Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Brenna JT et al. | alpha-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans. | 2009 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19269799 |
Kris-Etherton PM et al. | Dietary reference intakes for DHA and EPA. | 2009 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19525100 |
Sanders TA | DHA status of vegetarians. | 2009 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19500961 |
Rapoport SI and Igarashi M | Can the rat liver maintain normal brain DHA metabolism in the absence of dietary DHA? | 2009 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19540098 |
Simon JA et al. | The relation of alpha-linolenic acid to the risk of prostate cancer: a systematic review and meta-analysis. | 2009 | Am. J. Clin. Nutr. | pmid:19321563 |
Liu J et al. | Ganoderic acid DM: anti-androgenic osteoclastogenesis inhibitor. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19289282 |
Ogawa A et al. | Effect of dietary alpha-linolenic acid on vascular reactivity in aorta of spontaneously hypertensive rats. | 2009 | J Oleo Sci | pmid:19367077 |
Indo Y et al. | Functional expression of a humanized gene for an omega-3 fatty acid desaturase from scarlet flax in transfected bovine adipocytes and bovine embryos cloned from the cells. | 2009 | Biochim. Biophys. Acta | pmid:19367764 |
Tooker JF and De Moraes CM | A gall-inducing caterpillar species increases essential fatty acid content of its host plant without concomitant increases in phytohormone levels. | 2009 | Mol. Plant Microbe Interact. | pmid:19348573 |
Lemaitre RN et al. | Red blood cell membrane alpha-linolenic acid and the risk of sudden cardiac arrest. | 2009 | Metab. Clin. Exp. | pmid:19303975 |
Tsubura A et al. | Role of fatty acids in malignancy and visual impairment: epidemiological evidence and experimental studies. | 2009 | Histol. Histopathol. | pmid:19085838 |
Li M et al. | Solid phase extraction and enrichment of essential fatty acid methyl esters from soy-derived biodiesel by novel pi-complexing sorbents. | 2009 | Bioresour. Technol. | pmid:19692237 |
Brenna JT and Lapillonne A | Background paper on fat and fatty acid requirements during pregnancy and lactation. | 2009 | Ann. Nutr. Metab. | pmid:19752538 |
Galli C and Calder PC | Effects of fat and fatty acid intake on inflammatory and immune responses: a critical review. | 2009 | Ann. Nutr. Metab. | pmid:19752539 |
Padilla MN et al. | Functional characterization of two 13-lipoxygenase genes from olive fruit in relation to the biosynthesis of volatile compounds of virgin olive oil. | 2009 | J. Agric. Food Chem. | pmid:19722522 |
Kim JY et al. | Growth-inhibitory and proapoptotic effects of alpha-linolenic acid on estrogen-positive breast cancer cells. | 2009 | Ann. N. Y. Acad. Sci. | pmid:19723055 |
Yu JH et al. | Effects of omega-3 fatty acids on apoptosis of human gastric epithelial cells exposed to silica-immobilized glucose oxidase. | 2009 | Ann. N. Y. Acad. Sci. | pmid:19723076 |
Park KS et al. | Inhibitory mechanism of omega-3 fatty acids in pancreatic inflammation and apoptosis. | 2009 | Ann. N. Y. Acad. Sci. | pmid:19723085 |
Reza JZ et al. | Modulation peroxisome proliferators activated receptor alpha (PPAR alpha) and acyl coenzyme A: cholesterol acyltransferase1 (ACAT1) gene expression by fatty acids in foam cell. | 2009 | Lipids Health Dis | pmid:19725980 |
Brickner AE et al. | Effects of abomasal lipid infusion on liver triglyceride accumulation and adipose lipolysis during fatty liver induction in dairy cows. | 2009 | J. Dairy Sci. | pmid:19762812 |
Palladino RA et al. | Fatty acid intake and milk fatty acid composition of Holstein dairy cows under different grazing strategies: herbage mass and daily herbage allowance. | 2009 | J. Dairy Sci. | pmid:19762839 |
Nakashima Y et al. | Effect of plant- and fish-oil derived n-3 polyunsaturated fatty acids on counteraction of n-3 fatty acid shortage in adult rats fed a lard diet. | 2009 | J. Nutr. Sci. Vitaminol. | pmid:19763036 |
Katsoulieris E et al. | alpha-Linolenic acid protects renal cells against palmitic acid lipotoxicity via inhibition of endoplasmic reticulum stress. | 2009 | Eur. J. Pharmacol. | pmid:19765573 |
Ruiz-López N et al. | The synthesis and accumulation of stearidonic acid in transgenic plants: a novel source of 'heart-healthy' omega-3 fatty acids. | 2009 | Plant Biotechnol. J. | pmid:19702757 |
Ibrahim A et al. | Impact of maternal dietary fatty acid composition on glucose and lipid metabolism in male rat offspring aged 105 d. | 2009 | Br. J. Nutr. | pmid:19166630 |
Thiébaut AC et al. | Dietary intakes of omega-6 and omega-3 polyunsaturated fatty acids and the risk of breast cancer. | 2009 | Int. J. Cancer | pmid:19035453 |
Oku H et al. | The effects of 2-bromopalmitate on the fatty acid composition in differentiating adipocytes of red sea bream (Pagrus major). | 2009 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:19166960 |
Gao F et al. | Whole-body synthesis-secretion rates of long-chain n-3 PUFAs from circulating unesterified alpha-linolenic acid in unanesthetized rats. | 2009 | J. Lipid Res. | pmid:19074373 |
Schwartz J et al. | Modification of dietary polyunsaturated fatty acids via complementary food enhances n-3 long-chain polyunsaturated fatty acid synthesis in healthy infants: a double blinded randomised controlled trial. | 2009 | Arch. Dis. Child. | pmid:19193660 |
Coakley M et al. | Inhibitory effect of conjugated alpha-linolenic acid from bifidobacteria of intestinal origin on SW480 cancer cells. | 2009 | Lipids | pmid:19048324 |
Truong H et al. | Does genetic variation in the Delta6-desaturase promoter modify the association between alpha-linolenic acid and the prevalence of metabolic syndrome? | 2009 | Am. J. Clin. Nutr. | pmid:19144731 |
Hejazi L et al. | Determination of the composition of fatty acid mixtures using GC x FI-MS: a comprehensive two-dimensional separation approach. | 2009 | Anal. Chem. | pmid:19146461 |
Molkentin J | Authentication of organic milk using delta13C and the alpha-linolenic acid content of milk fat. | 2009 | J. Agric. Food Chem. | pmid:19132889 |
Khiaosa-Ard R et al. | Evidence for the inhibition of the terminal step of ruminal alpha-linolenic acid biohydrogenation by condensed tannins. | 2009 | J. Dairy Sci. | pmid:19109277 |
Wu D et al. | Determination of alpha-linolenic acid and linoleic acid in edible oils using near-infrared spectroscopy improved by wavelet transform and uninformative variable elimination. | 2009 | Anal. Chim. Acta | pmid:19185115 |
Yavin E et al. | Delayed cell migration in the developing rat brain following maternal omega 3 alpha linolenic acid dietary deficiency. | 2009 | Neuroscience | pmid:19447164 |
Zainal Z et al. | Modification of palm oil for anti-inflammatory nutraceutical properties. | 2009 | Lipids | pmid:19449050 |
DeFilippis AP et al. | Effect of baseline plasma fatty acids on eicosapentaenoic acid levels in individuals supplemented with alpha-linolenic acid. | 2009 | Int J Food Sci Nutr | pmid:19468954 |
Ogawa A et al. | Dietary alpha-linolenic acid inhibits angiotensin-converting enzyme activity and mRNA expression levels in the aorta of spontaneously hypertensive rats. | 2009 | J Oleo Sci | pmid:19491530 |
Sioen I et al. | Effect of ALA-enriched food supply on cardiovascular risk factors in males. | 2009 | Lipids | pmid:19452183 |
Devore EE et al. | Dietary intake of fish and omega-3 fatty acids in relation to long-term dementia risk. | 2009 | Am. J. Clin. Nutr. | pmid:19474131 |
Duda MK et al. | omega-3 polyunsaturated fatty acid supplementation for the treatment of heart failure: mechanisms and clinical potential. | 2009 | Cardiovasc. Res. | pmid:19474179 |
Extier A et al. | Differential effects of steroids on the synthesis of polyunsaturated fatty acids by human neuroblastoma cells. | 2009 | Neurochem. Int. | pmid:19576517 |
Prasad K | Flaxseed and cardiovascular health. | 2009 | J. Cardiovasc. Pharmacol. | pmid:19568181 |
Ishitsuka Y et al. | Effects of bolus injection of soybean-based fat emulsion and fatty acids on pulmonary gas exchange function. | 2009 | Biol. Pharm. Bull. | pmid:19252304 |
Peng CC et al. | Aqua-culture improved buckwheat sprouts with more abundant precious nutrients and hypolipidemic activity. | 2009 | Int J Food Sci Nutr | pmid:19568972 |
Gómez-Cortés P et al. | Characterization of cis-9 trans-11 trans-15 C18:3 in milk fat by GC and covalent adduct chemical ionization tandem MS. | 2009 | J. Lipid Res. | pmid:19542528 |
Patenaude A et al. | Bioavailability of alpha-linolenic acid from flaxseed diets as a function of the age of the subject. | 2009 | Eur J Clin Nutr | pmid:19584895 |
Marei WF et al. | The effect of linolenic Acid on bovine oocyte maturation and development. | 2009 | Biol. Reprod. | pmid:19587335 |
Morise A et al. | Hepatic lipid metabolism response to dietary fatty acids is differently modulated by PPARalpha in male and female mice. | 2009 | Eur J Nutr | pmid:19588182 |
Barden AE et al. | Flaxseed oil supplementation increases plasma F1-phytoprostanes in healthy men. | 2009 | J. Nutr. | pmid:19675101 |
Blondeau N et al. | Subchronic alpha-linolenic acid treatment enhances brain plasticity and exerts an antidepressant effect: a versatile potential therapy for stroke. | 2009 | Neuropsychopharmacology | pmid:19641487 |
Coates W and Ayerza R | Chia (Salvia hispanica L.) seed as an n-3 fatty acid source for finishing pigs: effects on fatty acid composition and fat stability of the meat and internal fat, growth performance, and meat sensory characteristics. | 2009 | J. Anim. Sci. | pmid:19648503 |
Barceló-Coblijn G and Murphy EJ | Alpha-linolenic acid and its conversion to longer chain n-3 fatty acids: benefits for human health and a role in maintaining tissue n-3 fatty acid levels. | 2009 | Prog. Lipid Res. | pmid:19619583 |
Bannenberg G et al. | Diversity of the enzymatic activity in the lipoxygenase gene family of Arabidopsis thaliana. | 2009 | Lipids | pmid:18949503 |
Rossi M et al. | Growth, lipid accumulation, and fatty acid composition in obligate psychrophilic, facultative psychrophilic, and mesophilic yeasts. | 2009 | FEMS Microbiol. Ecol. | pmid:19624740 |
Nieman DC et al. | Chia seed does not promote weight loss or alter disease risk factors in overweight adults. | 2009 | Nutr Res | pmid:19628108 |
Ishikawa C et al. | Efficient incorporation of free oxygen into volicitin in Spodoptera litura common cutworm larvae. | 2009 | Biosci. Biotechnol. Biochem. | pmid:19661708 |
Sertznig P et al. | Cross-talk between vitamin D receptor (VDR)- and peroxisome proliferator-activated receptor (PPAR)-signaling in melanoma cells. | 2009 | Anticancer Res. | pmid:19667161 |
Piccione G et al. | Daily pattern of some fatty acids in the athletic horse. | 2009 | J Anim Physiol Anim Nutr (Berl) | pmid:19386003 |
Umezawa M et al. | Effect of dietary unsaturated fatty acids on senile amyloidosis in senescence-accelerated mice. | 2009 | J. Gerontol. A Biol. Sci. Med. Sci. | pmid:19377016 |
He L et al. | Preparation of SiO2/(PMMA/Fe3O4) from monolayer linolenic acid modified Fe3O4 nanoparticles via miniemulsion polymerization. | 2009 | J Biomed Nanotechnol | pmid:20201438 |
Yang L et al. | Oxidative stability of conjugated linolenic acids. | 2009 | J. Agric. Food Chem. | pmid:19368396 |
Taha AY et al. | Dose-dependent anticonvulsant effects of linoleic and alpha-linolenic polyunsaturated fatty acids on pentylenetetrazol induced seizures in rats. | 2009 | Epilepsia | pmid:18657173 |
Raz R et al. | The influence of short-chain essential fatty acids on children with attention-deficit/hyperactivity disorder: a double-blind placebo-controlled study. | 2009 | J Child Adolesc Psychopharmacol | pmid:19364294 |
van der Walt AM et al. | Linolenic acid and folate in wild-growing African dark leafy vegetables (morogo). | 2009 | Public Health Nutr | pmid:18503724 |
van Rensburg SJ et al. | Changes in erythrocyte membrane fatty acids during a clinical trial of eicosapentaenoic acid (EPA) supplementation in schizophrenia. | 2009 | Metab Brain Dis | pmid:19826937 |
Chicco AG et al. | Dietary chia seed (Salvia hispanica L.) rich in alpha-linolenic acid improves adiposity and normalises hypertriacylglycerolaemia and insulin resistance in dyslipaemic rats. | 2009 | Br. J. Nutr. | pmid:18492301 |
Patwardhan AM et al. | Activation of TRPV1 in the spinal cord by oxidized linoleic acid metabolites contributes to inflammatory hyperalgesia. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19843694 |
Matsunaga H et al. | Omega-3 polyunsaturated fatty acids ameliorate the severity of ileitis in the senescence accelerated mice (SAM)P1/Yit mice model. | 2009 | Clin. Exp. Immunol. | pmid:19793338 |
Kunz HH et al. | The ABC transporter PXA1 and peroxisomal beta-oxidation are vital for metabolism in mature leaves of Arabidopsis during extended darkness. | 2009 | Plant Cell | pmid:19794119 |
Porta N et al. | Anticonvulsant effects of linolenic acid are unrelated to brain phospholipid cell membrane compositions. | 2009 | Epilepsia | pmid:18657178 |
Fedorova I et al. | Deficit in prepulse inhibition in mice caused by dietary n-3 fatty acid deficiency. | 2009 | Behav. Neurosci. | pmid:20001105 |
Whent M et al. | Effect of genotype, environment, and their interaction on chemical composition and antioxidant properties of low-linolenic soybeans grown in Maryland. | 2009 | J. Agric. Food Chem. | pmid:19817459 |
Shimizu T and Tomioka H | [Novel type of antimicrobial mechanism in host macrophages against mycobacterial infections]. | 2009 | Nihon Hansenbyo Gakkai Zasshi | pmid:19803380 |
Nishimura K et al. | Effects of siRNAs targeting the spacer sequence of plant RNAi vectors on the specificity and efficiency of RNAi. | 2009 | J. Biosci. Bioeng. | pmid:19804870 |
Clemente TE and Cahoon EB | Soybean oil: genetic approaches for modification of functionality and total content. | 2009 | Plant Physiol. | pmid:19783644 |
Gemeinhardt A et al. | The influence of linoleic and linolenic acid on the activity and intracellular localisation of phospholipase D in COS-1 cells. | 2009 | Biol. Chem. | pmid:19090716 |
Cherif A et al. | Phytosterols, unsaturated fatty acid composition and accumulation in the almond kernel during harvesting period: importance for development regulation. | 2009 | C. R. Biol. | pmid:19931844 |
Ulbricht C et al. | Chia (Salvia hispanica): a systematic review by the natural standard research collaboration. | 2009 | Rev Recent Clin Trials | pmid:20028328 |
McNamara RK et al. | Perinatal n-3 fatty acid deficiency selectively reduces myo-inositol levels in the adult rat PFC: an in vivo (1)H-MRS study. | 2009 | J. Lipid Res. | pmid:18802197 |
Poudel-Tandukar K et al. | Dietary intakes of alpha-linolenic and linoleic acids are inversely associated with serum C-reactive protein levels among Japanese men. | 2009 | Nutr Res | pmid:19628101 |
Sado-Kamdem SL et al. | Effect of alpha-linolenic, capric and lauric acid on the fatty acid biosynthesis in Staphylococcus aureus. | 2009 | Int. J. Food Microbiol. | pmid:19168249 |
Scheim DE | Cytotoxicity of unsaturated fatty acids in fresh human tumor explants: concentration thresholds and implications for clinical efficacy. | 2009 | Lipids Health Dis | pmid:20003514 |
Fincham JR et al. | Fatty acid metabolism and deposition in subcutaneous adipose tissue of pasture- and feedlot-finished cattle. | 2009 | J. Anim. Sci. | pmid:19617512 |
Venegas-Calerón M et al. | Effect of the ferredoxin electron donor on sunflower (Helianthus annuus) desaturases. | 2009 | Plant Physiol. Biochem. | pmid:19342250 |
Artwohl M et al. | Fatty acids induce apoptosis in human smooth muscle cells depending on chain length, saturation, and duration of exposure. | 2009 | Atherosclerosis | pmid:18597758 |
Cornish SM and Chilibeck PD | Alpha-linolenic acid supplementation and resistance training in older adults. | 2009 | Appl Physiol Nutr Metab | pmid:19234585 |
Bommareddy A et al. | Effects of dietary flaxseed on intestinal tumorigenesis in Apc(Min) mouse. | 2009 | Nutr Cancer | pmid:19235044 |
Küpper FC et al. | Free Fatty Acids and Methyl Jasmonate Trigger Defense Reactions in Laminaria digitata. | 2009 | Plant Cell Physiol. | pmid:19213737 |
Chojnacka A et al. | Enzymatic enrichment of egg-yolk phosphatidylcholine with alpha-linolenic acid. | 2009 | Biotechnol. Lett. | pmid:19165607 |
Chang HH et al. | Dietary perilla oil lowers serum lipids and ovalbumin-specific IgG1, but increases total IgE levels in ovalbumin-challenged mice. | 2009 | Food Chem. Toxicol. | pmid:19271319 |
Van Elswyk ME and Kuratko C | Achieving adequate DHA in maternal and infant diets. | 2009 | J Am Diet Assoc | pmid:19248850 |
Egert S et al. | Dietary alpha-linolenic acid, EPA, and DHA have differential effects on LDL fatty acid composition but similar effects on serum lipid profiles in normolipidemic humans. | 2009 | J. Nutr. | pmid:19261730 |
McNamara RK et al. | Omega-3 fatty acid deficiency during perinatal development increases serotonin turnover in the prefrontal cortex and decreases midbrain tryptophan hydroxylase-2 expression in adult female rats: dissociation from estrogenic effects. | 2009 | J Psychiatr Res | pmid:18986658 |
McNamara RK et al. | Chronic risperidone treatment preferentially increases rat erythrocyte and prefrontal cortex omega-3 fatty acid composition: evidence for augmented biosynthesis. | 2009 | Schizophr. Res. | pmid:18993032 |
Mène-Saffrané L et al. | Nonenzymatic oxidation of trienoic fatty acids contributes to reactive oxygen species management in Arabidopsis. | 2009 | J. Biol. Chem. | pmid:18996838 |
Venna VR et al. | PUFA induce antidepressant-like effects in parallel to structural and molecular changes in the hippocampus. | 2009 | Psychoneuroendocrinology | pmid:18848400 |
Jiménez-Gómez Y et al. | Olive oil and walnut breakfasts reduce the postprandial inflammatory response in mononuclear cells compared with a butter breakfast in healthy men. | 2009 | Atherosclerosis | pmid:18952211 |
Gouveia L and Oliveira AC | Microalgae as a raw material for biofuels production. | 2009 | J. Ind. Microbiol. Biotechnol. | pmid:18982369 |