alpha-linolenic acid

Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.

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Introduction

To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with alpha-linolenic acid?

alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid

MeSH term MeSH ID Detail
Night Blindness D009755 1 associated lipids
Stomatitis, Aphthous D013281 1 associated lipids
Conjunctivitis, Allergic D003233 1 associated lipids
Aging, Premature D019588 1 associated lipids
Hearing Loss, High-Frequency D006316 1 associated lipids
Otorhinolaryngologic Neoplasms D010039 2 associated lipids
Spinal Cord Ischemia D020760 2 associated lipids
Torsades de Pointes D016171 2 associated lipids
Sebaceous Gland Neoplasms D012626 2 associated lipids
Mental Fatigue D005222 3 associated lipids
Carcinogenesis D063646 3 associated lipids
Depression, Postpartum D019052 3 associated lipids
Dyskinesias D020820 3 associated lipids
Insect Bites and Stings D007299 4 associated lipids
Endomyocardial Fibrosis D004719 4 associated lipids
Amyloidosis D000686 4 associated lipids
Retinitis Pigmentosa D012174 6 associated lipids
Exocrine Pancreatic Insufficiency D010188 6 associated lipids
Pancytopenia D010198 6 associated lipids
Urinary Bladder Neoplasms D001749 7 associated lipids
Irritable Bowel Syndrome D043183 8 associated lipids
Community-Acquired Infections D017714 8 associated lipids
Paraplegia D010264 8 associated lipids
Hyperlipidemia, Familial Combined D006950 9 associated lipids
Tachycardia, Ventricular D017180 9 associated lipids
Retinal Degeneration D012162 9 associated lipids
Vitamin B 6 Deficiency D026681 10 associated lipids
Colorectal Neoplasms D015179 10 associated lipids
Long QT Syndrome D008133 10 associated lipids
Overweight D050177 11 associated lipids
Aortic Diseases D001018 11 associated lipids
Learning Disorders D007859 11 associated lipids
Cat Diseases D002371 12 associated lipids
Retinoblastoma D012175 12 associated lipids
Death, Sudden, Cardiac D016757 12 associated lipids
Deficiency Diseases D003677 12 associated lipids
Neoplasms D009369 13 associated lipids
Atrial Fibrillation D001281 16 associated lipids
Adenomatous Polyposis Coli D011125 16 associated lipids
Ventricular Fibrillation D014693 16 associated lipids
Bronchial Spasm D001986 18 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Carcinoma, Ductal, Breast D018270 19 associated lipids
Pregnancy Complications D011248 19 associated lipids
Prostatic Hyperplasia D011470 20 associated lipids
Diabetic Angiopathies D003925 20 associated lipids
Tuberculosis D014376 20 associated lipids
Myocardial Infarction D009203 21 associated lipids
Malaria, Falciparum D016778 22 associated lipids
Hypersensitivity D006967 22 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with alpha-linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with alpha-linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with alpha-linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with alpha-linolenic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with alpha-linolenic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with alpha-linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with alpha-linolenic acid

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Per page 10 20 50 100 | Total 2471
Authors Title Published Journal PubMed Link
Morisaki N et al. Metabolism of n-3 polyunsaturated fatty acids and modification of phospholipids in cultured rabbit aortic smooth muscle cells. 1985 J. Lipid Res. pmid:2864379
Stymne S and Stobart AK Involvement of acyl exchange between acyl-CoA and phosphatidylcholine in the remodelling of phosphatidylcholine in microsomal preparations of rat lung. 1985 Biochim. Biophys. Acta pmid:2865978
Booyens J et al. Chronic arachidonic acid eicosanoid imbalance: a common feature in coronary artery disease, hypercholesterolemia, cancer and other important diseases. Significance of desaturase enzyme inhibition and of the arachidonic acid desaturase-independent pathway. 1985 Med. Hypotheses pmid:2866439
Becker W et al. Uptake of radiolabelled alpha-linolenic, arachidonic and oleic acid in tissues of normal and essential fatty acid-deficient rats--an autoradiographic study. 1985 Ann. Nutr. Metab. pmid:2859826
Das UN Antibiotic-like action of essential fatty acids. 1985 Can Med Assoc J pmid:2860965
Carlin G Peroxidation of linolenic acid promoted by human polymorphonuclear leucocytes. 1985 J Free Radic Biol Med pmid:2873164
Towell JF An animated graphics program depicting the steps in lipid peroxidation. 1985 J Free Radic Biol Med pmid:2875091
Gutteridge JM et al. Aluminium salts accelerate peroxidation of membrane lipids stimulated by iron salts. 1985 Biochim. Biophys. Acta pmid:2861853
Nordøy A et al. Effect of dietary (n--3) fatty acids on platelet function and lipid metabolism in rats. 1985 Biochim. Biophys. Acta pmid:2861854
Budowski P and Crawford MA a-Linolenic acid as a regulator of the metabolism of arachidonic acid: dietary implications of the ratio, n-6:n-3 fatty acids. 1985 Proc Nutr Soc pmid:2864692
Crutchley DJ Hydroxyeicosatetraenoic acids and other unsaturated fatty acids inhibit endotoxin-induced thromboplastin activity in human monocytes. 1985 Biochem. Biophys. Res. Commun. pmid:2865954
Johnston NW Chronic degenerative radiculomyelopathy therapy. 1985 Dec 21-28 Vet. Rec. pmid:2869606
Azizova OA et al. [Initiation of nonenzymatic lipid peroxidation in a Fe2+-ascorbate-linolenate system]. 1985 Jan-Feb Biofizika pmid:2858224
Gotoh K et al. Effects of unsaturated fatty acids on the peroxisomal enzyme activities of Tetrahymena pyriformis. 1986 J. Biochem. pmid:2880840
Hiltunen JK et al. beta-Oxidation of polyunsaturated fatty acids by rat liver peroxisomes. A role for 2,4-dienoyl-coenzyme A reductase in peroxisomal beta-oxidation. 1986 J. Biol. Chem. pmid:2877988
Hansson A et al. Activation of protein kinase C by lipoxin A and other eicosanoids. Intracellular action of oxygenation products of arachidonic acid. 1986 Biochem. Biophys. Res. Commun. pmid:2418836
Pisanti FA et al. Effects of bonellin on lipids. 1986 Life Sci. pmid:2869393
Hagve TA et al. Desaturation and chain elongation of essential fatty acids in isolated liver cells from rat and rainbow trout. 1986 Lipids pmid:2871473
Dyerberg J Linolenate-derived polyunsaturated fatty acids and prevention of atherosclerosis. 1986 Nutr. Rev. pmid:2872640
Cholesterol metabolism and omega-3 polyenes in fish oils. 1986 Nutr. Rev. pmid:2872641
Meadows J et al. Uric acid protects membranes and linolenic acid from ozone-induced oxidation. 1986 Biochem. Biophys. Res. Commun. pmid:2872893
Adam O et al. Effect of alpha-linolenic acid in the human diet on linoleic acid metabolism and prostaglandin biosynthesis. 1986 J. Lipid Res. pmid:2873197
Takahashi K et al. Polyethylene glycol-modified hemin having peroxidase activity in organic solvents. 1986 Biochem. Biophys. Res. Commun. pmid:2874801
Berry EM and Hirsch J Does dietary linolenic acid influence blood pressure? 1986 Am. J. Clin. Nutr. pmid:2875645
Nouvelot A et al. Hepatic metabolism of dietary alpha-linolenic acid in suckling rats, and its possible importance in polyunsaturated fatty acid uptake by the brain. 1986 Ann. Nutr. Metab. pmid:2875687
Nakamoto S et al. Lipid peroxidation and cytotoxicity of Ehrlich ascites tumor cells by ferric nitrilotriacetate. 1986 Biochim. Biophys. Acta pmid:2876731
Acosta PB and Stepnick-Gropper S Problems related to diet management of maternal phenylketonuria. 1986 J. Inherit. Metab. Dis. pmid:2877116
Guesnet P et al. Dietary alpha-linolenic acid deficiency in the rat. I. Effects on reproduction and postnatal growth. 1986 Reprod Nutr Dev pmid:2877477
Nutrition classics. Lipids, June 1979 Volume 14, No. 6: Reproduction and survival of rainbow trout (Salmo gairdneri) fed linolenic acid as the only source of essential fatty acids. By T.C. Yu, R.O. Sinnhuber, and J.D. Hendricks. 1986 Nutr. Rev. pmid:2878402
Johnston PV and Fritsche KL Linolenate metabolism. 1986 Nutr. Rev. pmid:2878403
Holman RT Nutritional and functional requirements for essential fatty acids. 1986 Prog. Clin. Biol. Res. pmid:2878441
Anding RH and Hwang DH Effects of dietary linolenate on the fatty acid composition of brain lipids in rats. 1986 Lipids pmid:2879208
Sato M et al. [Experimental cerebral ischemia effects of fatty acid in Mongolian gerbils]. 1986 Rinsho Shinkeigaku pmid:2879661
Bjerve KS et al. [Essential linolenic fatty acid deficiency. Patients on long-term gastric tube feeding]. 1986 Tidsskr. Nor. Laegeforen. pmid:2880408
Zöllner N Dietary linolenic acid in man--an overview. 1986 Prog. Lipid Res. pmid:2892211
Leikin AI and Brenner RR Regulation of linoleic acid delta 6-desaturation by a cytosolic lipoprotein-like fraction in isolated rat liver microsomes. 1986 Biochim. Biophys. Acta pmid:2869785
Carlson SE et al. High fat diets varying in ratios of polyunsaturated to saturated fatty acid and linoleic to linolenic acid: a comparison of rat neural and red cell membrane phospholipids. 1986 J. Nutr. pmid:2871142
Leat WM et al. Retinal function in rats and guinea-pigs reared on diets low in essential fatty acids and supplemented with linoleic or linolenic acids. 1986 Ann. Nutr. Metab. pmid:2872851
Jenkins KJ and Kramer JK Influence of low linoleic and linolenic acids in milk replacer on calf performance and lipids in blood plasma, heart, and liver. 1986 J. Dairy Sci. pmid:2873158
Morson LA and Clandinin MT Diets varying in linoleic and linolenic acid content alter liver plasma membrane lipid composition and glucagon-stimulated adenylate cyclase activity. 1986 J. Nutr. pmid:2879899
Siegel I et al. Inhibition of sperm motility and agglutination of sperm cells by free fatty acids in whole semen. 1986 Fertil. Steril. pmid:2868925
Tabachnick M and Korcek L Effect of long-chain fatty acids on the binding of thyroxine and triiodothyronine to human thyroxine-binding globulin. 1986 Biochim. Biophys. Acta pmid:2869786
McDonald GB and Weidman M Partitioning of polar fatty acids into lymph and portal vein after intestinal absorption in the rat. 1987 Q J Exp Physiol pmid:2884690
Bursztyn P Does dietary linolenic acid influence blood pressure? 1987 Am. J. Clin. Nutr. pmid:2884863
Singer P et al. Changes of N-6 and N-3 fatty acids in liver from spontaneously hypertensive (SHR) and normotensive rats after diets supplemented with alpha-linolenic or eicosapentaenoic acids. 1987 Prostaglandins Leukot Med pmid:2888133
Vrignaud P and Robert J Free fatty acid uptake is increased in doxorubicin-resistant rat glioblastoma cells. 1987 Biochim. Biophys. Acta pmid:2886153
Yamamoto N et al. Effect of dietary alpha-linolenate/linoleate balance on brain lipid compositions and learning ability of rats. 1987 J. Lipid Res. pmid:2883248
Takahashi R et al. Impaired platelet aggregation and thromboxane generation in essential fatty acid-deficient rats. 1987 J. Nutr. pmid:2888839
Betteridge J Nutrition and platelet function in atherogenesis. 1987 Proc Nutr Soc pmid:2893383
Novo C et al. Altered fatty acid membrane composition modifies lymphocyte localization in vivo. 1987 Cell. Immunol. pmid:2882861