluation of ω-3 fatty acid desaturase genes for hyperfortifying α-linolenic acid in transgenic rice seed. | 2012 | J. Exp. Bot. | pmid:22378946 |
| Castro LF et al. | Functional desaturase Fads1 (Δ5) and Fads2 (Δ6) orthologues evolved before the origin of jawed vertebrates. | 2012 | PLoS ONE | pmid:22384110 |
| Caspar-Bauguil S et al. | Anorexia nervosa patients display a deficit in membrane long chain poly-unsaturated fatty acids. | 2012 | Clin Nutr | pmid:22385730 |
| Gao F et al. | Aging decreases rate of docosahexaenoic acid synthesis-secretion from circulating unesterified α-linolenic acid by rat liver. | 2013 | Age (Dordr) | pmid:22388930 |
| Tu WC et al. | Barramundi (Lates calcarifer) desaturase with Δ6/Δ8 dual activities. | 2012 | Biotechnol. Lett. | pmid:22391738 |
| Gorissen L et al. | Conjugated linoleic and linolenic acid production kinetics by bifidobacteria differ among strains. | 2012 | Int. J. Food Microbiol. | pmid:22405353 |
| Jiang MH et al. | Comparative GC/MS analysis of essential oils extracted by 3 methods from the bud of Citrus aurantium L. var. amara Engl. | 2011 Nov-Dec | J. Food Sci. | pmid:22416680 |
| Jung DM et al. | A gas chromatography-tandem quadrupole mass spectrometric analysis of policosanols in commercial vegetable oils. | 2011 | J. Food Sci. | pmid:22417487 |
| Yalcin H et al. | Effect of γ-irradiation on bioactivity, fatty acid compositions and volatile compounds of clary sage seed (Salvia sclarea L.). | 2011 | J. Food Sci. | pmid:22417543 |
| Karppi J et al. | Serum β-carotene in relation to risk of prostate cancer: the Kuopio Ischaemic Heart Disease Risk Factor study. | 2012 | Nutr Cancer | pmid:22420939 |
| Luo ZM et al. | A new norisoprenoid and other compounds from Fuzhuan brick tea. | 2012 | Molecules | pmid:22430120 |
| Chen T et al. | Analytical characterization of Hempseed (seed of Cannabis sativa L.) oil from eight regions in China. | 2010 | J Diet Suppl | pmid:22435611 |
| Smink W et al. | Linoleic and α-linolenic acid as precursor and inhibitor for the synthesis of long-chain polyunsaturated fatty acids in liver and brain of growing pigs. | 2012 | Animal | pmid:22436184 |
| Ogawa N et al. | Intestinal fatty acid infusion modulates food preference as well as calorie intake via the vagal nerve and midbrain-hypothalamic neural pathways in rats. | 2012 | Metab. Clin. Exp. | pmid:22445513 |
| Du Q et al. | Dairy fat blends high in α-linolenic acid are superior to n-3 fatty-acid-enriched palm oil blends for increasing DHA levels in the brains of young rats. | 2012 | J. Nutr. Biochem. | pmid:22445803 |
| Miyake Y et al. | Dietary meat and fat intake and prevalence of rhinoconjunctivitis in pregnant Japanese women: baseline data from the Kyushu Okinawa Maternal and Child Health Study. | 2012 | Nutr J | pmid:22449171 |
| Zhang G et al. | Erythrocyte n-3 fatty acids and metabolic syndrome in middle-aged and older Chinese. | 2012 | J. Clin. Endocrinol. Metab. | pmid:22456621 |
| Ishida Y et al. | Validation of thermally assisted hydrolysis and methylation-gas chromatography using a vertical microfurnace pyrolyzer for the compositional analysis of Fatty Acid components in microalgae. | 2012 | J. Agric. Food Chem. | pmid:22458968 |
| Mirmiran P et al. | Association between interaction and ratio of ω-3 and ω-6 polyunsaturated fatty acid and the metabolic syndrome in adults. | 2012 | Nutrition | pmid:22459553 |
| Smink W et al. | Effect of intake of linoleic acid and α-linolenic acid levels on conversion into long-chain polyunsaturated fatty acids in backfat and in intramuscular fat of growing pigs. | 2013 | J Anim Physiol Anim Nutr (Berl) | pmid:22463497 |
| Astiz M et al. | Exogenous arachidonate restores the dimethoate-induced inhibition of steroidogenesis in rat interstitial cells. | 2012 | Lipids | pmid:22476691 |
| Pham AT et al. | Combinations of mutant FAD2 and FAD3 genes to produce high oleic acid and low linolenic acid soybean oil. | 2012 | Theor. Appl. Genet. | pmid:22476873 |
| Rosa DD et al. | Fish oil improves the lipid profile and reduces inflammatory cytokines in Wistar rats with precancerous colon lesions. | 2012 | Nutr Cancer | pmid:22483364 |
| Nakamura YK et al. | Modulation of oxidative stress by γ-glutamylcysteine (GGC) and conjugated linoleic acid (CLA) isomer mixture in human umbilical vein endothelial cells. | 2012 | Food Chem. Toxicol. | pmid:22490668 |
| Zhang LH et al. | [Effects of alpha-linolenic acid on inflammation and oxidative stress in the diabetic rats]. | 2012 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:22493899 |
| Ling PR et al. | Purified fish oil eliminating linoleic and alpha linolenic acid meets essential fatty acid requirements in rats. | 2012 | Metab. Clin. Exp. | pmid:22512821 |
| Gibson RA et al. | Docosahexaenoic acid synthesis from alpha-linolenic acid is inhibited by diets high in polyunsaturated fatty acids. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22515943 |
| Shimpukade B et al. | Discovery of a potent and selective GPR120 agonist. | 2012 | J. Med. Chem. | pmid:22519963 |
| Tu WC et al. | Correlations between blood and tissue omega-3 LCPUFA status following dietary ALA intervention in rats. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22521090 |
| Shinohara N et al. | Jacaric acid, a linolenic acid isomer with a conjugated triene system, has a strong antitumor effect in vitro and in vivo. | 2012 | Biochim. Biophys. Acta | pmid:22521763 |
| Yang Q et al. | Identification of FAD2 and FAD3 genes in Brassica napus genome and development of allele-specific markers for high oleic and low linolenic acid contents. | 2012 | Theor. Appl. Genet. | pmid:22534790 |
| von Berlepsch S et al. | The acyl-acyl carrier protein synthetase from Synechocystis sp. PCC 6803 mediates fatty acid import. | 2012 | Plant Physiol. | pmid:22535424 |
| Jin F et al. | Supplementation of milled chia seeds increases plasma ALA and EPA in postmenopausal women. | 2012 | Plant Foods Hum Nutr | pmid:22538527 |
| Fatima T et al. | Fatty acid composition of developing sea buckthorn (Hippophae rhamnoides L.) berry and the transcriptome of the mature seed. | 2012 | PLoS ONE | pmid:22558083 |
| Msika O et al. | NGF blocks polyunsaturated fatty acids biosynthesis in n-3 fatty acid-supplemented PC12 cells. | 2012 | Biochim. Biophys. Acta | pmid:22564256 |
| Lakshmanan V et al. | Metabolomic analysis of patient plasma yields evidence of plant-like α-linolenic acid metabolism in Plasmodium falciparum. | 2012 | J. Infect. Dis. | pmid:22566569 |
| Warstedt K and Duchén K | Increased linoleic acid/α-linolenic acid ratio in Swedish cord blood samples collected between 1985 and 2005. | 2013 | Eur J Nutr | pmid:22584414 |
| Valentine CJ | Maternal dietary DHA supplementation to improve inflammatory outcomes in the preterm infant. | 2012 | Adv Nutr | pmid:22585914 |
| González-Mañán D et al. | Bioconversion of α-linolenic acid to n-3 LCPUFA and expression of PPAR-alpha, acyl Coenzyme A oxidase 1 and carnitine acyl transferase I are incremented after feeding rats with α-linolenic acid-rich oils. | 2012 | Food Funct | pmid:22588205 |
| Patarra RF et al. | Fatty acid composition of selected macrophytes. | 2013 | Nat. Prod. Res. | pmid:22591127 |
| Gerber M | Omega-3 fatty acids and cancers: a systematic update review of epidemiological studies. | 2012 | Br. J. Nutr. | pmid:22591896 |
| Jiang M et al. | [Protective effect of ALA on high glucose induced cellular injury of LLC-PK1 cell]. | 2012 | Wei Sheng Yan Jiu | pmid:22611923 |
| Ngaki MN et al. | Evolution of the chalcone-isomerase fold from fatty-acid binding to stereospecific catalysis. | 2012 | Nature | pmid:22622584 |
| Moodley R et al. | Elemental composition and fatty acid profile of the edible fruits of Amatungula (Carissa macrocarpa) and impact of soil quality on chemical characteristics. | 2012 | Anal. Chim. Acta | pmid:22632042 |
| Vecchio AJ et al. | Investigating substrate promiscuity in cyclooxygenase-2: the role of Arg-120 and residues lining the hydrophobic groove. | 2012 | J. Biol. Chem. | pmid:22637474 |
| Tu WC et al. | An alternative n-3 fatty acid elongation pathway utilising 18:3n-3 in barramundi (Lates calcarifer). | 2012 | Biochem. Biophys. Res. Commun. | pmid:22640739 |
| Monteiro J et al. | Menhaden oil, but not safflower or soybean oil, aids in restoring the polyunsaturated fatty acid profile in the novel delta-6-desaturase null mouse. | 2012 | Lipids Health Dis | pmid:22642787 |
| Chen CY and Inui A | What kind of polyunsaturated fatty acid should we eat to stay healthy? | 2012 | Nutrition | pmid:22658641 |
| Gómez-Cortés P et al. | Production of isotopically labeled standards from a uniformly labeled precursor for quantitative volatile metabolomic studies. | 2012 | Anal. Chem. | pmid:22662968 |
| Erdinest N et al. | Anti-inflammatory effects of alpha linolenic acid on human corneal epithelial cells. | 2012 | Invest. Ophthalmol. Vis. Sci. | pmid:22669722 |
| Pal M and Ghosh M | Prophylactic effect of α-linolenic acid and α-eleostearic acid against MeHg induced oxidative stress, DNA damage and structural changes in RBC membrane. | 2012 | Food Chem. Toxicol. | pmid:22683484 |
| Passos PP et al. | Dopaminergic cell populations of the rat substantia nigra are differentially affected by essential fatty acid dietary restriction over two generations. | 2012 | J. Chem. Neuroanat. | pmid:22687395 |
| Zhang H et al. | A mechanism underlying the effects of polyunsaturated fatty acids on breast cancer. | 2012 | Int. J. Mol. Med. | pmid:22692672 |
| Kronberg SL et al. | Treatment of flaxseed to reduce biohydrogenation of α-linolenic acid by ruminal microbes in sheep and cattle, and increase n-3 fatty acid concentrations in red meat. | 2012 | J. Anim. Sci. | pmid:22696616 |
| Marei WF et al. | Differential effects of linoleic and alpha-linolenic fatty acids on spatial and temporal mitochondrial distribution and activity in bovine oocytes. | 2012 | Reprod. Fertil. Dev. | pmid:22697118 |
| Turchini GM et al. | Jumping on the omega-3 bandwagon: distinguishing the role of long-chain and short-chain omega-3 fatty acids. | 2012 | Crit Rev Food Sci Nutr | pmid:22698270 |
| Maqbool A et al. | Relation between dietary fat intake type and serum fatty acid status in children with cystic fibrosis. | 2012 | J. Pediatr. Gastroenterol. Nutr. | pmid:22699835 |
| Botsoglou E et al. | Lipid and protein oxidation of α-linolenic acid-enriched pork during refrigerated storage as influenced by diet supplementation with olive leaves (Olea europea L.) or α-tocopheryl acetate. | 2012 | Meat Sci. | pmid:22710099 |
| Botsoglou E et al. | Olive leaves (Olea europea L.) and α-tocopheryl acetate as feed antioxidants for improving the oxidative stability of α-linolenic acid-enriched eggs. | 2013 | J Anim Physiol Anim Nutr (Berl) | pmid:22716021 |
| Moallem U and Zachut M | Short communication: the effects of supplementation of various n-3 fatty acids to late-pregnant dairy cows on plasma fatty acid composition of the newborn calves. | 2012 | J. Dairy Sci. | pmid:22720961 |
| Lemaitre RN et al. | Circulating and dietary α-linolenic acid and incidence of congestive heart failure in older adults: the Cardiovascular Health Study. | 2012 | Am. J. Clin. Nutr. | pmid:22743310 |
| Zhang L et al. | Quantitative genomics of 30 complex phenotypes in Wagyu x Angus Fâ‚ progeny. | 2012 | Int. J. Biol. Sci. | pmid:22745575 |
| Fink BD et al. | Endothelial cell and platelet bioenergetics: effect of glucose and nutrient composition. | 2012 | PLoS ONE | pmid:22745753 |
| Janssen S et al. | Sensing of fatty acids for octanoylation of ghrelin involves a gustatory G-protein. | 2012 | PLoS ONE | pmid:22768248 |
| Garneau V et al. | Omega-3 fatty acids status in human subjects estimated using a food frequency questionnaire and plasma phospholipids levels. | 2012 | Nutr J | pmid:22775977 |
| Shen J et al. | Effect of essential fatty acids on glucose-induced cytotoxicity to retinal vascular endothelial cells. | 2012 | Lipids Health Dis | pmid:22781401 |
| Gladine C et al. | Optimized rapeseed oil enriched with healthy micronutrients: a relevant nutritional approach to prevent cardiovascular diseases. Results of the Optim'Oils randomized intervention trial. | 2013 | J. Nutr. Biochem. | pmid:22784432 |
| Egert S et al. | Margarines fortified with α-linolenic acid, eicosapentaenoic acid, or docosahexaenoic acid alter the fatty acid composition of erythrocytes but do not affect the antioxidant status of healthy adults. | 2012 | J. Nutr. | pmid:22810989 |