Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Barre DE et al. | High dose flaxseed oil supplementation may affect fasting blood serum glucose management in human type 2 diabetics. | 2008 | J Oleo Sci | pmid:18391475 |
Chou YC et al. | Bioassay-guided purification and identification of PPARalpha/gamma agonists from Chlorella sorokiniana. | 2008 | Phytother Res | pmid:18398904 |
Davison GW et al. | In vitro electron paramagnetic resonance characterization of free radicals: relevance to exercise-induced lipid peroxidation and implications of ascorbate prophylaxis. | 2008 | Free Radic. Res. | pmid:18404537 |
Simopoulos AP | The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. | 2008 | Exp. Biol. Med. (Maywood) | pmid:18408140 |
Su M et al. | Effects of nanoanatase on the photosynthetic improvement of chloroplast damaged by linolenic acid. | 2008 | Biol Trace Elem Res | pmid:18425432 |
Chua AC et al. | Characterization of oil bodies in jelly fig achenes. | 2008 May-Jun | Plant Physiol. Biochem. | pmid:18434174 |
Adachi T et al. | Administration of perilla oil coated with Calshell increases glucagon-like peptide secretion. | 2008 | Biol. Pharm. Bull. | pmid:18451539 |
Igarashi M et al. | Rat heart cannot synthesize docosahexaenoic acid from circulating alpha-linolenic acid because it lacks elongase-2. | 2008 | J. Lipid Res. | pmid:18456640 |
Bloedon LT et al. | Flaxseed and cardiovascular risk factors: results from a double blind, randomized, controlled clinical trial. | 2008 | J Am Coll Nutr | pmid:18460483 |
DeMar JC et al. | Effect of dietary docosahexaenoic acid on biosynthesis of docosahexaenoic acid from alpha-linolenic acid in young rats. | 2008 | J. Lipid Res. | pmid:18469302 |
Berquin IM et al. | Multi-targeted therapy of cancer by omega-3 fatty acids. | 2008 | Cancer Lett. | pmid:18479809 |
Takahara Y et al. | Pharmacogenomics of cardiovascular pharmacology: development of an informatics system for analysis of DNA microarray data with a focus on lipid metabolism. | 2008 | J. Pharmacol. Sci. | pmid:18490852 |
Chicco AG et al. | Dietary chia seed (Salvia hispanica L.) rich in alpha-linolenic acid improves adiposity and normalises hypertriacylglycerolaemia and insulin resistance in dyslipaemic rats. | 2009 | Br. J. Nutr. | pmid:18492301 |
van der Walt AM et al. | Linolenic acid and folate in wild-growing African dark leafy vegetables (morogo). | 2009 | Public Health Nutr | pmid:18503724 |
Stark AH et al. | Update on alpha-linolenic acid. | 2008 | Nutr. Rev. | pmid:18522621 |
Yamauchi Y et al. | Malondialdehyde generated from peroxidized linolenic acid causes protein modification in heat-stressed plants. | 2008 Aug-Sep | Plant Physiol. Biochem. | pmid:18538576 |
Zilkowski BW et al. | Analysis of 2,4,6-nonatrienal geometrical isomers from male flea beetles, Epitrix hirtipennis and E. fuscula. | 2008 | J. Agric. Food Chem. | pmid:18553913 |
Andersen G et al. | Dietary eicosapentaenoic acid and docosahexaenoic acid are more effective than alpha-linolenic acid in improving insulin sensitivity in rats. | 2008 | Ann. Nutr. Metab. | pmid:18562792 |
Meguid NA et al. | Role of polyunsaturated fatty acids in the management of Egyptian children with autism. | 2008 | Clin. Biochem. | pmid:18582451 |
Rao S et al. | Characteristics of high alpha-linolenic acid accumulation in seed oils. | 2008 | Lipids | pmid:18597133 |
Artwohl M et al. | Fatty acids induce apoptosis in human smooth muscle cells depending on chain length, saturation, and duration of exposure. | 2009 | Atherosclerosis | pmid:18597758 |
Harris WS | Cardiovascular risk and alpha-linolenic acid: can Costa Rica clarify? | 2008 | Circulation | pmid:18606912 |
Campos H et al. | Alpha-linolenic acid and risk of nonfatal acute myocardial infarction. | 2008 | Circulation | pmid:18606916 |
Wang S et al. | Fasting serum free fatty acid composition, waist/hip ratio and insulin activity in essential hypertensive patients. | 2008 | Hypertens. Res. | pmid:18633173 |
Taha AY et al. | Dose-dependent anticonvulsant effects of linoleic and alpha-linolenic polyunsaturated fatty acids on pentylenetetrazol induced seizures in rats. | 2009 | Epilepsia | pmid:18657173 |
Porta N et al. | Anticonvulsant effects of linolenic acid are unrelated to brain phospholipid cell membrane compositions. | 2009 | Epilepsia | pmid:18657178 |
Grewe C and Griehl C | Time- and media-dependent secondary carotenoid accumulation in Haematococcus pluvialis. | 2008 | Biotechnol J | pmid:18683169 |
Austria JA et al. | Bioavailability of alpha-linolenic acid in subjects after ingestion of three different forms of flaxseed. | 2008 | J Am Coll Nutr | pmid:18689552 |
Singh S et al. | Evaluation of anti-inflammatory activity of plant lipids containing alpha-linolenic acid. | 2008 | Indian J. Exp. Biol. | pmid:18697604 |
Levant B et al. | Decreased brain docosahexaenoic acid content produces neurobiological effects associated with depression: Interactions with reproductive status in female rats. | 2008 | Psychoneuroendocrinology | pmid:18707812 |
Frost CJ et al. | Priming defense genes and metabolites in hybrid poplar by the green leaf volatile cis-3-hexenyl acetate. | 2008 | New Phytol. | pmid:18721163 |
Pawlosky RJ et al. | Compartmental analysis of plasma and liver n-3 essential fatty acids in alcohol-dependent men during withdrawal. | 2009 | J. Lipid Res. | pmid:18723835 |
Kamvissis VN et al. | A novel photometric method for evaluation of the oxidative stability of virgin olive oils. | 2008 Jul-Aug | J AOAC Int | pmid:18727539 |
Trattner S et al. | Sesamin supplementation increases white muscle docosahexaenoic acid (DHA) levels in rainbow trout (Oncorhynchus mykiss) fed high alpha-linolenic acid (ALA) containing vegetable oil: metabolic actions. | 2008 | Lipids | pmid:18781351 |
Trattner S et al. | Sesamin increases alpha-linolenic acid conversion to docosahexaenoic acid in atlantic salmon (Salmo salar L.) hepatocytes: role of altered gene expression. | 2008 | Lipids | pmid:18784949 |
Williams M and Harwood JL | Characterisation of lipoxygenase isoforms from olive callus cultures. | 2008 | Phytochemistry | pmid:18790508 |
Sado Kamdem S et al. | Effect of capric, lauric and alpha-linolenic acids on the division time distributions of single cells of Staphylococcus aureus. | 2008 | Int. J. Food Microbiol. | pmid:18793815 |
McNamara RK et al. | Perinatal n-3 fatty acid deficiency selectively reduces myo-inositol levels in the adult rat PFC: an in vivo (1)H-MRS study. | 2009 | J. Lipid Res. | pmid:18802197 |
Wang L et al. | The role of fatty acids and caveolin-1 in tumor necrosis factor alpha-induced endothelial cell activation. | 2008 | Metab. Clin. Exp. | pmid:18803934 |
Venna VR et al. | PUFA induce antidepressant-like effects in parallel to structural and molecular changes in the hippocampus. | 2009 | Psychoneuroendocrinology | pmid:18848400 |
HILDITCH TP and SHRIVASTAVA RK | The spectrophotometric determination of small proportions of linolenic acid in fats. | 1947 | Analyst | pmid:18901122 |
Miller MR et al. | Increased elongase and desaturase gene expression with stearidonic acid enriched diet does not enhance long-chain (n-3) content of seawater Atlantic salmon (Salmo salar L.). | 2008 | J. Nutr. | pmid:18936216 |
Hibi M et al. | Greater fat oxidation with diacylglycerol oil consumption for 14 days compared with triacylglycerol oil consumption in overweight men and women. | 2008 | Int J Obes (Lond) | pmid:18936764 |
Bannenberg G et al. | Diversity of the enzymatic activity in the lipoxygenase gene family of Arabidopsis thaliana. | 2009 | Lipids | pmid:18949503 |
Brouwer IA | Omega-3 PUFA: good or bad for prostate cancer? | 2008 Sep-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18951003 |
Jiménez-Gómez Y et al. | Olive oil and walnut breakfasts reduce the postprandial inflammatory response in mononuclear cells compared with a butter breakfast in healthy men. | 2009 | Atherosclerosis | pmid:18952211 |
Kai K et al. | Structure and biological activity of novel FN analogs as flowering inducers. | 2008 | Bioorg. Med. Chem. | pmid:18952445 |
Gouveia L and Oliveira AC | Microalgae as a raw material for biofuels production. | 2009 | J. Ind. Microbiol. Biotechnol. | pmid:18982369 |
McNamara RK et al. | Omega-3 fatty acid deficiency during perinatal development increases serotonin turnover in the prefrontal cortex and decreases midbrain tryptophan hydroxylase-2 expression in adult female rats: dissociation from estrogenic effects. | 2009 | J Psychiatr Res | pmid:18986658 |
Xin HL et al. | [Alpha-linolenic acid and linoleic acid in extract of Portulaca oleracea L. determined by high-performance liquid chromatography]. | 2008 | Zhong Xi Yi Jie He Xue Bao | pmid:18990345 |
McNamara RK et al. | Chronic risperidone treatment preferentially increases rat erythrocyte and prefrontal cortex omega-3 fatty acid composition: evidence for augmented biosynthesis. | 2009 | Schizophr. Res. | pmid:18993032 |
Mène-Saffrané L et al. | Nonenzymatic oxidation of trienoic fatty acids contributes to reactive oxygen species management in Arabidopsis. | 2009 | J. Biol. Chem. | pmid:18996838 |
Suzuki T et al. | Identification of G protein-coupled receptor 120-selective agonists derived from PPARgamma agonists. | 2008 | J. Med. Chem. | pmid:19007110 |
Egert S et al. | Effects of dietary alpha-linolenic acid, eicosapentaenoic acid or docosahexaenoic acid on parameters of glucose metabolism in healthy volunteers. | 2008 | Ann. Nutr. Metab. | pmid:19011281 |
Thiébaut AC et al. | Dietary intakes of omega-6 and omega-3 polyunsaturated fatty acids and the risk of breast cancer. | 2009 | Int. J. Cancer | pmid:19035453 |
Coakley M et al. | Inhibitory effect of conjugated alpha-linolenic acid from bifidobacteria of intestinal origin on SW480 cancer cells. | 2009 | Lipids | pmid:19048324 |
Maruyama C et al. | Differences in serum phospholipid fatty acid compositions and estimated desaturase activities between Japanese men with and without metabolic syndrome. | 2008 | J. Atheroscler. Thromb. | pmid:19060426 |
Gao F et al. | Whole-body synthesis-secretion rates of long-chain n-3 PUFAs from circulating unesterified alpha-linolenic acid in unanesthetized rats. | 2009 | J. Lipid Res. | pmid:19074373 |
Tsubura A et al. | Role of fatty acids in malignancy and visual impairment: epidemiological evidence and experimental studies. | 2009 | Histol. Histopathol. | pmid:19085838 |
Gemeinhardt A et al. | The influence of linoleic and linolenic acid on the activity and intracellular localisation of phospholipase D in COS-1 cells. | 2009 | Biol. Chem. | pmid:19090716 |
Dybkowska E et al. | [The comparison of fat, trans isomers and cholesterol intake in the diet of Warsaw inhabitants in relation to Polish food ration]. | 2004 | Rocz Panstw Zakl Hig | pmid:19097583 |
Khiaosa-Ard R et al. | Evidence for the inhibition of the terminal step of ruminal alpha-linolenic acid biohydrogenation by condensed tannins. | 2009 | J. Dairy Sci. | pmid:19109277 |
Schmelz EA et al. | Phytohormone-based activity mapping of insect herbivore-produced elicitors. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19124770 |
Molkentin J | Authentication of organic milk using delta13C and the alpha-linolenic acid content of milk fat. | 2009 | J. Agric. Food Chem. | pmid:19132889 |
Truong H et al. | Does genetic variation in the Delta6-desaturase promoter modify the association between alpha-linolenic acid and the prevalence of metabolic syndrome? | 2009 | Am. J. Clin. Nutr. | pmid:19144731 |
Hejazi L et al. | Determination of the composition of fatty acid mixtures using GC x FI-MS: a comprehensive two-dimensional separation approach. | 2009 | Anal. Chem. | pmid:19146461 |
Extier A et al. | Gender affects liver desaturase expression in a rat model of n-3 fatty acid repletion. | 2010 | J. Nutr. Biochem. | pmid:19157821 |
Chojnacka A et al. | Enzymatic enrichment of egg-yolk phosphatidylcholine with alpha-linolenic acid. | 2009 | Biotechnol. Lett. | pmid:19165607 |
Ibrahim A et al. | Impact of maternal dietary fatty acid composition on glucose and lipid metabolism in male rat offspring aged 105 d. | 2009 | Br. J. Nutr. | pmid:19166630 |
Oku H et al. | The effects of 2-bromopalmitate on the fatty acid composition in differentiating adipocytes of red sea bream (Pagrus major). | 2009 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:19166960 |
Sado-Kamdem SL et al. | Effect of alpha-linolenic, capric and lauric acid on the fatty acid biosynthesis in Staphylococcus aureus. | 2009 | Int. J. Food Microbiol. | pmid:19168249 |
Wu D et al. | Determination of alpha-linolenic acid and linoleic acid in edible oils using near-infrared spectroscopy improved by wavelet transform and uninformative variable elimination. | 2009 | Anal. Chim. Acta | pmid:19185115 |
Schwartz J et al. | Modification of dietary polyunsaturated fatty acids via complementary food enhances n-3 long-chain polyunsaturated fatty acid synthesis in healthy infants: a double blinded randomised controlled trial. | 2009 | Arch. Dis. Child. | pmid:19193660 |
Küpper FC et al. | Free Fatty Acids and Methyl Jasmonate Trigger Defense Reactions in Laminaria digitata. | 2009 | Plant Cell Physiol. | pmid:19213737 |
Cornish SM and Chilibeck PD | Alpha-linolenic acid supplementation and resistance training in older adults. | 2009 | Appl Physiol Nutr Metab | pmid:19234585 |
Bommareddy A et al. | Effects of dietary flaxseed on intestinal tumorigenesis in Apc(Min) mouse. | 2009 | Nutr Cancer | pmid:19235044 |
Yazawa H et al. | Production of polyunsaturated fatty acids in yeast Saccharomyces cerevisiae and its relation to alkaline pH tolerance. | 2009 | Yeast | pmid:19243079 |
Van Elswyk ME and Kuratko C | Achieving adequate DHA in maternal and infant diets. | 2009 | J Am Diet Assoc | pmid:19248850 |
Ishitsuka Y et al. | Effects of bolus injection of soybean-based fat emulsion and fatty acids on pulmonary gas exchange function. | 2009 | Biol. Pharm. Bull. | pmid:19252304 |
Egert S et al. | Dietary alpha-linolenic acid, EPA, and DHA have differential effects on LDL fatty acid composition but similar effects on serum lipid profiles in normolipidemic humans. | 2009 | J. Nutr. | pmid:19261730 |
Brenna JT et al. | alpha-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans. | 2009 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19269799 |
Chang HH et al. | Dietary perilla oil lowers serum lipids and ovalbumin-specific IgG1, but increases total IgE levels in ovalbumin-challenged mice. | 2009 | Food Chem. Toxicol. | pmid:19271319 |
Liu J et al. | Ganoderic acid DM: anti-androgenic osteoclastogenesis inhibitor. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19289282 |
Lemaitre RN et al. | Red blood cell membrane alpha-linolenic acid and the risk of sudden cardiac arrest. | 2009 | Metab. Clin. Exp. | pmid:19303975 |
Hejazi L et al. | Discrimination among geometrical isomers of alpha-linolenic acid methyl ester using low energy electron ionization mass spectrometry. | 2009 | J. Am. Soc. Mass Spectrom. | pmid:19318230 |
Kishino S et al. | Metabolic diversity in biohydrogenation of polyunsaturated fatty acids by lactic acid bacteria involving conjugated fatty acid production. | 2009 | Appl. Microbiol. Biotechnol. | pmid:19319523 |
Simon JA et al. | The relation of alpha-linolenic acid to the risk of prostate cancer: a systematic review and meta-analysis. | 2009 | Am. J. Clin. Nutr. | pmid:19321563 |
Sekine S et al. | Alpha-linolenic acid-rich flaxseed oil ingestion increases plasma adiponectin level in rats. | 2008 Jul-Sep | Int J Vitam Nutr Res | pmid:19326346 |
Huan ML et al. | Conjugation with alpha-linolenic acid improves cancer cell uptake and cytotoxicity of doxorubicin. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19329312 |
Venegas-Calerón M et al. | Effect of the ferredoxin electron donor on sunflower (Helianthus annuus) desaturases. | 2009 | Plant Physiol. Biochem. | pmid:19342250 |
Tooker JF and De Moraes CM | A gall-inducing caterpillar species increases essential fatty acid content of its host plant without concomitant increases in phytohormone levels. | 2009 | Mol. Plant Microbe Interact. | pmid:19348573 |
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Raz R et al. | The influence of short-chain essential fatty acids on children with attention-deficit/hyperactivity disorder: a double-blind placebo-controlled study. | 2009 | J Child Adolesc Psychopharmacol | pmid:19364294 |
Ogawa A et al. | Effect of dietary alpha-linolenic acid on vascular reactivity in aorta of spontaneously hypertensive rats. | 2009 | J Oleo Sci | pmid:19367077 |
Indo Y et al. | Functional expression of a humanized gene for an omega-3 fatty acid desaturase from scarlet flax in transfected bovine adipocytes and bovine embryos cloned from the cells. | 2009 | Biochim. Biophys. Acta | pmid:19367764 |
Yang L et al. | Oxidative stability of conjugated linolenic acids. | 2009 | J. Agric. Food Chem. | pmid:19368396 |
Umezawa M et al. | Effect of dietary unsaturated fatty acids on senile amyloidosis in senescence-accelerated mice. | 2009 | J. Gerontol. A Biol. Sci. Med. Sci. | pmid:19377016 |
Piccione G et al. | Daily pattern of some fatty acids in the athletic horse. | 2009 | J Anim Physiol Anim Nutr (Berl) | pmid:19386003 |
Yavin E et al. | Delayed cell migration in the developing rat brain following maternal omega 3 alpha linolenic acid dietary deficiency. | 2009 | Neuroscience | pmid:19447164 |
Zainal Z et al. | Modification of palm oil for anti-inflammatory nutraceutical properties. | 2009 | Lipids | pmid:19449050 |