Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Hejazi L et al. | Discrimination among geometrical isomers of alpha-linolenic acid methyl ester using low energy electron ionization mass spectrometry. | 2009 | J. Am. Soc. Mass Spectrom. | pmid:19318230 |
Kishino S et al. | Metabolic diversity in biohydrogenation of polyunsaturated fatty acids by lactic acid bacteria involving conjugated fatty acid production. | 2009 | Appl. Microbiol. Biotechnol. | pmid:19319523 |
Schmelz EA et al. | Phytohormone-based activity mapping of insect herbivore-produced elicitors. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19124770 |
Yazawa H et al. | Production of polyunsaturated fatty acids in yeast Saccharomyces cerevisiae and its relation to alkaline pH tolerance. | 2009 | Yeast | pmid:19243079 |
Huan ML et al. | Conjugation with alpha-linolenic acid improves cancer cell uptake and cytotoxicity of doxorubicin. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19329312 |
Pawlosky RJ et al. | Compartmental analysis of plasma and liver n-3 essential fatty acids in alcohol-dependent men during withdrawal. | 2009 | J. Lipid Res. | pmid:18723835 |
Brouwer IA | Omega-3 PUFA: good or bad for prostate cancer? | 2008 Sep-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18951003 |
Chua AC et al. | Characterization of oil bodies in jelly fig achenes. | 2008 May-Jun | Plant Physiol. Biochem. | pmid:18434174 |
Sekine S et al. | Alpha-linolenic acid-rich flaxseed oil ingestion increases plasma adiponectin level in rats. | 2008 Jul-Sep | Int J Vitam Nutr Res | pmid:19326346 |
Kamvissis VN et al. | A novel photometric method for evaluation of the oxidative stability of virgin olive oils. | 2008 Jul-Aug | J AOAC Int | pmid:18727539 |
Yamauchi Y et al. | Malondialdehyde generated from peroxidized linolenic acid causes protein modification in heat-stressed plants. | 2008 Aug-Sep | Plant Physiol. Biochem. | pmid:18538576 |
Kim CH et al. | Effects of emulsified octadecanic acids on gas production and cellulolysis by the rumen anaerobic fungus, Piromyces communis M014. | 2008 | Anaerobe | pmid:17996466 |
Matsuo T and Yagi K | Interaction between alpha-linolenic acid-enriched oil and ACE inhibitor concerning the decrease in blood pressure in SHR. | 2008 | J Oleo Sci | pmid:18075218 |
Egert S et al. | Effects of dietary alpha-linolenic acid, eicosapentaenoic acid or docosahexaenoic acid on parameters of glucose metabolism in healthy volunteers. | 2008 | Ann. Nutr. Metab. | pmid:19011281 |
Suzuki T et al. | Identification of G protein-coupled receptor 120-selective agonists derived from PPARgamma agonists. | 2008 | J. Med. Chem. | pmid:19007110 |
Tattersall AL and Wilkins RJ | Effects of hexosamines and omega-3/omega-6 fatty acids on pH regulation by interleukin 1-treated isolated bovine articular chondrocytes. | 2008 | Pflugers Arch. | pmid:18204856 |
Zheng Y et al. | A 49-kDa mini-lipoxygenase from Anabaena sp. PCC 7120 retains catalytically complete functionality. | 2008 | J. Biol. Chem. | pmid:18070874 |
Pomponi M and Pomponi M | DHA deficiency and Alzheimer's disease. | 2008 | Clin Nutr | pmid:18037538 |
Upchurch RG | Fatty acid unsaturation, mobilization, and regulation in the response of plants to stress. | 2008 | Biotechnol. Lett. | pmid:18227974 |
Berquin IM et al. | Multi-targeted therapy of cancer by omega-3 fatty acids. | 2008 | Cancer Lett. | pmid:18479809 |
Suji G and Sivakami S | Malondialdehyde, a lipid-derived aldehyde alters the reactivity of Cys34 and the esterase activity of serum albumin. | 2008 | Toxicol In Vitro | pmid:18206343 |
Ogawa N et al. | The vagal afferent pathway does not play a major role in the induction of satiety by intestinal fatty acid in rats. | 2008 | Neurosci. Lett. | pmid:18248897 |
Flores T et al. | Silencing of GmFAD3 gene by siRNA leads to low alpha-linolenic acids (18:3) of fad3-mutant phenotype in soybean [Glycine max (Merr.)]. | 2008 | Transgenic Res. | pmid:18256901 |
Xin HL et al. | [Alpha-linolenic acid and linoleic acid in extract of Portulaca oleracea L. determined by high-performance liquid chromatography]. | 2008 | Zhong Xi Yi Jie He Xue Bao | pmid:18990345 |
Meguid NA et al. | Role of polyunsaturated fatty acids in the management of Egyptian children with autism. | 2008 | Clin. Biochem. | pmid:18582451 |
Wang L et al. | The role of fatty acids and caveolin-1 in tumor necrosis factor alpha-induced endothelial cell activation. | 2008 | Metab. Clin. Exp. | pmid:18803934 |
Tanaka T et al. | Cloning and characterization of the rat free fatty acid receptor GPR120: in vivo effect of the natural ligand on GLP-1 secretion and proliferation of pancreatic beta cells. | 2008 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:18320172 |
Fuentes F et al. | Chronic effects of a high-fat diet enriched with virgin olive oil and a low-fat diet enriched with alpha-linolenic acid on postprandial endothelial function in healthy men. | 2008 | Br. J. Nutr. | pmid:18275619 |
Su M et al. | Effects of nanoanatase on the photosynthetic improvement of chloroplast damaged by linolenic acid. | 2008 | Biol Trace Elem Res | pmid:18425432 |
Varga Z | [Omega-3 polyunsaturated fatty acids in the prevention of atherosclerosis]. | 2008 | Orv Hetil | pmid:18375362 |
Barre DE et al. | High dose flaxseed oil supplementation may affect fasting blood serum glucose management in human type 2 diabetics. | 2008 | J Oleo Sci | pmid:18391475 |
Chang HH et al. | Dietary perilla oil inhibits proinflammatory cytokine production in the bronchoalveolar lavage fluid of ovalbumin-challenged mice. | 2008 | Lipids | pmid:18386091 |
DiRienzo MA et al. | Effect of substitution of high stearic low linolenic acid soybean oil for hydrogenated soybean oil on fatty acid intake. | 2008 | Lipids | pmid:18365266 |
Williams M and Harwood JL | Characterisation of lipoxygenase isoforms from olive callus cultures. | 2008 | Phytochemistry | pmid:18790508 |
Maeda H et al. | Tocopherols modulate extraplastidic polyunsaturated fatty acid metabolism in Arabidopsis at low temperature. | 2008 | Plant Cell | pmid:18314499 |
Rashid S et al. | Topical omega-3 and omega-6 fatty acids for treatment of dry eye. | 2008 | Arch. Ophthalmol. | pmid:18268213 |
Igarashi M et al. | Rat heart cannot synthesize docosahexaenoic acid from circulating alpha-linolenic acid because it lacks elongase-2. | 2008 | J. Lipid Res. | pmid:18456640 |
Bloedon LT et al. | Flaxseed and cardiovascular risk factors: results from a double blind, randomized, controlled clinical trial. | 2008 | J Am Coll Nutr | pmid:18460483 |
Rao S et al. | Characteristics of high alpha-linolenic acid accumulation in seed oils. | 2008 | Lipids | pmid:18597133 |
Adachi T et al. | Administration of perilla oil coated with Calshell increases glucagon-like peptide secretion. | 2008 | Biol. Pharm. Bull. | pmid:18451539 |
Wang L et al. | Changing ratios of omega-6 to omega-3 fatty acids can differentially modulate polychlorinated biphenyl toxicity in endothelial cells. | 2008 | Chem. Biol. Interact. | pmid:18155686 |
DeMar JC et al. | Effect of dietary docosahexaenoic acid on biosynthesis of docosahexaenoic acid from alpha-linolenic acid in young rats. | 2008 | J. Lipid Res. | pmid:18469302 |
Austria JA et al. | Bioavailability of alpha-linolenic acid in subjects after ingestion of three different forms of flaxseed. | 2008 | J Am Coll Nutr | pmid:18689552 |
Harris WS | Cardiovascular risk and alpha-linolenic acid: can Costa Rica clarify? | 2008 | Circulation | pmid:18606912 |
Campos H et al. | Alpha-linolenic acid and risk of nonfatal acute myocardial infarction. | 2008 | Circulation | pmid:18606916 |
Takahara Y et al. | Pharmacogenomics of cardiovascular pharmacology: development of an informatics system for analysis of DNA microarray data with a focus on lipid metabolism. | 2008 | J. Pharmacol. Sci. | pmid:18490852 |
Wang S et al. | Fasting serum free fatty acid composition, waist/hip ratio and insulin activity in essential hypertensive patients. | 2008 | Hypertens. Res. | pmid:18633173 |
Jäger AK et al. | Isolation of linoleic and alpha-linolenic acids as COX-1 and -2 inhibitors in rose hip. | 2008 | Phytother Res | pmid:18389471 |
Stark AH et al. | Update on alpha-linolenic acid. | 2008 | Nutr. Rev. | pmid:18522621 |
Chou YC et al. | Bioassay-guided purification and identification of PPARalpha/gamma agonists from Chlorella sorokiniana. | 2008 | Phytother Res | pmid:18398904 |
Trattner S et al. | Sesamin supplementation increases white muscle docosahexaenoic acid (DHA) levels in rainbow trout (Oncorhynchus mykiss) fed high alpha-linolenic acid (ALA) containing vegetable oil: metabolic actions. | 2008 | Lipids | pmid:18781351 |
Trattner S et al. | Sesamin increases alpha-linolenic acid conversion to docosahexaenoic acid in atlantic salmon (Salmo salar L.) hepatocytes: role of altered gene expression. | 2008 | Lipids | pmid:18784949 |
Davison GW et al. | In vitro electron paramagnetic resonance characterization of free radicals: relevance to exercise-induced lipid peroxidation and implications of ascorbate prophylaxis. | 2008 | Free Radic. Res. | pmid:18404537 |
Frost CJ et al. | Priming defense genes and metabolites in hybrid poplar by the green leaf volatile cis-3-hexenyl acetate. | 2008 | New Phytol. | pmid:18721163 |
Simopoulos AP | The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. | 2008 | Exp. Biol. Med. (Maywood) | pmid:18408140 |
Singh S et al. | Evaluation of anti-inflammatory activity of plant lipids containing alpha-linolenic acid. | 2008 | Indian J. Exp. Biol. | pmid:18697604 |
Zilkowski BW et al. | Analysis of 2,4,6-nonatrienal geometrical isomers from male flea beetles, Epitrix hirtipennis and E. fuscula. | 2008 | J. Agric. Food Chem. | pmid:18553913 |
Andersen G et al. | Dietary eicosapentaenoic acid and docosahexaenoic acid are more effective than alpha-linolenic acid in improving insulin sensitivity in rats. | 2008 | Ann. Nutr. Metab. | pmid:18562792 |
Levant B et al. | Decreased brain docosahexaenoic acid content produces neurobiological effects associated with depression: Interactions with reproductive status in female rats. | 2008 | Psychoneuroendocrinology | pmid:18707812 |
Masuelli L et al. | Intercalated disk remodeling in delta-sarcoglycan-deficient hamsters fed with an alpha-linolenic acid-enriched diet. | 2008 | Int. J. Mol. Med. | pmid:18097614 |
Warensjö E et al. | Effects of saturated and unsaturated fatty acids on estimated desaturase activities during a controlled dietary intervention. | 2008 | Nutr Metab Cardiovasc Dis | pmid:18367385 |
Khodadadi I et al. | Differential effects of long-chain fatty acids and clofibrate on gene expression profiles in cardiomyocytes. | 2008 | Arch Iran Med | pmid:18154422 |
Guizy M et al. | Modulation of the atrial specific Kv1.5 channel by the n-3 polyunsaturated fatty acid, alpha-linolenic acid. | 2008 | J. Mol. Cell. Cardiol. | pmid:18155022 |
Sado Kamdem S et al. | Effect of capric, lauric and alpha-linolenic acids on the division time distributions of single cells of Staphylococcus aureus. | 2008 | Int. J. Food Microbiol. | pmid:18793815 |
Grewe C and Griehl C | Time- and media-dependent secondary carotenoid accumulation in Haematococcus pluvialis. | 2008 | Biotechnol J | pmid:18683169 |
Alessandri JM et al. | Estradiol favors the formation of eicosapentaenoic acid (20:5n-3) and n-3 docosapentaenoic acid (22:5n-3) from alpha-linolenic acid (18:3n-3) in SH-SY5Y neuroblastoma cells. | 2008 | Lipids | pmid:17912567 |
Zatonski W et al. | Rapid declines in coronary heart disease mortality in Eastern Europe are associated with increased consumption of oils rich in alpha-linolenic acid. | 2008 | Eur. J. Epidemiol. | pmid:17955332 |
Mert-Türk F et al. | Nitrogen and fungicide applications against Erysiphe cruciferarum affect quality components of oilseed rape. | 2008 | Mycopathologia | pmid:17934794 |
Su M et al. | Nano-anatase relieves the inhibition of electron transport caused by linolenic acid in chloroplasts of spinach. | 2008 | Biol Trace Elem Res | pmid:17962910 |
Miller MR et al. | Increased elongase and desaturase gene expression with stearidonic acid enriched diet does not enhance long-chain (n-3) content of seawater Atlantic salmon (Salmo salar L.). | 2008 | J. Nutr. | pmid:18936216 |
Cui PH et al. | Monoepoxy octadecadienoates and monoepoxy octadecatrienoates 1: NMR spectral characterization. | 2008 | Chem. Phys. Lipids | pmid:18339314 |
Hibi M et al. | Greater fat oxidation with diacylglycerol oil consumption for 14 days compared with triacylglycerol oil consumption in overweight men and women. | 2008 | Int J Obes (Lond) | pmid:18936764 |
Maruyama C et al. | Differences in serum phospholipid fatty acid compositions and estimated desaturase activities between Japanese men with and without metabolic syndrome. | 2008 | J. Atheroscler. Thromb. | pmid:19060426 |
Kai K et al. | Structure and biological activity of novel FN analogs as flowering inducers. | 2008 | Bioorg. Med. Chem. | pmid:18952445 |
Astorg P et al. | Plasma n-6 and n-3 polyunsaturated fatty acids as biomarkers of their dietary intakes: a cross-sectional study within a cohort of middle-aged French men and women. | 2008 | Eur J Clin Nutr | pmid:17622261 |
Rao SS et al. | Sensitivity of fetus and pups to excess levels of maternal intakes of alpha linolenic acid at marginal protein levels in Wistar rats. | 2007 Nov-Dec | Reprod. Toxicol. | pmid:17825521 |
Pazirandeh S et al. | Supplementation of arachidonic acid plus docosahexaenoic acid in cirrhotic patients awaiting liver transplantation: a preliminary study. | 2007 Nov-Dec | JPEN J Parenter Enteral Nutr | pmid:17947609 |
Bourre JM | Dietary omega-3 fatty acids for women. | 2007 Feb-Apr | Biomed. Pharmacother. | pmid:17254747 |
Giovannucci E et al. | Risk factors for prostate cancer incidence and progression in the health professionals follow-up study. | 2007 | Int. J. Cancer | pmid:17450530 |
Sun S et al. | Singlet oxygen generation from the decomposition of alpha-linolenic acid hydroperoxide by cytochrome c and lactoperoxidase. | 2007 | Biochemistry | pmid:17497889 |
Norton G et al. | Characterisation of recombinant Hevea brasiliensis allene oxide synthase: effects of cycloxygenase inhibitors, lipoxygenase inhibitors and salicylates on enzyme activity. | 2007 | Plant Physiol. Biochem. | pmid:17344058 |
Vos E et al. | alpha-Linolenic acid and fish oil n-3 fatty acids and cardiovascular disease risk. | 2007 | Am. J. Clin. Nutr. | pmid:17344517 |
Shimizu T et al. | Effects of alpha-linolenic acid on colonic secretion in rats with experimental colitis. | 2007 | J. Gastroenterol. | pmid:17351801 |
Karapanagiotidis IT et al. | Replacement of dietary fish oils by alpha-linolenic acid-rich oils lowers omega 3 content in tilapia flesh. | 2007 | Lipids | pmid:17473942 |
Ben-Shabat S et al. | Conjugates of unsaturated fatty acids with propylene glycol as potentially less-irritant skin penetration enhancers. | 2007 | Drug Dev Ind Pharm | pmid:18058312 |
Nelson TL et al. | Adiponectin levels are reduced, independent of polymorphisms in the adiponectin gene, after supplementation with alpha-linolenic acid among healthy adults. | 2007 | Metab. Clin. Exp. | pmid:17697863 |
Sánchez-Ortiz A et al. | Cultivar differences on nonesterified polyunsaturated fatty acid as a limiting factor for the biogenesis of virgin olive oil aroma. | 2007 | J. Agric. Food Chem. | pmid:17708640 |
Igarashi M et al. | Dietary n-3 PUFA deprivation for 15 weeks upregulates elongase and desaturase expression in rat liver but not brain. | 2007 | J. Lipid Res. | pmid:17715424 |
Lin YH and Salem N | Whole body distribution of deuterated linoleic and alpha-linolenic acids and their metabolites in the rat. | 2007 | J. Lipid Res. | pmid:17876057 |
The power of 3. Omega-3 fatty acids. | 2007 | Mayo Clin Health Lett | pmid:17715541 | |
Zhang W et al. | Alpha-linolenic acid attenuates high glucose-induced apoptosis in cultured human umbilical vein endothelial cells via PI3K/Akt/eNOS pathway. | 2007 | Nutrition | pmid:17716867 |
Yara A et al. | Disease resistance against Magnaporthe grisea is enhanced in transgenic rice with suppression of omega-3 fatty acid desaturases. | 2007 | Plant Cell Physiol. | pmid:17716996 |
Chen J et al. | Flaxseed alone or in combination with tamoxifen inhibits MCF-7 breast tumor growth in ovariectomized athymic mice with high circulating levels of estrogen. | 2007 | Exp. Biol. Med. (Maywood) | pmid:17720953 |
Sato I et al. | Identification of COX inhibitors in the hexane extract of Japanese horse chestnut (Aesculus turbinata) seeds. | 2007 | J. Vet. Med. Sci. | pmid:17675801 |
Vaysse-Boué C et al. | Moderate dietary intake of myristic and alpha-linolenic acids increases lecithin-cholesterol acyltransferase activity in humans. | 2007 | Lipids | pmid:17564735 |
Ander BP et al. | Differential sensitivities of the NCX1.1 and NCX1.3 isoforms of the Na+-Ca2+ exchanger to alpha-linolenic acid. | 2007 | Cardiovasc. Res. | pmid:17059813 |
Pankiewicz E et al. | Maternal adipose tissue, maternal and cord blood essential fatty acids and their long-chain polyunsaturated derivatives composition after elective caesarean section. | 2007 | Early Hum. Dev. | pmid:17059872 |
Simon JA et al. | Lack of effect of walnuts on serum levels of prostate specific antigen: a brief report. | 2007 | J Am Coll Nutr | pmid:17906182 |
Plourde M et al. | Conjugated alpha-linolenic acid isomers in bovine milk and muscle. | 2007 | J. Dairy Sci. | pmid:17954767 |
Barre DE | The role of consumption of alpha-linolenic, eicosapentaenoic and docosahexaenoic acids in human metabolic syndrome and type 2 diabetes--a mini-review. | 2007 | J Oleo Sci | pmid:17898498 |