alpha-linolenic acid

Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.

Cross Reference

Introduction

To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with alpha-linolenic acid?

alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Adenoma D000236 40 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Amyloidosis D000686 4 associated lipids
Aortic Diseases D001018 11 associated lipids
Arteriosclerosis D001161 86 associated lipids
Arthritis D001168 41 associated lipids
Atrial Fibrillation D001281 16 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Birth Weight D001724 23 associated lipids
Urinary Bladder Neoplasms D001749 7 associated lipids
Body Weight D001835 333 associated lipids
Breast Neoplasms D001943 24 associated lipids
Bronchial Spasm D001986 18 associated lipids
Cat Diseases D002371 12 associated lipids
Cattle Diseases D002418 24 associated lipids
Brain Ischemia D002545 89 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Conjunctivitis, Allergic D003233 1 associated lipids
Per page 10 20 50 100 | Total 104

PubChem Associated disorders and diseases

What pathways are associated with alpha-linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with alpha-linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with alpha-linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with alpha-linolenic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with alpha-linolenic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with alpha-linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with alpha-linolenic acid

Download all related citations
Per page 10 20 50 100 | Total 2471
Authors Title Published Journal PubMed Link
Brush MG et al. Abnormal essential fatty acid levels in plasma of women with premenstrual syndrome. 1984 Am. J. Obstet. Gynecol. pmid:6091462
Bolton-Smith C et al. Comparative aspects of omega-3 and omega-6 polyunsaturated fatty acids in rabbits and rats: effects on platelet function, thromboxane and prostacyclin generation, tissue phospholipid fatty acids and membrane fluidity. 1984 Br J Clin Pract Suppl pmid:6091719
Osipov AN et al. [Study of radicals formed in the interaction of organic hydroperoxides with ferric ions using the spin trap method]. 1984 Jul-Aug Biofizika pmid:6091781
Golbeck JH and Warden JT Interaction of linolenic acid with bound quinone molecules in Photosystem II. Time-resolved optical and electron spin resonance studies. 1984 Biochim. Biophys. Acta pmid:6093871
Hagve TA and Christophersen BO Effect of dietary fats on arachidonic acid and eicosapentaenoic acid biosynthesis and conversion to C22 fatty acids in isolated rat liver cells. 1984 Biochim. Biophys. Acta pmid:6093889
Cocchi M et al. Effect of C 18:3 (n-3) dietary supplementation on the fatty acid composition of the rat brain. 1984 Acta Vitaminol. Enzymol. pmid:6098183
Codde JP et al. Dissociation of effects of dietary fatty acids on blood pressure and prostanoid metabolism in Goldblatt hypertensive rats. 1984 J. Hypertens. pmid:6099384
Frankel EN Chemistry of free radical and singlet oxidation of lipids. 1984 Prog. Lipid Res. pmid:6100997
Volpe JJ and Obert KA Coordinate regulation of cholesterol synthesis and 3-hydroxy-3-methylglutaryl coenzyme A synthase but not 3-hydroxy-3-methylglutaryl coenzyme A reductase in C-6 glia. 1981 Arch. Biochem. Biophys. pmid:6118099
Renaud S and Nordøy A "Small is beautiful": alpha-linolenic acid and eicosapentaenoic acid in man. 1983 Lancet pmid:6133188
Poisson JP and Blond JP [Effect of supplementation with gamma-linolenic acid on the fatty acid composition of lipids from the liver and plasma in the diabetic rat]. 1983 Arch. Int. Physiol. Biochim. pmid:6204605
Budowski P et al. [Protective effect of alpha-linolenic acid in encephalomalacia in chickens]. 1980 Ann Nutr Aliment pmid:6254420
François M et al. [Effects of a dietary deficiency of alpha-linolenic acid in the rat]. 1980 Ann Nutr Aliment pmid:6254422
Vergroesen AJ et al. Cardiovascular effects of linoleic acid. 1980 Prog Food Nutr Sci pmid:6256818
Cowey CB et al. Tissue distribution, uptake, and requirement for alpha-tocopherol of rainbow trout (Salmo gairdneri) fed diets with a minimal content of unsaturated fatty acids. 1981 J. Nutr. pmid:6268765
Yoshino M and Murakami K Effect of spermine on the inhibition by fatty acid on AMP deaminase reaction as a control system of the adenylate energy charge in yeast. 1981 Biochem. Biophys. Res. Commun. pmid:6272814
Dusting GJ et al. Increased conversion of arachidonic acid to vasodilator prostanoids in spontaneously hypertensive rats. 1981 Sep-Oct Clin. Exp. Pharmacol. Physiol. pmid:6276057
Torinuki W et al. Chemiluminescence of UV-irradiated linolenic acid and squalene. 1982 Tohoku J. Exp. Med. pmid:6280339
Quadt JF and ten Hoor F Effects of dietary alpha-linolenic acid on the production of a PGI-like substance of the isolated pulsatingly perfused rat aorta. 1981 Prog. Lipid Res. pmid:6281803
Marshall LA and Johnston PV alpha-Linolenic and linoleic acids and the immune response. 1981 Prog. Lipid Res. pmid:6281806
Scherhag R et al. Dietary administration of eicosapentaenoic and linolenic acid increases arterial blood pressure and suppresses vascular prostacyclin synthesis in the rat. 1982 Prostaglandins pmid:6285420
Yoshino M and Murakami K AMP deaminase as a control system of glycolysis in yeast. Mechanism of the inhibition of glycolysis by fatty acid and citrate. 1982 J. Biol. Chem. pmid:6286666
Tinoco J Dietary requirements and functions of alpha-linolenic acid in animals. 1982 Prog. Lipid Res. pmid:6287500
Ayala S and Brenner RR Effect of polyunsaturated fatty acids of the alpha-linolenic series in the lipid composition of rat testicles during development. 1980 Acta Physiol Lat Am pmid:6287807
Bozian RC and Moussavian SN Human linolenic acid deficiency. 1982 Am. J. Clin. Nutr. pmid:6293298
Rosenthal MD and Whitehurst MC Selective utilization of omega 6 and omega 3 polyunsaturated fatty acids by human skin fibroblasts. 1982 J. Cell. Physiol. pmid:6294123
Yoshino M and Murakami K The regulatory role of spermine and fatty acid in the interaction of AMP deaminase with phosphofructokinase. 1982 Biochim. Biophys. Acta pmid:6295506
Rosenthal MD and Whitehurst MC Fatty acyl delta 6 desaturation activity of cultured human endothelial cells. Modulation by fetal bovine serum. 1983 Biochim. Biophys. Acta pmid:6297606
Oliw EH Oxygenation of linolenic and linoleic acid to novel vicinal dihydroxy acids by hepatic microsomes of the rabbit. 1983 Biochem. Biophys. Res. Commun. pmid:6301473
Frankel EN Volatile lipid oxidation products. 1983 Prog. Lipid Res. pmid:6306693
Sanders TA Dietary fat and platelet function. 1983 Clin. Sci. pmid:6309463
Byrne WJ Intralipid or Liposyn--comparable products? 1982 J. Pediatr. Gastroenterol. Nutr. pmid:6310073
Magrum LJ and Johnston PV Modulation of prostaglandin synthesis in rat peritoneal macrophages with omega-3 fatty acids. 1983 Lipids pmid:6312240
Marshall LA et al. Dietary alpha-linolenic acid and prostaglandin synthesis: a time course study. 1983 Am. J. Clin. Nutr. pmid:6316775
Neuringer M et al. Dietary omega-3 fatty acid deficiency and visual loss in infant rhesus monkeys. 1984 J. Clin. Invest. pmid:6317716
Hansen HS and Jensen B Urinary prostaglandin E2 and vasopressin excretion in essential fatty acid-deficient rats: effect of linolenic acid supplementation. 1983 Lipids pmid:6318006
Marshall LA and Johnston PV The effect of dietary alpha-linolenic acid in the rat on fatty acid profiles of immunocompetent cell populations. 1983 Lipids pmid:6318008
Nicholson T and Omer SA The application of cumulative sum analysis to the investigation of reticulum motility in ruminant animals. 1983 Zentralbl Veterinarmed A pmid:6318476
Gutteridge JM et al. Superoxide-dependent lipid peroxidation. Problems with the use of catalase as a specific probe for fenton-derived hydroxyl radicals. 1983 Biochem. Biophys. Res. Commun. pmid:6320819
McCarty MF Hormonal and nutritional enhancement of Na+-K+-ATPase activity may aid the prevention and treatment of essential hypertension. 1984 Med. Hypotheses pmid:6328233
Manku MS et al. Essential fatty acids in the plasma phospholipids of patients with atopic eczema. 1984 Br. J. Dermatol. pmid:6329254
Watanabe T et al. Immobilization of lipases on polyethylene and application to perilla oil hydrolysis for production of alpha-linolenic acid. 1995 J. Nutr. Sci. Vitaminol. pmid:7472675
Francès H et al. Effects of dietary alpha-linolenic acid deficiency on neuromuscular and cognitive functions in mice. 1995 Life Sci. pmid:7475943
Muñoz SF et al. Protective capability of dietary Zizyphus mistol seed oil, rich in 18:3, n-3, on the development of two murine mammary gland adenocarcinomas with high or low metastatic potential. 1995 Prostaglandins Leukot. Essent. Fatty Acids pmid:7480075
Tsutsumi T et al. Effect of a high alpha-linolenate and high linoleate diet on membrane-associated enzyme activities in rat brain--modulation of Na+, K+- ATPase activity at suboptimal concentrations of ATP. 1995 Biol. Pharm. Bull. pmid:7492979
Hartman IS alpha-Linolenic acid: a preventive in secondary coronary events? 1995 Nutr. Rev. pmid:7494621
Ahn DU et al. Effects of dietary alpha-linolenic acid and strain of hen on the fatty acid composition, storage stability, and flavor characteristics of chicken eggs. 1995 Poult. Sci. pmid:7501600
Kawasaki M et al. Effect of alpha-linolenic acid on the metabolism of omega-3 and omega-6 polyunsaturated fatty acids and histamine release in RBL-2H3 cells. 1994 Biol. Pharm. Bull. pmid:7533019
Larsson-Backström C et al. Effects of dietary alpha- and gamma-linolenic acids on liver fatty acids, lipid metabolism, and survival in sepsis. 1995 Shock pmid:7552772
Fujiyama-Fujiwara Y et al. Effects of sesamin on the fatty acid composition of the liver of rats fed N-6 and N-3 fatty acid-rich diet. 1995 J. Nutr. Sci. Vitaminol. pmid:7562115