Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Allman-Farinelli MA et al. | Comparison of the effects of two low fat diets with different alpha-linolenic:linoleic acid ratios on coagulation and fibrinolysis. | 1999 | Atherosclerosis | pmid:9920517 |
Levy R and Herzberg GR | Hydrolysis of long-chain, n-3 fatty acid enriched chylomicrons by cardiac lipoprotein lipase. | 1999 | Can. J. Physiol. Pharmacol. | pmid:10588486 |
Su HM et al. | Bioequivalence of dietary alpha-linolenic and docosahexaenoic acids as sources of docosahexaenoate accretion in brain and associated organs of neonatal baboons. | 1999 | Pediatr. Res. | pmid:9890614 |
Billman GE et al. | Prevention of sudden cardiac death by dietary pure omega-3 polyunsaturated fatty acids in dogs. | 1999 | Circulation | pmid:10318669 |
Hun CS et al. | Increased uncoupling protein2 mRNA in white adipose tissue, and decrease in leptin, visceral fat, blood glucose, and cholesterol in KK-Ay mice fed with eicosapentaenoic and docosahexaenoic acids in addition to linolenic acid. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10334920 |
MartÃn M et al. | Antisense-mediated depletion of potato leaf omega3 fatty acid desaturase lowers linolenic acid content and reduces gene activation in response to wounding. | 1999 | Eur. J. Biochem. | pmid:10336609 |
Burke PA et al. | Conditionally essential fatty acid deficiencies in end-stage liver disease. | 1999 | Nutrition | pmid:10319364 |
Schultz JR and Clarke CF | Characterization of Saccharomyces cerevisiae ubiquinone-deficient mutants. | 1999 | Biofactors | pmid:10416023 |
Delton-Vandenbroucke I et al. | A role for cerebral and retinal endothelial cells in the supply of docosahexaenoic acid to the brain and the retina? | 1999 | Lipids | pmid:10419115 |
Haggarty P et al. | Effect of maternal polyunsaturated fatty acid concentration on transport by the human placenta. | 1999 | Biol. Neonate | pmid:10325438 |
Vermunt SH et al. | Effects of age and dietary n-3 fatty acids on the metabolism of [13C]-alpha-linolenic acid. | 1999 | Lipids | pmid:10419119 |
Turpeinen AM et al. | A high linoleic acid diet increases oxidative stress in vivo and affects nitric oxide metabolism in humans. | 1999 | Lipids | pmid:10419181 |
Su HM et al. | Dietary 18:3n-3 and 22:6n-3 as sources of 22:6n-3 accretion in neonatal baboon brain and associated organs. | 1999 | Lipids | pmid:10419199 |
Ihara-Watanabe M et al. | Effects of dietary alpha- or gamma-linolenic acid on levels and fatty acid compositions of serum and hepatic lipids, and activity and mRNA abundance of 3-hydroxy-3-methylglutaryl CoA reductase in rats. | 1999 | Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. | pmid:10327618 |
Abedin L et al. | The effects of dietary alpha-linolenic acid compared with docosahexaenoic acid on brain, retina, liver, and heart in the guinea pig. | 1999 | Lipids | pmid:10380119 |
Tan X et al. | [Supercritical-CO2 fluid extraction of fatty oils from Perilla frutescens seeds and pharmacological study]. | 1999 | Zhong Yao Cai | pmid:12571915 |
Muñoz SE et al. | Differential effects of dietary Oenothera, Zizyphus mistol, and corn oils, and essential fatty acid deficiency on the progression of a murine mammary gland adenocarcinoma. | 1999 | Nutrition | pmid:10198915 |
Becker CC et al. | Effects of butter oil blends with increased concentrations of stearic, oleic and linolenic acid on blood lipids in young adults. | 1999 | Eur J Clin Nutr | pmid:10452408 |
Khozin-Goldberg I et al. | Salicylhydroxamic acid inhibits delta6 desaturation in the microalga Porphyridium cruentum. | 1999 | Biochim. Biophys. Acta | pmid:10446425 |
Bowen RA et al. | Does increasing dietary linolenic acid content increase the docosahexaenoic acid content of phospholipids in neuronal cells of neonatal rats? | 1999 | Pediatr. Res. | pmid:10367771 |
Bhatia KS and Singh J | Effect of linolenic acid/ethanol or limonene/ethanol and iontophoresis on the in vitro percutaneous absorption of LHRH and ultrastructure of human epidermis. | 1999 | Int J Pharm | pmid:10370194 |
Connor WE | Alpha-linolenic acid in health and disease. | 1999 | Am. J. Clin. Nutr. | pmid:10232618 |
Li D et al. | Effect of dietary alpha-linolenic acid on thrombotic risk factors in vegetarian men. | 1999 | Am. J. Clin. Nutr. | pmid:10232625 |
Hu FB et al. | Dietary intake of alpha-linolenic acid and risk of fatal ischemic heart disease among women. | 1999 | Am. J. Clin. Nutr. | pmid:10232627 |
Leaf A | Dietary prevention of coronary heart disease: the Lyon Diet Heart Study. | 1999 | Circulation | pmid:9989956 |
Weisinger HS et al. | Effects of dietary n-3 fatty acid deficiency and repletion in the guinea pig retina. | 1999 | Invest. Ophthalmol. Vis. Sci. | pmid:9950590 |
Arun Kumar C and Das UN | Lipid peroxides, nitric oxide and essential fatty acids in patients with Plasmodium falciparum malaria. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10574650 |
Alava MA et al. | Fatty acid desaturation: effect of alphafetoprotein on alpha-linolenic acid conversion by fetal rat hepatocytes. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10359023 |
Sugihara N et al. | Anti- and pro-oxidative effects of flavonoids on metal-induced lipid hydroperoxide-dependent lipid peroxidation in cultured hepatocytes loaded with alpha-linolenic acid. | 1999 | Free Radic. Biol. Med. | pmid:10641726 |
Wensing AG et al. | Effects of dietary n-3 polyunsaturated fatty acids from plant and marine origin on platelet aggregation in healthy elderly subjects. | 1999 | Br. J. Nutr. | pmid:10655965 |
Elmore JS et al. | Effect of the polyunsaturated fatty acid composition of beef muscle on the profile of aroma volatiles. | 1999 | J. Agric. Food Chem. | pmid:10564028 |
Nitsan Z et al. | Enrichment of poultry products with omega3 fatty acids by dietary supplementation with the alga Nannochloropsis and mantur oil. | 1999 | J. Agric. Food Chem. | pmid:10606584 |
Leng GC et al. | Essential fatty acids and cardiovascular disease: the Edinburgh Artery Study. | 1999 | Vasc Med | pmid:10613625 |
Hanley K et al. | Fetal epidermal differentiation and barrier development In vivo is accelerated by nuclear hormone receptor activators. | 1999 | J. Invest. Dermatol. | pmid:10571735 |
Baudouin E et al. | Short communication: unsaturated fatty acids inhibit MP2C, a protein phosphatase 2C involved in the wound-induced MAP kinase pathway regulation. | 1999 | Plant J. | pmid:10571894 |
Ezaki O et al. | Long-term effects of dietary alpha-linolenic acid from perilla oil on serum fatty acids composition and on the risk factors of coronary heart disease in Japanese elderly subjects. | 1999 | J. Nutr. Sci. Vitaminol. | pmid:10737229 |
Warnotte C et al. | Unbound rather than total concentration and saturation rather than unsaturation determine the potency of fatty acids on insulin secretion. | 1999 | Mol. Cell. Endocrinol. | pmid:10459862 |
Kankaanpää P et al. | Dietary fatty acids and allergy. | 1999 | Ann. Med. | pmid:10480759 |
Angerosa F et al. | Virgin olive oil volatile compounds from lipoxygenase pathway and characterization of some italian cultivars. | 1999 | J. Agric. Food Chem. | pmid:10552376 |
Chyb S et al. | Polyunsaturated fatty acids activate the Drosophila light-sensitive channels TRP and TRPL. | 1999 | Nature | pmid:9930700 |
Bourre JM et al. | Changes in auditory brainstem responses in alpha-linolenic acid deficiency as a function of age in rats. | 1999 Jan-Feb | Audiology | pmid:10052831 |
McGahon BM et al. | Age-related changes in oxidative mechanisms and LTP are reversed by dietary manipulation. | 1999 Nov-Dec | Neurobiol. Aging | pmid:10674430 |
Okamoto M et al. | Effects of dietary supplementation with n-3 fatty acids compared with n-6 fatty acids on bronchial asthma. | 2000 | Intern. Med. | pmid:10732825 |
Grechkin AN et al. | Lipoxygenase pathway in tulip: biosynthesis of ketols. | 2000 | Biochem. Soc. Trans. | pmid:11171230 |
Nuñez A et al. | Anaerobic lipoxygenase activity from Chlorella pyrenoidosa. | 2000 | Biochem. Soc. Trans. | pmid:11171268 |
Kaushik N and Agnihotri A | GLC analysis of Indian rapeseed-mustard to study the variability of fatty acid composition. | 2000 | Biochem. Soc. Trans. | pmid:11171132 |
Cheon SH et al. | Effect of dietary linoleate/alpha-linolenate balance on the brain lipid composition, reproductive outcome and behavior of rats during their prenatal and postnatal development. | 2000 | Biosci. Biotechnol. Biochem. | pmid:11193394 |
Du M et al. | Effects of dietary conjugated linoleic acid and linoleic:linolenic acid ratio on polyunsaturated fatty acid status in laying hens. | 2000 | Poult. Sci. | pmid:11194037 |
Loï C et al. | Incorporation and metabolism of dietary trans isomers of linolenic acid alter the fatty acid profile of rat tissues. | 2000 | J. Nutr. | pmid:11015488 |
MarÃn MC et al. | Dietary long-chain fatty acids and visual response in malnourished nursing infants. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11133176 |
Harbige LS et al. | The protective effects of omega-6 fatty acids in experimental autoimmune encephalomyelitis (EAE) in relation to transforming growth factor-beta 1 (TGF-beta1) up-regulation and increased prostaglandin E2 (PGE2) production. | 2000 | Clin. Exp. Immunol. | pmid:11122253 |
Sijben JW et al. | Dietary linoleic acid divergently affects immune responsiveness of growing layer hens. | 2000 | Poult. Sci. | pmid:10947178 |
Min Y et al. | Pregnancy reduces arachidonic and docosahexaenoic in plasma triacylglycerols of Korean women. | 2000 | Int J Vitam Nutr Res | pmid:10804459 |
Granot E et al. | Breast-fed and formula-fed infants do not differ in immunocompetent cell cytokine production despite differences in cell membrane fatty acid composition. | 2000 | Am. J. Clin. Nutr. | pmid:11063450 |
Richieri GV et al. | Fatty acid binding proteins from different tissues show distinct patterns of fatty acid interactions. | 2000 | Biochemistry | pmid:10852718 |
Larqué E et al. | Dietary trans fatty acids affect docosahexaenoic acid concentrations in plasma and liver but not brain of pregnant and fetal rats. | 2000 | Pediatr. Res. | pmid:10674359 |
Glocker TM | [Pathology of placenta of rats induced by fatty acid deficiency]. | 2000 | Rev Fac Cien Med Univ Nac Cordoba | pmid:12934235 |
Dobson G | Leaf lipids of Ribes nigrum: a plant containing 16:3, alpha-18:3, gamma-18:3 and 18:4 fatty acids. | 2000 | Biochem. Soc. Trans. | pmid:11171133 |
Rao GN et al. | Effect of melatonin and linolenic acid on mammary cancer in transgenic mice with c-neu breast cancer oncogene. | 2000 | Breast Cancer Res. Treat. | pmid:11200779 |
Okolo SN et al. | The fatty acid composition of human milk in northern Nigeria. | 2000 | J Hum Lact | pmid:11138221 |
Utsunomiya T et al. | Correspondence re: M. Kondo et al., Increased expression of COX-2 in nontumor liver tissue is associated with shorter disease-free survival in patients with hepatocellular carcinoma. Clin. Cancer Res., 5: 4005-4012, 1999. | 2000 | Clin. Cancer Res. | pmid:11156258 |
Makrides M et al. | A randomized trial of different ratios of linoleic to alpha-linolenic acid in the diet of term infants: effects on visual function and growth. | 2000 | Am. J. Clin. Nutr. | pmid:10617956 |
Connor WE | Importance of n-3 fatty acids in health and disease. | 2000 | Am. J. Clin. Nutr. | pmid:10617967 |
Ide T | Effect of dietary alpha-linolenic acid on the activity and gene expression of hepatic fatty acid oxidation enzymes. | 2000 | Biofactors | pmid:11237206 |
Auestad N and Innis SM | Dietary n-3 fatty acid restriction during gestation in rats: neuronal cell body and growth-cone fatty acids. | 2000 | Am. J. Clin. Nutr. | pmid:10617988 |
James MJ et al. | Dietary polyunsaturated fatty acids and inflammatory mediator production. | 2000 | Am. J. Clin. Nutr. | pmid:10617994 |
Crawford M et al. | Role of plant-derived omega-3 fatty acids in human nutrition. | 2000 | Ann. Nutr. Metab. | pmid:11146334 |
Berghaus TM et al. | Essential fatty acids and their long-chain polyunsaturated metabolites in maternal and cord plasma triglycerides during late gestation. | 2000 | Biol. Neonate | pmid:10657686 |
Dhiman TR et al. | Conjugated linoleic acid (CLA) content of milk from cows offered diets rich in linoleic and linolenic acid. | 2000 | J. Dairy Sci. | pmid:10821577 |
Yokoyama M et al. | Stress-induced factor involved in flower formation of Lemna is an alpha-ketol derivative of linolenic acid. | 2000 | Plant Cell Physiol. | pmid:10750715 |
Imbusch R and Mueller MJ | Formation of isoprostane F(2)-like compounds (phytoprostanes F(1)) from alpha-linolenic acid in plants. | 2000 | Free Radic. Biol. Med. | pmid:10754267 |
Schneider C et al. | Enantiomeric separation of hydroxy eicosanoids by chiral column chromatography: effect of the alcohol modifier. | 2000 | Anal. Biochem. | pmid:11078601 |
Charnock JS | Gamma-linolenic acid provides additional protection against ventricular fibrillation in aged rats fed linoleic acid rich diets. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10780878 |
Kurvinen JP et al. | The effect of low alpha-linolenic acid diet on glycerophospholipid molecular species in guinea pig brain. | 2000 | Lipids | pmid:11026621 |
Takahashi Y and Ide T | Dietary n-3 fatty acids affect mRNA level of brown adipose tissue uncoupling protein 1, and white adipose tissue leptin and glucose transporter 4 in the rat. | 2000 | Br. J. Nutr. | pmid:11029968 |
Armstrong RA et al. | No effect of dietary trans isomers of alpha-linolenic acid on platelet aggregation and haemostatic factors in european healthy men. The TRANSLinE study. | 2000 | Thromb. Res. | pmid:11108899 |
Ikemoto A et al. | Lysosomal enzyme activities are decreased in the retina and their circadian rhythms are different from those in the pineal gland of rats fed an alpha-linolenic acid-restricted diet. | 2000 | J. Nutr. | pmid:11110869 |
Babin F et al. | Alpha linolenic acid in cholesterol esters: a marker of alphalinolenic acid intake in newborns. | 2000 | Eur J Clin Nutr | pmid:11114678 |
Punchard NA et al. | Analysis of the intestinal absorption of essential fatty acids in vivo in the rat. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10765976 |
Ikemoto A et al. | Diurnal rhythms of retinal phospholipid synthetic enzymes are retained but their activities are decreased in rats under alpha-linolenic acid deficiency. | 2000 | Arch. Biochem. Biophys. | pmid:11097182 |
Gonzalez-Esquerra R and Leeson S | Effects of menhaden oil and flaxseed in broiler diets on sensory quality and lipid composition of poultry meat. | 2000 | Br. Poult. Sci. | pmid:11128390 |
Contreras MA et al. | Nutritional deprivation of alpha-linolenic acid decreases but does not abolish turnover and availability of unacylated docosahexaenoic acid and docosahexaenoyl-CoA in rat brain. | 2000 | J. Neurochem. | pmid:11080190 |
Frey M et al. | An herbivore elicitor activates the gene for indole emission in maize. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11106389 |
Colditz GA | Changing dietary patterns and cancer prevention: alpha-linolenic acid health risks and benefits. | 2000 | Cancer Causes Control | pmid:11065003 |
McCarty MF | Activation of PPARgamma may mediate a portion of the anticancer activity of conjugated linoleic acid. | 2000 | Med. Hypotheses | pmid:10985906 |
Lapillonne A et al. | Effects of liver transplantation on long-chain polyunsaturated fatty acid status in infants with biliary atresia. | 2000 | J. Pediatr. Gastroenterol. Nutr. | pmid:10817283 |
Petrik MB et al. | Highly unsaturated (n-3) fatty acids, but not alpha-linolenic, conjugated linoleic or gamma-linolenic acids, reduce tumorigenesis in Apc(Min/+) mice. | 2000 | J. Nutr. | pmid:11015469 |
Zamora R et al. | Contribution of pyrrole formation and polymerization to the nonenzymatic browning produced by amino-carbonyl reactions. | 2000 | J. Agric. Food Chem. | pmid:10956084 |
Maccarrone M et al. | Activation of different lipoxygenase isozymes induces apoptosis in human erythroleukemia and neuroblastoma cells. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10833416 |
Nenseter MS et al. | Effect of Norwegian fish powder on risk factors for coronary heart disease among hypercholesterolemic individuals. | 2000 | Nutr Metab Cardiovasc Dis | pmid:11302007 |
Sea MM et al. | Weight cycling-induced alteration in fatty acid metabolism. | 2000 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:10956277 |
Sauer LA et al. | Mechanism for the antitumor and anticachectic effects of n-3 fatty acids. | 2000 | Cancer Res. | pmid:11016660 |
Kaya A | Properties and stability of butter oil obtained from milk and yoghurt. | 2000 | Nahrung | pmid:10795582 |
Decsi T and Koletzko B | Effects of protein-energy malnutrition and human immunodeficiency virus-1 infection on essential fatty acid metabolism in children. | 2000 | Nutrition | pmid:10869902 |
Simopoulos AP | Human requirement for N-3 polyunsaturated fatty acids. | 2000 | Poult. Sci. | pmid:10901194 |
de la Presa Owens S and Innis SM | Diverse, region-specific effects of addition of arachidonic and docosahexanoic acids to formula with low or adequate linoleic and alpha-linolenic acids on piglet brain monoaminergic neurotransmitters. | 2000 | Pediatr. Res. | pmid:10879811 |
Bartsch H and Nair J | New DNA-based biomarkers for oxidative stress and cancer chemoprevention studies. | 2000 | Eur. J. Cancer | pmid:10882861 |
McCarty MF | Toward practical prevention of type 2 diabetes. | 2000 | Med. Hypotheses | pmid:10859688 |
Mantzioris E et al. | Biochemical effects of a diet containing foods enriched with n-3 fatty acids. | 2000 | Am. J. Clin. Nutr. | pmid:10871559 |
Sébédio JL et al. | The effect of dietary trans alpha-linolenic acid on plasma lipids and platelet fatty acid composition: the TransLinE study. | 2000 | Eur J Clin Nutr | pmid:10694780 |