Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Kronberg SL et al. | Flaxseed treatments to reduce biohydrogenation of alpha-linolenic acid by rumen microbes in cattle. | 2007 | Lipids | pmid:17985170 |
Su M et al. | Nano-anatase relieves the inhibition of electron transport caused by linolenic acid in chloroplasts of spinach. | 2008 | Biol Trace Elem Res | pmid:17962910 |
Zatonski W et al. | Rapid declines in coronary heart disease mortality in Eastern Europe are associated with increased consumption of oils rich in alpha-linolenic acid. | 2008 | Eur. J. Epidemiol. | pmid:17955332 |
Plourde M et al. | Conjugated alpha-linolenic acid isomers in bovine milk and muscle. | 2007 | J. Dairy Sci. | pmid:17954767 |
Pazirandeh S et al. | Supplementation of arachidonic acid plus docosahexaenoic acid in cirrhotic patients awaiting liver transplantation: a preliminary study. | 2007 Nov-Dec | JPEN J Parenter Enteral Nutr | pmid:17947609 |
Mert-Türk F et al. | Nitrogen and fungicide applications against Erysiphe cruciferarum affect quality components of oilseed rape. | 2008 | Mycopathologia | pmid:17934794 |
Alessandri JM et al. | Estradiol favors the formation of eicosapentaenoic acid (20:5n-3) and n-3 docosapentaenoic acid (22:5n-3) from alpha-linolenic acid (18:3n-3) in SH-SY5Y neuroblastoma cells. | 2008 | Lipids | pmid:17912567 |
Simon JA et al. | Lack of effect of walnuts on serum levels of prostate specific antigen: a brief report. | 2007 | J Am Coll Nutr | pmid:17906182 |
Murano Y et al. | Effect of dietary lard containing higher alpha-linolenic acid on plasma triacylglycerol in rats. | 2007 | J Oleo Sci | pmid:17898502 |
Takeuchi H et al. | Antihypertensive effect and safety of dietary alpha-linolenic acid in subjects with high-normal blood pressure and mild hypertension. | 2007 | J Oleo Sci | pmid:17898501 |
Sekine S et al. | Lowering systolic blood pressure and increases in vasodilator levels in SHR with oral alpha-linolenic acid administration. | 2007 | J Oleo Sci | pmid:17898500 |
Barre DE | The role of consumption of alpha-linolenic, eicosapentaenoic and docosahexaenoic acids in human metabolic syndrome and type 2 diabetes--a mini-review. | 2007 | J Oleo Sci | pmid:17898498 |
Lin YH and Salem N | Whole body distribution of deuterated linoleic and alpha-linolenic acids and their metabolites in the rat. | 2007 | J. Lipid Res. | pmid:17876057 |
Rao SS et al. | Sensitivity of fetus and pups to excess levels of maternal intakes of alpha linolenic acid at marginal protein levels in Wistar rats. | 2007 Nov-Dec | Reprod. Toxicol. | pmid:17825521 |
Chen J et al. | Flaxseed alone or in combination with tamoxifen inhibits MCF-7 breast tumor growth in ovariectomized athymic mice with high circulating levels of estrogen. | 2007 | Exp. Biol. Med. (Maywood) | pmid:17720953 |
Yara A et al. | Disease resistance against Magnaporthe grisea is enhanced in transgenic rice with suppression of omega-3 fatty acid desaturases. | 2007 | Plant Cell Physiol. | pmid:17716996 |
Zhang W et al. | Alpha-linolenic acid attenuates high glucose-induced apoptosis in cultured human umbilical vein endothelial cells via PI3K/Akt/eNOS pathway. | 2007 | Nutrition | pmid:17716867 |
The power of 3. Omega-3 fatty acids. | 2007 | Mayo Clin Health Lett | pmid:17715541 | |
Igarashi M et al. | Dietary n-3 PUFA deprivation for 15 weeks upregulates elongase and desaturase expression in rat liver but not brain. | 2007 | J. Lipid Res. | pmid:17715424 |
Sánchez-Ortiz A et al. | Cultivar differences on nonesterified polyunsaturated fatty acid as a limiting factor for the biogenesis of virgin olive oil aroma. | 2007 | J. Agric. Food Chem. | pmid:17708640 |
DiRienzo MA et al. | Effect of substitution of low linolenic acid soybean oil for hydrogenated soybean oil on fatty acid intake. | 2006 | Lipids | pmid:17707981 |
Nelson TL et al. | Adiponectin levels are reduced, independent of polymorphisms in the adiponectin gene, after supplementation with alpha-linolenic acid among healthy adults. | 2007 | Metab. Clin. Exp. | pmid:17697863 |
Dhar P et al. | Antioxidative effect of conjugated linolenic acid in diabetic and non-diabetic blood: an in vitro study. | 2006 | J Oleo Sci | pmid:17693694 |
Ren J et al. | In vivo and in vitro anti-inflammatory activities of alpha-linolenic acid isolated from Actinidia polygama fruits. | 2007 | Arch. Pharm. Res. | pmid:17679548 |
Sato I et al. | Identification of COX inhibitors in the hexane extract of Japanese horse chestnut (Aesculus turbinata) seeds. | 2007 | J. Vet. Med. Sci. | pmid:17675801 |
Lohner S et al. | [Dietary supplementation of obese children with 1000 mg alpha-linolenic acid per day: a placebo-controlled double blind study]. | 2007 | Orv Hetil | pmid:17675277 |
Bongiovanni KD et al. | Neonatal growth rate and development of mice raised on milk transgenically enriched with omega-3 fatty acids. | 2007 | Pediatr. Res. | pmid:17667849 |
Schubert R et al. | Influence of low-dose polyunsaturated fatty acids supplementation on the inflammatory response of healthy adults. | 2007 | Nutrition | pmid:17664057 |
Wang S and Zhang A | Facile and efficient syntheses of (3Z,6Z,9Z)-3,6,9-nonadecatriene and homologues: pheromone and attractant components of lepidoptera. | 2007 | J. Agric. Food Chem. | pmid:17661482 |
Bryan RM et al. | Starring TREK-1: the next generation of vascular K+ channels. | 2007 | Circ. Res. | pmid:17641234 |
Paschos GK et al. | Effects of flaxseed oil supplementation on plasma adiponectin levels in dyslipidemic men. | 2007 | Eur J Nutr | pmid:17623225 |
Plourde M and Cunnane SC | Extremely limited synthesis of long chain polyunsaturates in adults: implications for their dietary essentiality and use as supplements. | 2007 | Appl Physiol Nutr Metab | pmid:17622276 |
Astorg P et al. | Plasma n-6 and n-3 polyunsaturated fatty acids as biomarkers of their dietary intakes: a cross-sectional study within a cohort of middle-aged French men and women. | 2008 | Eur J Clin Nutr | pmid:17622261 |
Szilágyi A et al. | Membrane curvature stress controls the maximal conversion of violaxanthin to zeaxanthin in the violaxanthin cycle--influence of alpha-tocopherol, cetylethers, linolenic acid, and temperature. | 2007 | Biochim. Biophys. Acta | pmid:17618598 |
Nelson TL et al. | Inflammatory markers are not altered by an eight week dietary alpha-linolenic acid intervention in healthy abdominally obese adult males and females. | 2007 | Cytokine | pmid:17613244 |
Lauretani F et al. | Omega-6 and omega-3 fatty acids predict accelerated decline of peripheral nerve function in older persons. | 2007 | Eur. J. Neurol. | pmid:17594339 |
Järvenpää S et al. | A probiotic, Lactobacillus fermentum ME-3, has antioxidative capacity in soft cheese spreads with different fats. | 2007 | J. Dairy Sci. | pmid:17582099 |
Vaysse-Boué C et al. | Moderate dietary intake of myristic and alpha-linolenic acids increases lecithin-cholesterol acyltransferase activity in humans. | 2007 | Lipids | pmid:17564735 |
Blondeau N et al. | Polyunsaturated fatty acids are cerebral vasodilators via the TREK-1 potassium channel. | 2007 | Circ. Res. | pmid:17556656 |
Ueshima H et al. | Food omega-3 fatty acid intake of individuals (total, linolenic acid, long-chain) and their blood pressure: INTERMAP study. | 2007 | Hypertension | pmid:17548718 |
Faintuch J et al. | Systemic inflammation in morbidly obese subjects: response to oral supplementation with alpha-linolenic acid. | 2007 | Obes Surg | pmid:17546842 |
Okuyama H et al. | Dietary lipids impacts on healthy ageing. | 2007 | Lipids | pmid:17546469 |
Ren J and Chung SH | Anti-inflammatory effect of alpha-linolenic acid and its mode of action through the inhibition of nitric oxide production and inducible nitric oxide synthase gene expression via NF-kappaB and mitogen-activated protein kinase pathways. | 2007 | J. Agric. Food Chem. | pmid:17542608 |
Lu M et al. | Dietary linolenic acid intake is positively associated with five-year change in eye lens nuclear density. | 2007 | J Am Coll Nutr | pmid:17536124 |
Ayalew-Pervanchon A et al. | Long-term effect of dietary {alpha}-linolenic acid or decosahexaenoic acid on incorporation of decosahexaenoic acid in membranes and its influence on rat heart in vivo. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17526653 |
Sun S et al. | Singlet oxygen generation from the decomposition of alpha-linolenic acid hydroperoxide by cytochrome c and lactoperoxidase. | 2007 | Biochemistry | pmid:17497889 |
Kim JH et al. | Effect of dietary supplementation with conjugated linoleic acid, with oleic, linoleic, or linolenic acid, on egg quality characteristics and fat accumulation in the egg yolk. | 2007 | Poult. Sci. | pmid:17495090 |
Szabó E et al. | trans Octadecenoic acid and trans octadecadienoic acid are inversely related to long-chain polyunsaturates in human milk: results of a large birth cohort study. | 2007 | Am. J. Clin. Nutr. | pmid:17490969 |
Kiliç T et al. | Fatty acid composition of seeds of some species of Nepeta L. | 2007 | Nat. Prod. Res. | pmid:17487620 |
Sánchez-Sampedro A et al. | Metabolomic alterations in elicitor treated Silybum marianum suspension cultures monitored by nuclear magnetic resonance spectroscopy. | 2007 | J. Biotechnol. | pmid:17475356 |
Karapanagiotidis IT et al. | Replacement of dietary fish oils by alpha-linolenic acid-rich oils lowers omega 3 content in tilapia flesh. | 2007 | Lipids | pmid:17473942 |
Tanaka T et al. | Metabolic pathway that produces essential fatty acids from polymethylene-interrupted polyunsaturated fatty acids in animal cells. | 2007 | FEBS J. | pmid:17451430 |
Giovannucci E et al. | Risk factors for prostate cancer incidence and progression in the health professionals follow-up study. | 2007 | Int. J. Cancer | pmid:17450530 |
Reinprecht Y et al. | Seed and agronomic QTL in low linolenic acid, lipoxygenase-free soybean (Glycine max (L.) Merrill) germplasm. | 2006 | Genome | pmid:17426766 |
Portolesi R et al. | Competition between 24:5n-3 and ALA for Delta 6 desaturase may limit the accumulation of DHA in HepG2 cell membranes. | 2007 | J. Lipid Res. | pmid:17409318 |
Molkentin J and Giesemann A | Differentiation of organically and conventionally produced milk by stable isotope and fatty acid analysis. | 2007 | Anal Bioanal Chem | pmid:17393158 |
Conklin SM et al. | Serum omega-3 fatty acids are associated with variation in mood, personality and behavior in hypercholesterolemic community volunteers. | 2007 | Psychiatry Res | pmid:17383013 |
Liou YA et al. | Decreasing linoleic acid with constant alpha-linolenic acid in dietary fats increases (n-3) eicosapentaenoic acid in plasma phospholipids in healthy men. | 2007 | J. Nutr. | pmid:17374659 |
Dewhurst RJ et al. | Apparent recovery of duodenal odd- and branched-chain fatty acids in milk of dairy cows. | 2007 | J. Dairy Sci. | pmid:17369218 |
Ayerza R and Coates W | Effect of dietary alpha-linolenic fatty acid derived from chia when fed as ground seed, whole seed and oil on lipid content and fatty acid composition of rat plasma. | 2007 | Ann. Nutr. Metab. | pmid:17356263 |
Shimizu T et al. | Effects of alpha-linolenic acid on colonic secretion in rats with experimental colitis. | 2007 | J. Gastroenterol. | pmid:17351801 |
Vos E et al. | alpha-Linolenic acid and fish oil n-3 fatty acids and cardiovascular disease risk. | 2007 | Am. J. Clin. Nutr. | pmid:17344517 |
Norton G et al. | Characterisation of recombinant Hevea brasiliensis allene oxide synthase: effects of cycloxygenase inhibitors, lipoxygenase inhibitors and salicylates on enzyme activity. | 2007 | Plant Physiol. Biochem. | pmid:17344058 |
Myung K et al. | Interaction with and effects on the profile of proteins of Botrytis cinerea by C6 aldehydes. | 2007 | J. Agric. Food Chem. | pmid:17323971 |
Decsi T et al. | Low contribution of n-3 polyunsaturated fatty acids to plasma and erythrocyte membrane lipids in diabetic young adults. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17321122 |
Deng YM et al. | Anti-asthmatic effects of Perilla seed oil in the guinea pig in vitro and in vivo. | 2007 | Planta Med. | pmid:17315310 |
Aboshi T et al. | Efficient incorporation of unsaturated fatty acids into volicitin-related compounds in Spodoptera litura (Lepidoptera: Noctuidae). | 2007 | Biosci. Biotechnol. Biochem. | pmid:17284824 |
Baylin A et al. | alpha-Linolenic acid, Delta6-desaturase gene polymorphism, and the risk of nonfatal myocardial infarction. | 2007 | Am. J. Clin. Nutr. | pmid:17284757 |
Zhao G et al. | Dietary alpha-linolenic acid inhibits proinflammatory cytokine production by peripheral blood mononuclear cells in hypercholesterolemic subjects. | 2007 | Am. J. Clin. Nutr. | pmid:17284733 |
Igarashi M et al. | Docosahexaenoic acid synthesis from alpha-linolenic acid by rat brain is unaffected by dietary n-3 PUFA deprivation. | 2007 | J. Lipid Res. | pmid:17277380 |
Attar-Bashi NM et al. | Failure of conjugated linoleic acid supplementation to enhance biosynthesis of docosahexaenoic acid from alpha-linolenic acid in healthy human volunteers. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17275274 |
Paschos GK et al. | Dietary supplementation with flaxseed oil lowers blood pressure in dyslipidaemic patients. | 2007 | Eur J Clin Nutr | pmid:17268413 |
Shen SR et al. | Fatty acids in tea shoots (Camellia sinensis (L.) O. Kuntze) and their effects on the growth of retinal RF/6A endothelial cell lines. | 2007 | Mol Nutr Food Res | pmid:17262883 |
Segovia-Siapco G et al. | Validation of a food-frequency questionnaire for measurement of nutrient intake in a dietary intervention study. | 2007 | Public Health Nutr | pmid:17261227 |
Bourre JM | Dietary omega-3 fatty acids for women. | 2007 Feb-Apr | Biomed. Pharmacother. | pmid:17254747 |
Mohn T et al. | Quantification of active principles and pigments in leaf extracts of Isatis tinctoria by HPLC/UV/MS. | 2007 | Planta Med. | pmid:17236114 |
Inouye S et al. | The vapor activity of oregano, perilla, tea tree, lavender, clove, and geranium oils against a Trichophyton mentagrophytes in a closed box. | 2006 | J. Infect. Chemother. | pmid:17235639 |
Mosley SA et al. | Effect of varying levels of fatty acids from palm oil on feed intake and milk production in Holstein cows. | 2007 | J. Dairy Sci. | pmid:17235176 |
Takajo T et al. | Intramolecular rearrangement of linolenate peroxyl radicals in lipoxygenase reactions at lower oxygen content. | 2007 | J. Lipid Res. | pmid:17227895 |
Griel AE et al. | An increase in dietary n-3 fatty acids decreases a marker of bone resorption in humans. | 2007 | Nutr J | pmid:17227589 |
Javadi M et al. | The influence of dietary linoleic and alpha-linolenic acid on body composition and the activities of key enzymes of hepatic lipogenesis and fatty acid oxidation in mice. | 2007 | J Anim Physiol Anim Nutr (Berl) | pmid:17217386 |
Agostoni C et al. | Double-blind, placebo-controlled trial comparing effects of supplementation of two micronutrient sprinkles on fatty acid status in Cambodian infants. | 2007 | J. Pediatr. Gastroenterol. Nutr. | pmid:17204967 |
Taha AY et al. | Markedly raised intake of saturated and monounsaturated fatty acids in rats on a high-fat ketogenic diet does not inhibit carbon recycling of 13C-alpha-linolenate. | 2006 | Lipids | pmid:17180881 |
Kukoba TV et al. | [The effects of alpha-linolenic acid on the functioning of the isolated heart during acute myocardial ischemia/reperfusion]. | 2006 | Fiziol Zh | pmid:17176834 |
Okuyama H et al. | Why isn't the causal relationship between linoleic acid and mortalities from coronary heart disease and stroke revealed by clinical studies? | 2007 | World Rev Nutr Diet | pmid:17167283 |
Okuyama H et al. | Omega3 fatty acids effectively prevent coronary heart disease and other late-onset diseases--the excessive linoleic acid syndrome. | 2007 | World Rev Nutr Diet | pmid:17167282 |
Griffin MD et al. | Effects of altering the ratio of dietary n-6 to n-3 fatty acids on insulin sensitivity, lipoprotein size, and postprandial lipemia in men and postmenopausal women aged 45-70 y: the OPTILIP Study. | 2006 | Am. J. Clin. Nutr. | pmid:17158408 |
Sýkora J et al. | High-performance liquid chromatography with nuclear magnetic resonance detection--A method for quantification of alpha- and gamma-linolenic acids in their mixtures with free fatty acids. | 2007 | J Chromatogr A | pmid:17157864 |
Why not flaxseed oil? There's no mercury to worry about, and it does contain omega-3 fats...but not the best kind. | 2006 | Harv Health Lett | pmid:17152637 | |
Fiaccavento R et al. | Alpha-linolenic acid-enriched diet prevents myocardial damage and expands longevity in cardiomyopathic hamsters. | 2006 | Am. J. Pathol. | pmid:17148657 |
Kimura Y | [Fish, n-3 polyunsaturated fatty acid and colorectal cancer prevention: a review of experimental and epidemiological studies]. | 2006 | Nihon Koshu Eisei Zasshi | pmid:17144568 |
Glew RS and Vanderjagt D | Coping strategies and nutritional health in rural Niger: recommendations for consumption of wild plant foods in the Sahel. | 2006 Aug-Sep | Int J Food Sci Nutr | pmid:17135022 |
Menéndez JA et al. | HER2 (erbB-2)-targeted effects of the omega-3 polyunsaturated fatty acid, alpha-linolenic acid (ALA; 18:3n-3), in breast cancer cells: the "fat features" of the "Mediterranean diet" as an "anti-HER2 cocktail". | 2006 | Clin Transl Oncol | pmid:17134970 |
Al-Khalifa A et al. | Effect of dietary hempseed intake on cardiac ischemia-reperfusion injury. | 2007 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:17122327 |
Cao Y et al. | Identification and characterization of conjugated linolenic acid isomers by Ag+-HPLC and NMR. | 2006 | J. Agric. Food Chem. | pmid:17117784 |
Veltri BC et al. | Adipose fatty acid composition and rate of incorporation of alpha-linolenic acid differ between normal and lipoprotein lipase-deficient cats. | 2006 | J. Nutr. | pmid:17116707 |
Acar N et al. | The retina is more susceptible than the brain and the liver to the incorporation of trans isomers of DHA in rats consuming trans isomers of alpha-linolenic acid. | 2006 Sep-Oct | Reprod. Nutr. Dev. | pmid:17107641 |
Almendingen K et al. | Familial adenomatous polyposis patients have high levels of arachidonic acid and docosahexaenoic acid and low levels of linoleic acid and alpha-linolenic acid in serum phospholipids. | 2007 | Int. J. Cancer | pmid:17096349 |
Arab K et al. | Conjugated linoleic acid, unlike other unsaturated fatty acids, strongly induces glutathione synthesis without any lipoperoxidation. | 2006 | Br. J. Nutr. | pmid:17092368 |
Landmark K and Alm CS | [Alpha-linolenic acid, cardiovascular disease and sudden death]. | 2006 | Tidsskr. Nor. Laegeforen. | pmid:17086218 |