| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Adenoma | D000236 | 40 associated lipids |
| Adrenoleukodystrophy | D000326 | 29 associated lipids |
| Amyloidosis | D000686 | 4 associated lipids |
| Aortic Diseases | D001018 | 11 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Atrial Fibrillation | D001281 | 16 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Birth Weight | D001724 | 23 associated lipids |
| Urinary Bladder Neoplasms | D001749 | 7 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Bronchial Spasm | D001986 | 18 associated lipids |
| Cat Diseases | D002371 | 12 associated lipids |
| Cattle Diseases | D002418 | 24 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Conjunctivitis, Allergic | D003233 | 1 associated lipids |
alpha-linolenic acid
Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
Cross Reference
Introduction
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with alpha-linolenic acid?
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
PubChem Associated disorders and diseases
What pathways are associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with alpha-linolenic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with alpha-linolenic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with alpha-linolenic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Schuchardt JP et al. | Comparison of free serum oxylipin concentrations in hyper- vs. normolipidemic men. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23694766 |
| MarÃn MC et al. | Dietary long-chain fatty acids and visual response in malnourished nursing infants. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11133176 |
| Suzuki R et al. | Effects of n-3 polyunsaturated fatty acids on dermatitis in NC/Nga mice. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12054914 |
| Burdge GC | Metabolism of alpha-linolenic acid in humans. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16828546 |
| Galli C and Marangoni F | N-3 fatty acids in the Mediterranean diet. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16837180 |
| Fokkema MR et al. | Short-term supplementation of low-dose gamma-linolenic acid (GLA), alpha-linolenic acid (ALA), or GLA plus ALA does not augment LCP omega 3 status of Dutch vegans to an appreciable extent. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11090255 |
| Abeywardena MY et al. | Dietary n-3 and n-6 polyunsaturated oils and airway contractility. | 2001 Apr-May | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11418024 |
| de Groot RH et al. | Alpha-linolenic acid supplementation during human pregnancy does not effect cognitive functioning. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:14643178 |
| Decsi T et al. | Polyunsaturated fatty acids in plasma and erythrocyte membrane lipids of diabetic children. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12401433 |
| Kris-Etherton PM et al. | Dietary reference intakes for DHA and EPA. | 2009 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19525100 |
| Sanders TA | DHA status of vegetarians. | 2009 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19500961 |
| Rapoport SI and Igarashi M | Can the rat liver maintain normal brain DHA metabolism in the absence of dietary DHA? | 2009 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19540098 |
| Gueck T et al. | Effects of essential fatty acids on mediators of mast cells in culture. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12711248 |
| Motaung E et al. | Cytotoxicity of combined essential fatty acids on a human prostate cancer cell line. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10670696 |
| Smuts CM et al. | The effect of iron fortification on the fatty acid composition of plasma and erythrocyte membranes in primary school children with and without iron deficiency. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7708822 |
| Papies B et al. | Ischemic myocardial damage in spontaneously hypertensive rats (SHR) is enhanced after long-term feeding of an alpha-linolenic acid enriched diet. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1679554 |
| Rapoport SI et al. | Quantitative contributions of diet and liver synthesis to docosahexaenoic acid homeostasis. | 2010 Apr-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20226642 |
| Chavali SR et al. | Dietary alpha-linolenic acid increases TNF-alpha, and decreases IL-6, IL-10 in response to LPS: effects of sesamin on the delta-5 desaturation of omega6 and omega3 fatty acids in mice. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9610840 |
| Joshi K et al. | Supplementation with flax oil and vitamin C improves the outcome of Attention Deficit Hyperactivity Disorder (ADHD). | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16314082 |
| Tu WC et al. | Correlations between blood and tissue omega-3 LCPUFA status following dietary ALA intervention in rats. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22521090 |
| McNamara RK et al. | Omega-3 fatty acid deficiency increases constitutive pro-inflammatory cytokine production in rats: relationship with central serotonin turnover. | 2010 Oct-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20817496 |
| Shannon J et al. | Erythrocyte fatty acids and prostate cancer risk: a comparison of methods. | 2010 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20630734 |
| Hurst S et al. | Dietary fatty acids and arthritis. | 2010 Apr-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20189789 |
| Guesnet P et al. | α-Linolenate reduces the dietary requirement for linoleate in the growing rat. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21880475 |
| Arun Kumar C and Das UN | Lipid peroxides, nitric oxide and essential fatty acids in patients with Plasmodium falciparum malaria. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10574650 |
| Zhou D et al. | Vitamin A deficiency reduces liver and colon docosahexaenoic acid levels in rats fed high linoleic and low alpha-linolenic acid diet. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15519497 |
| Alava MA et al. | Fatty acid desaturation: effect of alphafetoprotein on alpha-linolenic acid conversion by fetal rat hepatocytes. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10359023 |
| Kartikasari LR et al. | Dietary alpha-linolenic acid enhances omega-3 long chain polyunsaturated fatty acid levels in chicken tissues. | 2012 Oct-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22925778 |
| Harland DR et al. | Acute effects of prostaglandin E1 and E2 on vascular reactivity and blood flow in situ in the chick chorioallantoic membrane. | 2012 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22858445 |
| Hrelia S et al. | Role of gamma-linolenic acid in counteracting doxorubicin-induced damage in cultured rat cardiomyocytes. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11334548 |
| Gibson RA et al. | Docosahexaenoic acid synthesis from alpha-linolenic acid is inhibited by diets high in polyunsaturated fatty acids. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22515943 |
| Schimke I et al. | Influence of long-term supplementation with alpha-linolenic acid on myocardial lipid peroxidation and antioxidative capacity in spontaneously hypertensive rats. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9431820 |
| Hofacer R et al. | Omega-3 fatty acid deficiency increases stearoyl-CoA desaturase expression and activity indices in rat liver: positive association with non-fasting plasma triglyceride levels. | 2012 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22047910 |
| Taha AY et al. | Threshold changes in rat brain docosahexaenoic acid incorporation and concentration following graded reductions in dietary alpha-linolenic acid. | 2016 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:26869088 |
| Brenna JT et al. | alpha-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans. | 2009 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19269799 |
| Dhobale MV et al. | Reduced levels of placental long chain polyunsaturated fatty acids in preterm deliveries. | 2011 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21816593 |
| Leroy C et al. | Fatty acid-binding protein3 expression in BeWo cells, a human placental choriocarcinoma cell line. | 2017 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:28515017 |
| Singer P et al. | Changes of N-6 and N-3 fatty acids in liver from spontaneously hypertensive (SHR) and normotensive rats after diets supplemented with alpha-linolenic or eicosapentaenoic acids. | 1987 | Prostaglandins Leukot Med | pmid:2888133 |
| Hashimoto A et al. | Effect of the dietary alpha-linolenate/linoleate balance on leukotriene production and histamine release in rats. | 1988 | Prostaglandins | pmid:2459732 |
| Scherhag R et al. | Dietary administration of eicosapentaenoic and linolenic acid increases arterial blood pressure and suppresses vascular prostacyclin synthesis in the rat. | 1982 | Prostaglandins | pmid:6285420 |
| Frankel EN | Chemistry of free radical and singlet oxidation of lipids. | 1984 | Prog. Lipid Res. | pmid:6100997 |
| Cunnane SC | Problems with essential fatty acids: time for a new paradigm? | 2003 | Prog. Lipid Res. | pmid:14559071 |
| Barceló-Coblijn G and Murphy EJ | Alpha-linolenic acid and its conversion to longer chain n-3 fatty acids: benefits for human health and a role in maintaining tissue n-3 fatty acid levels. | 2009 | Prog. Lipid Res. | pmid:19619583 |
| Tinoco J | Dietary requirements and functions of alpha-linolenic acid in animals. | 1982 | Prog. Lipid Res. | pmid:6287500 |
| Zöllner N | Dietary linolenic acid in man--an overview. | 1986 | Prog. Lipid Res. | pmid:2892211 |
| Frankel EN | Volatile lipid oxidation products. | 1983 | Prog. Lipid Res. | pmid:6306693 |
| Poudyal H et al. | Omega-3 fatty acids and metabolic syndrome: effects and emerging mechanisms of action. | 2011 | Prog. Lipid Res. | pmid:21762726 |
| Quadt JF and ten Hoor F | Effects of dietary alpha-linolenic acid on the production of a PGI-like substance of the isolated pulsatingly perfused rat aorta. | 1981 | Prog. Lipid Res. | pmid:6281803 |
| Marshall LA and Johnston PV | alpha-Linolenic and linoleic acids and the immune response. | 1981 | Prog. Lipid Res. | pmid:6281806 |
| Domenichiello AF et al. | Is docosahexaenoic acid synthesis from α-linolenic acid sufficient to supply the adult brain? | 2015 | Prog. Lipid Res. | pmid:25920364 |