| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Adenoma | D000236 | 40 associated lipids |
| Adrenoleukodystrophy | D000326 | 29 associated lipids |
| Amyloidosis | D000686 | 4 associated lipids |
| Aortic Diseases | D001018 | 11 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Atrial Fibrillation | D001281 | 16 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Birth Weight | D001724 | 23 associated lipids |
| Urinary Bladder Neoplasms | D001749 | 7 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Bronchial Spasm | D001986 | 18 associated lipids |
| Cat Diseases | D002371 | 12 associated lipids |
| Cattle Diseases | D002418 | 24 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Conjunctivitis, Allergic | D003233 | 1 associated lipids |
alpha-linolenic acid
Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
Cross Reference
Introduction
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with alpha-linolenic acid?
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
PubChem Associated disorders and diseases
What pathways are associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with alpha-linolenic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with alpha-linolenic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with alpha-linolenic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Crastes de Paulet A et al. | [Biological effects on premature neonates of a milk formula enriched with alpha-linolenic acid: a multicenter study]. | 1994 | Bull. Acad. Natl. Med. | pmid:7913655 |
| Makrides M et al. | Fatty acid composition of brain, retina, and erythrocytes in breast- and formula-fed infants. | 1994 | Am. J. Clin. Nutr. | pmid:7913291 |
| Yang X and Dick TA | Dietary alpha-linolenic and linoleic acids competitively affect metabolism of polyunsaturated fatty acids in Arctic charr (Salvelinus alpinus). | 1994 | J. Nutr. | pmid:7913126 |
| Lapenna D et al. | Hypochlorous acid-induced zinc release from thiolate bonds: a potential protective mechanism towards biomolecules oxidant damage during inflammation. | 1994 | Free Radic. Res. | pmid:7912612 |
| Caffieri S et al. | Psoralen-fatty acid cycloadducts activate protein kinase C (PKC) in human platelets. | 1994 | J. Photochem. Photobiol. B, Biol. | pmid:7912265 |
| Chen Q and Nilsson A | Interconversion of alpha-linolenic acid in rat intestinal mucosa: studies in vivo and in isolated villus and crypt cells. | 1994 | J. Lipid Res. | pmid:7911819 |
| Yehuda S et al. | Essential fatty acid preparation (SR-3) raises the seizure threshold in rats. | 1994 | Eur. J. Pharmacol. | pmid:7911428 |
| de Lorgeril M et al. | Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease. | 1994 | Lancet | pmid:7911176 |
| McKeigue P | Diets for secondary prevention of coronary heart disease: can linolenic acid substitute for oily fish? | 1994 | Lancet | pmid:7911171 |
| Anderson GJ and Connor WE | Accretion of n-3 fatty acids in the brain and retina of chicks fed a low-linolenic acid diet supplemented with docosahexaenoic acid. | 1994 | Am. J. Clin. Nutr. | pmid:7911000 |
| Mantzioris E et al. | Dietary substitution with an alpha-linolenic acid-rich vegetable oil increases eicosapentaenoic acid concentrations in tissues. | 1994 | Am. J. Clin. Nutr. | pmid:7910999 |
| Huang YS et al. | Differences in the metabolism of 18:2n-6 and 18:3n-6 by the liver and kidney may explain the anti-hypertensive effect of 18:3n-6. | 1994 | Biochem. Med. Metab. Biol. | pmid:7910749 |
| Franke AA et al. | Effects of micronutrients and antioxidants on lipid peroxidation in human plasma and in cell culture. | 1994 | Cancer Lett. | pmid:7910514 |
| Ohta S et al. | Anti methicillin-resistant Staphylococcus aureus (MRSA) activity by linolenic acid isolated from the marine microalga Chlorococcum HS-101. | 1994 | Bull Environ Contam Toxicol | pmid:7910498 |
| Laethem RM et al. | Epoxidation of arachidonic acid as an active-site probe of cytochrome P-450 2B isoforms. | 1994 | Biochim. Biophys. Acta | pmid:7910485 |
| Grandgirard A et al. | Incorporation of trans long-chain n-3 polyunsaturated fatty acids in rat brain structures and retina. | 1994 | Lipids | pmid:7909911 |
| Zakhariv OIa and Ianovych VH | [Use of [1-14C]linolenic acid in lipid synthesis in ruminant tissues during the prenatal and postnatal periods of development in vitro]. | 1993 Sep-Oct | Ukr. Biokhim. Zh. | pmid:7909179 |
| Mibu H et al. | A study on lipid peroxide-induced lens damage in vitro. | 1994 | Exp. Eye Res. | pmid:7908884 |
| Narisawa T et al. | Colon cancer prevention with a small amount of dietary perilla oil high in alpha-linolenic acid in an animal model. | 1994 | Cancer | pmid:7908858 |
| Mourente G and Tocher DR | In vivo metabolism of [1-14C]linolenic acid (18:3(n-3)) and [1-14C]eicosapentaenoic acid (20:5(n-3)) in a marine fish: time-course of the desaturation/elongation pathway. | 1994 | Biochim. Biophys. Acta | pmid:7908832 |
| Uauy R et al. | Safety and efficacy of omega-3 fatty acids in the nutrition of very low birth weight infants: soy oil and marine oil supplementation of formula. | 1994 | J. Pediatr. | pmid:7908693 |
| Lockwood K et al. | Partial and complete regression of breast cancer in patients in relation to dosage of coenzyme Q10. | 1994 | Biochem. Biophys. Res. Commun. | pmid:7908519 |
| Okuley J et al. | Arabidopsis FAD2 gene encodes the enzyme that is essential for polyunsaturated lipid synthesis. | 1994 | Plant Cell | pmid:7907506 |
| Saad Aida MA et al. | Role of dietary lipids and butylated hydroxy anisol (BHA) administration on albino rats. Part I. Serum unsaturated fatty acids. | 1993 | Nahrung | pmid:7907168 |
| Jiang Z and Sim JS | Consumption of n-3 polyunsaturated fatty acid-enriched eggs and changes in plasma lipids of human subjects. | 1993 Nov-Dec | Nutrition | pmid:7906572 |
| Regdel D et al. | On the reaction specificity of the lipoxygenase from tomato fruits. | 1994 | Biochim. Biophys. Acta | pmid:7905748 |
| Green P and Yavin E | Elongation, desaturation, and esterification of essential fatty acids by fetal rat brain in vivo. | 1993 | J. Lipid Res. | pmid:7905509 |
| Tang AB et al. | Preferential reduction in adipose tissue alpha-linolenic acid (18:3 omega 3) during very low calorie dieting despite supplementation with 18:3 omega 3. | 1993 | Lipids | pmid:7904040 |
| Carter J | Flax seed as a source of alpha linolenic acid. | 1993 | J Am Coll Nutr | pmid:7903325 |
| Bierenbaum ML et al. | Reducing atherogenic risk in hyperlipemic humans with flax seed supplementation: a preliminary report. | 1993 | J Am Coll Nutr | pmid:7903324 |
| Cao J et al. | Inhibition of fatty acid delta 6- and delta 5-desaturation by cyclopropene fatty acids in rat liver microsomes. | 1993 | Biochim. Biophys. Acta | pmid:7903050 |
| Wang N and Anderson RE | Synthesis of docosahexaenoic acid by retina and retinal pigment epithelium. | 1993 | Biochemistry | pmid:7903049 |
| Yehuda S and Carasso RL | Modulation of learning, pain thresholds, and thermoregulation in the rat by preparations of free purified alpha-linolenic and linoleic acids: determination of the optimal omega 3-to-omega 6 ratio. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7901853 |
| Kardinaal AF et al. | Relations between antioxidant vitamins in adipose tissue, plasma, and diet. | 1995 | Am. J. Epidemiol. | pmid:7879788 |
| Santos MJ et al. | Influence of dietary supplementation with fish on plasma fatty acid composition in coronary heart disease patients. | 1995 | Ann. Nutr. Metab. | pmid:7872656 |
| Moore SA | Local synthesis and targeting of essential fatty acids at the cellular interface between blood and brain: a role for cerebral endothelium and astrocytes in the accretion of CNS docosahexaenoic acid. | 1994 | World Rev Nutr Diet | pmid:7871814 |
| Pawlosky R et al. | Essential fatty acid metabolism in the feline: relationship between liver and brain production of long-chain polyunsaturated fatty acids. | 1994 | J. Lipid Res. | pmid:7868981 |
| Lawrence JF et al. | An incident of elevated levels of unsaturated free fatty acids in mussels from Nova Scotia and their toxic effect in mice after intraperitoneal injection. | 1994 | Nat. Toxins | pmid:7866668 |
| Chen ZY et al. | Moderate, selective depletion of linoleate and alpha-linolenate in weight-cycled rats. | 1995 | Am. J. Physiol. | pmid:7864247 |
| Goré J et al. | Linoleic acid uptake by isolated enterocytes: influence of alpha-linolenic acid on absorption. | 1994 | Lipids | pmid:7861937 |
| Kojima S et al. | Antioxidative activity of benzylideneascorbate and its effect on adriamycin-induced cardiotoxicity. | 1994 Sep-Oct | Anticancer Res. | pmid:7847820 |
| Ingram AJ et al. | Effects of flaxseed and flax oil diets in a rat-5/6 renal ablation model. | 1995 | Am. J. Kidney Dis. | pmid:7847360 |
| Yuasa H et al. | Gastric emptying-limited oral absorption of alpha-linolenic acid administered as a milk fat-globule membrane (MFGM) emulsion in rats. | 1994 | Biol. Pharm. Bull. | pmid:7841950 |
| Ghafoorunissa | Dietary lipids and heart disease--the Indian context. | 1994 Nov-Dec | Natl Med J India | pmid:7841878 |
| Mantzioris E et al. | Differences exist in the relationships between dietary linoleic and alpha-linolenic acids and their respective long-chain metabolites. | 1995 | Am. J. Clin. Nutr. | pmid:7840069 |
| Oulhaj H et al. | [Utilization of linoleate and alpha-linolenate in peritubular cells and Sertoli cells in culture]. | 1994 | C. R. Seances Soc. Biol. Fil. | pmid:7834508 |
| Cunnane SC et al. | Nutritional attributes of traditional flaxseed in healthy young adults. | 1995 | Am. J. Clin. Nutr. | pmid:7825540 |
| Kirmani ZA et al. | Effects of supplemented omega-3 and omega-6 fatty acid rich oils on the cardiovascular system of thermally injured rabbits: changes in plasma and platelet fatty acids. | 1995 Mar-Apr | J Burn Care Rehabil | pmid:7775514 |
| Kumar GS and Das UN | Free radical-dependent suppression of growth of mouse myeloma cells by alpha-linolenic and eicosapentaenoic acids in vitro. | 1995 | Cancer Lett. | pmid:7757958 |
| Numata M | [Antitumor effects of alpha-linolenic acid on the human tumor transplanted in nude mice and on the metastasis of Vx-7 tumor in rabbit]. | 1995 | Hokkaido Igaku Zasshi | pmid:7744366 |