Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Grechkin AN et al. | The lipoxygenase pathway in garlic (Allium sativum L.) bulbs: detection of the novel divinyl ether oxylipins. | 1995 | FEBS Lett. | pmid:7672118 |
Kardinaal AF et al. | Relations between antioxidant vitamins in adipose tissue, plasma, and diet. | 1995 | Am. J. Epidemiol. | pmid:7879788 |
Degousée N et al. | Measurement of thermally produced volatile alkanes: an assay for plant hydroperoxy fatty acid evaluation. | 1995 | Anal. Biochem. | pmid:7733454 |
Tezabwala BU et al. | Immunotoxicity of polyunsaturated fatty acids in serum-free medium. | 1995 | Immunopharmacol Immunotoxicol | pmid:7650296 |
Cunnane SC et al. | Nutritional attributes of traditional flaxseed in healthy young adults. | 1995 | Am. J. Clin. Nutr. | pmid:7825540 |
Ingram AJ et al. | Effects of flaxseed and flax oil diets in a rat-5/6 renal ablation model. | 1995 | Am. J. Kidney Dis. | pmid:7847360 |
Numata M | [Antitumor effects of alpha-linolenic acid on the human tumor transplanted in nude mice and on the metastasis of Vx-7 tumor in rabbit]. | 1995 | Hokkaido Igaku Zasshi | pmid:7744366 |
Kumar GS and Das UN | Free radical-dependent suppression of growth of mouse myeloma cells by alpha-linolenic and eicosapentaenoic acids in vitro. | 1995 | Cancer Lett. | pmid:7757958 |
Antras-Ferry J et al. | Fatty acids and fibrates are potent inducers of transcription of the phosphenolpyruvate carboxykinase gene in adipocytes. | 1995 | Eur. J. Biochem. | pmid:8536680 |
Fuhrmann H and Sallmann HP | Alpha-tocopherol and phospholipase A2 in liver and brain of chicks posthatching: the influence of dietary fat and vitamin E. | 1995 | Ann. Nutr. Metab. | pmid:8585700 |
Périchon R and Bourre JM | Peroxisomal beta-oxidation activity and catalase activity during development and aging in mouse liver. | 1995 | Biochimie | pmid:8589059 |
Mantzioris E et al. | Differences exist in the relationships between dietary linoleic and alpha-linolenic acids and their respective long-chain metabolites. | 1995 | Am. J. Clin. Nutr. | pmid:7840069 |
Sheaff RC et al. | Conversion of alpha-linolenate to docosahexaenoate is not depressed by high dietary levels of linoleate in young rats: tracer evidence using high precision mass spectrometry. | 1995 | J. Lipid Res. | pmid:7658170 |
Guo W and Hamilton JA | Phase behavior and crystalline structures of cholesteryl ester mixtures: a C-13 MASNMR study. | 1995 | Biophys. J. | pmid:7647242 |
Smuts CM et al. | The effect of iron fortification on the fatty acid composition of plasma and erythrocyte membranes in primary school children with and without iron deficiency. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7708822 |
Saradhi PP et al. | Proline accumulates in plants exposed to UV radiation and protects them against UV induced peroxidation. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7726821 |
Santos MJ et al. | Influence of dietary supplementation with fish on plasma fatty acid composition in coronary heart disease patients. | 1995 | Ann. Nutr. Metab. | pmid:7872656 |
Lhuillery C et al. | Time-course study of adipose tissue fatty acid composition during mammary tumor growth in rats with controlled fat intake. | 1995 | Nutr Cancer | pmid:8610049 |
Fournier J et al. | [Lipid peroxidation in the presence of inorganic compounds. Relation to oxidative stress mechanisms]. | 1995 | C. R. Seances Soc. Biol. Fil. | pmid:8521091 |
Watanabe T et al. | Immobilization of lipases on polyethylene and application to perilla oil hydrolysis for production of alpha-linolenic acid. | 1995 | J. Nutr. Sci. Vitaminol. | pmid:7472675 |
Francès H et al. | Effects of dietary alpha-linolenic acid deficiency on neuromuscular and cognitive functions in mice. | 1995 | Life Sci. | pmid:7475943 |
Muñoz SF et al. | Protective capability of dietary Zizyphus mistol seed oil, rich in 18:3, n-3, on the development of two murine mammary gland adenocarcinomas with high or low metastatic potential. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7480075 |
Tsutsumi T et al. | Effect of a high alpha-linolenate and high linoleate diet on membrane-associated enzyme activities in rat brain--modulation of Na+, K+- ATPase activity at suboptimal concentrations of ATP. | 1995 | Biol. Pharm. Bull. | pmid:7492979 |
Hartman IS | alpha-Linolenic acid: a preventive in secondary coronary events? | 1995 | Nutr. Rev. | pmid:7494621 |
Ahn DU et al. | Effects of dietary alpha-linolenic acid and strain of hen on the fatty acid composition, storage stability, and flavor characteristics of chicken eggs. | 1995 | Poult. Sci. | pmid:7501600 |
Sugihara N et al. | High susceptibility to paraquat-driven lipid peroxidation of cultured hepatocytes loaded with linolenic acid. | 1995 | J. Pharmacol. Exp. Ther. | pmid:7616398 |
Mantzioris E et al. | Nutritional attributes of dietary flaxseed oil. | 1995 | Am. J. Clin. Nutr. | pmid:7572718 |
Fujiyama-Fujiwara Y et al. | Effects of sesamin on the fatty acid composition of the liver of rats fed N-6 and N-3 fatty acid-rich diet. | 1995 | J. Nutr. Sci. Vitaminol. | pmid:7562115 |
Kang JX et al. | Free, long-chain, polyunsaturated fatty acids reduce membrane electrical excitability in neonatal rat cardiac myocytes. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7732020 |
Weisinger HS et al. | Dietary manipulation of long-chain polyunsaturated fatty acids in the retina and brain of guinea pigs. | 1995 | Lipids | pmid:7637569 |
Romans JR et al. | Effects of ground flaxseed in swine diets on pig performance and on physical and sensory characteristics and omega-3 fatty acid content of pork: I. Dietary level of flaxseed. | 1995 | J. Anim. Sci. | pmid:7592082 |
Nordström DC et al. | Alpha-linolenic acid in the treatment of rheumatoid arthritis. A double-blind, placebo-controlled and randomized study: flaxseed vs. safflower seed. | 1995 | Rheumatol. Int. | pmid:7597378 |
Ferrier LK et al. | alpha-Linolenic acid- and docosahexaenoic acid-enriched eggs from hens fed flaxseed: influence on blood lipids and platelet phospholipid fatty acids in humans. | 1995 | Am. J. Clin. Nutr. | pmid:7598070 |
Lok E et al. | The effect of different levels of dietary alpha-linolenic and other fatty acids on mammary gland ductular cell proliferation in female Swiss Webster mice. | 1995 | Cancer Lett. | pmid:7600535 |
Wijkander J et al. | 5-Lipoxygenase products modulate the activity of the 85-kDa phospholipase A2 in human neutrophils. | 1995 | J. Biol. Chem. | pmid:7592874 |
Decsi T et al. | Essential fatty acids in full term infants fed breast milk or formula. | 1995 | Arch. Dis. Child. Fetal Neonatal Ed. | pmid:7743279 |
Larsson-Backström C et al. | Effects of dietary alpha- and gamma-linolenic acids on liver fatty acids, lipid metabolism, and survival in sepsis. | 1995 | Shock | pmid:7552772 |
Chen ZY et al. | Moderate, selective depletion of linoleate and alpha-linolenate in weight-cycled rats. | 1995 | Am. J. Physiol. | pmid:7864247 |
Kirmani ZA et al. | Effects of supplemented omega-3 and omega-6 fatty acid rich oils on the cardiovascular system of thermally injured rabbits: changes in plasma and platelet fatty acids. | 1995 Mar-Apr | J Burn Care Rehabil | pmid:7775514 |
Ikeda A et al. | Effects of intravenous perilla oil emulsion on nutritional status, polyunsaturated fatty acid composition of tissue phospholipids, and thromboxane A2 production in streptozotocin-induced diabetic rats. | 1995 Sep-Oct | Nutrition | pmid:8748197 |
Woods J et al. | Is docosahexaenoic acid necessary in infant formula? Evaluation of high linolenate diets in the neonatal rat. | 1996 | Pediatr. Res. | pmid:8910933 |
Francès H et al. | Influence of a dietary alpha-linolenic acid deficiency on learning in the Morris water maze and on the effects of morphine. | 1996 | Eur. J. Pharmacol. | pmid:8846819 |
Ferretti A and Flanagan VP | Antithromboxane activity of dietary alpha-linolenic acid: a pilot study. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8888358 |
Applegate TJ and Sell JL | Effect of dietary linoleic to linolenic acid ratio and vitamin E supplementation on vitamin E status of poults. | 1996 | Poult. Sci. | pmid:8966177 |
Hudson JA et al. | Hydration of oleic acid by a Selenomonas strain from the ovine rumen. | 1996 | Lett. Appl. Microbiol. | pmid:8862016 |
Babu US et al. | Impact of in vitro fatty acid uptake on nitric oxide production and antilisterial activity of WEHI-3 cells. | 1996 | Ann. N. Y. Acad. Sci. | pmid:8993386 |
Mensink R | Essential and trans-fatty acids. | 1996 | Curr. Opin. Lipidol. | pmid:8925181 |
Mutanen M and Freese R | Polyunsaturated fatty acids and platelet aggregation. | 1996 | Curr. Opin. Lipidol. | pmid:8925182 |
Sugano M and Ikeda I | Metabolic interactions between essential and trans-fatty acids. | 1996 | Curr. Opin. Lipidol. | pmid:8925188 |
Schingoethe DJ et al. | Lactational responses of dairy cows fed unsaturated fat from extruded soybeans or sunflower seeds. | 1996 | J. Dairy Sci. | pmid:8872718 |
Ntambi JM et al. | A model cell line to study regulation of stearoyl-CoA desaturase gene 1 expression by insulin and polyunsaturated fatty acids. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8607881 |
Kankofer M et al. | The analysis of fatty acid content and phospholipase A2 activity in placenta of cows with and without retained fetal membranes. | 1996 | Zentralbl Veterinarmed A | pmid:8940891 |
Siguel EN | Dietary sources of long-chain n-3 polyunsaturated fatty acids. | 1996 | JAMA | pmid:8596214 |
Frances H et al. | Effect of dietary alpha-linolenic acid deficiency on habituation. | 1996 | Life Sci. | pmid:8637406 |
Delion S et al. | alpha-Linolenic acid dietary deficiency alters age-related changes of dopaminergic and serotoninergic neurotransmission in the rat frontal cortex. | 1996 | J. Neurochem. | pmid:8627314 |
Furono K et al. | Effects of metal ions on lipid peroxidation in cultured rat hepatocytes loaded with alpha-linolenic acid. | 1996 | J Toxicol Environ Health | pmid:8642620 |
Awad AB et al. | The effect of unsaturated fatty acids on membrane composition and signal transduction in HT-29 human colon cancer cells. | 1996 | Cancer Lett. | pmid:8950205 |
Engberg RM et al. | Inclusion of oxidized vegetable oil in broiler diets. Its influence on nutrient balance and on the antioxidative status of broilers. | 1996 | Poult. Sci. | pmid:8829233 |
Do TQ et al. | Enhanced sensitivity of ubiquinone-deficient mutants of Saccharomyces cerevisiae to products of autoxidized polyunsaturated fatty acids. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8755509 |
Komaki C et al. | Synergistic suppression of azoxymethane-induced foci of colonic aberrant crypts by the combination of beta-carotene and perilla oil in rats. | 1996 | Carcinogenesis | pmid:8824511 |
Chardigny JM et al. | Identification of novel trans isomers of 20:5n-3 in liver lipids of rats fed a heated oil. | 1996 | Lipids | pmid:8835404 |
Dalençon F et al. | Liposomes bearing platelet proteins: a model for surface functions studies. | 1996 | Biochim. Biophys. Acta | pmid:8765146 |
Onogi N et al. | Suppressing effect of perilla oil on azoxymethane-induced foci of colonic aberrant crypts in rats. | 1996 | Carcinogenesis | pmid:8681445 |
Lim BO et al. | Effects of n-3 polyunsaturated fatty acids and lectins on immunoglobulin production by spleen lymphocytes of Sprague-Dawley rats. | 1996 | Biosci. Biotechnol. Biochem. | pmid:8695902 |
Ascherio A et al. | Dietary fat and risk of coronary heart disease in men: cohort follow up study in the United States. | 1996 | BMJ | pmid:8688759 |
Ide T et al. | Stimulation of the activities of hepatic fatty acid oxidation enzymes by dietary fat rich in alpha-linolenic acid in rats. | 1996 | J. Lipid Res. | pmid:8728310 |
Waters KM and Ntambi JM | Polyunsaturated fatty acids inhibit hepatic stearoyl-CoA desaturase-1 gene in diabetic mice. | 1996 | Lipids | pmid:8729090 |
Valsta LM et al. | Alpha-linolenic acid in rapeseed oil partly compensates for the effect of fish restriction on plasma long chain n-3 fatty acids. | 1996 | Eur J Clin Nutr | pmid:8730609 |
Chen ZY et al. | Accumulation of polyunsaturates is decreased by weight-cycling: whole-body analysis in young, growing rats. | 1996 | Br. J. Nutr. | pmid:8672410 |
Leece EA and Allman MA | The relationships between dietary alpha-linolenic:linoleic acid and rat platelet eicosapentaenoic and arachidonic acids. | 1996 | Br. J. Nutr. | pmid:8881716 |
Buzzi M et al. | The desaturation and elongation of linolenic acid and eicosapentaenoic acid by hepatocytes and liver microsomes from rainbow trout (Oncorhynchus mykiss) fed diets containing fish oil or olive oil. | 1996 | Biochim. Biophys. Acta | pmid:8555269 |
Carnielli VP et al. | Medium-chain triacylglycerols in formulas for preterm infants: effect on plasma lipids, circulating concentrations of medium-chain fatty acids, and essential fatty acids. | 1996 | Am. J. Clin. Nutr. | pmid:8694014 |
Carlson SE et al. | Effect of long-chain n-3 fatty acid supplementation on visual acuity and growth of preterm infants with and without bronchopulmonary dysplasia. | 1996 | Am. J. Clin. Nutr. | pmid:8615350 |
Sadi AM et al. | Dietary effects of corn oil, oleic acid, perilla oil, and evening [corrected] primrose oil on plasma and hepatic lipid level and atherosclerosis in Japanese quail. | 1996 | Exp. Anim. | pmid:8689581 |
Cunnane SC | The Canadian Society for Nutritional Sciences 1995 Young Scientist Award Lecture. Recent studies on the synthesis, beta-oxidation, and deficiency of linoleate and alpha-linolenate: are essential fatty acids more aptly named indispensable or conditionally dispensable fatty acids? | 1996 | Can. J. Physiol. Pharmacol. | pmid:8909772 |
Cunnane SC and Likhodii SS | 13C NMR spectroscopy and gas chromatograph--combustion--isotope ratio mass spectrometry: complementary applications in monitoring the metabolism of 13C-labelled polyunsaturated fatty acids. | 1996 | Can. J. Physiol. Pharmacol. | pmid:8909789 |
Guil JL et al. | Identification of fatty acids in edible wild plants by gas chromatography. | 1996 | J Chromatogr A | pmid:8589832 |
Luukkainen P et al. | Impact of solid food on plasma arachidonic and docosahexaenoic acid status of term infants at 8 months of age. | 1996 | J. Pediatr. Gastroenterol. Nutr. | pmid:8890071 |
Rupp H et al. | Dietary linolenic acid-mediated increase in vascular prostacyclin formation. | 1996 | Mol. Cell. Biochem. | pmid:8905626 |
Voskuil DW et al. | Intake and sources of alpha-linolenic acid in Dutch elderly men. | 1996 | Eur J Clin Nutr | pmid:8968698 |
Inui K et al. | The nutritional effect of a-linolenic acid-rich emulsion with total parenteral nutrition in a rat model with inflammatory bowel disease. | 1996 | Ann. Nutr. Metab. | pmid:8886251 |
Fukui H et al. | 0/w-emulsion of alpha-linolenic acid stabilized with hydrophobized polysaccharide. Its effect on the growth of human colon cancer cells. | 1996 | J Biomater Sci Polym Ed | pmid:8836830 |
Organisciak DT et al. | Retinal light damage in rats with altered levels of rod outer segment docosahexaenoate. | 1996 | Invest. Ophthalmol. Vis. Sci. | pmid:8843911 |
Inui K et al. | The effect of alpha-linolenic acid-rich emulsion on fatty acid metabolism and leukotriene generation of the colon in a rat model with inflammatory bowel disease. | 1996 | Ann. Nutr. Metab. | pmid:8862700 |
Ovesen L et al. | The effect of microwave heating on vitamins B1 and E, and linoleic and linolenic acids, and immunoglobulins in human milk. | 1996 | Int J Food Sci Nutr | pmid:8889628 |
Klein AS et al. | Allopurinol: discrimination of antioxidant from enzyme inhibitory activities. | 1996 | Free Radic. Biol. Med. | pmid:8891675 |
Conconi A et al. | The octadecanoid signalling pathway in plants mediates a response to ultraviolet radiation. | 1996 | Nature | pmid:8893008 |
Scheideler SE and Froning GW | The combined influence of dietary flaxseed variety, level, form, and storage conditions on egg production and composition among vitamin E-supplemented hens. | 1996 | Poult. Sci. | pmid:8893298 |
Kawano Y and Noma T | Inhibition by lecithin-bound iodine (LBI) of inducible allergen-specific T lymphocytes' responses in allergic diseases. | 1996 | Int. J. Immunopharmacol. | pmid:8894803 |
Carnielli VP et al. | The very low birth weight premature infant is capable of synthesizing arachidonic and docosahexaenoic acids from linoleic and linolenic acids. | 1996 | Pediatr. Res. | pmid:8798265 |
Howe GA et al. | An octadecanoid pathway mutant (JL5) of tomato is compromised in signaling for defense against insect attack. | 1996 | Plant Cell | pmid:8953771 |
Kabir Y and Ide T | Activity of hepatic fatty acid oxidation enzymes in rats fed alpha-linolenic acid. | 1996 | Biochim. Biophys. Acta | pmid:8954134 |
Venuta A et al. | Essential fatty acids: the effects of dietary supplementation among children with recurrent respiratory infections. | 1996 Jul-Aug | J. Int. Med. Res. | pmid:8854285 |
Poon WW et al. | Sensitivity to treatment with polyunsaturated fatty acids is a general characteristic of the ubiquinone-deficient yeast coq mutants. | 1997 | Mol. Aspects Med. | pmid:9266513 |
Kudo N and Kawashima Y | Fish oil-feeding prevents perfluorooctanoic acid-induced fatty liver in mice. | 1997 | Toxicol. Appl. Pharmacol. | pmid:9266801 |
Specht-Overholt S et al. | Fatty acid composition of commercially manufactured omega-3 enriched pork products, haddock, and mackerel. | 1997 | J. Anim. Sci. | pmid:9303450 |
Hardwick SJ et al. | Toxicity of polyunsaturated fatty acid esters for human monocyte-macrophages: the anomalous behaviour of cholesteryl linolenate. | 1997 | Free Radic. Res. | pmid:9167940 |
Guesnet P et al. | Modifying the n-3 fatty acid content of the maternal diet to determine the requirements of the fetal and suckling rat. | 1997 | Lipids | pmid:9168459 |
Dänicke S et al. | Interactions between dietary fat type and xylanase supplementation when rye-based diets are fed to broiler chickens 2. Performance, nutrient digestibility and the fat-soluble vitamin status of livers. | 1997 | Br. Poult. Sci. | pmid:9511000 |
Oh-hashi K et al. | Possible mechanisms for the differential effects of high linoleate safflower oil and high alpha-linolenate perilla oil diets on platelet-activating factor production by rat polymorphonuclear leukocytes. | 1997 | J Lipid Mediat Cell Signal | pmid:9524928 |