alpha-linolenic acid
Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
Cross Reference
Introduction
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with alpha-linolenic acid?
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
PubChem Associated disorders and diseases
What pathways are associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with alpha-linolenic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with alpha-linolenic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with alpha-linolenic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Schuchardt JP et al. | Comparison of free serum oxylipin concentrations in hyper- vs. normolipidemic men. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23694766 |
| Ferretti A and Flanagan VP | Antithromboxane activity of dietary alpha-linolenic acid: a pilot study. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8888358 |
| MarÃn MC et al. | Dietary long-chain fatty acids and visual response in malnourished nursing infants. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11133176 |
| Suzuki R et al. | Effects of n-3 polyunsaturated fatty acids on dermatitis in NC/Nga mice. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12054914 |
| Fokkema MR et al. | Short-term supplementation of low-dose gamma-linolenic acid (GLA), alpha-linolenic acid (ALA), or GLA plus ALA does not augment LCP omega 3 status of Dutch vegans to an appreciable extent. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11090255 |
| Abeywardena MY et al. | Dietary n-3 and n-6 polyunsaturated oils and airway contractility. | 2001 Apr-May | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11418024 |
| Bourre JM et al. | Function of dietary polyunsaturated fatty acids in the nervous system. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8093816 |
| Li D et al. | Omega 6 to omega 3 fatty acid imbalance early in life leads to persistent reductions in DHA levels in glycerophospholipids in rat hypothalamus even after long-term omega 3 fatty acid repletion. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16716580 |
| Rapoport SI and Igarashi M | Can the rat liver maintain normal brain DHA metabolism in the absence of dietary DHA? | 2009 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19540098 |
| Blanchard H et al. | Comparative effects of well-balanced diets enriched in α-linolenic or linoleic acids on LC-PUFA metabolism in rat tissues. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23579035 |
| Gueck T et al. | Effects of essential fatty acids on mediators of mast cells in culture. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12711248 |
| Motaung E et al. | Cytotoxicity of combined essential fatty acids on a human prostate cancer cell line. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10670696 |
| Smuts CM et al. | The effect of iron fortification on the fatty acid composition of plasma and erythrocyte membranes in primary school children with and without iron deficiency. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7708822 |
| Papies B et al. | Ischemic myocardial damage in spontaneously hypertensive rats (SHR) is enhanced after long-term feeding of an alpha-linolenic acid enriched diet. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1679554 |
| Seppänen-Laakso T et al. | Elevated plasma fibrinogen caused by inadequate alpha-linolenic acid intake can be reduced by replacing fat with canola-type rapeseed oil. | 2010 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20206485 |
| Rapoport SI et al. | Quantitative contributions of diet and liver synthesis to docosahexaenoic acid homeostasis. | 2010 Apr-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20226642 |
| Chavali SR et al. | Dietary alpha-linolenic acid increases TNF-alpha, and decreases IL-6, IL-10 in response to LPS: effects of sesamin on the delta-5 desaturation of omega6 and omega3 fatty acids in mice. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9610840 |
| Burdge GC and Wootton SA | Conversion of alpha-linolenic acid to palmitic, palmitoleic, stearic and oleic acids in men and women. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12907139 |
| Oliva ME et al. | Dietary Salba (Salvia hispanica L) seed rich in α-linolenic acid improves adipose tissue dysfunction and the altered skeletal muscle glucose and lipid metabolism in dyslipidemic insulin-resistant rats. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24120122 |
| Hanke D et al. | A diet high in α-linolenic acid and monounsaturated fatty acids attenuates hepatic steatosis and alters hepatic phospholipid fatty acid profile in diet-induced obese rats. | 2013 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24140006 |
| Vancassel S et al. | Plasma fatty acid levels in autistic children. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11487301 |
| Kurowska EM et al. | Bioavailability of omega-3 essential fatty acids from perilla seed oil. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12591004 |
| Strandvik B | The omega-6/omega-3 ratio is of importance! | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21945460 |
| Childs CE et al. | Maternal diet during pregnancy has tissue-specific effects upon fetal fatty acid composition and alters fetal immune parameters. | 2010 Oct-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20817424 |
| McNamara RK et al. | Omega-3 fatty acid deficiency increases constitutive pro-inflammatory cytokine production in rats: relationship with central serotonin turnover. | 2010 Oct-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20817496 |
| Shannon J et al. | Erythrocyte fatty acids and prostate cancer risk: a comparison of methods. | 2010 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20630734 |
| Gibson R and Makrides M | α-Linolenate reduces the dietary requirement for linoleate in the growing rat. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22019216 |
| Hurst S et al. | Dietary fatty acids and arthritis. | 2010 Apr-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20189789 |
| Guesnet P et al. | α-Linolenate reduces the dietary requirement for linoleate in the growing rat. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21880475 |
| Arun Kumar C and Das UN | Lipid peroxides, nitric oxide and essential fatty acids in patients with Plasmodium falciparum malaria. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10574650 |
| Tocher DR and Dick JR | Effects of essential fatty acid deficiency and supplementation with docosahexaenoic acid (DHA; 22:6n-3) on cellular fatty acid compositions and fatty acyl desaturation in a cell culture model. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11161581 |
| Alava MA et al. | Fatty acid desaturation: effect of alphafetoprotein on alpha-linolenic acid conversion by fetal rat hepatocytes. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10359023 |
| Kartikasari LR et al. | Dietary alpha-linolenic acid enhances omega-3 long chain polyunsaturated fatty acid levels in chicken tissues. | 2012 Oct-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22925778 |
| Harland DR et al. | Acute effects of prostaglandin E1 and E2 on vascular reactivity and blood flow in situ in the chick chorioallantoic membrane. | 2012 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22858445 |
| Hrelia S et al. | Role of gamma-linolenic acid in counteracting doxorubicin-induced damage in cultured rat cardiomyocytes. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11334548 |
| Charnock JS | Gamma-linolenic acid provides additional protection against ventricular fibrillation in aged rats fed linoleic acid rich diets. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10780878 |
| Schimke I et al. | Influence of long-term supplementation with alpha-linolenic acid on myocardial lipid peroxidation and antioxidative capacity in spontaneously hypertensive rats. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9431820 |
| Kim HW et al. | Regulation of rat brain polyunsaturated fatty acid (PUFA) metabolism during graded dietary n-3 PUFA deprivation. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21880477 |
| Punchard NA et al. | Analysis of the intestinal absorption of essential fatty acids in vivo in the rat. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10765976 |
| Glew RH et al. | Fatty acid composition of the milk lipids of Nepalese women: correlation between fatty acid composition of serum phospholipids and melting point. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11728165 |
| Brenna JT et al. | alpha-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans. | 2009 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19269799 |
| Lorenzini A et al. | Age-related changes in essential fatty acid metabolism in cultured rat heart myocytes. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9250697 |
| Dhobale MV et al. | Reduced levels of placental long chain polyunsaturated fatty acids in preterm deliveries. | 2011 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21816593 |
| Leroy C et al. | Fatty acid-binding protein3 expression in BeWo cells, a human placental choriocarcinoma cell line. | 2017 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:28515017 |
| Delplanque B et al. | A dairy fat matrix providing alpha-linolenic acid (ALA) is better than a vegetable fat mixture to increase brain DHA accretion in young rats. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22884780 |
| Brouwer IA | Omega-3 PUFA: good or bad for prostate cancer? | 2008 Sep-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18951003 |
| Sravan Kumar G and Das UN | Cytotoxic action of alpha-linolenic and eicosapentaenoic acids on myeloma cells in vitro. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9150374 |
| Attar-Bashi NM et al. | Failure of conjugated linoleic acid supplementation to enhance biosynthesis of docosahexaenoic acid from alpha-linolenic acid in healthy human volunteers. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17275274 |
| Rapoport SI et al. | Docosahexaenoic acid (DHA) incorporation into the brain from plasma, as an in vivo biomarker of brain DHA metabolism and neurotransmission. | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21704722 |
| Conklin SM et al. | Serum omega-3 fatty acids are associated with variation in mood, personality and behavior in hypercholesterolemic community volunteers. | 2007 | Psychiatry Res | pmid:17383013 |
| Rabinovitz S et al. | Anticonvulsant efficiency, behavioral performance and cortisol levels: a comparison of carbamazepine (CBZ) and a fatty acid compound (SR-3). | 2004 | Psychoneuroendocrinology | pmid:14604595 |
| Levant B et al. | Decreased brain docosahexaenoic acid content produces neurobiological effects associated with depression: Interactions with reproductive status in female rats. | 2008 | Psychoneuroendocrinology | pmid:18707812 |
| Venna VR et al. | PUFA induce antidepressant-like effects in parallel to structural and molecular changes in the hippocampus. | 2009 | Psychoneuroendocrinology | pmid:18848400 |
| Segovia-Siapco G et al. | Validation of a food-frequency questionnaire for measurement of nutrient intake in a dietary intervention study. | 2007 | Public Health Nutr | pmid:17261227 |
| Petrogianni M et al. | Additional benefit in CVD risk indices derived from the consumption of fortified milk when combined with a lifestyle intervention. | 2014 | Public Health Nutr | pmid:23249766 |
| van der Walt AM et al. | Linolenic acid and folate in wild-growing African dark leafy vegetables (morogo). | 2009 | Public Health Nutr | pmid:18503724 |
| Maqbool A et al. | The skinny on tuna fat: health implications. | 2011 | Public Health Nutr | pmid:21324226 |
| Ghisolfi J et al. | Nutrient intakes of children aged 1-2 years as a function of milk consumption, cows' milk or growing-up milk. | 2013 | Public Health Nutr | pmid:23098567 |
| McDonald GB and Weidman M | Partitioning of polar fatty acids into lymph and portal vein after intestinal absorption in the rat. | 1987 | Q J Exp Physiol | pmid:2884690 |
| Marotta F et al. | Liver exposure to xenobiotics: the aging factor and potentials for functional foods. | 2006 | Rejuvenation Res | pmid:16706665 |
| Guesnet P et al. | Dietary alpha-linolenic acid deficiency in the rat. I. Effects on reproduction and postnatal growth. | 1986 | Reprod Nutr Dev | pmid:2877477 |
| Guesnet P et al. | Effects of dietary alpha-linolenic acid deficiency during pregnancy and lactation on lipid fatty acid composition of liver and serum in the rat. | 1988 | Reprod Nutr Dev | pmid:2897705 |
| Kiernan M et al. | The effect of the in vitro supplementation of exogenous long-chain fatty acids on bovine sperm cell function. | 2013 | Reprod. Fertil. Dev. | pmid:23036717 |
| Marei WF et al. | Differential effects of linoleic and alpha-linolenic fatty acids on spatial and temporal mitochondrial distribution and activity in bovine oocytes. | 2012 | Reprod. Fertil. Dev. | pmid:22697118 |
| Acar N et al. | The retina is more susceptible than the brain and the liver to the incorporation of trans isomers of DHA in rats consuming trans isomers of alpha-linolenic acid. | 2006 Sep-Oct | Reprod. Nutr. Dev. | pmid:17107641 |
| Bretillon L et al. | In vivo oxidation of [9-14C] cyclic fatty acids derived from linolenic acid in the rat. | 2006 Mar-Apr | Reprod. Nutr. Dev. | pmid:16597424 |
| Burdge GC and Calder PC | Conversion of alpha-linolenic acid to longer-chain polyunsaturated fatty acids in human adults. | 2005 Sep-Oct | Reprod. Nutr. Dev. | pmid:16188209 |
| De Lorgeril M and Salen P | Use and misuse of dietary fatty acids for the prevention and treatment of coronary heart disease. | 2004 May-Jun | Reprod. Nutr. Dev. | pmid:15460167 |
| Morise A et al. | Dose effect of alpha-linolenic acid on lipid metabolism in the hamster. | 2005 Jul-Aug | Reprod. Nutr. Dev. | pmid:16045889 |
| Ponter AA et al. | Effect of a supplement rich in linolenic acid added to the diet of post partum dairy cows on ovarian follicle growth, and milk and plasma fatty acid compositions. | 2006 Jan-Feb | Reprod. Nutr. Dev. | pmid:16438912 |
| Rao SS et al. | Sensitivity of fetus and pups to excess levels of maternal intakes of alpha linolenic acid at marginal protein levels in Wistar rats. | 2007 Nov-Dec | Reprod. Toxicol. | pmid:17825521 |
| Moallem U et al. | Dietary α-linolenic acid from flaxseed oil improved folliculogenesis and IVF performance in dairy cows, similar to eicosapentaenoic and docosahexaenoic acids from fish oil. | 2013 | Reproduction | pmid:24062566 |
| Robinson RS et al. | Effects of dietary polyunsaturated fatty acids on ovarian and uterine function in lactating dairy cows. | 2002 | Reproduction | pmid:12090925 |
| Smith GM and Isopenko A | Effect of doses of protected polyunsaturated fatty acids on indicators of selenium status of sheep. | 1997 Jan-Feb | Res. Vet. Sci. | pmid:9160431 |
| Glocker TM | [Pathology of placenta of rats induced by fatty acid deficiency]. | 2000 | Rev Fac Cien Med Univ Nac Cordoba | pmid:12934235 |
| MandaÅŸescu S et al. | Flaxseed supplementation in hyperlipidemic patients. | 2005 Jul-Sep | Rev Med Chir Soc Med Nat Iasi | pmid:16607740 |
| Ulbricht C et al. | Chia (Salvia hispanica): a systematic review by the natural standard research collaboration. | 2009 | Rev Recent Clin Trials | pmid:20028328 |
| Nordström DC et al. | Alpha-linolenic acid in the treatment of rheumatoid arthritis. A double-blind, placebo-controlled and randomized study: flaxseed vs. safflower seed. | 1995 | Rheumatol. Int. | pmid:7597378 |
| Sato M et al. | [Experimental cerebral ischemia effects of fatty acid in Mongolian gerbils]. | 1986 | Rinsho Shinkeigaku | pmid:2879661 |
| Dybkowska E et al. | [The comparison of fat, trans isomers and cholesterol intake in the diet of Warsaw inhabitants in relation to Polish food ration]. | 2004 | Rocz Panstw Zakl Hig | pmid:19097583 |
| McNamara RK et al. | Chronic risperidone treatment preferentially increases rat erythrocyte and prefrontal cortex omega-3 fatty acid composition: evidence for augmented biosynthesis. | 2009 | Schizophr. Res. | pmid:18993032 |
| Fu X et al. | Regulation of formation of volatile compounds of tea (Camellia sinensis) leaves by single light wavelength. | 2015 | Sci Rep | pmid:26567525 |
| Wu MH et al. | A novel sodium N-fatty acyl amino acid surfactant using silkworm pupae as stock material. | 2014 | Sci Rep | pmid:24651079 |
| Liu X et al. | APA-style human milk fat analogue from silkworm pupae oil: Enzymatic production and improving storage stability using alkyl caffeates. | 2015 | Sci Rep | pmid:26643045 |
| Liechti R and Farmer EE | Jasmonate biochemical pathway. | 2006 | Sci. STKE | pmid:16478937 |
| KORN ED and GREENBLATT CL | SYNTHESIS OF ALPHA-LINOLENIC ACID BY LEISHMANIA ENRIETTII. | 1963 | Science | pmid:14074842 |
| Bellaloui N and Mengistu A | Effects of boron nutrition and water stress on nitrogen fixation, seed δ15N and δ13C dynamics, and seed composition in soybean cultivars differing in maturities. | 2015 | ScientificWorldJournal | pmid:25667936 |
| Wang Q et al. | [Determination of alpha-linolenic acid in perilla oil by reversed-phase high performance liquid chromatography coupled with evaporative light-scattering detector]. | 2006 | Se Pu | pmid:16827313 |
| Cui K et al. | [Analysis of triacylglycerol composition of perilla oil by combination of non-aqueous reversed-phase high performance liquid chromatography with gas chromatography]. | 1997 | Se Pu | pmid:15739324 |
| Uauy R and Hoffman DR | Essential fatty acid requirements for normal eye and brain development. | 1991 | Semin. Perinatol. | pmid:1687090 |
| Fan WX | [Alpha-linolenic acid and its metabolites EPA and DHA]. | 1988 | Sheng Li Ke Xue Jin Zhan | pmid:2901141 |
| Zhang HT et al. | [Functional expression of an omega-3 fatty acid desaturase gene from Glycine max in Saccharomyces cerevisiae]. | 2006 | Sheng Wu Gong Cheng Xue Bao | pmid:16572837 |
| Liu L et al. | [Expression of delta 6-fatty acid desaturase gene from Mortierella alpina in Saccharomyces cerevisiae]. | 2001 | Sheng Wu Gong Cheng Xue Bao | pmid:11411223 |
| Larsson-Backström C et al. | Effects of dietary alpha- and gamma-linolenic acids on liver fatty acids, lipid metabolism, and survival in sepsis. | 1995 | Shock | pmid:7552772 |
| Trommer H et al. | Mass spectrometric examinations of stratum corneum lipid models exposed to ultraviolet irradiation. | 2003 Sep-Oct | Skin Pharmacol. Appl. Skin Physiol. | pmid:12907834 |
| Chambron E | [Dietetics in coronary patients]. | 2005 | Soins | pmid:15999643 |
| Hisha H et al. | Treatment of Shwachman syndrome by Japanese herbal medicine (Juzen-taiho-to): stimulatory effects of its fatty acids on hemopoiesis in patients. | 2002 | Stem Cells | pmid:12110700 |
| Ramaprasad TR et al. | Spray-dried milk supplemented with alpha-linolenic acid or eicosapentaenoic acid and docosahexaenoic acid decreases HMG Co A reductase activity and increases biliary secretion of lipids in rats. | 2006 | Steroids | pmid:16499938 |
| Schreck U et al. | Intraindividual comparison of two different skin care conceptions in patients undergoing radiotherapy of the head-and-neck region. Creme or powder? | 2002 | Strahlenther Onkol | pmid:12122788 |
| Hejazi L et al. | Identification of the geometrical isomers of α-linolenic acid using gas chromatography/mass spectrometry with a binary decision tree. | 2011 | Talanta | pmid:21215858 |