alpha-linolenic acid

Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.

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Introduction

To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with alpha-linolenic acid?

alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid

MeSH term MeSH ID Detail
Stomatitis, Aphthous D013281 1 associated lipids
Conjunctivitis, Allergic D003233 1 associated lipids
Hearing Loss, High-Frequency D006316 1 associated lipids
Aging, Premature D019588 1 associated lipids
Night Blindness D009755 1 associated lipids
Otorhinolaryngologic Neoplasms D010039 2 associated lipids
Spinal Cord Ischemia D020760 2 associated lipids
Torsades de Pointes D016171 2 associated lipids
Sebaceous Gland Neoplasms D012626 2 associated lipids
Mental Fatigue D005222 3 associated lipids
Carcinogenesis D063646 3 associated lipids
Depression, Postpartum D019052 3 associated lipids
Dyskinesias D020820 3 associated lipids
Endomyocardial Fibrosis D004719 4 associated lipids
Amyloidosis D000686 4 associated lipids
Insect Bites and Stings D007299 4 associated lipids
Retinitis Pigmentosa D012174 6 associated lipids
Exocrine Pancreatic Insufficiency D010188 6 associated lipids
Pancytopenia D010198 6 associated lipids
Urinary Bladder Neoplasms D001749 7 associated lipids
Irritable Bowel Syndrome D043183 8 associated lipids
Community-Acquired Infections D017714 8 associated lipids
Paraplegia D010264 8 associated lipids
Hyperlipidemia, Familial Combined D006950 9 associated lipids
Tachycardia, Ventricular D017180 9 associated lipids
Retinal Degeneration D012162 9 associated lipids
Vitamin B 6 Deficiency D026681 10 associated lipids
Colorectal Neoplasms D015179 10 associated lipids
Long QT Syndrome D008133 10 associated lipids
Overweight D050177 11 associated lipids
Aortic Diseases D001018 11 associated lipids
Learning Disorders D007859 11 associated lipids
Retinoblastoma D012175 12 associated lipids
Death, Sudden, Cardiac D016757 12 associated lipids
Deficiency Diseases D003677 12 associated lipids
Cat Diseases D002371 12 associated lipids
Neoplasms D009369 13 associated lipids
Adenomatous Polyposis Coli D011125 16 associated lipids
Ventricular Fibrillation D014693 16 associated lipids
Atrial Fibrillation D001281 16 associated lipids
Bronchial Spasm D001986 18 associated lipids
Carcinoma, Ductal, Breast D018270 19 associated lipids
Pregnancy Complications D011248 19 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Diabetic Angiopathies D003925 20 associated lipids
Tuberculosis D014376 20 associated lipids
Prostatic Hyperplasia D011470 20 associated lipids
Myocardial Infarction D009203 21 associated lipids
Hypersensitivity D006967 22 associated lipids
Malaria, Falciparum D016778 22 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with alpha-linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with alpha-linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with alpha-linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with alpha-linolenic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with alpha-linolenic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with alpha-linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with alpha-linolenic acid

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Authors Title Published Journal PubMed Link
Abdel-Lateff A et al. A new antioxidant isobenzofuranone derivative from the algicolous marine fungus Epicoccum sp. 2003 Planta Med. pmid:14598209
Mohn T et al. Quantification of active principles and pigments in leaf extracts of Isatis tinctoria by HPLC/UV/MS. 2007 Planta Med. pmid:17236114
Aliferis KA et al. A metabolic profiling strategy for the dissection of plant defense against fungal pathogens. 2014 PLoS ONE pmid:25369450
Azrad M et al. Prostatic alpha-linolenic acid (ALA) is positively associated with aggressive prostate cancer: a relationship which may depend on genetic variation in ALA metabolism. 2012 PLoS ONE pmid:23285256
Emery JA et al. Δ-6 Desaturase substrate competition: dietary linoleic acid (18:2n-6) has only trivial effects on α-linolenic acid (18:3n-3) bioconversion in the teleost rainbow trout. 2013 PLoS ONE pmid:23460861
Howard TD et al. DNA methylation in an enhancer region of the FADS cluster is associated with FADS activity in human liver. 2014 PLoS ONE pmid:24842322
Tian E et al. Detection and molecular characterization of two FAD3 genes controlling linolenic acid content and development of allele-specific markers in yellow mustard (Sinapis alba). 2014 PLoS ONE pmid:24823372
Zhu G et al. Enhanced production of docosahexaenoic acid in mammalian cells. 2014 PLoS ONE pmid:24788769
Enos RT et al. Reducing the dietary omega-6:omega-3 utilizing α-linolenic acid; not a sufficient therapy for attenuating high-fat-diet-induced obesity development nor related detrimental metabolic and adipose tissue inflammatory outcomes. 2014 PLoS ONE pmid:24733548
Pany S et al. PKC activation by resveratrol derivatives with unsaturated aliphatic chain. 2012 PLoS ONE pmid:23285216
Chen S et al. Profiling of volatile compounds and associated gene expression and enzyme activity during fruit development in two cucumber cultivars. 2015 PLoS ONE pmid:25799542
Barrett E et al. Bifidobacterium breve with α-linolenic acid and linoleic acid alters fatty acid metabolism in the maternal separation model of irritable bowel syndrome. 2012 PLoS ONE pmid:23185248
Hoque M et al. Oleic acid may be the key contributor in the BAMLET-induced erythrocyte hemolysis and tumoricidal action. 2013 PLoS ONE pmid:24039698
Zhang W et al. Alpha-linolenic acid exerts an endothelial protective effect against high glucose injury via PI3K/Akt pathway. 2013 PLoS ONE pmid:23861910
Brouwer IA et al. Effect of alpha linolenic acid supplementation on serum prostate specific antigen (PSA): results from the alpha omega trial. 2013 PLoS ONE pmid:24349086
Beaulieu A et al. Leptin reverts pro-apoptotic and antiproliferative effects of α-linolenic acids in BCR-ABL positive leukemic cells: involvement of PI3K pathway. 2011 PLoS ONE pmid:21991326
Alhazzaa R et al. Bioconversion of α-linolenic acid into n-3 long-chain polyunsaturated fatty acid in hepatocytes and ad hoc cell culture optimisation. 2013 PLoS ONE pmid:24040040
Jung SW et al. Mechanism of antibacterial activity of liposomal linolenic acid against Helicobacter pylori. 2015 PLoS ONE pmid:25793403
Janssen S et al. Sensing of fatty acids for octanoylation of ghrelin involves a gustatory G-protein. 2012 PLoS ONE pmid:22768248
de Goede J et al. Alpha-linolenic acid intake and 10-year incidence of coronary heart disease and stroke in 20,000 middle-aged men and women in the Netherlands. 2011 PLoS ONE pmid:21464993
Fink BD et al. Endothelial cell and platelet bioenergetics: effect of glucose and nutrient composition. 2012 PLoS ONE pmid:22745753
Qiu J et al. Subinhibitory concentrations of perilla oil affect the expression of secreted virulence factor genes in Staphylococcus aureus. 2011 PLoS ONE pmid:21283822
Kjær MA et al. Regulation of the Omega-3 Fatty Acid Biosynthetic Pathway in Atlantic Salmon Hepatocytes. 2016 PLoS ONE pmid:27973547
Cao X et al. Transcriptional Responses and Gentiopicroside Biosynthesis in Methyl Jasmonate-Treated Gentiana macrophylla Seedlings. 2016 PLoS ONE pmid:27851826
Wolters M et al. Associations of Whole Blood n-3 and n-6 Polyunsaturated Fatty Acids with Blood Pressure in Children and Adolescents - Results from the IDEFICS/I.Family Cohort. 2016 PLoS ONE pmid:27806134
Nuez-Ortín WG et al. Preliminary Validation of a High Docosahexaenoic Acid (DHA) and -Linolenic Acid (ALA) Dietary Oil Blend: Tissue Fatty Acid Composition and Liver Proteome Response in Atlantic Salmon (Salmo salar) Smolts. 2016 PLoS ONE pmid:27556399
Benbrook CM et al. Organic production enhances milk nutritional quality by shifting fatty acid composition: a United States-wide, 18-month study. 2013 PLoS ONE pmid:24349282
Fatima T et al. Fatty acid composition of developing sea buckthorn (Hippophae rhamnoides L.) berry and the transcriptome of the mature seed. 2012 PLoS ONE pmid:22558083
Alsharari ZD et al. Serum Fatty Acids, Desaturase Activities and Abdominal Obesity - A Population-Based Study of 60-Year Old Men and Women. 2017 PLoS ONE pmid:28125662
Duscharla D et al. Prostate Cancer Associated Lipid Signatures in Serum Studied by ESI-Tandem Mass Spectrometryas Potential New Biomarkers. 2016 PLoS ONE pmid:26958841
Kim KR et al. Selective Production of 9R-Hydroxy-10E,12Z,15Z-Octadecatrienoic Acid from α-Linolenic Acid in Perilla Seed Oil Hydrolyzate by a Lipoxygenase from Nostoc Sp. SAG 25.82. 2015 PLoS ONE pmid:26379279
Mansara PP et al. Differential Ratios of Omega Fatty Acids (AA/EPA+DHA) Modulate Growth, Lipid Peroxidation and Expression of Tumor Regulatory MARBPs in Breast Cancer Cell Lines MCF7 and MDA-MB-231. 2015 PLoS ONE pmid:26325577
Castro LF et al. Functional desaturase Fads1 (Δ5) and Fads2 (Δ6) orthologues evolved before the origin of jawed vertebrates. 2012 PLoS ONE pmid:22384110
Białek A et al. [Conjugated linolenic acids (CLnA, super CLA)--natural sources and biological activity]. 2014 Postepy Hig Med Dosw (Online) pmid:25380206
Applegate TJ and Sell JL Effect of dietary linoleic to linolenic acid ratio and vitamin E supplementation on vitamin E status of poults. 1996 Poult. Sci. pmid:8966177
Du M et al. Effects of dietary conjugated linoleic acid and linoleic:linolenic acid ratio on polyunsaturated fatty acid status in laying hens. 2000 Poult. Sci. pmid:11194037
Sijben JW et al. Dietary linoleic acid divergently affects immune responsiveness of growing layer hens. 2000 Poult. Sci. pmid:10947178
Parmentier HK et al. Dietary unsaturated fatty acids affect antibody responses and growth of chickens divergently selected for humoral responses to sheep red blood cells. 1997 Poult. Sci. pmid:9251147
Carrillo-Domínguez S et al. Cholesterol and n-3 and n-6 fatty acid content in eggs from laying hens fed with red crab meal (Pleuroncodes planipes). 2005 Poult. Sci. pmid:15685957
Engberg RM et al. Inclusion of oxidized vegetable oil in broiler diets. Its influence on nutrient balance and on the antioxidative status of broilers. 1996 Poult. Sci. pmid:8829233
Puthpongsiriporn U and Scheideler SE Effects of dietary ratio of linoleic to linolenic acid on performance, antibody production, and in vitro lymphocyte proliferation in two strains of leghorn pullet chicks. 2005 Poult. Sci. pmid:15971520
Sijben JW et al. Interactions and antigen dependence of dietary n-3 and n-6 polyunsaturated fatty acids on antibody responsiveness in growing layer hens. 2001 Poult. Sci. pmid:11469650
Wang YW et al. Maternal dietary ratio of linoleic acid to alpha-linolenic acid affects the passive immunity of hatching chicks. 2004 Poult. Sci. pmid:15615018
Bou R et al. Effect of dietary fat sources and zinc and selenium supplements on the composition and consumer acceptability of chicken meat. 2005 Poult. Sci. pmid:16050130
Ahn DU et al. Effects of dietary alpha-linolenic acid and strain of hen on the fatty acid composition, storage stability, and flavor characteristics of chicken eggs. 1995 Poult. Sci. pmid:7501600
Allen PC et al. Effects of nutritionally balanced and stabilized flaxmeal-based diets on Eimeria tenella infections in chickens. 2000 Poult. Sci. pmid:10780643
Cherian G and Sim JS Maternal dietary alpha-linolenic acid (18:3n-3) alters n-3 polyunsaturated fatty acid metabolism and liver enzyme activity in hatched chicks. 2001 Poult. Sci. pmid:11469652
Scheideler SE and Froning GW The combined influence of dietary flaxseed variety, level, form, and storage conditions on egg production and composition among vitamin E-supplemented hens. 1996 Poult. Sci. pmid:8893298
Simopoulos AP Human requirement for N-3 polyunsaturated fatty acids. 2000 Poult. Sci. pmid:10901194
Kim JH et al. Effect of dietary supplementation with conjugated linoleic acid, with oleic, linoleic, or linolenic acid, on egg quality characteristics and fat accumulation in the egg yolk. 2007 Poult. Sci. pmid:17495090
Gao YC and Charter EA Nutritionally important fatty acids in hen egg yolks from different sources. 2000 Poult. Sci. pmid:10875777
Muramatsu T et al. Higher dietary intake of alpha-linolenic acid is associated with lower insulin resistance in middle-aged Japanese. 2010 May-Jun Prev Med pmid:20211645
Williams CM and Burdge G Long-chain n-3 PUFA: plant v. marine sources. 2006 Proc Nutr Soc pmid:16441943
Budowski P and Crawford MA a-Linolenic acid as a regulator of the metabolism of arachidonic acid: dietary implications of the ratio, n-6:n-3 fatty acids. 1985 Proc Nutr Soc pmid:2864692
Betteridge J Nutrition and platelet function in atherogenesis. 1987 Proc Nutr Soc pmid:2893383
Thamphiwatana S et al. In vivo treatment of Helicobacter pylori infection with liposomal linolenic acid reduces colonization and ameliorates inflammation. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:25422427
De Moraes CM and Mescher MC Biochemical crypsis in the avoidance of natural enemies by an insect herbivore. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:15184664
Schmelz EA et al. Phytohormone-based activity mapping of insect herbivore-produced elicitors. 2009 Proc. Natl. Acad. Sci. U.S.A. pmid:19124770
Huang H et al. Inhibition of hepatitis C virus replication by peroxidation of arachidonate and restoration by vitamin E. 2007 Proc. Natl. Acad. Sci. U.S.A. pmid:18003907
Kis M et al. Light-induced expression of fatty acid desaturase genes. 1998 Proc. Natl. Acad. Sci. U.S.A. pmid:9539715
Yehuda S and Carasso RL Modulation of learning, pain thresholds, and thermoregulation in the rat by preparations of free purified alpha-linolenic and linoleic acids: determination of the optimal omega 3-to-omega 6 ratio. 1993 Proc. Natl. Acad. Sci. U.S.A. pmid:7901853
Do TQ et al. Enhanced sensitivity of ubiquinone-deficient mutants of Saccharomyces cerevisiae to products of autoxidized polyunsaturated fatty acids. 1996 Proc. Natl. Acad. Sci. U.S.A. pmid:8755509
Patwardhan AM et al. Activation of TRPV1 in the spinal cord by oxidized linoleic acid metabolites contributes to inflammatory hyperalgesia. 2009 Proc. Natl. Acad. Sci. U.S.A. pmid:19843694
Kang JX et al. Free, long-chain, polyunsaturated fatty acids reduce membrane electrical excitability in neonatal rat cardiac myocytes. 1995 Proc. Natl. Acad. Sci. U.S.A. pmid:7732020
Kitajka K et al. The role of n-3 polyunsaturated fatty acids in brain: modulation of rat brain gene expression by dietary n-3 fatty acids. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:11880617
Zhang W et al. Crystal structure of FAS thioesterase domain with polyunsaturated fatty acyl adduct and inhibition by dihomo-gamma-linolenic acid. 2011 Proc. Natl. Acad. Sci. U.S.A. pmid:21908709
Frey M et al. An herbivore elicitor activates the gene for indole emission in maize. 2000 Proc. Natl. Acad. Sci. U.S.A. pmid:11106389
He K Fish, long-chain omega-3 polyunsaturated fatty acids and prevention of cardiovascular disease--eat fish or take fish oil supplement? 2009 Sep-Oct Prog Cardiovasc Dis pmid:19732603
Vergroesen AJ et al. Cardiovascular effects of linoleic acid. 1980 Prog Food Nutr Sci pmid:6256818
Olaf A Effects of linoleic and alpha linolenic acids intake on blood pressure in man. 1989 Prog. Clin. Biol. Res. pmid:2571995
Holman RT Nutritional and functional requirements for essential fatty acids. 1986 Prog. Clin. Biol. Res. pmid:2878441
Frankel EN Chemistry of free radical and singlet oxidation of lipids. 1984 Prog. Lipid Res. pmid:6100997
Cunnane SC Problems with essential fatty acids: time for a new paradigm? 2003 Prog. Lipid Res. pmid:14559071
Barceló-Coblijn G and Murphy EJ Alpha-linolenic acid and its conversion to longer chain n-3 fatty acids: benefits for human health and a role in maintaining tissue n-3 fatty acid levels. 2009 Prog. Lipid Res. pmid:19619583
Tinoco J Dietary requirements and functions of alpha-linolenic acid in animals. 1982 Prog. Lipid Res. pmid:6287500
Zöllner N Dietary linolenic acid in man--an overview. 1986 Prog. Lipid Res. pmid:2892211
Frankel EN Volatile lipid oxidation products. 1983 Prog. Lipid Res. pmid:6306693
Poudyal H et al. Omega-3 fatty acids and metabolic syndrome: effects and emerging mechanisms of action. 2011 Prog. Lipid Res. pmid:21762726
Quadt JF and ten Hoor F Effects of dietary alpha-linolenic acid on the production of a PGI-like substance of the isolated pulsatingly perfused rat aorta. 1981 Prog. Lipid Res. pmid:6281803
Marshall LA and Johnston PV alpha-Linolenic and linoleic acids and the immune response. 1981 Prog. Lipid Res. pmid:6281806
Domenichiello AF et al. Is docosahexaenoic acid synthesis from α-linolenic acid sufficient to supply the adult brain? 2015 Prog. Lipid Res. pmid:25920364
Hashimoto A et al. Effect of the dietary alpha-linolenate/linoleate balance on leukotriene production and histamine release in rats. 1988 Prostaglandins pmid:2459732
Scherhag R et al. Dietary administration of eicosapentaenoic and linolenic acid increases arterial blood pressure and suppresses vascular prostacyclin synthesis in the rat. 1982 Prostaglandins pmid:6285420
Singer P et al. Changes of N-6 and N-3 fatty acids in liver from spontaneously hypertensive (SHR) and normotensive rats after diets supplemented with alpha-linolenic or eicosapentaenoic acids. 1987 Prostaglandins Leukot Med pmid:2888133
Schuchardt JP et al. Comparison of free serum oxylipin concentrations in hyper- vs. normolipidemic men. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23694766
Ferretti A and Flanagan VP Antithromboxane activity of dietary alpha-linolenic acid: a pilot study. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8888358
Abeywardena MY et al. Dietary n-3 and n-6 polyunsaturated oils and airway contractility. 2001 Apr-May Prostaglandins Leukot. Essent. Fatty Acids pmid:11418024
Bourre JM et al. Function of dietary polyunsaturated fatty acids in the nervous system. 1993 Prostaglandins Leukot. Essent. Fatty Acids pmid:8093816
Li D et al. Omega 6 to omega 3 fatty acid imbalance early in life leads to persistent reductions in DHA levels in glycerophospholipids in rat hypothalamus even after long-term omega 3 fatty acid repletion. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16716580
Rapoport SI and Igarashi M Can the rat liver maintain normal brain DHA metabolism in the absence of dietary DHA? 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19540098
Chavali SR et al. Dietary alpha-linolenic acid increases TNF-alpha, and decreases IL-6, IL-10 in response to LPS: effects of sesamin on the delta-5 desaturation of omega6 and omega3 fatty acids in mice. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9610840
Burdge GC and Wootton SA Conversion of alpha-linolenic acid to palmitic, palmitoleic, stearic and oleic acids in men and women. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12907139
Vancassel S et al. Plasma fatty acid levels in autistic children. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11487301
Hurst S et al. Dietary fatty acids and arthritis. 2010 Apr-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:20189789
Kartikasari LR et al. Dietary alpha-linolenic acid enhances omega-3 long chain polyunsaturated fatty acid levels in chicken tissues. 2012 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:22925778
Harland DR et al. Acute effects of prostaglandin E1 and E2 on vascular reactivity and blood flow in situ in the chick chorioallantoic membrane. 2012 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:22858445
Charnock JS Gamma-linolenic acid provides additional protection against ventricular fibrillation in aged rats fed linoleic acid rich diets. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10780878
Punchard NA et al. Analysis of the intestinal absorption of essential fatty acids in vivo in the rat. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10765976
Brenna JT et al. alpha-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans. 2009 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:19269799
Lorenzini A et al. Age-related changes in essential fatty acid metabolism in cultured rat heart myocytes. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9250697