alpha-linolenic acid

Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.

Cross Reference

Introduction

To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with alpha-linolenic acid?

alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Adenoma D000236 40 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Amyloidosis D000686 4 associated lipids
Aortic Diseases D001018 11 associated lipids
Arteriosclerosis D001161 86 associated lipids
Arthritis D001168 41 associated lipids
Atrial Fibrillation D001281 16 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Birth Weight D001724 23 associated lipids
Urinary Bladder Neoplasms D001749 7 associated lipids
Body Weight D001835 333 associated lipids
Breast Neoplasms D001943 24 associated lipids
Bronchial Spasm D001986 18 associated lipids
Cat Diseases D002371 12 associated lipids
Cattle Diseases D002418 24 associated lipids
Brain Ischemia D002545 89 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Conjunctivitis, Allergic D003233 1 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Coronary Disease D003327 70 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Deficiency Diseases D003677 12 associated lipids
Dermatitis D003872 30 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Angiopathies D003925 20 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Edema D004487 152 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Endomyocardial Fibrosis D004719 4 associated lipids
Epilepsy D004827 35 associated lipids
Mental Fatigue D005222 3 associated lipids
Fatty Liver D005234 48 associated lipids
Hearing Loss, High-Frequency D006316 1 associated lipids
Heart Failure D006333 36 associated lipids
Hemolysis D006461 131 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Hyperlipidemias D006949 73 associated lipids
Hyperlipidemia, Familial Combined D006950 9 associated lipids
Hypersensitivity D006967 22 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Hypertension D006973 115 associated lipids
Inflammation D007249 119 associated lipids
Insect Bites and Stings D007299 4 associated lipids
Insulin Resistance D007333 99 associated lipids
Learning Disorders D007859 11 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Liver Diseases D008107 31 associated lipids
Long QT Syndrome D008133 10 associated lipids
Lung Neoplasms D008175 171 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Myocardial Infarction D009203 21 associated lipids
Neoplasms D009369 13 associated lipids
Neuroblastoma D009447 66 associated lipids
Night Blindness D009755 1 associated lipids
Otorhinolaryngologic Neoplasms D010039 2 associated lipids
Pain D010146 64 associated lipids
Exocrine Pancreatic Insufficiency D010188 6 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Pancytopenia D010198 6 associated lipids
Paraplegia D010264 8 associated lipids
Adenomatous Polyposis Coli D011125 16 associated lipids
Precancerous Conditions D011230 48 associated lipids
Pregnancy Complications D011248 19 associated lipids
Prostatic Hyperplasia D011470 20 associated lipids
Pseudomonas Infections D011552 25 associated lipids
Retinal Degeneration D012162 9 associated lipids
Retinitis Pigmentosa D012174 6 associated lipids
Retinoblastoma D012175 12 associated lipids
Sebaceous Gland Neoplasms D012626 2 associated lipids
Seizures D012640 87 associated lipids
Stomatitis, Aphthous D013281 1 associated lipids
Thrombosis D013927 49 associated lipids
Tuberculosis D014376 20 associated lipids
Ventricular Fibrillation D014693 16 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Colorectal Neoplasms D015179 10 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Weight Gain D015430 101 associated lipids
Torsades de Pointes D016171 2 associated lipids
Death, Sudden, Cardiac D016757 12 associated lipids
Malaria, Falciparum D016778 22 associated lipids
Tachycardia, Ventricular D017180 9 associated lipids
Community-Acquired Infections D017714 8 associated lipids
Carcinoma, Ductal, Breast D018270 19 associated lipids
Depression, Postpartum D019052 3 associated lipids
Aging, Premature D019588 1 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Neurotoxicity Syndromes D020258 34 associated lipids
Stroke D020521 32 associated lipids
Spinal Cord Ischemia D020760 2 associated lipids
Dyskinesias D020820 3 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Vitamin B 6 Deficiency D026681 10 associated lipids
Per page 10 20 50 100 | Total 104

PubChem Associated disorders and diseases

What pathways are associated with alpha-linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with alpha-linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with alpha-linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with alpha-linolenic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with alpha-linolenic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with alpha-linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with alpha-linolenic acid

Download all related citations
Per page 10 20 50 100 | Total 2471
Authors Title Published Journal PubMed Link
Szabó E et al. trans Octadecenoic acid and trans octadecadienoic acid are inversely related to long-chain polyunsaturates in human milk: results of a large birth cohort study. 2007 Am. J. Clin. Nutr. pmid:17490969
Hunter JE n-3 fatty acids from vegetable oils. 1990 Am. J. Clin. Nutr. pmid:1970702
Simon JA et al. The relation of alpha-linolenic acid to the risk of prostate cancer: a systematic review and meta-analysis. 2009 Am. J. Clin. Nutr. pmid:19321563
Vos E et al. alpha-Linolenic acid and fish oil n-3 fatty acids and cardiovascular disease risk. 2007 Am. J. Clin. Nutr. pmid:17344517
Visioli F and Galli C Alpha-linolenic acid and cardiovascular disease. 2002 Am. J. Clin. Nutr. pmid:12036822
Rajaram S Health benefits of plant-derived α-linolenic acid. 2014 Am. J. Clin. Nutr. pmid:24898228
Wang C et al. n-3 Fatty acids from fish or fish-oil supplements, but not alpha-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: a systematic review. 2006 Am. J. Clin. Nutr. pmid:16825676
Djoussé L et al. Dietary linolenic acid and carotid atherosclerosis: the National Heart, Lung, and Blood Institute Family Heart Study. 2003 Am. J. Clin. Nutr. pmid:12663278
Renaud SC and Lanzmann-Petithory D The beneficial effect of alpha-linolenic acid in coronary artery disease is not questionable. 2002 Am. J. Clin. Nutr. pmid:12324307
Devore EE et al. Dietary intake of fish and omega-3 fatty acids in relation to long-term dementia risk. 2009 Am. J. Clin. Nutr. pmid:19474131
Bjerve KS et al. alpha-Linolenic acid and long-chain omega-3 fatty acid supplementation in three patients with omega-3 fatty acid deficiency: effect on lymphocyte function, plasma and red cell lipids, and prostanoid formation. 1989 Am. J. Clin. Nutr. pmid:2563625
Hennig B and Watkins BA Linoleic acid and linolenic acid: effect on permeability properties of cultured endothelial cell monolayers. 1989 Am. J. Clin. Nutr. pmid:2563626
DeLany JP et al. Differential oxidation of individual dietary fatty acids in humans. 2000 Am. J. Clin. Nutr. pmid:11010930
Mantzioris E et al. Differences exist in the relationships between dietary linoleic and alpha-linolenic acids and their respective long-chain metabolites. 1995 Am. J. Clin. Nutr. pmid:7840069
Innis SM and Elias SL Intakes of essential n-6 and n-3 polyunsaturated fatty acids among pregnant Canadian women. 2003 Am. J. Clin. Nutr. pmid:12540410
Vos E and Cunnane SC Alpha-linolenic acid, linoleic acid, coronary artery disease, and overall mortality. 2003 Am. J. Clin. Nutr. pmid:12540417
Leitzmann MF et al. Dietary intake of n-3 and n-6 fatty acids and the risk of prostate cancer. 2004 Am. J. Clin. Nutr. pmid:15213050
Finnegan YE et al. Plant- and marine-derived n-3 polyunsaturated fatty acids have differential effects on fasting and postprandial blood lipid concentrations and on the susceptibility of LDL to oxidative modification in moderately hyperlipidemic subjects. 2003 Am. J. Clin. Nutr. pmid:12663273
Granot E et al. Breast-fed and formula-fed infants do not differ in immunocompetent cell cytokine production despite differences in cell membrane fatty acid composition. 2000 Am. J. Clin. Nutr. pmid:11063450
Berry EM and Hirsch J Does dietary linolenic acid influence blood pressure? 1986 Am. J. Clin. Nutr. pmid:2875645
Vedtofte MS et al. Dietary α-linolenic acid, linoleic acid, and n-3 long-chain PUFA and risk of ischemic heart disease. 2011 Am. J. Clin. Nutr. pmid:21865326
Djoussé L et al. Dietary linolenic acid is inversely associated with plasma triacylglycerol: the National Heart, Lung, and Blood Institute Family Heart Study. 2003 Am. J. Clin. Nutr. pmid:14668270
Kestin M et al. n-3 fatty acids of marine origin lower systolic blood pressure and triglycerides but raise LDL cholesterol compared with n-3 and n-6 fatty acids from plants. 1990 Am. J. Clin. Nutr. pmid:1971991
Lanzmann-Petithory D et al. Primary prevention of cardiovascular diseases by alpha-linolenic acid. 2002 Am. J. Clin. Nutr. pmid:12450919
Dai J et al. High habitual dietary alpha-linolenic acid intake is associated with decreased plasma soluble interleukin-6 receptor concentrations in male twins. 2010 Am. J. Clin. Nutr. pmid:20463041
Bjerve KS et al. Alpha-linolenic acid deficiency in patients on long-term gastric-tube feeding: estimation of linolenic acid and long-chain unsaturated n-3 fatty acid requirement in man. 1987 Am. J. Clin. Nutr. pmid:2879436
Connor WE Alpha-linolenic acid in health and disease. 1999 Am. J. Clin. Nutr. pmid:10232618
Li D et al. Effect of dietary alpha-linolenic acid on thrombotic risk factors in vegetarian men. 1999 Am. J. Clin. Nutr. pmid:10232625
Hu FB et al. Dietary intake of alpha-linolenic acid and risk of fatal ischemic heart disease among women. 1999 Am. J. Clin. Nutr. pmid:10232627
Bozian RC and Moussavian SN Human linolenic acid deficiency. 1982 Am. J. Clin. Nutr. pmid:6293298
Thies F et al. Dietary supplementation with eicosapentaenoic acid, but not with other long-chain n-3 or n-6 polyunsaturated fatty acids, decreases natural killer cell activity in healthy subjects aged >55 y. 2001 Am. J. Clin. Nutr. pmid:11237929
Decsi T and Kennedy K Sex-specific differences in essential fatty acid metabolism. 2011 Am. J. Clin. Nutr. pmid:22089435
Sanders TA Polyunsaturated fatty acids in the food chain in Europe. 2000 Am. J. Clin. Nutr. pmid:10617968
Uauy R and Hoffman DR Essential fat requirements of preterm infants. 2000 Am. J. Clin. Nutr. pmid:10617979
Gibson RA and Makrides M n-3 polyunsaturated fatty acid requirements of term infants. 2000 Am. J. Clin. Nutr. pmid:10617980
Crawford M Placental delivery of arachidonic and docosahexaenoic acids: implications for the lipid nutrition of preterm infants. 2000 Am. J. Clin. Nutr. pmid:10617983
Dutta-Roy AK Transport mechanisms for long-chain polyunsaturated fatty acids in the human placenta. 2000 Am. J. Clin. Nutr. pmid:10617989
Gopinath B et al. Consumption of polyunsaturated fatty acids, fish, and nuts and risk of inflammatory disease mortality. 2011 Am. J. Clin. Nutr. pmid:21411616
Horrobin DF Essential fatty acid metabolism and its modification in atopic eczema. 2000 Am. J. Clin. Nutr. pmid:10617999
Lucas M et al. Dietary intake of n-3 and n-6 fatty acids and the risk of clinical depression in women: a 10-y prospective follow-up study. 2011 Am. J. Clin. Nutr. pmid:21471279
Oomen CM et al. alpha-Linolenic acid intake is not beneficially associated with 10-y risk of coronary artery disease incidence: the Zutphen Elderly Study. 2001 Am. J. Clin. Nutr. pmid:11566643
Welch AA et al. Dietary intake and status of n-3 polyunsaturated fatty acids in a population of fish-eating and non-fish-eating meat-eaters, vegetarians, and vegans and the product-precursor ratio [corrected] of α-linolenic acid to long-chain n-3 polyunsaturated fatty acids: results from the EPIC-Norfolk cohort. 2010 Am. J. Clin. Nutr. pmid:20861171
Cunnane S Cholesterol lowering by alpha-linolenic acid. 1992 Am. J. Clin. Nutr. pmid:1345883
Ferrier LK et al. alpha-Linolenic acid- and docosahexaenoic acid-enriched eggs from hens fed flaxseed: influence on blood lipids and platelet phospholipid fatty acids in humans. 1995 Am. J. Clin. Nutr. pmid:7598070
Baylin A et al. alpha-Linolenic acid, Delta6-desaturase gene polymorphism, and the risk of nonfatal myocardial infarction. 2007 Am. J. Clin. Nutr. pmid:17284757
Bemelmans WJ et al. Effect of an increased intake of alpha-linolenic acid and group nutritional education on cardiovascular risk factors: the Mediterranean Alpha-linolenic Enriched Groningen Dietary Intervention (MARGARIN) study. 2002 Am. J. Clin. Nutr. pmid:11815311
Djoussé L et al. Plasma omega-3 fatty acids and incident diabetes in older adults. 2011 Am. J. Clin. Nutr. pmid:21593500
Heskey CE et al. Adipose tissue α-linolenic acid is inversely associated with insulin resistance in adults. 2016 Am. J. Clin. Nutr. pmid:26912497
Mantzioris E et al. Biochemical effects of a diet containing foods enriched with n-3 fatty acids. 2000 Am. J. Clin. Nutr. pmid:10871559
Chan JK et al. Dietary alpha-linolenic acid is as effective as oleic acid and linoleic acid in lowering blood cholesterol in normolipidemic men. 1991 Am. J. Clin. Nutr. pmid:1673589