Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Berger A and German JB | Phospholipid fatty acid composition of various mouse tissues after feeding alpha-linolenate (18:3n-3) or eicosatrienoate (20:3n-3). | 1990 | Lipids | pmid:1977067 |
Wien M et al. | Decreasing the linoleic acid to alpha-linolenic acid diet ratio increases eicosapentaenoic acid in erythrocytes in adults. | 2010 | Lipids | pmid:20496049 |
Stamey Lanier J et al. | Mammary uptake of fatty acids supplied by intravenous triacylglycerol infusion to lactating dairy cows. | 2013 | Lipids | pmid:23504269 |
Coakley M et al. | Inhibitory effect of conjugated alpha-linolenic acid from bifidobacteria of intestinal origin on SW480 cancer cells. | 2009 | Lipids | pmid:19048324 |
Guesnet P et al. | Modifying the n-3 fatty acid content of the maternal diet to determine the requirements of the fetal and suckling rat. | 1997 | Lipids | pmid:9168459 |
Spitzer V et al. | Structure analysis of an allene-containing estolide tetraester triglyceride in the seed oil of Sebastiana commersoniana (Euphorbiaceae). | 1997 | Lipids | pmid:9168462 |
Zhou D et al. | Vitamin A deficiency enhances docosahexaenoic and osbond acids in liver of rats fed an alpha linolenic acid-adequate diet. | 2006 | Lipids | pmid:16711595 |
Dinh TK et al. | Effect of age and alpha-linolenic acid deficiency on delta 6 desaturase activity and liver lipids in rats. | 1993 | Lipids | pmid:8102769 |
Javouhey-Donzel A et al. | Rat vitamin E status and heart lipid peroxidation: effect of dietary alpha-linolenic acid and marine n-3 fatty acids. | 1993 | Lipids | pmid:8102771 |
Bell MV et al. | Tissue deposition of n-3 FA pathway intermediates in the synthesis of DHA in rainbow trout (Oncorhynchus mykiss). | 2003 | Lipids | pmid:14584600 |
Morise A et al. | Dose effect of alpha-linolenic acid on PUFA conversion, bioavailability, and storage in the hamster. | 2004 | Lipids | pmid:15357020 |
Bannenberg G et al. | Diversity of the enzymatic activity in the lipoxygenase gene family of Arabidopsis thaliana. | 2009 | Lipids | pmid:18949503 |
Chang HH et al. | Dietary perilla oil inhibits proinflammatory cytokine production in the bronchoalveolar lavage fluid of ovalbumin-challenged mice. | 2008 | Lipids | pmid:18386091 |
Gavino VC et al. | Kinetic analysis of the selectivity of acylcarnitine synthesis in rat mitochondria. | 2003 | Lipids | pmid:12848298 |
DiRienzo MA et al. | Effect of substitution of high stearic low linolenic acid soybean oil for hydrogenated soybean oil on fatty acid intake. | 2008 | Lipids | pmid:18365266 |
Kim Y et al. | Synergism of α-linolenic acid, conjugated linoleic acid and calcium in decreasing adipocyte and increasing osteoblast cell growth. | 2013 | Lipids | pmid:23757205 |
He ML et al. | Inclusion of flaxseed in hay- and barley silage diets increases alpha-linolenic acid in cow plasma independent of forage type. | 2011 | Lipids | pmid:21336984 |
Igarashi M and Miyazawa T | Preparation and fractionation of conjugated trienes from alpha-linolenic acid and their growth-inhibitory effects on human tumor cells and fibroblasts. | 2005 | Lipids | pmid:15825836 |
Rao S et al. | Characteristics of high alpha-linolenic acid accumulation in seed oils. | 2008 | Lipids | pmid:18597133 |
Aki T et al. | Regulation of polyunsaturated fatty acid biosynthesis by seaweed fucoxanthin and its metabolite in cultured hepatocytes. | 2014 | Lipids | pmid:24174374 |
Hennessy AA et al. | The production of conjugated α-linolenic, γ-linolenic and stearidonic acids by strains of bifidobacteria and propionibacteria. | 2012 | Lipids | pmid:22160449 |
Chardigny JM et al. | Identification of novel trans isomers of 20:5n-3 in liver lipids of rats fed a heated oil. | 1996 | Lipids | pmid:8835404 |
Jernerén F et al. | Linolenate 9R-dioxygenase and allene oxide synthase activities of Lasiodiplodia theobromae. | 2012 | Lipids | pmid:22048860 |
Trattner S et al. | Sesamin supplementation increases white muscle docosahexaenoic acid (DHA) levels in rainbow trout (Oncorhynchus mykiss) fed high alpha-linolenic acid (ALA) containing vegetable oil: metabolic actions. | 2008 | Lipids | pmid:18781351 |
Trattner S et al. | Sesamin increases alpha-linolenic acid conversion to docosahexaenoic acid in atlantic salmon (Salmo salar L.) hepatocytes: role of altered gene expression. | 2008 | Lipids | pmid:18784949 |
Bazinet RP et al. | Dietary alpha-linolenic acid increases the n-3 PUFA content of sow's milk and the tissues of the suckling piglet. | 2003 | Lipids | pmid:14669969 |
Ghafoorunissa A et al. | Effects of dietary alpha-linolenic acid from blended oils on biochemical indices of coronary heart disease in Indians. | 2002 | Lipids | pmid:12558058 |
Legrand P et al. | The consumption of food products from linseed-fed animals maintains erythrocyte omega-3 fatty acids in obese humans. | 2010 | Lipids | pmid:20012223 |
Waters KM and Ntambi JM | Polyunsaturated fatty acids inhibit hepatic stearoyl-CoA desaturase-1 gene in diabetic mice. | 1996 | Lipids | pmid:8729090 |
Cleland LG et al. | Paradoxical effect of n-3-containing vegetable oils on long-chain n-3 fatty acids in rat heart. | 2005 | Lipids | pmid:16382570 |
Sinclair AJ et al. | What is the role of alpha-linolenic acid for mammals? | 2002 | Lipids | pmid:12617463 |
Wolff RL | Are trans isomers of alpha-linolenic acid of nutritional significance for certain populations? | 2002 | Lipids | pmid:12617467 |
Talahalli RR et al. | Lower efficacy in the utilization of dietary ALA as compared to preformed EPA + DHA on long chain n-3 PUFA levels in rats. | 2010 | Lipids | pmid:20734237 |
Anding RH and Hwang DH | Effects of dietary linolenate on the fatty acid composition of brain lipids in rats. | 1986 | Lipids | pmid:2879208 |
Tang AB et al. | Preferential reduction in adipose tissue alpha-linolenic acid (18:3 omega 3) during very low calorie dieting despite supplementation with 18:3 omega 3. | 1993 | Lipids | pmid:7904040 |
Nakamura T | Red pigment-forming substances from autoxidized linolenate: identification of prostaglandin-like substances. | 1985 | Lipids | pmid:2859511 |
McCullough RS et al. | The alpha linolenic acid content of flaxseed is associated with an induction of adipose leptin expression. | 2011 | Lipids | pmid:22031167 |
Zhou J et al. | Trans-membrane uptake and intracellular metabolism of fatty acids in Atlantic salmon (Salmo salar L.) hepatocytes. | 2010 | Lipids | pmid:20186497 |
Miranda J et al. | cis-9,trans-11,cis-15 and cis-9,trans-13,cis-15 CLNA mixture activates PPARα in HEK293 and reduces triacylglycerols in 3T3-L1 cells. | 2011 | Lipids | pmid:21984112 |
Bharadwaj AS et al. | Dietary source of stearidonic acid promotes higher muscle DHA concentrations than linolenic acid in hybrid striped bass. | 2010 | Lipids | pmid:20049582 |
Hansen HS and Jensen B | Urinary prostaglandin E2 and vasopressin excretion in essential fatty acid-deficient rats: effect of linolenic acid supplementation. | 1983 | Lipids | pmid:6318006 |
Marshall LA and Johnston PV | The effect of dietary alpha-linolenic acid in the rat on fatty acid profiles of immunocompetent cell populations. | 1983 | Lipids | pmid:6318008 |
Arbuckle LD and Innis SM | Docosahexaenoic acid in developing brain and retina of piglets fed high or low alpha-linolenate formula with and without fish oil. | 1992 | Lipids | pmid:1349717 |
Kurvinen JP et al. | The effect of low alpha-linolenic acid diet on glycerophospholipid molecular species in guinea pig brain. | 2000 | Lipids | pmid:11026621 |
Hennessy AA et al. | The health promoting properties of the conjugated isomers of α-linolenic acid. | 2011 | Lipids | pmid:21161605 |
Kim HK and Choi H | Dietary alpha-linolenic acid lowers postprandial lipid levels with increase of eicosapentaenoic and docosahexaenoic acid contents in rat hepatic membrane. | 2001 | Lipids | pmid:11834085 |
Levant B et al. | Differential effects of modulation of docosahexaenoic acid content during development in specific regions of rat brain. | 2006 | Lipids | pmid:16933785 |
Huang MZ et al. | Unusual effects of some vegetable oils on the survival time of stroke-prone spontaneously hypertensive rats. | 1997 | Lipids | pmid:9252963 |
Sugiyama K et al. | Correlation of suppressed linoleic acid metabolism with the hypocholesterolemic action of eritadenine in rats. | 1997 | Lipids | pmid:9270978 |
Wolff RL et al. | Alpha-linolenic acid and its delta5-desaturation product, coniferonic acid, in the seed lipids of Tsuga and Hesperopeuce as a taxonomic means to differentiate the two genera. | 2001 | Lipids | pmid:11269703 |
Okuyama H et al. | Dietary lipids impacts on healthy ageing. | 2007 | Lipids | pmid:17546469 |
Goré J et al. | Linoleic acid uptake by isolated enterocytes: influence of alpha-linolenic acid on absorption. | 1994 | Lipids | pmid:7861937 |
Shomonov-Wagner L et al. | Alpha linolenic acid in maternal diet halts the lipid disarray due to saturated fatty acids in the liver of mice offspring at weaning. | 2015 | Lipids Health Dis | pmid:25889505 |
Reza JZ et al. | Modulation peroxisome proliferators activated receptor alpha (PPAR alpha) and acyl coenzyme A: cholesterol acyltransferase1 (ACAT1) gene expression by fatty acids in foam cell. | 2009 | Lipids Health Dis | pmid:19725980 |
Baumgartner J et al. | Providing male rats deficient in iron and n-3 fatty acids with iron and alpha-linolenic acid alone affects brain serotonin and cognition differently from combined provision. | 2014 | Lipids Health Dis | pmid:24928171 |
Høstmark AT and Haug A | The inverse association between relative abundances of oleic acid and arachidonic acid is related to alpha -linolenic acid. | 2014 | Lipids Health Dis | pmid:24885640 |
Zhang Y et al. | α-Linolenic acid prevents endoplasmic reticulum stress-mediated apoptosis of stearic acid lipotoxicity on primary rat hepatocytes. | 2011 | Lipids Health Dis | pmid:21592363 |
Botelho PB et al. | Effect of Echium oil compared with marine oils on lipid profile and inhibition of hepatic steatosis in LDLr knockout mice. | 2013 | Lipids Health Dis | pmid:23510369 |
Cedernaes J et al. | Adipose tissue stearoyl-CoA desaturase 1 index is increased and linoleic acid is decreased in obesity-prone rats fed a high-fat diet. | 2013 | Lipids Health Dis | pmid:23298201 |
Grindel A et al. | Cheek cell fatty acids reflect n-3 PUFA in blood fractions during linseed oil supplementation: a controlled human intervention study. | 2013 | Lipids Health Dis | pmid:24229084 |
Dai J et al. | Effects of polyunsaturated fatty acids on the growth of gastric cancer cells in vitro. | 2013 | Lipids Health Dis | pmid:23663688 |
Arm JP et al. | Impact of botanical oils on polyunsaturated fatty acid metabolism and leukotriene generation in mild asthmatics. | 2013 | Lipids Health Dis | pmid:24088297 |
Mirabi P et al. | The role of fatty acids on ICSI outcomes: a prospective cohort study. | 2017 | Lipids Health Dis | pmid:28109274 |
Zhang T et al. | High-fat diet from perilla oil induces insulin resistance despite lower serum lipids and increases hepatic fatty acid oxidation in rats. | 2014 | Lipids Health Dis | pmid:24422660 |
Svensson J et al. | Postprandial lipid responses to an alpha-linolenic acid-rich oil, olive oil and butter in women: a randomized crossover trial. | 2011 | Lipids Health Dis | pmid:21711508 |
Shen J et al. | Effect of essential fatty acids on glucose-induced cytotoxicity to retinal vascular endothelial cells. | 2012 | Lipids Health Dis | pmid:22781401 |
Scheim DE | Cytotoxicity of unsaturated fatty acids in fresh human tumor explants: concentration thresholds and implications for clinical efficacy. | 2009 | Lipids Health Dis | pmid:20003514 |
Zhang Y et al. | Effect of α-linolenic acid on endoplasmic reticulum stress-mediated apoptosis of palmitic acid lipotoxicity in primary rat hepatocytes. | 2011 | Lipids Health Dis | pmid:21787405 |
Muralikumar S et al. | Probing the intermolecular interactions of PPARγ-LBD with polyunsaturated fatty acids and their anti-inflammatory metabolites to infer most potential binding moieties. | 2017 | Lipids Health Dis | pmid:28109294 |
Zhao N et al. | α-Linolenic acid increases the G0/G1 switch gene 2 mRNA expression in peripheral blood mononuclear cells from obese patients: a pilot study. | 2016 | Lipids Health Dis | pmid:26912161 |
Monteiro J et al. | Menhaden oil, but not safflower or soybean oil, aids in restoring the polyunsaturated fatty acid profile in the novel delta-6-desaturase null mouse. | 2012 | Lipids Health Dis | pmid:22642787 |
Deng Q et al. | Single frequency intake of α-linolenic acid rich phytosterol esters attenuates atherosclerosis risk factors in hamsters fed a high fat diet. | 2016 | Lipids Health Dis | pmid:26843021 |
Imran M et al. | Impact of extrusion processing conditions on lipid peroxidation and storage stability of full-fat flaxseed meal. | 2015 | Lipids Health Dis | pmid:26286266 |
Mason JK et al. | α-linolenic acid and docosahexaenoic acid, alone and combined with trastuzumab, reduce HER2-overexpressing breast cancer cell growth but differentially regulate HER2 signaling pathways. | 2015 | Lipids Health Dis | pmid:26282560 |
Yamaguchi Y et al. | Preventive effects of magnesium on raised serum lipid peroxide levels and aortic cholesterol deposition in mice fed an atherogenic diet. | 1994 | Magnes Res | pmid:7914418 |
Pereira H et al. | Polyunsaturated Fatty acids of marine macroalgae: potential for nutritional and pharmaceutical applications. | 2012 | Mar Drugs | pmid:23118712 |
Vaezi R et al. | Identification and functional characterization of genes encoding omega-3 polyunsaturated fatty acid biosynthetic activities from unicellular microalgae. | 2013 | Mar Drugs | pmid:24351909 |
Hastings N et al. | Molecular cloning and functional characterization of fatty acyl desaturase and elongase cDNAs involved in the production of eicosapentaenoic and docosahexaenoic acids from alpha-linolenic acid in Atlantic salmon (Salmo salar). | 2004 Sep-Oct | Mar. Biotechnol. | pmid:15549653 |
Keim SA and Branum AM | Dietary intake of polyunsaturated fatty acids and fish among US children 12-60 months of age. | 2015 | Matern Child Nutr | pmid:24034437 |
Yang Z and Huffman SL | Modelling linoleic acid and α-linolenic acid requirements for infants and young children in developing countries. | 2013 | Matern Child Nutr | pmid:23167585 |
Michaelsen KF et al. | Food sources and intake of n-6 and n-3 fatty acids in low-income countries with emphasis on infants, young children (6-24 months), and pregnant and lactating women. | 2011 | Matern Child Nutr | pmid:21366872 |
Gibson RA et al. | Conversion of linoleic acid and alpha-linolenic acid to long-chain polyunsaturated fatty acids (LCPUFAs), with a focus on pregnancy, lactation and the first 2 years of life. | 2011 | Matern Child Nutr | pmid:21366864 |
Lauritzen L and Carlson SE | Maternal fatty acid status during pregnancy and lactation and relation to newborn and infant status. | 2011 | Matern Child Nutr | pmid:21366866 |
Brenna JT | Animal studies of the functional consequences of suboptimal polyunsaturated fatty acid status during pregnancy, lactation and early post-natal life. | 2011 | Matern Child Nutr | pmid:21366867 |
Briend A et al. | Fatty acid status in early life in low-income countries--overview of the situation, policy and research priorities. | 2011 | Matern Child Nutr | pmid:21366873 |
Parra-Cabrera S et al. | Dietary intakes of polyunsaturated fatty acids among pregnant Mexican women. | 2011 | Matern Child Nutr | pmid:21410881 |
The power of 3. Omega-3 fatty acids. | 2007 | Mayo Clin Health Lett | pmid:17715541 | |
O'Keefe JH and Harris WS | From Inuit to implementation: omega-3 fatty acids come of age. | 2000 | Mayo Clin. Proc. | pmid:10852422 |
Ponnampalam EN et al. | Health beneficial long chain omega-3 fatty acid levels in Australian lamb managed under extensive finishing systems. | 2014 | Meat Sci. | pmid:23643471 |
Mapiye C et al. | Effects of feeding flaxseed or sunflower-seed in high-forage diets on beef production, quality and fatty acid composition. | 2013 | Meat Sci. | pmid:23669875 |
Moloney AP et al. | Colour of fat, and colour, fatty acid composition and sensory characteristics of muscle from heifers offered alternative forages to grass silage in a finishing ration. | 2013 | Meat Sci. | pmid:23806853 |
Van Ba H et al. | Significant influence of particular unsaturated fatty acids and pH on the volatile compounds in meat-like model systems. | 2013 | Meat Sci. | pmid:23632107 |
Ladeira MM et al. | Fatty acid profile, color and lipid oxidation of meat from young bulls fed ground soybean or rumen protected fat with or without monensin. | 2014 | Meat Sci. | pmid:24018278 |
Nassu RT et al. | The effects of feeding flaxseed to beef cows given forage based diets on fatty acids of longissimus thoracis muscle and backfat. | 2011 | Meat Sci. | pmid:21645974 |
Berasategi I et al. | Healthy reduced-fat Bologna sausages enriched in ALA and DHA and stabilized with Melissa officinalis extract. | 2014 | Meat Sci. | pmid:24334039 |
Berasategi I et al. | "High in omega-3 fatty acids" bologna-type sausages stabilized with an aqueous-ethanol extract of Melissa officinalis. | 2011 | Meat Sci. | pmid:21439735 |
López-López I et al. | Effect of cooking on the chemical composition of low-salt, low-fat Wakame/olive oil added beef patties with special reference to fatty acid content. | 2011 | Meat Sci. | pmid:21497025 |
Dal Bosco A et al. | Effect of dietary alfalfa on the fatty acid composition and indexes of lipid metabolism of rabbit meat. | 2014 | Meat Sci. | pmid:24036258 |
Berthelot V et al. | Utilization of extruded linseed to modify fatty composition of intensively-reared lamb meat: effect of associated cereals (wheat vs. corn) and linoleic acid content of the diet. | 2010 | Meat Sci. | pmid:20374762 |
Botsoglou E et al. | Lipid and protein oxidation of α-linolenic acid-enriched pork during refrigerated storage as influenced by diet supplementation with olive leaves (Olea europea L.) or α-tocopheryl acetate. | 2012 | Meat Sci. | pmid:22710099 |