Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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pmid:28582540 | ||||
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pmid:28605735 | ||||
Das UN | Antibiotic-like action of essential fatty acids. | 1985 | Can Med Assoc J | pmid:2860965 |
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pmid:28628798 | ||||
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pmid:28643621 | ||||
Morisaki N et al. | Metabolism of n-3 polyunsaturated fatty acids and modification of phospholipids in cultured rabbit aortic smooth muscle cells. | 1985 | J. Lipid Res. | pmid:2864379 |
pmid:28646265 | ||||
Budowski P and Crawford MA | a-Linolenic acid as a regulator of the metabolism of arachidonic acid: dietary implications of the ratio, n-6:n-3 fatty acids. | 1985 | Proc Nutr Soc | pmid:2864692 |
pmid:28651693 | ||||
pmid:28651694 | ||||
Crutchley DJ | Hydroxyeicosatetraenoic acids and other unsaturated fatty acids inhibit endotoxin-induced thromboplastin activity in human monocytes. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2865954 |
Stymne S and Stobart AK | Involvement of acyl exchange between acyl-CoA and phosphatidylcholine in the remodelling of phosphatidylcholine in microsomal preparations of rat lung. | 1985 | Biochim. Biophys. Acta | pmid:2865978 |
pmid:28660529 | ||||
Booyens J et al. | Chronic arachidonic acid eicosanoid imbalance: a common feature in coronary artery disease, hypercholesterolemia, cancer and other important diseases. Significance of desaturase enzyme inhibition and of the arachidonic acid desaturase-independent pathway. | 1985 | Med. Hypotheses | pmid:2866439 |
Siegel I et al. | Inhibition of sperm motility and agglutination of sperm cells by free fatty acids in whole semen. | 1986 | Fertil. Steril. | pmid:2868925 |
Pisanti FA et al. | Effects of bonellin on lipids. | 1986 | Life Sci. | pmid:2869393 |
Johnston NW | Chronic degenerative radiculomyelopathy therapy. | 1985 Dec 21-28 | Vet. Rec. | pmid:2869606 |
Leikin AI and Brenner RR | Regulation of linoleic acid delta 6-desaturation by a cytosolic lipoprotein-like fraction in isolated rat liver microsomes. | 1986 | Biochim. Biophys. Acta | pmid:2869785 |
Tabachnick M and Korcek L | Effect of long-chain fatty acids on the binding of thyroxine and triiodothyronine to human thyroxine-binding globulin. | 1986 | Biochim. Biophys. Acta | pmid:2869786 |
pmid:28703829 | ||||
Carlson SE et al. | High fat diets varying in ratios of polyunsaturated to saturated fatty acid and linoleic to linolenic acid: a comparison of rat neural and red cell membrane phospholipids. | 1986 | J. Nutr. | pmid:2871142 |
Hagve TA et al. | Desaturation and chain elongation of essential fatty acids in isolated liver cells from rat and rainbow trout. | 1986 | Lipids | pmid:2871473 |
Dyerberg J | Linolenate-derived polyunsaturated fatty acids and prevention of atherosclerosis. | 1986 | Nutr. Rev. | pmid:2872640 |
Cholesterol metabolism and omega-3 polyenes in fish oils. | 1986 | Nutr. Rev. | pmid:2872641 | |
Leat WM et al. | Retinal function in rats and guinea-pigs reared on diets low in essential fatty acids and supplemented with linoleic or linolenic acids. | 1986 | Ann. Nutr. Metab. | pmid:2872851 |
Meadows J et al. | Uric acid protects membranes and linolenic acid from ozone-induced oxidation. | 1986 | Biochem. Biophys. Res. Commun. | pmid:2872893 |
Jenkins KJ and Kramer JK | Influence of low linoleic and linolenic acids in milk replacer on calf performance and lipids in blood plasma, heart, and liver. | 1986 | J. Dairy Sci. | pmid:2873158 |
Carlin G | Peroxidation of linolenic acid promoted by human polymorphonuclear leucocytes. | 1985 | J Free Radic Biol Med | pmid:2873164 |
Adam O et al. | Effect of alpha-linolenic acid in the human diet on linoleic acid metabolism and prostaglandin biosynthesis. | 1986 | J. Lipid Res. | pmid:2873197 |
Takahashi K et al. | Polyethylene glycol-modified hemin having peroxidase activity in organic solvents. | 1986 | Biochem. Biophys. Res. Commun. | pmid:2874801 |
Towell JF | An animated graphics program depicting the steps in lipid peroxidation. | 1985 | J Free Radic Biol Med | pmid:2875091 |
Berry EM and Hirsch J | Does dietary linolenic acid influence blood pressure? | 1986 | Am. J. Clin. Nutr. | pmid:2875645 |
Nouvelot A et al. | Hepatic metabolism of dietary alpha-linolenic acid in suckling rats, and its possible importance in polyunsaturated fatty acid uptake by the brain. | 1986 | Ann. Nutr. Metab. | pmid:2875687 |
pmid:28764049 | ||||
Nakamoto S et al. | Lipid peroxidation and cytotoxicity of Ehrlich ascites tumor cells by ferric nitrilotriacetate. | 1986 | Biochim. Biophys. Acta | pmid:2876731 |
Acosta PB and Stepnick-Gropper S | Problems related to diet management of maternal phenylketonuria. | 1986 | J. Inherit. Metab. Dis. | pmid:2877116 |
Guesnet P et al. | Dietary alpha-linolenic acid deficiency in the rat. I. Effects on reproduction and postnatal growth. | 1986 | Reprod Nutr Dev | pmid:2877477 |
Hiltunen JK et al. | beta-Oxidation of polyunsaturated fatty acids by rat liver peroxisomes. A role for 2,4-dienoyl-coenzyme A reductase in peroxisomal beta-oxidation. | 1986 | J. Biol. Chem. | pmid:2877988 |
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Johnston PV and Fritsche KL | Linolenate metabolism. | 1986 | Nutr. Rev. | pmid:2878403 |