Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Agostoni C | The difficult balance between dietary polyunsaturated fatty acids. | 2003 | Acta Paediatr. | pmid:14971782 |
Ayala S and Brenner RR | Effect of polyunsaturated fatty acids of the alpha-linolenic series in the lipid composition of rat testicles during development. | 1980 | Acta Physiol Lat Am | pmid:6287807 |
Cocchi M et al. | Effect of C 18:3 (n-3) dietary supplementation on the fatty acid composition of the rat brain. | 1984 | Acta Vitaminol. Enzymol. | pmid:6098183 |
Ermidou-Pollet S et al. | Influence of subcutaneous injection of essential fatty acids on the stress-induced modifications of rat platelet aggregation and membrane lipid composition. | 2005 | Acta. Biol. Hung. | pmid:16196200 |
Fleming JA and Kris-Etherton PM | The evidence for α-linolenic acid and cardiovascular disease benefits: Comparisons with eicosapentaenoic acid and docosahexaenoic acid. | 2014 | Adv Nutr | pmid:25398754 |
Valentine CJ | Maternal dietary DHA supplementation to improve inflammatory outcomes in the preterm infant. | 2012 | Adv Nutr | pmid:22585914 |
Devassy JG et al. | Omega-3 Polyunsaturated Fatty Acids and Oxylipins in Neuroinflammation and Management of Alzheimer Disease. | 2016 | Adv Nutr | pmid:27633106 |
López-Alarcón M et al. | Breastfeeding protects against the anorectic response to infection in infants: possible role of DHA. | 2004 | Adv. Exp. Med. Biol. | pmid:15384603 |
Hamberg M | Transformations of alpha-linolenic acid in leaves of corn (Zea mays L.). | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1671803 |
Bjerve KS et al. | Alpha-linolenic acid deficiency in man: effect of essential fatty acids on fatty acid composition. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2890285 |
Gao F et al. | Aging decreases rate of docosahexaenoic acid synthesis-secretion from circulating unesterified α-linolenic acid by rat liver. | 2013 | Age (Dordr) | pmid:22388930 |
Jayatilleke A and Shaw S | Stimulation of monocyte interleukin-8 by lipid peroxidation products: a mechanism for alcohol-induced liver injury. | 1998 | Alcohol | pmid:9665313 |
Nielsen AA et al. | Omega-3 fatty acids inhibit an increase of proinflammatory cytokines in patients with active Crohn's disease compared with omega-6 fatty acids. | 2005 | Aliment. Pharmacol. Ther. | pmid:16305726 |
Logan AC | Neurobehavioral aspects of omega-3 fatty acids: possible mechanisms and therapeutic value in major depression. | 2003 | Altern Med Rev | pmid:14653768 |
Mozaffarian D | Does alpha-linolenic acid intake reduce the risk of coronary heart disease? A review of the evidence. | 2005 May-Jun | Altern Ther Health Med | pmid:15945135 |
DeFilippis AP and Sperling LS | Understanding omega-3's. | 2006 | Am. Heart J. | pmid:16504616 |
Szabó E et al. | trans Octadecenoic acid and trans octadecadienoic acid are inversely related to long-chain polyunsaturates in human milk: results of a large birth cohort study. | 2007 | Am. J. Clin. Nutr. | pmid:17490969 |
Hunter JE | n-3 fatty acids from vegetable oils. | 1990 | Am. J. Clin. Nutr. | pmid:1970702 |
Simon JA et al. | The relation of alpha-linolenic acid to the risk of prostate cancer: a systematic review and meta-analysis. | 2009 | Am. J. Clin. Nutr. | pmid:19321563 |
Griffin MD et al. | Effects of altering the ratio of dietary n-6 to n-3 fatty acids on insulin sensitivity, lipoprotein size, and postprandial lipemia in men and postmenopausal women aged 45-70 y: the OPTILIP Study. | 2006 | Am. J. Clin. Nutr. | pmid:17158408 |
Visioli F and Galli C | Alpha-linolenic acid and cardiovascular disease. | 2002 | Am. J. Clin. Nutr. | pmid:12036822 |
Rajaram S | Health benefits of plant-derived α-linolenic acid. | 2014 | Am. J. Clin. Nutr. | pmid:24898228 |
Wang C et al. | n-3 Fatty acids from fish or fish-oil supplements, but not alpha-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: a systematic review. | 2006 | Am. J. Clin. Nutr. | pmid:16825676 |
Truong H et al. | Does genetic variation in the Delta6-desaturase promoter modify the association between alpha-linolenic acid and the prevalence of metabolic syndrome? | 2009 | Am. J. Clin. Nutr. | pmid:19144731 |
Renaud SC and Lanzmann-Petithory D | The beneficial effect of alpha-linolenic acid in coronary artery disease is not questionable. | 2002 | Am. J. Clin. Nutr. | pmid:12324307 |
Cunnane SC et al. | Nutritional attributes of traditional flaxseed in healthy young adults. | 1995 | Am. J. Clin. Nutr. | pmid:7825540 |
Devore EE et al. | Dietary intake of fish and omega-3 fatty acids in relation to long-term dementia risk. | 2009 | Am. J. Clin. Nutr. | pmid:19474131 |
Bjerve KS et al. | alpha-Linolenic acid and long-chain omega-3 fatty acid supplementation in three patients with omega-3 fatty acid deficiency: effect on lymphocyte function, plasma and red cell lipids, and prostanoid formation. | 1989 | Am. J. Clin. Nutr. | pmid:2563625 |
Mantzioris E et al. | Dietary substitution with an alpha-linolenic acid-rich vegetable oil increases eicosapentaenoic acid concentrations in tissues. | 1994 | Am. J. Clin. Nutr. | pmid:7910999 |
Anderson GJ and Connor WE | Accretion of n-3 fatty acids in the brain and retina of chicks fed a low-linolenic acid diet supplemented with docosahexaenoic acid. | 1994 | Am. J. Clin. Nutr. | pmid:7911000 |
Pan A et al. | α-Linolenic acid and risk of cardiovascular disease: a systematic review and meta-analysis. | 2012 | Am. J. Clin. Nutr. | pmid:23076616 |
DeLany JP et al. | Differential oxidation of individual dietary fatty acids in humans. | 2000 | Am. J. Clin. Nutr. | pmid:11010930 |
Mantzioris E et al. | Differences exist in the relationships between dietary linoleic and alpha-linolenic acids and their respective long-chain metabolites. | 1995 | Am. J. Clin. Nutr. | pmid:7840069 |
Erkkilä AT et al. | n-3 Fatty acids and 5-y risks of death and cardiovascular disease events in patients with coronary artery disease. | 2003 | Am. J. Clin. Nutr. | pmid:12816772 |
Gillingham LG et al. | Dietary oils and FADS1-FADS2 genetic variants modulate [13C]α-linolenic acid metabolism and plasma fatty acid composition. | 2013 | Am. J. Clin. Nutr. | pmid:23221573 |
Leitzmann MF et al. | Dietary intake of n-3 and n-6 fatty acids and the risk of prostate cancer. | 2004 | Am. J. Clin. Nutr. | pmid:15213050 |
Granot E et al. | Breast-fed and formula-fed infants do not differ in immunocompetent cell cytokine production despite differences in cell membrane fatty acid composition. | 2000 | Am. J. Clin. Nutr. | pmid:11063450 |
Jeppesen PB et al. | Differences in essential fatty acid requirements by enteral and parenteral routes of administration in patients with fat malabsorption. | 1999 | Am. J. Clin. Nutr. | pmid:10393142 |
James MJ et al. | Metabolism of stearidonic acid in human subjects: comparison with the metabolism of other n-3 fatty acids. | 2003 | Am. J. Clin. Nutr. | pmid:12716664 |
Kew S et al. | Lack of effect of foods enriched with plant- or marine-derived n-3 fatty acids on human immune function. | 2003 | Am. J. Clin. Nutr. | pmid:12716684 |
de Groot RH et al. | Effect of alpha-linolenic acid supplementation during pregnancy on maternal and neonatal polyunsaturated fatty acid status and pregnancy outcome. | 2004 | Am. J. Clin. Nutr. | pmid:14749231 |
Lemaitre RN et al. | n-3 Polyunsaturated fatty acids, fatal ischemic heart disease, and nonfatal myocardial infarction in older adults: the Cardiovascular Health Study. | 2003 | Am. J. Clin. Nutr. | pmid:12540389 |
Pawlosky RJ et al. | Effects of beef- and fish-based diets on the kinetics of n-3 fatty acid metabolism in human subjects. | 2003 | Am. J. Clin. Nutr. | pmid:12600844 |
Berry EM and Hirsch J | Does dietary linolenic acid influence blood pressure? | 1986 | Am. J. Clin. Nutr. | pmid:2875645 |
Carnielli VP et al. | Medium-chain triacylglycerols in formulas for preterm infants: effect on plasma lipids, circulating concentrations of medium-chain fatty acids, and essential fatty acids. | 1996 | Am. J. Clin. Nutr. | pmid:8694014 |
Djoussé L et al. | Dietary linolenic acid is inversely associated with plasma triacylglycerol: the National Heart, Lung, and Blood Institute Family Heart Study. | 2003 | Am. J. Clin. Nutr. | pmid:14668270 |
Kestin M et al. | n-3 fatty acids of marine origin lower systolic blood pressure and triglycerides but raise LDL cholesterol compared with n-3 and n-6 fatty acids from plants. | 1990 | Am. J. Clin. Nutr. | pmid:1971991 |
Carlson SE et al. | Effect of long-chain n-3 fatty acid supplementation on visual acuity and growth of preterm infants with and without bronchopulmonary dysplasia. | 1996 | Am. J. Clin. Nutr. | pmid:8615350 |
Lanzmann-Petithory D et al. | Primary prevention of cardiovascular diseases by alpha-linolenic acid. | 2002 | Am. J. Clin. Nutr. | pmid:12450919 |
Dai J et al. | High habitual dietary alpha-linolenic acid intake is associated with decreased plasma soluble interleukin-6 receptor concentrations in male twins. | 2010 | Am. J. Clin. Nutr. | pmid:20463041 |
Bjerve KS et al. | Alpha-linolenic acid deficiency in patients on long-term gastric-tube feeding: estimation of linolenic acid and long-chain unsaturated n-3 fatty acid requirement in man. | 1987 | Am. J. Clin. Nutr. | pmid:2879436 |
Li D et al. | Effect of dietary alpha-linolenic acid on thrombotic risk factors in vegetarian men. | 1999 | Am. J. Clin. Nutr. | pmid:10232625 |
Hu FB et al. | Dietary intake of alpha-linolenic acid and risk of fatal ischemic heart disease among women. | 1999 | Am. J. Clin. Nutr. | pmid:10232627 |
Lin YH et al. | Compartmental analyses of 2H5-alpha-linolenic acid and C-U-eicosapentaenoic acid toward synthesis of plasma labeled 22:6n-3 in newborn term infants. | 2010 | Am. J. Clin. Nutr. | pmid:20534748 |
Giltay EJ et al. | Effects of n-3 fatty acids on depressive symptoms and dispositional optimism after myocardial infarction. | 2011 | Am. J. Clin. Nutr. | pmid:22030221 |
Bozian RC and Moussavian SN | Human linolenic acid deficiency. | 1982 | Am. J. Clin. Nutr. | pmid:6293298 |
Makrides M et al. | A randomized trial of different ratios of linoleic to alpha-linolenic acid in the diet of term infants: effects on visual function and growth. | 2000 | Am. J. Clin. Nutr. | pmid:10617956 |
Thies F et al. | Dietary supplementation with eicosapentaenoic acid, but not with other long-chain n-3 or n-6 polyunsaturated fatty acids, decreases natural killer cell activity in healthy subjects aged >55 y. | 2001 | Am. J. Clin. Nutr. | pmid:11237929 |
Cho E et al. | Prospective study of dietary fat and the risk of age-related macular degeneration. | 2001 | Am. J. Clin. Nutr. | pmid:11157315 |
Connor WE | Importance of n-3 fatty acids in health and disease. | 2000 | Am. J. Clin. Nutr. | pmid:10617967 |
Auestad N and Innis SM | Dietary n-3 fatty acid restriction during gestation in rats: neuronal cell body and growth-cone fatty acids. | 2000 | Am. J. Clin. Nutr. | pmid:10617988 |
Marshall LA et al. | Dietary alpha-linolenic acid and prostaglandin synthesis: a time course study. | 1983 | Am. J. Clin. Nutr. | pmid:6316775 |
James MJ et al. | Dietary polyunsaturated fatty acids and inflammatory mediator production. | 2000 | Am. J. Clin. Nutr. | pmid:10617994 |
Sanders TA | Polyunsaturated fatty acids in the food chain in Europe. | 2000 | Am. J. Clin. Nutr. | pmid:10617968 |
Uauy R and Hoffman DR | Essential fat requirements of preterm infants. | 2000 | Am. J. Clin. Nutr. | pmid:10617979 |
Gibson RA and Makrides M | n-3 polyunsaturated fatty acid requirements of term infants. | 2000 | Am. J. Clin. Nutr. | pmid:10617980 |
Baylin A et al. | Adipose tissue biomarkers of fatty acid intake. | 2002 | Am. J. Clin. Nutr. | pmid:12324287 |
Crawford M | Placental delivery of arachidonic and docosahexaenoic acids: implications for the lipid nutrition of preterm infants. | 2000 | Am. J. Clin. Nutr. | pmid:10617983 |
Wilk JB et al. | Plasma and dietary omega-3 fatty acids, fish intake, and heart failure risk in the Physicians' Health Study. | 2012 | Am. J. Clin. Nutr. | pmid:22952185 |
Gopinath B et al. | Consumption of polyunsaturated fatty acids, fish, and nuts and risk of inflammatory disease mortality. | 2011 | Am. J. Clin. Nutr. | pmid:21411616 |
Koletzko B and Cunnane S | Human alpha-linolenic acid deficiency. | 1988 | Am. J. Clin. Nutr. | pmid:2897782 |
Mantzioris E et al. | Nutritional attributes of dietary flaxseed oil. | 1995 | Am. J. Clin. Nutr. | pmid:7572718 |
Chiu CC et al. | Associations between n-3 PUFA concentrations and cognitive function after recovery from late-life depression. | 2012 | Am. J. Clin. Nutr. | pmid:22218153 |
Lemaitre RN et al. | Circulating and dietary α-linolenic acid and incidence of congestive heart failure in older adults: the Cardiovascular Health Study. | 2012 | Am. J. Clin. Nutr. | pmid:22743310 |
Welch AA et al. | Dietary intake and status of n-3 polyunsaturated fatty acids in a population of fish-eating and non-fish-eating meat-eaters, vegetarians, and vegans and the product-precursor ratio [corrected] of α-linolenic acid to long-chain n-3 polyunsaturated fatty acids: results from the EPIC-Norfolk cohort. | 2010 | Am. J. Clin. Nutr. | pmid:20861171 |
Kwon JS et al. | Effects of diets high in saturated fatty acids, canola oil, or safflower oil on platelet function, thromboxane B2 formation, and fatty acid composition of platelet phospholipids. | 1991 | Am. J. Clin. Nutr. | pmid:1677525 |
Cunnane S | Cholesterol lowering by alpha-linolenic acid. | 1992 | Am. J. Clin. Nutr. | pmid:1345883 |
Ferrier LK et al. | alpha-Linolenic acid- and docosahexaenoic acid-enriched eggs from hens fed flaxseed: influence on blood lipids and platelet phospholipid fatty acids in humans. | 1995 | Am. J. Clin. Nutr. | pmid:7598070 |
Baylin A et al. | alpha-Linolenic acid, Delta6-desaturase gene polymorphism, and the risk of nonfatal myocardial infarction. | 2007 | Am. J. Clin. Nutr. | pmid:17284757 |
Burdge GC | Polyunsaturated fatty acid intakes and α-linolenic acid metabolism. | 2011 | Am. J. Clin. Nutr. | pmid:21191139 |
Sanders TA et al. | Effect of varying the ratio of n-6 to n-3 fatty acids by increasing the dietary intake of alpha-linolenic acid, eicosapentaenoic and docosahexaenoic acid, or both on fibrinogen and clotting factors VII and XII in persons aged 45-70 y: the OPTILIP study. | 2006 | Am. J. Clin. Nutr. | pmid:16960164 |
Salem N and Kuratko CN | Lack of evidence for increased α-linolenic acid metabolism in vegetarians. | 2011 | Am. J. Clin. Nutr. | pmid:21430120 |
Arterburn LM et al. | Distribution, interconversion, and dose response of n-3 fatty acids in humans. | 2006 | Am. J. Clin. Nutr. | pmid:16841856 |
Breslow JL | n-3 fatty acids and cardiovascular disease. | 2006 | Am. J. Clin. Nutr. | pmid:16841857 |
Feskens EJ | The prevention of type 2 diabetes: should we recommend vegetable oils instead of fatty fish? | 2011 | Am. J. Clin. Nutr. | pmid:21733879 |
Bork CS et al. | Dietary intake and adipose tissue content of α-linolenic acid and risk of myocardial infarction: a Danish cohort study. | 2016 | Am. J. Clin. Nutr. | pmid:27169831 |
Djoussé L et al. | Relation between dietary linolenic acid and coronary artery disease in the National Heart, Lung, and Blood Institute Family Heart Study. | 2001 | Am. J. Clin. Nutr. | pmid:11684529 |
Bemelmans WJ et al. | Effect of an increased intake of alpha-linolenic acid and group nutritional education on cardiovascular risk factors: the Mediterranean Alpha-linolenic Enriched Groningen Dietary Intervention (MARGARIN) study. | 2002 | Am. J. Clin. Nutr. | pmid:11815311 |
Djoussé L et al. | Plasma omega-3 fatty acids and incident diabetes in older adults. | 2011 | Am. J. Clin. Nutr. | pmid:21593500 |
Goyens PL et al. | Conversion of alpha-linolenic acid in humans is influenced by the absolute amounts of alpha-linolenic acid and linoleic acid in the diet and not by their ratio. | 2006 | Am. J. Clin. Nutr. | pmid:16825680 |
Venäläinen TM et al. | Effect of a 2-y dietary and physical activity intervention on plasma fatty acid composition and estimated desaturase and elongase activities in children: the Physical Activity and Nutrition in Children Study. | 2016 | Am. J. Clin. Nutr. | pmid:27581473 |
Almario RU et al. | Effects of walnut consumption on plasma fatty acids and lipoproteins in combined hyperlipidemia. | 2001 | Am. J. Clin. Nutr. | pmid:11451720 |
Mantzioris E et al. | Biochemical effects of a diet containing foods enriched with n-3 fatty acids. | 2000 | Am. J. Clin. Nutr. | pmid:10871559 |
Makrides M et al. | Fatty acid composition of brain, retina, and erythrocytes in breast- and formula-fed infants. | 1994 | Am. J. Clin. Nutr. | pmid:7913291 |
Zhao G et al. | Dietary alpha-linolenic acid inhibits proinflammatory cytokine production by peripheral blood mononuclear cells in hypercholesterolemic subjects. | 2007 | Am. J. Clin. Nutr. | pmid:17284733 |
Elias SL and Innis SM | Infant plasma trans, n-6, and n-3 fatty acids and conjugated linoleic acids are related to maternal plasma fatty acids, length of gestation, and birth weight and length. | 2001 | Am. J. Clin. Nutr. | pmid:11273857 |
Merchant AT et al. | Intake of n-6 and n-3 fatty acids and fish and risk of community-acquired pneumonia in US men. | 2005 | Am. J. Clin. Nutr. | pmid:16155282 |
Freese R and Mutanen M | Alpha-linolenic acid and marine long-chain n-3 fatty acids differ only slightly in their effects on hemostatic factors in healthy subjects. | 1997 | Am. J. Clin. Nutr. | pmid:9280178 |
Chan JK et al. | Dietary alpha-linolenic acid is as effective as oleic acid and linoleic acid in lowering blood cholesterol in normolipidemic men. | 1991 | Am. J. Clin. Nutr. | pmid:1673589 |
Harris WS | n-3 fatty acids and serum lipoproteins: human studies. | 1997 | Am. J. Clin. Nutr. | pmid:9129504 |