alpha-linolenic acid
Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
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Introduction
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with alpha-linolenic acid?
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
PubChem Associated disorders and diseases
What pathways are associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with alpha-linolenic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with alpha-linolenic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with alpha-linolenic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Uauy R et al. | Safety and efficacy of omega-3 fatty acids in the nutrition of very low birth weight infants: soy oil and marine oil supplementation of formula. | 1994 | J. Pediatr. | pmid:7908693 |
| Mourente G and Tocher DR | In vivo metabolism of [1-14C]linolenic acid (18:3(n-3)) and [1-14C]eicosapentaenoic acid (20:5(n-3)) in a marine fish: time-course of the desaturation/elongation pathway. | 1994 | Biochim. Biophys. Acta | pmid:7908832 |
| Narisawa T et al. | Colon cancer prevention with a small amount of dietary perilla oil high in alpha-linolenic acid in an animal model. | 1994 | Cancer | pmid:7908858 |
| Mibu H et al. | A study on lipid peroxide-induced lens damage in vitro. | 1994 | Exp. Eye Res. | pmid:7908884 |
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| Grandgirard A et al. | Incorporation of trans long-chain n-3 polyunsaturated fatty acids in rat brain structures and retina. | 1994 | Lipids | pmid:7909911 |
| Laethem RM et al. | Epoxidation of arachidonic acid as an active-site probe of cytochrome P-450 2B isoforms. | 1994 | Biochim. Biophys. Acta | pmid:7910485 |
| Ohta S et al. | Anti methicillin-resistant Staphylococcus aureus (MRSA) activity by linolenic acid isolated from the marine microalga Chlorococcum HS-101. | 1994 | Bull Environ Contam Toxicol | pmid:7910498 |
| Franke AA et al. | Effects of micronutrients and antioxidants on lipid peroxidation in human plasma and in cell culture. | 1994 | Cancer Lett. | pmid:7910514 |
| Huang YS et al. | Differences in the metabolism of 18:2n-6 and 18:3n-6 by the liver and kidney may explain the anti-hypertensive effect of 18:3n-6. | 1994 | Biochem. Med. Metab. Biol. | pmid:7910749 |
| Mantzioris E et al. | Dietary substitution with an alpha-linolenic acid-rich vegetable oil increases eicosapentaenoic acid concentrations in tissues. | 1994 | Am. J. Clin. Nutr. | pmid:7910999 |
| Anderson GJ and Connor WE | Accretion of n-3 fatty acids in the brain and retina of chicks fed a low-linolenic acid diet supplemented with docosahexaenoic acid. | 1994 | Am. J. Clin. Nutr. | pmid:7911000 |
| McKeigue P | Diets for secondary prevention of coronary heart disease: can linolenic acid substitute for oily fish? | 1994 | Lancet | pmid:7911171 |
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| Yehuda S et al. | Essential fatty acid preparation (SR-3) raises the seizure threshold in rats. | 1994 | Eur. J. Pharmacol. | pmid:7911428 |
| Chen Q and Nilsson A | Interconversion of alpha-linolenic acid in rat intestinal mucosa: studies in vivo and in isolated villus and crypt cells. | 1994 | J. Lipid Res. | pmid:7911819 |
| Caffieri S et al. | Psoralen-fatty acid cycloadducts activate protein kinase C (PKC) in human platelets. | 1994 | J. Photochem. Photobiol. B, Biol. | pmid:7912265 |
| Lapenna D et al. | Hypochlorous acid-induced zinc release from thiolate bonds: a potential protective mechanism towards biomolecules oxidant damage during inflammation. | 1994 | Free Radic. Res. | pmid:7912612 |
| Yang X and Dick TA | Dietary alpha-linolenic and linoleic acids competitively affect metabolism of polyunsaturated fatty acids in Arctic charr (Salvelinus alpinus). | 1994 | J. Nutr. | pmid:7913126 |
| Makrides M et al. | Fatty acid composition of brain, retina, and erythrocytes in breast- and formula-fed infants. | 1994 | Am. J. Clin. Nutr. | pmid:7913291 |
| Crastes de Paulet A et al. | [Biological effects on premature neonates of a milk formula enriched with alpha-linolenic acid: a multicenter study]. | 1994 | Bull. Acad. Natl. Med. | pmid:7913655 |
| Emken EA et al. | Dietary linoleic acid influences desaturation and acylation of deuterium-labeled linoleic and linolenic acids in young adult males. | 1994 | Biochim. Biophys. Acta | pmid:7914092 |
| Mantzioris E et al. | Mediterranean diet. | 1994 | Lancet | pmid:7914327 |
| Yang J et al. | Application of the balance method to determining accumulation, metabolism, and apparent oxidation of linoleic and alpha-linolenic acids in the pregnant rat. | 1994 | Metab. Clin. Exp. | pmid:7914345 |
| Yamaguchi Y et al. | Preventive effects of magnesium on raised serum lipid peroxide levels and aortic cholesterol deposition in mice fed an atherogenic diet. | 1994 | Magnes Res | pmid:7914418 |
| Bougnoux P et al. | alpha-Linolenic acid content of adipose breast tissue: a host determinant of the risk of early metastasis in breast cancer. | 1994 | Br. J. Cancer | pmid:7914425 |
| Sacks GS et al. | Failure of topical vegetable oils to prevent essential fatty acid deficiency in a critically ill patient receiving long-term parenteral nutrition. | 1994 May-Jun | JPEN J Parenter Enteral Nutr | pmid:7914941 |
| Cunnane SC and McIntosh D | alpha-Linolenic acid and reduction of cardiac deaths. | 1994 | Lancet | pmid:7914995 |
| Marckmann P and Jespersen J | alpha-Linolenic acid and reduction of cardiac deaths. | 1994 | Lancet | pmid:7914996 |
| Ulmann L et al. | Incorporation of delta 6- and delta 5-desaturation fatty acids in liver microsomal lipid classes of obese Zucker rats fed n - 6 or n - 3 fatty acids. | 1994 | Biochim. Biophys. Acta | pmid:7915142 |
| Watanabe S et al. | A high alpha-linolenate diet suppresses antigen-induced immunoglobulin E response and anaphylactic shock in mice. | 1994 | J. Nutr. | pmid:7916376 |
| Winters BL et al. | Linolenic acid provides a source of docosahexaenoic acid for artificially reared rat pups. | 1994 | J. Nutr. | pmid:7916377 |
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| Ackman RG | alpha-Linolenic acid in human adipose tissue. | 1994 | Lipids | pmid:7916440 |
| Stillwell W et al. | Cholesterol condensation of alpha-linolenic and gamma-linolenic acid-containing phosphatidylcholine monolayers and bilayers. | 1994 | Biochim. Biophys. Acta | pmid:7918592 |
| Mlakar A and Spiteller G | Reinvestigation of lipid peroxidation of linolenic acid. | 1994 | Biochim. Biophys. Acta | pmid:7918602 |
| del Carmen Boyano-Adánez M et al. | Protein kinase C-mediated phospholipase D activity is increased by linolenic acid supplementation in NG 108-15 cells. | 1994 | Biochim. Biophys. Acta | pmid:7918608 |
| Yuasa H et al. | Evaluation of milk fat-globule membrane (MFGM) emulsion for oral administration: absorption of alpha-linolenic acid in rats and the effect of emulsion droplet size. | 1994 | Biol. Pharm. Bull. | pmid:7920450 |
| Richieri GV et al. | Equilibrium constants for the binding of fatty acids with fatty acid-binding proteins from adipocyte, intestine, heart, and liver measured with the fluorescent probe ADIFAB. | 1994 | J. Biol. Chem. | pmid:7929039 |
| Ikeda I et al. | alpha-Linolenic, eicosapentaenoic and docosahexaenoic acids affect lipid metabolism differently in rats. | 1994 | J. Nutr. | pmid:7931698 |
| Brown RO et al. | Comparison of specialized and standard enteral formulas in trauma patients. | 1994 May-Jun | Pharmacotherapy | pmid:7937272 |
| Oe H et al. | Calcium overload and cardiac myocyte cell damage induced by arachidonate lipoxygenation. | 1994 | Am. J. Physiol. | pmid:7943384 |
| Macrì F et al. | Lipoxygenase activity associated to isolated soybean plasma membranes. | 1994 | Biochim. Biophys. Acta | pmid:7947991 |
| Gibson RA et al. | Ratios of linoleic acid to alpha-linolenic acid in formulas for term infants. | 1994 | J. Pediatr. | pmid:7965453 |
| Yang JG et al. | Determination of the contents of EPA and DHA and lipid constituents in main fresh water fishes in China. | 1994 | J. Tongji Med. Univ. | pmid:7966518 |
| Bourre JM et al. | Function of dietary polyunsaturated fatty acids in the nervous system. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8093816 |
| Nakashima Y et al. | Effect of a high linoleate and a high alpha-linolenate diet on general behavior and drug sensitivity in mice. | 1993 | J. Lipid Res. | pmid:8094090 |
| Hanai T et al. | Comparison of prostanoids and their precursor fatty acids in human hepatocellular carcinoma and noncancerous reference tissues. | 1993 | J. Surg. Res. | pmid:8094103 |
| Ferrari-Iliou R et al. | In vitro photodynamic lipid peroxidation of total lipophilic extracts from leaves of bean plants. | 1993 | Biochim. Biophys. Acta | pmid:8094299 |
| Cantrill RC et al. | Comparison of the metabolism of alpha-linolenic acid and its delta 6 desaturation product, stearidonic acid, in cultured NIH-3T3 cells. | 1993 | Lipids | pmid:8096621 |