Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Booyens J et al. | Chronic arachidonic acid eicosanoid imbalance: a common feature in coronary artery disease, hypercholesterolemia, cancer and other important diseases. Significance of desaturase enzyme inhibition and of the arachidonic acid desaturase-independent pathway. | 1985 | Med. Hypotheses | pmid:2866439 |
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Budowski P and Crawford MA | a-Linolenic acid as a regulator of the metabolism of arachidonic acid: dietary implications of the ratio, n-6:n-3 fatty acids. | 1985 | Proc Nutr Soc | pmid:2864692 |
Crutchley DJ | Hydroxyeicosatetraenoic acids and other unsaturated fatty acids inhibit endotoxin-induced thromboplastin activity in human monocytes. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2865954 |
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Gotoh K et al. | Effects of unsaturated fatty acids on the peroxisomal enzyme activities of Tetrahymena pyriformis. | 1986 | J. Biochem. | pmid:2880840 |
Hiltunen JK et al. | beta-Oxidation of polyunsaturated fatty acids by rat liver peroxisomes. A role for 2,4-dienoyl-coenzyme A reductase in peroxisomal beta-oxidation. | 1986 | J. Biol. Chem. | pmid:2877988 |
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Pisanti FA et al. | Effects of bonellin on lipids. | 1986 | Life Sci. | pmid:2869393 |
Hagve TA et al. | Desaturation and chain elongation of essential fatty acids in isolated liver cells from rat and rainbow trout. | 1986 | Lipids | pmid:2871473 |
Dyerberg J | Linolenate-derived polyunsaturated fatty acids and prevention of atherosclerosis. | 1986 | Nutr. Rev. | pmid:2872640 |
Cholesterol metabolism and omega-3 polyenes in fish oils. | 1986 | Nutr. Rev. | pmid:2872641 | |
Meadows J et al. | Uric acid protects membranes and linolenic acid from ozone-induced oxidation. | 1986 | Biochem. Biophys. Res. Commun. | pmid:2872893 |
Adam O et al. | Effect of alpha-linolenic acid in the human diet on linoleic acid metabolism and prostaglandin biosynthesis. | 1986 | J. Lipid Res. | pmid:2873197 |
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Berry EM and Hirsch J | Does dietary linolenic acid influence blood pressure? | 1986 | Am. J. Clin. Nutr. | pmid:2875645 |
Nouvelot A et al. | Hepatic metabolism of dietary alpha-linolenic acid in suckling rats, and its possible importance in polyunsaturated fatty acid uptake by the brain. | 1986 | Ann. Nutr. Metab. | pmid:2875687 |
Nakamoto S et al. | Lipid peroxidation and cytotoxicity of Ehrlich ascites tumor cells by ferric nitrilotriacetate. | 1986 | Biochim. Biophys. Acta | pmid:2876731 |
Acosta PB and Stepnick-Gropper S | Problems related to diet management of maternal phenylketonuria. | 1986 | J. Inherit. Metab. Dis. | pmid:2877116 |
Guesnet P et al. | Dietary alpha-linolenic acid deficiency in the rat. I. Effects on reproduction and postnatal growth. | 1986 | Reprod Nutr Dev | pmid:2877477 |
Nutrition classics. Lipids, June 1979 Volume 14, No. 6: Reproduction and survival of rainbow trout (Salmo gairdneri) fed linolenic acid as the only source of essential fatty acids. By T.C. Yu, R.O. Sinnhuber, and J.D. Hendricks. | 1986 | Nutr. Rev. | pmid:2878402 | |
Johnston PV and Fritsche KL | Linolenate metabolism. | 1986 | Nutr. Rev. | pmid:2878403 |
Holman RT | Nutritional and functional requirements for essential fatty acids. | 1986 | Prog. Clin. Biol. Res. | pmid:2878441 |
Anding RH and Hwang DH | Effects of dietary linolenate on the fatty acid composition of brain lipids in rats. | 1986 | Lipids | pmid:2879208 |
Sato M et al. | [Experimental cerebral ischemia effects of fatty acid in Mongolian gerbils]. | 1986 | Rinsho Shinkeigaku | pmid:2879661 |
Bjerve KS et al. | [Essential linolenic fatty acid deficiency. Patients on long-term gastric tube feeding]. | 1986 | Tidsskr. Nor. Laegeforen. | pmid:2880408 |
Zöllner N | Dietary linolenic acid in man--an overview. | 1986 | Prog. Lipid Res. | pmid:2892211 |
Leikin AI and Brenner RR | Regulation of linoleic acid delta 6-desaturation by a cytosolic lipoprotein-like fraction in isolated rat liver microsomes. | 1986 | Biochim. Biophys. Acta | pmid:2869785 |
Carlson SE et al. | High fat diets varying in ratios of polyunsaturated to saturated fatty acid and linoleic to linolenic acid: a comparison of rat neural and red cell membrane phospholipids. | 1986 | J. Nutr. | pmid:2871142 |
Leat WM et al. | Retinal function in rats and guinea-pigs reared on diets low in essential fatty acids and supplemented with linoleic or linolenic acids. | 1986 | Ann. Nutr. Metab. | pmid:2872851 |
Jenkins KJ and Kramer JK | Influence of low linoleic and linolenic acids in milk replacer on calf performance and lipids in blood plasma, heart, and liver. | 1986 | J. Dairy Sci. | pmid:2873158 |
Morson LA and Clandinin MT | Diets varying in linoleic and linolenic acid content alter liver plasma membrane lipid composition and glucagon-stimulated adenylate cyclase activity. | 1986 | J. Nutr. | pmid:2879899 |
Siegel I et al. | Inhibition of sperm motility and agglutination of sperm cells by free fatty acids in whole semen. | 1986 | Fertil. Steril. | pmid:2868925 |
Tabachnick M and Korcek L | Effect of long-chain fatty acids on the binding of thyroxine and triiodothyronine to human thyroxine-binding globulin. | 1986 | Biochim. Biophys. Acta | pmid:2869786 |
McDonald GB and Weidman M | Partitioning of polar fatty acids into lymph and portal vein after intestinal absorption in the rat. | 1987 | Q J Exp Physiol | pmid:2884690 |
Bursztyn P | Does dietary linolenic acid influence blood pressure? | 1987 | Am. J. Clin. Nutr. | pmid:2884863 |
Singer P et al. | Changes of N-6 and N-3 fatty acids in liver from spontaneously hypertensive (SHR) and normotensive rats after diets supplemented with alpha-linolenic or eicosapentaenoic acids. | 1987 | Prostaglandins Leukot Med | pmid:2888133 |
Vrignaud P and Robert J | Free fatty acid uptake is increased in doxorubicin-resistant rat glioblastoma cells. | 1987 | Biochim. Biophys. Acta | pmid:2886153 |
Yamamoto N et al. | Effect of dietary alpha-linolenate/linoleate balance on brain lipid compositions and learning ability of rats. | 1987 | J. Lipid Res. | pmid:2883248 |
Takahashi R et al. | Impaired platelet aggregation and thromboxane generation in essential fatty acid-deficient rats. | 1987 | J. Nutr. | pmid:2888839 |
Betteridge J | Nutrition and platelet function in atherogenesis. | 1987 | Proc Nutr Soc | pmid:2893383 |
Novo C et al. | Altered fatty acid membrane composition modifies lymphocyte localization in vivo. | 1987 | Cell. Immunol. | pmid:2882861 |