Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Mapiye C et al. | Effects of feeding flaxseed or sunflower-seed in high-forage diets on beef production, quality and fatty acid composition. | 2013 | Meat Sci. | pmid:23669875 |
Sengupta A and Ghosh M | Protective effect of eicosapentaenoic acid-docosahexaenoic acid and alpha-linolenic acid rich phytosterol ester on brain antioxidant status and brain lipid composition in hypercholesterolemic rats. | 2013 | Indian J. Exp. Biol. | pmid:23678545 |
Rao CV et al. | Prevention of familial adenomatous polyp development in APC min mice and azoxymethane-induced colon carcinogenesis in F344 Rats by ω-3 fatty acid rich perilla oil. | 2013 | Nutr Cancer | pmid:23682783 |
Hutchins AM et al. | Daily flaxseed consumption improves glycemic control in obese men and women with pre-diabetes: a randomized study. | 2013 | Nutr Res | pmid:23684438 |
Oh HJ et al. | Production of 10-hydroxy-12,15(Z,Z)-octadecadienoic acid from α-linolenic acid by permeabilized cells of recombinant Escherichia coli expressing the oleate hydratase gene of Stenotrophomonas maltophilia. | 2013 | Biotechnol. Lett. | pmid:23690042 |
Schuchardt JP et al. | Comparison of free serum oxylipin concentrations in hyper- vs. normolipidemic men. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23694766 |
Lai YH et al. | Association of dietary omega-3 fatty acids with prevalence of metabolic syndrome: the National Heart, Lung, and Blood Institute Family Heart Study. | 2013 | Clin Nutr | pmid:23711994 |
Liu M et al. | Characterization and biological effects of di-hydroxylated compounds deriving from the lipoxygenation of ALA. | 2013 | J. Lipid Res. | pmid:23740966 |
Monteiro J et al. | Oils rich in α-linolenic acid independently protect against characteristics of fatty liver disease in the Δ6-desaturase null mouse. | 2013 | Can. J. Physiol. Pharmacol. | pmid:23746194 |
Kim Y et al. | Synergism of α-linolenic acid, conjugated linoleic acid and calcium in decreasing adipocyte and increasing osteoblast cell growth. | 2013 | Lipids | pmid:23757205 |
pmid:23774275 | ||||
Wei M et al. | Perilla oil and exercise decrease expressions of tumor necrosis factor-alpha, plasminogen activator inhibitor-1 and highly sensitive C-reactive protein in patients with hyperlipidemia. | 2013 | J Tradit Chin Med | pmid:23789212 |
Stivala S et al. | Dietary α-linolenic acid increases the platelet count in ApoE-/- mice by reducing clearance. | 2013 | Blood | pmid:23801636 |
Moloney AP et al. | Colour of fat, and colour, fatty acid composition and sensory characteristics of muscle from heifers offered alternative forages to grass silage in a finishing ration. | 2013 | Meat Sci. | pmid:23806853 |
Esselburn KM et al. | Intake of specific fatty acids and fat alters growth, health, and titers following vaccination in dairy calves. | 2013 | J. Dairy Sci. | pmid:23810586 |
Cao AH et al. | Composition of long chain polyunsaturated fatty acids (LC-PUFAs) in different encephalic regions and its association with behavior in spontaneous hypertensive rat (SHR). | 2013 | Brain Res. | pmid:23811335 |
Zheng JS et al. | Intake of fish and marine n-3 polyunsaturated fatty acids and risk of breast cancer: meta-analysis of data from 21 independent prospective cohort studies. | 2013 | BMJ | pmid:23814120 |
Lagarde M et al. | Lipidomics of essential fatty acids and oxygenated metabolites. | 2013 | Mol Nutr Food Res | pmid:23818385 |
Pan X et al. | Identification of a pair of phospholipid:diacylglycerol acyltransferases from developing flax (Linum usitatissimum L.) seed catalyzing the selective production of trilinolenin. | 2013 | J. Biol. Chem. | pmid:23824186 |
Khaw KT | Dietary fats and breast cancer risk. | 2013 | BMJ | pmid:23861431 |
Zhang W et al. | Alpha-linolenic acid exerts an endothelial protective effect against high glucose injury via PI3K/Akt pathway. | 2013 | PLoS ONE | pmid:23861910 |
Randall KM et al. | Effects of dietary supplementation of coriander oil, in canola oil diets, on the metabolism of [1-(14)C] 18:3n-3 and [1-(14)C] 18:2n-6 in rainbow trout hepatocytes. | 2013 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:23867781 |
Almario RU and Karakas SE | Lignan content of the flaxseed influences its biological effects in healthy men and women. | 2013 | J Am Coll Nutr | pmid:23885993 |
Yu X et al. | α-Linolenic acid attenuates doxorubicin-induced cardiotoxicity in rats through suppression of oxidative stress and apoptosis. | 2013 | Acta Biochim. Biophys. Sin. (Shanghai) | pmid:23896563 |
Caligiuri SP et al. | Dietary linoleic acid and α-linolenic acid differentially affect renal oxylipins and phospholipid fatty acids in diet-induced obese rats. | 2013 | J. Nutr. | pmid:23902961 |
Lagunas B et al. | A temporal regulatory mechanism controls the different contribution of endoplasmic reticulum and plastidial ω-3 desaturases to trienoic fatty acid content during leaf development in soybean (Glycine max cv Volania). | 2013 | Phytochemistry | pmid:23928132 |
Kwon TY et al. | Headspace-solid phase microextraction-gas chromatography-tandem mass spectrometry (HS-SPME-GC-MS2) method for the determination of pyrazines in perilla seed oils: impact of roasting on the pyrazines in perilla seed oils. | 2013 | J. Agric. Food Chem. | pmid:23968142 |
Lund AS et al. | N-3 polyunsaturated fatty acids, body fat and inflammation. | 2013 | Obes Facts | pmid:23970146 |
Sun L et al. | The neuroprotective effects of Coccomyxa gloeobotrydiformis on the ischemic stroke in a rat model. | 2013 | Int. J. Biol. Sci. | pmid:23983614 |
Al-Bishri WM | Favorable effects of flaxseed supplemented diet on liver and kidney functions in hypertensive Wistar rats. | 2013 | J Oleo Sci | pmid:24005015 |
pmid:24005871 | ||||
Ladeira MM et al. | Fatty acid profile, color and lipid oxidation of meat from young bulls fed ground soybean or rumen protected fat with or without monensin. | 2014 | Meat Sci. | pmid:24018278 |
pmid:24026545 | ||||
Arya E et al. | Effect of Perilla frutescens fixed oil on experimental esophagitis in albino Wistar rats. | 2013 | Biomed Res Int | pmid:24027769 |
pmid:24029409 | ||||
Keim SA and Branum AM | Dietary intake of polyunsaturated fatty acids and fish among US children 12-60 months of age. | 2015 | Matern Child Nutr | pmid:24034437 |
pmid:24035021 | ||||
Dal Bosco A et al. | Effect of dietary alfalfa on the fatty acid composition and indexes of lipid metabolism of rabbit meat. | 2014 | Meat Sci. | pmid:24036258 |
Hoque M et al. | Oleic acid may be the key contributor in the BAMLET-induced erythrocyte hemolysis and tumoricidal action. | 2013 | PLoS ONE | pmid:24039698 |
Alhazzaa R et al. | Bioconversion of α-linolenic acid into n-3 long-chain polyunsaturated fatty acid in hepatocytes and ad hoc cell culture optimisation. | 2013 | PLoS ONE | pmid:24040040 |
Carotenuto F et al. | A diet supplemented with ALA-rich flaxseed prevents cardiomyocyte apoptosis by regulating caveolin-3 expression. | 2013 | Cardiovasc. Res. | pmid:24042018 |
Chechetkin IR et al. | Isolation and structure elucidation of linolipins C and D, complex oxylipins from flax leaves. | 2013 | Phytochemistry | pmid:24042063 |
Moallem U et al. | Dietary α-linolenic acid from flaxseed oil improved folliculogenesis and IVF performance in dairy cows, similar to eicosapentaenoic and docosahexaenoic acids from fish oil. | 2013 | Reproduction | pmid:24062566 |
Hoffmann I and Oliw EH | Discovery of a linoleate 9S-dioxygenase and an allene oxide synthase in a fusion protein of Fusarium oxysporum. | 2013 | J. Lipid Res. | pmid:24082064 |
Reinders I et al. | Associations of serum n-3 and n-6 polyunsaturated fatty acids with echocardiographic measures among older adults: the Hoorn Study. | 2013 | Eur J Clin Nutr | pmid:24084512 |
Végner L et al. | Experimental confirmation of new drug-target interactions predicted by Drug Profile Matching. | 2013 | J. Med. Chem. | pmid:24088053 |
Arm JP et al. | Impact of botanical oils on polyunsaturated fatty acid metabolism and leukotriene generation in mild asthmatics. | 2013 | Lipids Health Dis | pmid:24088297 |
pmid:24101555 | ||||
Berasategi I et al. | Reduced-fat bologna sausages with improved lipid fraction. | 2014 | J. Sci. Food Agric. | pmid:24105447 |
Shibata E et al. | Free fatty acids inhibit protein tyrosine phosphatase 1B and activate Akt. | 2013 | Cell. Physiol. Biochem. | pmid:24107614 |
pmid:24119803 | ||||
Oliva ME et al. | Dietary Salba (Salvia hispanica L) seed rich in α-linolenic acid improves adipose tissue dysfunction and the altered skeletal muscle glucose and lipid metabolism in dyslipidemic insulin-resistant rats. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24120122 |
Shen JH et al. | Effect of α-linolenic acid on streptozotocin-induced diabetic retinopathy indices in vivo. | 2013 | Arch. Med. Res. | pmid:24120388 |
Rodriguez-Leyva D et al. | Potent antihypertensive action of dietary flaxseed in hypertensive patients. | 2013 | Hypertension | pmid:24126178 |
Hanke D et al. | A diet high in α-linolenic acid and monounsaturated fatty acids attenuates hepatic steatosis and alters hepatic phospholipid fatty acid profile in diet-induced obese rats. | 2013 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24140006 |
Mariutto M et al. | Reprogramming of fatty acid and oxylipin synthesis in rhizobacteria-induced systemic resistance in tomato. | 2014 | Plant Mol. Biol. | pmid:24146221 |
Aki T et al. | Regulation of polyunsaturated fatty acid biosynthesis by seaweed fucoxanthin and its metabolite in cultured hepatocytes. | 2014 | Lipids | pmid:24174374 |
Sonne DP and Knop FK | Cardiovascular effects of alpha-linolenic acid--a possible role of glucagon-like peptide-1. | 2013 | Exp. Biol. Med. (Maywood) | pmid:24174423 |
Afitlhile M et al. | A mutant of the Arabidopsis thaliana TOC159 gene accumulates reduced levels of linolenic acid and monogalactosyldiacylglycerol. | 2013 | Plant Physiol. Biochem. | pmid:24184455 |
Salazar MO et al. | A thin-layer chromatography autographic method for the detection of inhibitors of the Salmonella PhoP-PhoQ regulatory system. | 2014 Mar-Apr | Phytochem Anal | pmid:24185747 |
Hansson A et al. | Activation of protein kinase C by lipoxin A and other eicosanoids. Intracellular action of oxygenation products of arachidonic acid. | 1986 | Biochem. Biophys. Res. Commun. | pmid:2418836 |
Egusa Saiga A and Nishimura T | Antioxidative properties of peptides obtained from porcine myofibrillar proteins by a protease treatment in an Fe (II)-induced aqueous lipid peroxidation system. | 2013 | Biosci. Biotechnol. Biochem. | pmid:24200778 |
Domenichiello AF et al. | Whole body synthesis rates of DHA from α-linolenic acid are greater than brain DHA accretion and uptake rates in adult rats. | 2014 | J. Lipid Res. | pmid:24212299 |
Shimada TL et al. | Leaf oil body functions as a subcellular factory for the production of a phytoalexin in Arabidopsis. | 2014 | Plant Physiol. | pmid:24214535 |
Zhang W et al. | Alpha-linolenic acid intake prevents endothelial dysfunction in high-fat diet-fed streptozotocin rats and underlying mechanisms. | 2013 | VASA | pmid:24220118 |
Gong Z et al. | G protein-coupled receptor 120 signaling regulates ghrelin secretion in vivo and in vitro. | 2014 | Am. J. Physiol. Endocrinol. Metab. | pmid:24222669 |
Grindel A et al. | Cheek cell fatty acids reflect n-3 PUFA in blood fractions during linseed oil supplementation: a controlled human intervention study. | 2013 | Lipids Health Dis | pmid:24229084 |
Sánchez-Reyes OB et al. | Free fatty acids and protein kinase C activation induce GPR120 (free fatty acid receptor 4) phosphorylation. | 2014 | Eur. J. Pharmacol. | pmid:24239485 |
Reiner WB et al. | Fatty acids in mountain gorilla diets: implications for primate nutrition and health. | 2014 | Am. J. Primatol. | pmid:24243235 |
Lau BY et al. | Investigating the role of polyunsaturated fatty acids in bone development using animal models. | 2013 | Molecules | pmid:24248147 |
Lane K et al. | Bioavailability and potential uses of vegetarian sources of omega-3 fatty acids: a review of the literature. | 2014 | Crit Rev Food Sci Nutr | pmid:24261532 |
pmid:24261881 | ||||
Carbonera F et al. | Effect of dietary replacement of sunflower oil with perilla oil on the absolute fatty acid composition in Nile tilapia (GIFT). | 2014 | Food Chem | pmid:24262550 |
Ma T et al. | Effect of droplet size on autoxidation rates of methyl linoleate and α-linolenate in an oil-in-water emulsion. | 2013 | J Oleo Sci | pmid:24292352 |
MartÃnez-RamÃrez HR et al. | Retention of n-3 polyunsaturated fatty acids in trimmed loin and belly is independent of timing of feeding ground flaxseed to growing-finishing female pigs. | 2014 | J. Anim. Sci. | pmid:24305874 |
Canetti L et al. | Linoleic and alpha linolenic acids ameliorate streptozotocin-induced diabetes in mice. | 2014 | Arch. Physiol. Biochem. | pmid:24320056 |
Berasategi I et al. | Healthy reduced-fat Bologna sausages enriched in ALA and DHA and stabilized with Melissa officinalis extract. | 2014 | Meat Sci. | pmid:24334039 |
Sugasini D et al. | Lymphatic transport of α-linolenic acid and its conversion to long chain n-3 fatty acids in rats fed microemulsions of linseed oil. | 2014 | Lipids | pmid:24338560 |
O'Callaghan N et al. | Telomere shortening in elderly individuals with mild cognitive impairment may be attenuated with ω-3 fatty acid supplementation: a randomized controlled pilot study. | 2014 | Nutrition | pmid:24342530 |
Koh AS et al. | The association between dietary omega-3 fatty acids and cardiovascular death: the Singapore Chinese Health Study. | 2015 | Eur J Prev Cardiol | pmid:24343844 |
Brouwer IA et al. | Effect of alpha linolenic acid supplementation on serum prostate specific antigen (PSA): results from the alpha omega trial. | 2013 | PLoS ONE | pmid:24349086 |
Benbrook CM et al. | Organic production enhances milk nutritional quality by shifting fatty acid composition: a United States-wide, 18-month study. | 2013 | PLoS ONE | pmid:24349282 |
de Oliveira Otto MC et al. | Circulating and dietary omega-3 and omega-6 polyunsaturated fatty acids and incidence of CVD in the Multi-Ethnic Study of Atherosclerosis. | 2013 | J Am Heart Assoc | pmid:24351702 |
Vaezi R et al. | Identification and functional characterization of genes encoding omega-3 polyunsaturated fatty acid biosynthetic activities from unicellular microalgae. | 2013 | Mar Drugs | pmid:24351909 |
pmid:24355403 | ||||
Able JA et al. | Omega-3 fatty acid deficient male rats exhibit abnormal behavioral activation in the forced swim test following chronic fluoxetine treatment: association with altered 5-HT1A and alpha2A adrenergic receptor expression. | 2014 | J Psychiatr Res | pmid:24360505 |
pmid:24380374 | ||||
Djoussé L et al. | Repeated versus single measurement of plasma omega-3 fatty acids and risk of heart failure. | 2014 | Eur J Nutr | pmid:24395612 |
Dai XW et al. | Erythrocyte membrane n-3 fatty acid levels and carotid atherosclerosis in Chinese men and women. | 2014 | Atherosclerosis | pmid:24401220 |
pmid:24418278 | ||||
Zhang T et al. | High-fat diet from perilla oil induces insulin resistance despite lower serum lipids and increases hepatic fatty acid oxidation in rats. | 2014 | Lipids Health Dis | pmid:24422660 |
Saliba L et al. | Effect of feeding linseed oil in diets differing in forage to concentrate ratio: 1. Production performance and milk fat content of biohydrogenation intermediates of α-linolenic acid. | 2014 | J. Dairy Res. | pmid:24433586 |
MartÃnez-RamÃrez HR et al. | Whole-body retention of α-linolenic acid and its apparent conversion to other n-3 PUFA in growing pigs are reduced with the duration of feeding α-linolenic acid. | 2014 | Br. J. Nutr. | pmid:24438755 |
Shen J et al. | A 13-lipoxygenase, TomloxC, is essential for synthesis of C5 flavour volatiles in tomato. | 2014 | J. Exp. Bot. | pmid:24453226 |
Belayachi L et al. | Retama monosperma n-hexane extract induces cell cycle arrest and extrinsic pathway-dependent apoptosis in Jurkat cells. | 2014 | BMC Complement Altern Med | pmid:24460687 |
Soto-Cerda BJ et al. | Association mapping of seed quality traits using the Canadian flax (Linum usitatissimum L.) core collection. | 2014 | Theor. Appl. Genet. | pmid:24463785 |
Khodadoust S et al. | Identification and determination of the fatty acid composition of Quercus brantii growing in southwestern Iran by GC-MS. | 2014 | Nat. Prod. Res. | pmid:24499169 |
pmid:24524826 | ||||
pmid:24552275 | ||||
Jung JY et al. | Effect of dietary supplementation with omega-3 fatty acid and gamma-linolenic acid on acne vulgaris: a randomised, double-blind, controlled trial. | 2014 | Acta Derm. Venereol. | pmid:24553997 |