alpha-linolenic acid

Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.

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Introduction

To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with alpha-linolenic acid?

alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Adenoma D000236 40 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Amyloidosis D000686 4 associated lipids
Aortic Diseases D001018 11 associated lipids
Arteriosclerosis D001161 86 associated lipids
Arthritis D001168 41 associated lipids
Atrial Fibrillation D001281 16 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Birth Weight D001724 23 associated lipids
Urinary Bladder Neoplasms D001749 7 associated lipids
Body Weight D001835 333 associated lipids
Breast Neoplasms D001943 24 associated lipids
Bronchial Spasm D001986 18 associated lipids
Cat Diseases D002371 12 associated lipids
Cattle Diseases D002418 24 associated lipids
Brain Ischemia D002545 89 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Conjunctivitis, Allergic D003233 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with alpha-linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with alpha-linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with alpha-linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with alpha-linolenic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with alpha-linolenic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with alpha-linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with alpha-linolenic acid

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Authors Title Published Journal PubMed Link
Harper CR et al. Flaxseed oil increases the plasma concentrations of cardioprotective (n-3) fatty acids in humans. 2006 J. Nutr. pmid:16365063
Clapham WM et al. Fatty acid composition of traditional and novel forages. 2005 J. Agric. Food Chem. pmid:16366696
Cleland LG et al. Paradoxical effect of n-3-containing vegetable oils on long-chain n-3 fatty acids in rat heart. 2005 Lipids pmid:16382570
Bourre JM et al. Fatty acid alterations in liver peroxisomes from n-3-deficient mice. 2006 Ann. Nutr. Metab. pmid:16407648
Christensen JH et al. Prostate tissue and leukocyte levels of n-3 polyunsaturated fatty acids in men with benign prostate hyperplasia or prostate cancer. 2006 BJU Int. pmid:16430627
Calder PC Abnormal fatty acid profiles occur in atopic dermatitis but what do they mean? 2006 Clin. Exp. Allergy pmid:16433850
Laitinen K et al. Serum, cheek cell and breast milk fatty acid compositions in infants with atopic and non-atopic eczema. 2006 Clin. Exp. Allergy pmid:16433853
Ponter AA et al. Effect of a supplement rich in linolenic acid added to the diet of post partum dairy cows on ovarian follicle growth, and milk and plasma fatty acid compositions. 2006 Jan-Feb Reprod. Nutr. Dev. pmid:16438912
Mayes C et al. Variation in [U-13C] alpha linolenic acid absorption, beta-oxidation and conversion to docosahexaenoic acid in the pre-term infant fed a DHA-enriched formula. 2006 Pediatr. Res. pmid:16439591
Sanjurjo P et al. Fatty acid composition of skeletal muscle and adipose tissue in Spanish infants and children. 2006 Br. J. Nutr. pmid:16441930
Williams CM and Burdge G Long-chain n-3 PUFA: plant v. marine sources. 2006 Proc Nutr Soc pmid:16441943
Perez MA et al. Dietary docosahexaenoic acid alters pregnant rat reproductive tissue prostaglandin and matrix metalloproteinase production. 2006 J. Nutr. Biochem. pmid:16457997
Martínez-Ortiz JA et al. Dietary patterns and risk of nonfatal acute myocardial infarction in Costa Rican adults. 2006 Eur J Clin Nutr pmid:16465200
Hamazaki K et al. Effects of cooking plant oils on recurrent aphthous stomatitis: a randomized, placebo-controlled, double-blind trial. 2006 Nutrition pmid:16472981
Liechti R and Farmer EE Jasmonate biochemical pathway. 2006 Sci. STKE pmid:16478937
Mamalakis G et al. Depression and adipose and serum cholesteryl ester polyunsaturated fatty acids in the survivors of the seven countries study population of Crete. 2006 Eur J Clin Nutr pmid:16482070
Goyens PL and Mensink RP Effects of alpha-linolenic acid versus those of EPA/DHA on cardiovascular risk markers in healthy elderly subjects. 2006 Eur J Clin Nutr pmid:16482073
Dalen KT et al. PPARalpha activators and fasting induce the expression of adipose differentiation-related protein in liver. 2006 J. Lipid Res. pmid:16489205
Vijaimohan K et al. Beneficial effects of alpha linolenic acid rich flaxseed oil on growth performance and hepatic cholesterol metabolism in high fat diet fed rats. 2006 Life Sci. pmid:16490217
Yehuda S et al. Mixture of essential fatty acids lowers test anxiety. 2005 Nutr Neurosci pmid:16491653
Ramaprasad TR et al. Spray-dried milk supplemented with alpha-linolenic acid or eicosapentaenoic acid and docosahexaenoic acid decreases HMG Co A reductase activity and increases biliary secretion of lipids in rats. 2006 Steroids pmid:16499938
DeFilippis AP and Sperling LS Understanding omega-3's. 2006 Am. Heart J. pmid:16504616
Usami M et al. Phospholipid fatty acid composition and diamine oxidase activity of intestinal mucosa from rats treated with irinotecan hydrochloride (CPT-11) under vegetable oil-enriched diets: comparison between perilla oil and corn oil. 2006 Mar-Apr JPEN J Parenter Enteral Nutr pmid:16517957
Hoffman DR et al. Docosahexaenoic acid in red blood cells of term infants receiving two levels of long-chain polyunsaturated fatty acids. 2006 J. Pediatr. Gastroenterol. Nutr. pmid:16540798
I take ground flaxseed to help control my cholesterol. But I read that the alpha-linoleic acid (ALA) in flax increases the risk of prostate cancer. Is this true? Does the risk differ between ground flaxseed and concentrated flaxseed oil in capsules? 2006 Johns Hopkins Med Lett Health After 50 pmid:16548073
Heller AR et al. Omega-3 alpha linolenic acid does not reflect the entire omega-3 fatty acid family. 2006 Anesth. Analg. pmid:16551943
Turpeinen AM et al. Effects of conjugated linoleic acid on linoleic and linolenic acid metabolism in man. 2006 Br. J. Nutr. pmid:16571152
Djoussé L et al. Dietary linolenic acid and fasting glucose and insulin: the National Heart, Lung, and Blood Institute Family Heart Study. 2006 Obesity (Silver Spring) pmid:16571856
Zhang HT et al. [Functional expression of an omega-3 fatty acid desaturase gene from Glycine max in Saccharomyces cerevisiae]. 2006 Sheng Wu Gong Cheng Xue Bao pmid:16572837
Knudsen VK et al. Fish oil in various doses or flax oil in pregnancy and timing of spontaneous delivery: a randomised controlled trial. 2006 BJOG pmid:16579802
Bretillon L et al. In vivo oxidation of [9-14C] cyclic fatty acids derived from linolenic acid in the rat. 2006 Mar-Apr Reprod. Nutr. Dev. pmid:16597424
Aldámiz-Echevarría L et al. Effect of docosahexaenoic acid administration on plasma lipid profile and metabolic parameters of children with methylmalonic acidaemia. 2006 J. Inherit. Metab. Dis. pmid:16601869
MandaÅŸescu S et al. Flaxseed supplementation in hyperlipidemic patients. 2005 Jul-Sep Rev Med Chir Soc Med Nat Iasi pmid:16607740
Murayama SY et al. Construction and functional analysis of fatty acid desaturase gene disruptants in Candida albicans. 2006 Microbiology (Reading, Engl.) pmid:16622072
Shanker KS et al. Isolation and characterization of neutral lipids of desilked eri silkworm pupae grown on castor and tapioca leaves. 2006 J. Agric. Food Chem. pmid:16637689
Cornejo V et al. [Lipids composition diet in phenylketonuric children with early diagnosis]. 2005 Arch Latinoam Nutr pmid:16640195
Cristea M and Oliw EH A G316A mutation of manganese lipoxygenase augments hydroperoxide isomerase activity: mechanism of biosynthesis of epoxyalcohols. 2006 J. Biol. Chem. pmid:16641090
King VR et al. Omega-3 fatty acids improve recovery, whereas omega-6 fatty acids worsen outcome, after spinal cord injury in the adult rat. 2006 J. Neurosci. pmid:16641248
Blanco M et al. Ischemic preconditioning: a novel target for neuroprotective therapy. 2006 Cerebrovasc. Dis. pmid:16651813
Igarashi M et al. Low liver conversion rate of alpha-linolenic to docosahexaenoic acid in awake rats on a high-docosahexaenoate-containing diet. 2006 J. Lipid Res. pmid:16687661
Kelley DS et al. Dietary alpha-linolenic acid and immunocompetence in humans. 1991 Am. J. Clin. Nutr. pmid:1670594
Marotta F et al. Liver exposure to xenobiotics: the aging factor and potentials for functional foods. 2006 Rejuvenation Res pmid:16706665
Zhou D et al. Vitamin A deficiency enhances docosahexaenoic and osbond acids in liver of rats fed an alpha linolenic acid-adequate diet. 2006 Lipids pmid:16711595
Li D et al. Alpha-linolenic acid content of commonly available nuts in Hangzhou. 2006 Int J Vitam Nutr Res pmid:16711652
Oliw EH et al. Payne rearrangement during analysis of epoxyalcohols of linoleic and alpha-linolenic acids by normal phase liquid chromatography with tandem mass spectrometry. 2006 Anal. Biochem. pmid:16712763
Lemaitre RN et al. Trans-fatty acids and sudden cardiac death. 2006 Atheroscler Suppl pmid:16713398
Li D et al. Omega 6 to omega 3 fatty acid imbalance early in life leads to persistent reductions in DHA levels in glycerophospholipids in rat hypothalamus even after long-term omega 3 fatty acid repletion. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16716580
Hamberg M Transformations of alpha-linolenic acid in leaves of corn (Zea mays L.). 1991 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:1671803
Choi YH et al. NMR metabolomics to revisit the tobacco mosaic virus infection in Nicotiana tabacum leaves. 2006 J. Nat. Prod. pmid:16724833
Vanden Heuvel JP et al. Differential activation of nuclear receptors by perfluorinated fatty acid analogs and natural fatty acids: a comparison of human, mouse, and rat peroxisome proliferator-activated receptor-alpha, -beta, and -gamma, liver X receptor-beta, and retinoid X receptor-alpha. 2006 Toxicol. Sci. pmid:16731579