Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Radunz A et al. | State of the lipid and fatty acid composition in chloroplasts of Nicotiana tabacum under the influence of an increased CO2 partial pressure of 700 p.p.m. | 2000 | Biochem. Soc. Trans. | pmid:11171245 |
Nuñez A et al. | Anaerobic lipoxygenase activity from Chlorella pyrenoidosa. | 2000 | Biochem. Soc. Trans. | pmid:11171268 |
Schaller F | Enzymes of the biosynthesis of octadecanoid-derived signalling molecules. | 2001 | J. Exp. Bot. | pmid:11181709 |
Fein A and Cavar S | Divergent mechanisms for phototransduction of invertebrate microvillar photoreceptors. | 2000 Nov-Dec | Vis. Neurosci. | pmid:11193107 |
Cheon SH et al. | Effect of dietary linoleate/alpha-linolenate balance on the brain lipid composition, reproductive outcome and behavior of rats during their prenatal and postnatal development. | 2000 | Biosci. Biotechnol. Biochem. | pmid:11193394 |
Du M et al. | Effects of dietary conjugated linoleic acid and linoleic:linolenic acid ratio on polyunsaturated fatty acid status in laying hens. | 2000 | Poult. Sci. | pmid:11194037 |
Rao GN et al. | Effect of melatonin and linolenic acid on mammary cancer in transgenic mice with c-neu breast cancer oncogene. | 2000 | Breast Cancer Res. Treat. | pmid:11200779 |
Choi SB et al. | Transcriptional expression characteristics and subcellular localization of ADP-glucose pyrophosphorylase in the oil plant Perilla frutescens. | 2001 | Plant Cell Physiol. | pmid:11230568 |
Ide T | Effect of dietary alpha-linolenic acid on the activity and gene expression of hepatic fatty acid oxidation enzymes. | 2000 | Biofactors | pmid:11237206 |
Thies F et al. | Dietary supplementation with eicosapentaenoic acid, but not with other long-chain n-3 or n-6 polyunsaturated fatty acids, decreases natural killer cell activity in healthy subjects aged >55 y. | 2001 | Am. J. Clin. Nutr. | pmid:11237929 |
Zien CA et al. | In vivo substrates and the contribution of the common phospholipase D, PLDalpha, to wound-induced metabolism of lipids in Arabidopsis. | 2001 | Biochim. Biophys. Acta | pmid:11239826 |
Billeaud C et al. | Effects of preterm infant formula supplementation with alpha-linolenic acid with a linoleate/alpha-linolenate ratio of 6: a multicentric study. | 1997 | Eur J Clin Nutr | pmid:11248877 |
Korotkova M et al. | Maternal essential fatty acid deficiency depresses serum leptin levels in suckling rat pups. | 2001 | J. Lipid Res. | pmid:11254747 |
Moriguchi T et al. | Reversal of docosahexaenoic acid deficiency in the rat brain, retina, liver, and serum. | 2001 | J. Lipid Res. | pmid:11254754 |
Wolff RL et al. | Alpha-linolenic acid and its delta5-desaturation product, coniferonic acid, in the seed lipids of Tsuga and Hesperopeuce as a taxonomic means to differentiate the two genera. | 2001 | Lipids | pmid:11269703 |
Elias SL and Innis SM | Infant plasma trans, n-6, and n-3 fatty acids and conjugated linoleic acids are related to maternal plasma fatty acids, length of gestation, and birth weight and length. | 2001 | Am. J. Clin. Nutr. | pmid:11273857 |
Robertson RM and Smaha L | Can a Mediterranean-style diet reduce heart disease? | 2001 | Circulation | pmid:11282917 |
Kris-Etherton P et al. | AHA Science Advisory: Lyon Diet Heart Study. Benefits of a Mediterranean-style, National Cholesterol Education Program/American Heart Association Step I Dietary Pattern on Cardiovascular Disease. | 2001 | Circulation | pmid:11282918 |
Williard DE et al. | Identification of a fatty acid delta6-desaturase deficiency in human skin fibroblasts. | 2001 | J. Lipid Res. | pmid:11290821 |
Su HM et al. | Fetal baboons convert 18:3n-3 to 22:6n-3 in vivo. A stable isotope tracer study. | 2001 | J. Lipid Res. | pmid:11290830 |
Vermunt SH et al. | Dietary trans alpha-linolenic acid from deodorised rapeseed oil and plasma lipids and lipoproteins in healthy men: the TransLinE Study. | 2001 | Br. J. Nutr. | pmid:11299084 |
Nenseter MS et al. | Effect of Norwegian fish powder on risk factors for coronary heart disease among hypercholesterolemic individuals. | 2000 | Nutr Metab Cardiovasc Dis | pmid:11302007 |
Kaku S et al. | Interactions of dietary fats and proteins on fatty acid composition of immune cells and LTB4 production by peritoneal exudate cells of rats. | 2001 | Biosci. Biotechnol. Biochem. | pmid:11302164 |
Kawamoto S et al. | Lack of effect of the abnormal fatty acid metabolism in NC/Nga mice on their atopic dermatitis. | 2001 | Biosci. Biotechnol. Biochem. | pmid:11302182 |
Marmunti M and Catalá A | Incorporation of 1-(14)C linoleic acid in rat liver nuclei and chromatin fractions. | 2001 | Int. J. Biochem. Cell Biol. | pmid:11311857 |
Hrelia S et al. | Role of gamma-linolenic acid in counteracting doxorubicin-induced damage in cultured rat cardiomyocytes. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11334548 |
Watkins SM et al. | Unique phospholipid metabolism in mouse heart in response to dietary docosahexaenoic or alpha-linolenic acids. | 2001 | Lipids | pmid:11337979 |
Karlsson S et al. | Reactivity of Trametes laccases with fatty and resin acids. | 2001 | Appl. Microbiol. Biotechnol. | pmid:11341313 |
Murase T et al. | Abundant expression of uncoupling protein-2 in the small intestine: up-regulation by dietary fish oil and fibrates. | 2001 | Biochim. Biophys. Acta | pmid:11341955 |
Trommer H et al. | The examination of skin lipid model systems stressed by ultraviolet irradiation in the presence of transition metal ions. | 2001 | Eur J Pharm Biopharm | pmid:11343884 |
Dyer JM et al. | Chilling-sensitive, post-transcriptional regulation of a plant fatty acid desaturase expressed in yeast. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11352654 |
Kelder B et al. | Expression of fungal desaturase genes in cultured mammalian cells. | 2001 | Mol. Cell. Biochem. | pmid:11354256 |
Johnson LK et al. | [Diet and secondary prevention of coronary heart disease--are our recommendations good enough?]. | 2001 | Tidsskr. Nor. Laegeforen. | pmid:11354888 |
Barre DE | Potential of evening primrose, borage, black currant, and fungal oils in human health. | 2001 | Ann. Nutr. Metab. | pmid:11359029 |
Tijet N et al. | Biogenesis of volatile aldehydes from fatty acid hydroperoxides: molecular cloning of a hydroperoxide lyase (CYP74C) with specificity for both the 9- and 13-hydroperoxides of linoleic and linolenic acids. | 2001 | Arch. Biochem. Biophys. | pmid:11368353 |
Bretillon L et al. | Isomerization increases the postprandial oxidation of linoleic acid but not alpha-linolenic acid in men. | 2001 | J. Lipid Res. | pmid:11369808 |
Liu L et al. | [Expression of delta 6-fatty acid desaturase gene from Mortierella alpina in Saccharomyces cerevisiae]. | 2001 | Sheng Wu Gong Cheng Xue Bao | pmid:11411223 |
Inouye S et al. | In-vitro and in-vivo anti-Trichophyton activity of essential oils by vapour contact. | 2001 | Mycoses | pmid:11413931 |
Abeywardena MY et al. | Dietary n-3 and n-6 polyunsaturated oils and airway contractility. | 2001 Apr-May | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11418024 |
Blondeau N et al. | Activation of the nuclear factor-kappaB is a key event in brain tolerance. | 2001 | J. Neurosci. | pmid:11425894 |
Nomura T et al. | A long-lasting facilitation of hippocampal neurotransmission via a phospholipase A2 signaling pathway. | 2001 | Life Sci. | pmid:11432454 |
Thies F et al. | Dietary supplementation with gamma-linolenic acid or fish oil decreases T lymphocyte proliferation in healthy older humans. | 2001 | J. Nutr. | pmid:11435508 |
Avery AM and Avery SV | Saccharomyces cerevisiae expresses three phospholipid hydroperoxide glutathione peroxidases. | 2001 | J. Biol. Chem. | pmid:11445588 |
Almario RU et al. | Effects of walnut consumption on plasma fatty acids and lipoproteins in combined hyperlipidemia. | 2001 | Am. J. Clin. Nutr. | pmid:11451720 |
Renaud SC | Diet and stroke. | 2001 | J Nutr Health Aging | pmid:11458287 |
Lanzmann-Petithory D | Alpha-linolenic acid and cardiovascular diseases. | 2001 | J Nutr Health Aging | pmid:11458289 |
Kim E et al. | Effects of gamma-irradiated fats on plasma lipid concentrations and hepatic cholesterol metabolism in rats. | 2001 | Ann. Nutr. Metab. | pmid:11463998 |
Sijben JW et al. | Interactions and antigen dependence of dietary n-3 and n-6 polyunsaturated fatty acids on antibody responsiveness in growing layer hens. | 2001 | Poult. Sci. | pmid:11469650 |
Cherian G and Sim JS | Maternal dietary alpha-linolenic acid (18:3n-3) alters n-3 polyunsaturated fatty acid metabolism and liver enzyme activity in hatched chicks. | 2001 | Poult. Sci. | pmid:11469652 |
Sharma R et al. | Mulberry moracins: scavengers of UV stress-generated free radicals. | 2001 | Biosci. Biotechnol. Biochem. | pmid:11471743 |