alpha-linolenic acid

Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.

Cross Reference

Introduction

To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with alpha-linolenic acid?

alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid

MeSH term MeSH ID Detail
Night Blindness D009755 1 associated lipids
Stomatitis, Aphthous D013281 1 associated lipids
Conjunctivitis, Allergic D003233 1 associated lipids
Aging, Premature D019588 1 associated lipids
Hearing Loss, High-Frequency D006316 1 associated lipids
Otorhinolaryngologic Neoplasms D010039 2 associated lipids
Spinal Cord Ischemia D020760 2 associated lipids
Torsades de Pointes D016171 2 associated lipids
Sebaceous Gland Neoplasms D012626 2 associated lipids
Mental Fatigue D005222 3 associated lipids
Carcinogenesis D063646 3 associated lipids
Depression, Postpartum D019052 3 associated lipids
Dyskinesias D020820 3 associated lipids
Insect Bites and Stings D007299 4 associated lipids
Endomyocardial Fibrosis D004719 4 associated lipids
Amyloidosis D000686 4 associated lipids
Pancytopenia D010198 6 associated lipids
Retinitis Pigmentosa D012174 6 associated lipids
Exocrine Pancreatic Insufficiency D010188 6 associated lipids
Urinary Bladder Neoplasms D001749 7 associated lipids
Per page 10 20 50 100 | Total 104

PubChem Associated disorders and diseases

What pathways are associated with alpha-linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with alpha-linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with alpha-linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with alpha-linolenic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with alpha-linolenic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with alpha-linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with alpha-linolenic acid

Download all related citations
Per page 10 20 50 100 | Total 2471
Authors Title Published Journal PubMed Link
Reinprecht Y et al. Seed and agronomic QTL in low linolenic acid, lipoxygenase-free soybean (Glycine max (L.) Merrill) germplasm. 2006 Genome pmid:17426766
Menéndez JA et al. HER2 (erbB-2)-targeted effects of the omega-3 polyunsaturated fatty acid, alpha-linolenic acid (ALA; 18:3n-3), in breast cancer cells: the "fat features" of the "Mediterranean diet" as an "anti-HER2 cocktail". 2006 Clin Transl Oncol pmid:17134970
Why not flaxseed oil? There's no mercury to worry about, and it does contain omega-3 fats...but not the best kind. 2006 Harv Health Lett pmid:17152637
Griffin MD et al. Effects of altering the ratio of dietary n-6 to n-3 fatty acids on insulin sensitivity, lipoprotein size, and postprandial lipemia in men and postmenopausal women aged 45-70 y: the OPTILIP Study. 2006 Am. J. Clin. Nutr. pmid:17158408
Harper CR et al. Flaxseed oil supplementation does not affect plasma lipoprotein concentration or particle size in human subjects. 2006 J. Nutr. pmid:17056811
de Lorgeril M and Salen P The Mediterranean diet in secondary prevention of coronary heart disease. 2006 Clin Invest Med pmid:17058434
Tavilani H et al. Decreased polyunsaturated and increased saturated fatty acid concentration in spermatozoa from asthenozoospermic males as compared with normozoospermic males. 2006 Andrologia pmid:16961570
Dabadie H et al. Variations in daily intakes of myristic and alpha-linolenic acids in sn-2 position modify lipid profile and red blood cell membrane fluidity. 2006 Br. J. Nutr. pmid:16923222
I take ground flaxseed to help control my cholesterol. But I read that the alpha-linoleic acid (ALA) in flax increases the risk of prostate cancer. Is this true? Does the risk differ between ground flaxseed and concentrated flaxseed oil in capsules? 2006 Johns Hopkins Med Lett Health After 50 pmid:16548073
Blanco M et al. Ischemic preconditioning: a novel target for neuroprotective therapy. 2006 Cerebrovasc. Dis. pmid:16651813
Shanker KS et al. Isolation and characterization of neutral lipids of desilked eri silkworm pupae grown on castor and tapioca leaves. 2006 J. Agric. Food Chem. pmid:16637689
Cristea M and Oliw EH A G316A mutation of manganese lipoxygenase augments hydroperoxide isomerase activity: mechanism of biosynthesis of epoxyalcohols. 2006 J. Biol. Chem. pmid:16641090
King VR et al. Omega-3 fatty acids improve recovery, whereas omega-6 fatty acids worsen outcome, after spinal cord injury in the adult rat. 2006 J. Neurosci. pmid:16641248
Heller AR et al. Omega-3 alpha linolenic acid does not reflect the entire omega-3 fatty acid family. 2006 Anesth. Analg. pmid:16551943
Djoussé L et al. Influence of saturated fat and linolenic acid on the association between intake of dairy products and blood pressure. 2006 Hypertension pmid:16801477
Cancelo Hidalgo MJ et al. Effect of a compound containing isoflavones, primrose oil and vitamin E in two different doses on climacteric symptoms. 2006 J Obstet Gynaecol pmid:16753687
Martin CA et al. Trans polyunsaturated fatty acid contents in Brazilian refined soybean oil. 2006 Anal Sci pmid:16760612
Wang C et al. n-3 Fatty acids from fish or fish-oil supplements, but not alpha-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: a systematic review. 2006 Am. J. Clin. Nutr. pmid:16825676
Koralek DO et al. A prospective study of dietary alpha-linolenic acid and the risk of prostate cancer (United States). 2006 Cancer Causes Control pmid:16783606
Wang Q et al. [Determination of alpha-linolenic acid in perilla oil by reversed-phase high performance liquid chromatography coupled with evaporative light-scattering detector]. 2006 Se Pu pmid:16827313
Li D et al. Omega 6 to omega 3 fatty acid imbalance early in life leads to persistent reductions in DHA levels in glycerophospholipids in rat hypothalamus even after long-term omega 3 fatty acid repletion. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16716580
DiRienzo MA et al. Effect of substitution of low linolenic acid soybean oil for hydrogenated soybean oil on fatty acid intake. 2006 Lipids pmid:17707981
Igarashi M et al. Low liver conversion rate of alpha-linolenic to docosahexaenoic acid in awake rats on a high-docosahexaenoate-containing diet. 2006 J. Lipid Res. pmid:16687661
Choi YH et al. NMR metabolomics to revisit the tobacco mosaic virus infection in Nicotiana tabacum leaves. 2006 J. Nat. Prod. pmid:16724833
Knudsen VK et al. Fish oil in various doses or flax oil in pregnancy and timing of spontaneous delivery: a randomised controlled trial. 2006 BJOG pmid:16579802
Marotta F et al. Liver exposure to xenobiotics: the aging factor and potentials for functional foods. 2006 Rejuvenation Res pmid:16706665
Aldámiz-Echevarría L et al. Effect of docosahexaenoic acid administration on plasma lipid profile and metabolic parameters of children with methylmalonic acidaemia. 2006 J. Inherit. Metab. Dis. pmid:16601869
Dhar P et al. Antioxidative effect of conjugated linolenic acid in diabetic and non-diabetic blood: an in vitro study. 2006 J Oleo Sci pmid:17693694
Taha AY et al. Markedly raised intake of saturated and monounsaturated fatty acids in rats on a high-fat ketogenic diet does not inhibit carbon recycling of 13C-alpha-linolenate. 2006 Lipids pmid:17180881
Laitinen K et al. Serum, cheek cell and breast milk fatty acid compositions in infants with atopic and non-atopic eczema. 2006 Clin. Exp. Allergy pmid:16433853
Inouye S et al. The vapor activity of oregano, perilla, tea tree, lavender, clove, and geranium oils against a Trichophyton mentagrophytes in a closed box. 2006 J. Infect. Chemother. pmid:17235639
Kukoba TV et al. [The effects of alpha-linolenic acid on the functioning of the isolated heart during acute myocardial ischemia/reperfusion]. 2006 Fiziol Zh pmid:17176834
Joshi K et al. Supplementation with flax oil and vitamin C improves the outcome of Attention Deficit Hyperactivity Disorder (ADHD). 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16314082
Rodriguez-Cruz M et al. Synthesis of long-chain polyunsaturated fatty acids in lactating mammary gland: role of Delta5 and Delta6 desaturases, SREBP-1, PPARalpha, and PGC-1. 2006 J. Lipid Res. pmid:16333142
Harper CR et al. Flaxseed oil increases the plasma concentrations of cardioprotective (n-3) fatty acids in humans. 2006 J. Nutr. pmid:16365063
Leone A et al. Lipoxygenase involvement in ripening strawberry. 2006 J. Agric. Food Chem. pmid:16939347
Heurteaux C et al. Alpha-linolenic acid and riluzole treatment confer cerebral protection and improve survival after focal brain ischemia. 2006 Neuroscience pmid:16289892
Turpeinen AM et al. Effects of conjugated linoleic acid on linoleic and linolenic acid metabolism in man. 2006 Br. J. Nutr. pmid:16571152
Perez MA et al. Dietary docosahexaenoic acid alters pregnant rat reproductive tissue prostaglandin and matrix metalloproteinase production. 2006 J. Nutr. Biochem. pmid:16457997
Lehner F et al. Metabolic effects of intravenous LCT or MCT/LCT lipid emulsions in preterm infants. 2006 J. Lipid Res. pmid:16299352
Calder PC Abnormal fatty acid profiles occur in atopic dermatitis but what do they mean? 2006 Clin. Exp. Allergy pmid:16433850
Veltri BC et al. Adipose fatty acid composition and rate of incorporation of alpha-linolenic acid differ between normal and lipoprotein lipase-deficient cats. 2006 J. Nutr. pmid:17116707
Cunnane SC et al. Suckling rats actively recycle carbon from alpha-linolenate into newly synthesized lipids even during extreme dietary deficiency of n-3 polyunsaturates. 2006 Pediatr. Res. pmid:16326997
Langdon JH Has an aquatic diet been necessary for hominin brain evolution and functional development? 2006 Br. J. Nutr. pmid:16869985
Maillard V et al. Dietary beta-carotene inhibits mammary carcinogenesis in rats depending on dietary alpha-linolenic acid content. 2006 Br. J. Nutr. pmid:16869986
Moore CS et al. Oily fish reduces plasma triacylglycerols: a primary prevention study in overweight men and women. 2006 Nutrition pmid:17027436
Zhang HT et al. [Functional expression of an omega-3 fatty acid desaturase gene from Glycine max in Saccharomyces cerevisiae]. 2006 Sheng Wu Gong Cheng Xue Bao pmid:16572837
Sebei K et al. Evolution of phosphoenolpyruvate carboxylase activity and lipid content during seed maturation of two spring rapeseed cultivars (Brassica napus L.). 2006 C. R. Biol. pmid:16945838
Xiang M et al. Diet and gene expression: delta-5 and delta-6 desaturases in healthy Chinese and European subjects. 2006 Ann. Nutr. Metab. pmid:16988497
Wendland E et al. Effect of alpha linolenic acid on cardiovascular risk markers: a systematic review. 2006 Heart pmid:15890766
Yasui Y et al. Troglitazone and 9cis,11trans,13trans-conjugated linolenic acid: comparison of their antiproliferative and apoptosis-inducing effects on different colon cancer cell lines. 2006 Chemotherapy pmid:16899971
Murayama SY et al. Construction and functional analysis of fatty acid desaturase gene disruptants in Candida albicans. 2006 Microbiology (Reading, Engl.) pmid:16622072
Hoffman DR et al. Docosahexaenoic acid in red blood cells of term infants receiving two levels of long-chain polyunsaturated fatty acids. 2006 J. Pediatr. Gastroenterol. Nutr. pmid:16540798
Ambrose DJ et al. Lower pregnancy losses in lactating dairy cows fed a diet enriched in alpha-linolenic acid. 2006 J. Dairy Sci. pmid:16840624
Arterburn LM et al. Distribution, interconversion, and dose response of n-3 fatty acids in humans. 2006 Am. J. Clin. Nutr. pmid:16841856
Breslow JL n-3 fatty acids and cardiovascular disease. 2006 Am. J. Clin. Nutr. pmid:16841857
Levant B et al. Differential effects of modulation of docosahexaenoic acid content during development in specific regions of rat brain. 2006 Lipids pmid:16933785
Tsuzuki T et al. Conjugated linolenic acid is slowly absorbed in rat intestine, but quickly converted to conjugated linoleic acid. 2006 J. Nutr. pmid:16857834
Levant B et al. Diet (n-3) polyunsaturated fatty acid content and parity interact to alter maternal rat brain phospholipid fatty acid composition. 2006 J. Nutr. pmid:16857847
Djoussé L et al. Dietary linolenic acid and fasting glucose and insulin: the National Heart, Lung, and Blood Institute Family Heart Study. 2006 Obesity (Silver Spring) pmid:16571856
Ramaprasad TR et al. Spray-dried milk supplemented with alpha-linolenic acid or eicosapentaenoic acid and docosahexaenoic acid decreases HMG Co A reductase activity and increases biliary secretion of lipids in rats. 2006 Steroids pmid:16499938
DeFilippis AP and Sperling LS Understanding omega-3's. 2006 Am. Heart J. pmid:16504616
Martínez-Ortiz JA et al. Dietary patterns and risk of nonfatal acute myocardial infarction in Costa Rican adults. 2006 Eur J Clin Nutr pmid:16465200
Liechti R and Farmer EE Jasmonate biochemical pathway. 2006 Sci. STKE pmid:16478937
Mamalakis G et al. Depression and adipose and serum cholesteryl ester polyunsaturated fatty acids in the survivors of the seven countries study population of Crete. 2006 Eur J Clin Nutr pmid:16482070
Goyens PL and Mensink RP Effects of alpha-linolenic acid versus those of EPA/DHA on cardiovascular risk markers in healthy elderly subjects. 2006 Eur J Clin Nutr pmid:16482073
Mayes C et al. Variation in [U-13C] alpha linolenic acid absorption, beta-oxidation and conversion to docosahexaenoic acid in the pre-term infant fed a DHA-enriched formula. 2006 Pediatr. Res. pmid:16439591
Sanjurjo P et al. Fatty acid composition of skeletal muscle and adipose tissue in Spanish infants and children. 2006 Br. J. Nutr. pmid:16441930
Williams CM and Burdge G Long-chain n-3 PUFA: plant v. marine sources. 2006 Proc Nutr Soc pmid:16441943
Christensen JH et al. Prostate tissue and leukocyte levels of n-3 polyunsaturated fatty acids in men with benign prostate hyperplasia or prostate cancer. 2006 BJU Int. pmid:16430627
Oliw EH et al. Payne rearrangement during analysis of epoxyalcohols of linoleic and alpha-linolenic acids by normal phase liquid chromatography with tandem mass spectrometry. 2006 Anal. Biochem. pmid:16712763
Hamazaki K et al. Effects of cooking plant oils on recurrent aphthous stomatitis: a randomized, placebo-controlled, double-blind trial. 2006 Nutrition pmid:16472981
Dalen KT et al. PPARalpha activators and fasting induce the expression of adipose differentiation-related protein in liver. 2006 J. Lipid Res. pmid:16489205
Vijaimohan K et al. Beneficial effects of alpha linolenic acid rich flaxseed oil on growth performance and hepatic cholesterol metabolism in high fat diet fed rats. 2006 Life Sci. pmid:16490217
Pedersen JI [Does alpha-linolenic acid prevent cardiac death?]. 2006 Tidsskr. Nor. Laegeforen. pmid:17086215
Landmark K and Alm CS [Alpha-linolenic acid, cardiovascular disease and sudden death]. 2006 Tidsskr. Nor. Laegeforen. pmid:17086218
Burdge GC and Calder PC Conversion of alpha-linolenic acid to longer-chain polyunsaturated fatty acids in human adults. 2005 Sep-Oct Reprod. Nutr. Dev. pmid:16188209
Mozaffarian D Does alpha-linolenic acid intake reduce the risk of coronary heart disease? A review of the evidence. 2005 May-Jun Altern Ther Health Med pmid:15945135
MandaÅŸescu S et al. Flaxseed supplementation in hyperlipidemic patients. 2005 Jul-Sep Rev Med Chir Soc Med Nat Iasi pmid:16607740
Colombo C et al. Plant-based diet, serum fatty acid profile, and free radicals in postmenopausal women: the diet and androgens (DIANA) randomized trial. 2005 Jul-Sep Int. J. Biol. Markers pmid:16240844
Morise A et al. Dose effect of alpha-linolenic acid on lipid metabolism in the hamster. 2005 Jul-Aug Reprod. Nutr. Dev. pmid:16045889
Milne GL et al. The cyclopentenone (A2/J2) isoprostanes--unique, highly reactive products of arachidonate peroxidation. 2005 Jan-Feb Antioxid. Redox Signal. pmid:15650409
Paschos GK et al. Apolipoprotein E genotype in dyslipidemic patients and response of blood lipids and inflammatory markers to alpha-linolenic Acid. 2005 Jan-Feb Angiology pmid:15678256
Cheng Z et al. The effect of supplementation with n-6 polyunsaturated fatty acids on 1-, 2- and 3-series prostaglandin F production by ovine uterine epithelial cells. 2005 Biochim. Biophys. Acta pmid:16140575
Wang YL et al. LC-DAD-APCI-MS-based screening and analysis of the absorption and metabolite components in plasma from a rabbit administered an oral solution of danggui. 2005 Anal Bioanal Chem pmid:16132135
Kim EJ et al. Fatty acid profiles associated with microbial colonization of freshly ingested grass and rumen biohydrogenation. 2005 J. Dairy Sci. pmid:16107412
Clapham WM et al. Fatty acid composition of traditional and novel forages. 2005 J. Agric. Food Chem. pmid:16366696
Patch CS et al. The use of novel foods enriched with long-chain n-3 fatty acids to increase dietary intake: a comparison of methodologies assessing nutrient intake. 2005 J Am Diet Assoc pmid:16321598
Cleland LG et al. Paradoxical effect of n-3-containing vegetable oils on long-chain n-3 fatty acids in rat heart. 2005 Lipids pmid:16382570
Addis M et al. Milk and cheese fatty acid composition in sheep fed Mediterranean forages with reference to conjugated linoleic acid cis-9,trans-11. 2005 J. Dairy Sci. pmid:16162517
Paré PW et al. Elicitors and priming agents initiate plant defense responses. 2005 Photosyn. Res. pmid:16075316
Jula A et al. Effects of diet and simvastatin on fatty acid composition in hypercholesterolemic men: a randomized controlled trial. 2005 Arterioscler. Thromb. Vasc. Biol. pmid:16020749
Bou R et al. Effect of dietary fat sources and zinc and selenium supplements on the composition and consumer acceptability of chicken meat. 2005 Poult. Sci. pmid:16050130
Bergamo P et al. Butterfat fatty acids differentially regulate growth and differentiation in Jurkat T-cells. 2005 J. Cell. Biochem. pmid:16052483
Vrinten P et al. Two FAD3 desaturase genes control the level of linolenic acid in flax seed. 2005 Plant Physiol. pmid:16113219
Harris WS Alpha-linolenic acid: a gift from the land? 2005 Circulation pmid:15939831
Yang L et al. Alpha-linolenic acid but not conjugated linolenic acid is hypocholesterolaemic in hamsters. 2005 Br. J. Nutr. pmid:15946404
Araujo P et al. Chemometric approaches in calibration experiments of trilinolenoylglycerol by liquid chromatography ion-trap mass spectrometry. 2005 J. Am. Soc. Mass Spectrom. pmid:15734332
Rastogi SK and Singh J Effect of chemical penetration enhancer and iontophoresis on the in vitro percutaneous absorption enhancement of insulin through porcine epidermis. 2005 Pharm Dev Technol pmid:15776817
Zhao G et al. Anti-inflammatory effects of polyunsaturated fatty acids in THP-1 cells. 2005 Biochem. Biophys. Res. Commun. pmid:16169525