alpha-linolenic acid
Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
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Introduction
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with alpha-linolenic acid?
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
PubChem Associated disorders and diseases
What pathways are associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with alpha-linolenic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with alpha-linolenic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with alpha-linolenic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Loreau O et al. | Large-scale preparation of (9Z,12E)-[1-(13)C]-octadeca-9,12-dienoic acid, (9Z,12Z,15E)-[1-(13)C]-octadeca-9,12,15-trienoic acid and their [1-(13)C] all-cis isomers. | 2000 | Chem. Phys. Lipids | pmid:10878236 |
| Okamoto M et al. | Effects of perilla seed oil supplementation on leukotriene generation by leucocytes in patients with asthma associated with lipometabolism. | 2000 | Int. Arch. Allergy Immunol. | pmid:10878492 |
| de la Presa Owens S and Innis SM | Diverse, region-specific effects of addition of arachidonic and docosahexanoic acids to formula with low or adequate linoleic and alpha-linolenic acids on piglet brain monoaminergic neurotransmitters. | 2000 | Pediatr. Res. | pmid:10879811 |
| Bartsch H and Nair J | New DNA-based biomarkers for oxidative stress and cancer chemoprevention studies. | 2000 | Eur. J. Cancer | pmid:10882861 |
| Freiberger CE et al. | Nutrient content of the edible leaves of seven wild plants from Niger. | 1998 | Plant Foods Hum Nutr | pmid:10890758 |
| Simopoulos AP | Human requirement for N-3 polyunsaturated fatty acids. | 2000 | Poult. Sci. | pmid:10901194 |
| Matthews KR et al. | Effect of whole linseed (Linum usitatissimum) in the diet of finishing pigs on growth performance and on the quality and fatty acid composition of various tissues. | 2000 | Br. J. Nutr. | pmid:10911772 |
| Wenger FA et al. | Does alpha-linolenic acid in combination with linoleic acid influence liver metastasis and hepatic lipid peroxidation in BOP-induced pancreatic cancer in Syrian hamsters? | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10913224 |
| Christensen JH et al. | Alpha-linolenic acid and heart rate variability. | 2000 | Nutr Metab Cardiovasc Dis | pmid:10919169 |
| Sijben JW et al. | Dietary linoleic acid divergently affects immune responsiveness of growing layer hens. | 2000 | Poult. Sci. | pmid:10947178 |
| Hennig B et al. | Fatty acid-mediated activation of vascular endothelial cells. | 2000 | Metab. Clin. Exp. | pmid:10954018 |
| Zamora R et al. | Contribution of pyrrole formation and polymerization to the nonenzymatic browning produced by amino-carbonyl reactions. | 2000 | J. Agric. Food Chem. | pmid:10956084 |
| Sea MM et al. | Weight cycling-induced alteration in fatty acid metabolism. | 2000 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:10956277 |
| Kajita M et al. | Enhanced enteral bioavailability of vancomycin using water-in-oil-in-water multiple emulsion incorporating highly purified unsaturated fatty acid. | 2000 | J Pharm Sci | pmid:10980499 |
| McCarty MF | Activation of PPARgamma may mediate a portion of the anticancer activity of conjugated linoleic acid. | 2000 | Med. Hypotheses | pmid:10985906 |
| Meinelt T et al. | Correlation of diets high in n-6 polyunsaturated fatty acids with high growth rate in zebrafish (Danio rerio). | 2000 | Comp. Med. | pmid:10987667 |
| Schaffrath U et al. | Characterization of RCI-1, a chloroplastic rice lipoxygenase whose synthesis is induced by chemical plant resistance activators. | 2000 | Eur. J. Biochem. | pmid:10998053 |
| DeLany JP et al. | Differential oxidation of individual dietary fatty acids in humans. | 2000 | Am. J. Clin. Nutr. | pmid:11010930 |
| Petrik MB et al. | Highly unsaturated (n-3) fatty acids, but not alpha-linolenic, conjugated linoleic or gamma-linolenic acids, reduce tumorigenesis in Apc(Min/+) mice. | 2000 | J. Nutr. | pmid:11015469 |
| Loï C et al. | Incorporation and metabolism of dietary trans isomers of linolenic acid alter the fatty acid profile of rat tissues. | 2000 | J. Nutr. | pmid:11015488 |
| Sauer LA et al. | Mechanism for the antitumor and anticachectic effects of n-3 fatty acids. | 2000 | Cancer Res. | pmid:11016660 |
| Kurvinen JP et al. | The effect of low alpha-linolenic acid diet on glycerophospholipid molecular species in guinea pig brain. | 2000 | Lipids | pmid:11026621 |
| Takahashi Y and Ide T | Dietary n-3 fatty acids affect mRNA level of brown adipose tissue uncoupling protein 1, and white adipose tissue leptin and glucose transporter 4 in the rat. | 2000 | Br. J. Nutr. | pmid:11029968 |
| Smith HL et al. | Development of a serum-free system for the in vitro cultivation of Brugia malayi infective-stage larvae. | 2000 | Exp. Parasitol. | pmid:11038308 |
| Granot E et al. | Breast-fed and formula-fed infants do not differ in immunocompetent cell cytokine production despite differences in cell membrane fatty acid composition. | 2000 | Am. J. Clin. Nutr. | pmid:11063450 |
| Colditz GA | Changing dietary patterns and cancer prevention: alpha-linolenic acid health risks and benefits. | 2000 | Cancer Causes Control | pmid:11065003 |
| Schneider C et al. | Enantiomeric separation of hydroxy eicosanoids by chiral column chromatography: effect of the alcohol modifier. | 2000 | Anal. Biochem. | pmid:11078601 |
| Contreras MA et al. | Nutritional deprivation of alpha-linolenic acid decreases but does not abolish turnover and availability of unacylated docosahexaenoic acid and docosahexaenoyl-CoA in rat brain. | 2000 | J. Neurochem. | pmid:11080190 |
| Fokkema MR et al. | Short-term supplementation of low-dose gamma-linolenic acid (GLA), alpha-linolenic acid (ALA), or GLA plus ALA does not augment LCP omega 3 status of Dutch vegans to an appreciable extent. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11090255 |
| Ueno S et al. | Polymorphism of linoleic acid (cis-9, cis-12-octadecadienoic acid) and alpha-linolenic acid (cis-9, cis-12, cis-15-octadecatrienoic acid). | 2000 | Chem. Phys. Lipids | pmid:11090846 |
| Ikemoto A et al. | Diurnal rhythms of retinal phospholipid synthetic enzymes are retained but their activities are decreased in rats under alpha-linolenic acid deficiency. | 2000 | Arch. Biochem. Biophys. | pmid:11097182 |
| Frey M et al. | An herbivore elicitor activates the gene for indole emission in maize. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11106389 |
| Armstrong RA et al. | No effect of dietary trans isomers of alpha-linolenic acid on platelet aggregation and haemostatic factors in european healthy men. The TRANSLinE study. | 2000 | Thromb. Res. | pmid:11108899 |
| Ikemoto A et al. | Lysosomal enzyme activities are decreased in the retina and their circadian rhythms are different from those in the pineal gland of rats fed an alpha-linolenic acid-restricted diet. | 2000 | J. Nutr. | pmid:11110869 |
| Innis SM | The role of dietary n-6 and n-3 fatty acids in the developing brain. | 2000 Sep-Dec | Dev. Neurosci. | pmid:11111165 |
| Babin F et al. | Alpha linolenic acid in cholesterol esters: a marker of alphalinolenic acid intake in newborns. | 2000 | Eur J Clin Nutr | pmid:11114678 |
| Harbige LS et al. | The protective effects of omega-6 fatty acids in experimental autoimmune encephalomyelitis (EAE) in relation to transforming growth factor-beta 1 (TGF-beta1) up-regulation and increased prostaglandin E2 (PGE2) production. | 2000 | Clin. Exp. Immunol. | pmid:11122253 |
| Gonzalez-Esquerra R and Leeson S | Effects of menhaden oil and flaxseed in broiler diets on sensory quality and lipid composition of poultry meat. | 2000 | Br. Poult. Sci. | pmid:11128390 |
| MarÃn MC et al. | Dietary long-chain fatty acids and visual response in malnourished nursing infants. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11133176 |
| Okolo SN et al. | The fatty acid composition of human milk in northern Nigeria. | 2000 | J Hum Lact | pmid:11138221 |
| Crawford M et al. | Role of plant-derived omega-3 fatty acids in human nutrition. | 2000 | Ann. Nutr. Metab. | pmid:11146334 |
| Utsunomiya T et al. | Correspondence re: M. Kondo et al., Increased expression of COX-2 in nontumor liver tissue is associated with shorter disease-free survival in patients with hepatocellular carcinoma. Clin. Cancer Res., 5: 4005-4012, 1999. | 2000 | Clin. Cancer Res. | pmid:11156258 |
| Cho E et al. | Prospective study of dietary fat and the risk of age-related macular degeneration. | 2001 | Am. J. Clin. Nutr. | pmid:11157315 |
| Tocher DR and Dick JR | Effects of essential fatty acid deficiency and supplementation with docosahexaenoic acid (DHA; 22:6n-3) on cellular fatty acid compositions and fatty acyl desaturation in a cell culture model. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11161581 |
| Soppela P and Nieminen M | The effect of wintertime undernutrition on the fatty acid composition of leg bone marrow fats in reindeer (Rangifer tarandus tarandus L.). | 2001 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:11163305 |
| Wiesenfeld PW et al. | Effect of long-chain fatty acids in the culture medium on fatty acid composition of WEHI-3 and J774A.1 cells. | 2001 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:11163311 |
| Dikalov SI and Mason RP | Spin trapping of polyunsaturated fatty acid-derived peroxyl radicals: reassignment to alkoxyl radical adducts. | 2001 | Free Radic. Biol. Med. | pmid:11163536 |
| Kaushik N and Agnihotri A | GLC analysis of Indian rapeseed-mustard to study the variability of fatty acid composition. | 2000 | Biochem. Soc. Trans. | pmid:11171132 |
| Dobson G | Leaf lipids of Ribes nigrum: a plant containing 16:3, alpha-18:3, gamma-18:3 and 18:4 fatty acids. | 2000 | Biochem. Soc. Trans. | pmid:11171133 |
| Grechkin AN et al. | Lipoxygenase pathway in tulip: biosynthesis of ketols. | 2000 | Biochem. Soc. Trans. | pmid:11171230 |
| Radunz A et al. | State of the lipid and fatty acid composition in chloroplasts of Nicotiana tabacum under the influence of an increased CO2 partial pressure of 700 p.p.m. | 2000 | Biochem. Soc. Trans. | pmid:11171245 |
| Nuñez A et al. | Anaerobic lipoxygenase activity from Chlorella pyrenoidosa. | 2000 | Biochem. Soc. Trans. | pmid:11171268 |
| Schaller F | Enzymes of the biosynthesis of octadecanoid-derived signalling molecules. | 2001 | J. Exp. Bot. | pmid:11181709 |
| Fein A and Cavar S | Divergent mechanisms for phototransduction of invertebrate microvillar photoreceptors. | 2000 Nov-Dec | Vis. Neurosci. | pmid:11193107 |
| Cheon SH et al. | Effect of dietary linoleate/alpha-linolenate balance on the brain lipid composition, reproductive outcome and behavior of rats during their prenatal and postnatal development. | 2000 | Biosci. Biotechnol. Biochem. | pmid:11193394 |
| Du M et al. | Effects of dietary conjugated linoleic acid and linoleic:linolenic acid ratio on polyunsaturated fatty acid status in laying hens. | 2000 | Poult. Sci. | pmid:11194037 |
| Rao GN et al. | Effect of melatonin and linolenic acid on mammary cancer in transgenic mice with c-neu breast cancer oncogene. | 2000 | Breast Cancer Res. Treat. | pmid:11200779 |
| Choi SB et al. | Transcriptional expression characteristics and subcellular localization of ADP-glucose pyrophosphorylase in the oil plant Perilla frutescens. | 2001 | Plant Cell Physiol. | pmid:11230568 |
| Ide T | Effect of dietary alpha-linolenic acid on the activity and gene expression of hepatic fatty acid oxidation enzymes. | 2000 | Biofactors | pmid:11237206 |
| Thies F et al. | Dietary supplementation with eicosapentaenoic acid, but not with other long-chain n-3 or n-6 polyunsaturated fatty acids, decreases natural killer cell activity in healthy subjects aged >55 y. | 2001 | Am. J. Clin. Nutr. | pmid:11237929 |
| Zien CA et al. | In vivo substrates and the contribution of the common phospholipase D, PLDalpha, to wound-induced metabolism of lipids in Arabidopsis. | 2001 | Biochim. Biophys. Acta | pmid:11239826 |
| Billeaud C et al. | Effects of preterm infant formula supplementation with alpha-linolenic acid with a linoleate/alpha-linolenate ratio of 6: a multicentric study. | 1997 | Eur J Clin Nutr | pmid:11248877 |
| Korotkova M et al. | Maternal essential fatty acid deficiency depresses serum leptin levels in suckling rat pups. | 2001 | J. Lipid Res. | pmid:11254747 |
| Moriguchi T et al. | Reversal of docosahexaenoic acid deficiency in the rat brain, retina, liver, and serum. | 2001 | J. Lipid Res. | pmid:11254754 |
| Wolff RL et al. | Alpha-linolenic acid and its delta5-desaturation product, coniferonic acid, in the seed lipids of Tsuga and Hesperopeuce as a taxonomic means to differentiate the two genera. | 2001 | Lipids | pmid:11269703 |
| Elias SL and Innis SM | Infant plasma trans, n-6, and n-3 fatty acids and conjugated linoleic acids are related to maternal plasma fatty acids, length of gestation, and birth weight and length. | 2001 | Am. J. Clin. Nutr. | pmid:11273857 |
| Robertson RM and Smaha L | Can a Mediterranean-style diet reduce heart disease? | 2001 | Circulation | pmid:11282917 |
| Kris-Etherton P et al. | AHA Science Advisory: Lyon Diet Heart Study. Benefits of a Mediterranean-style, National Cholesterol Education Program/American Heart Association Step I Dietary Pattern on Cardiovascular Disease. | 2001 | Circulation | pmid:11282918 |
| Williard DE et al. | Identification of a fatty acid delta6-desaturase deficiency in human skin fibroblasts. | 2001 | J. Lipid Res. | pmid:11290821 |
| Su HM et al. | Fetal baboons convert 18:3n-3 to 22:6n-3 in vivo. A stable isotope tracer study. | 2001 | J. Lipid Res. | pmid:11290830 |
| Vermunt SH et al. | Dietary trans alpha-linolenic acid from deodorised rapeseed oil and plasma lipids and lipoproteins in healthy men: the TransLinE Study. | 2001 | Br. J. Nutr. | pmid:11299084 |
| Nenseter MS et al. | Effect of Norwegian fish powder on risk factors for coronary heart disease among hypercholesterolemic individuals. | 2000 | Nutr Metab Cardiovasc Dis | pmid:11302007 |
| Kaku S et al. | Interactions of dietary fats and proteins on fatty acid composition of immune cells and LTB4 production by peritoneal exudate cells of rats. | 2001 | Biosci. Biotechnol. Biochem. | pmid:11302164 |
| Kawamoto S et al. | Lack of effect of the abnormal fatty acid metabolism in NC/Nga mice on their atopic dermatitis. | 2001 | Biosci. Biotechnol. Biochem. | pmid:11302182 |
| Marmunti M and Catalá A | Incorporation of 1-(14)C linoleic acid in rat liver nuclei and chromatin fractions. | 2001 | Int. J. Biochem. Cell Biol. | pmid:11311857 |
| Hrelia S et al. | Role of gamma-linolenic acid in counteracting doxorubicin-induced damage in cultured rat cardiomyocytes. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11334548 |
| Watkins SM et al. | Unique phospholipid metabolism in mouse heart in response to dietary docosahexaenoic or alpha-linolenic acids. | 2001 | Lipids | pmid:11337979 |
| Karlsson S et al. | Reactivity of Trametes laccases with fatty and resin acids. | 2001 | Appl. Microbiol. Biotechnol. | pmid:11341313 |
| Murase T et al. | Abundant expression of uncoupling protein-2 in the small intestine: up-regulation by dietary fish oil and fibrates. | 2001 | Biochim. Biophys. Acta | pmid:11341955 |
| Trommer H et al. | The examination of skin lipid model systems stressed by ultraviolet irradiation in the presence of transition metal ions. | 2001 | Eur J Pharm Biopharm | pmid:11343884 |
| Dyer JM et al. | Chilling-sensitive, post-transcriptional regulation of a plant fatty acid desaturase expressed in yeast. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11352654 |
| Kelder B et al. | Expression of fungal desaturase genes in cultured mammalian cells. | 2001 | Mol. Cell. Biochem. | pmid:11354256 |
| Johnson LK et al. | [Diet and secondary prevention of coronary heart disease--are our recommendations good enough?]. | 2001 | Tidsskr. Nor. Laegeforen. | pmid:11354888 |
| Barre DE | Potential of evening primrose, borage, black currant, and fungal oils in human health. | 2001 | Ann. Nutr. Metab. | pmid:11359029 |
| Tijet N et al. | Biogenesis of volatile aldehydes from fatty acid hydroperoxides: molecular cloning of a hydroperoxide lyase (CYP74C) with specificity for both the 9- and 13-hydroperoxides of linoleic and linolenic acids. | 2001 | Arch. Biochem. Biophys. | pmid:11368353 |
| Bretillon L et al. | Isomerization increases the postprandial oxidation of linoleic acid but not alpha-linolenic acid in men. | 2001 | J. Lipid Res. | pmid:11369808 |
| Liu L et al. | [Expression of delta 6-fatty acid desaturase gene from Mortierella alpina in Saccharomyces cerevisiae]. | 2001 | Sheng Wu Gong Cheng Xue Bao | pmid:11411223 |
| Inouye S et al. | In-vitro and in-vivo anti-Trichophyton activity of essential oils by vapour contact. | 2001 | Mycoses | pmid:11413931 |
| Abeywardena MY et al. | Dietary n-3 and n-6 polyunsaturated oils and airway contractility. | 2001 Apr-May | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11418024 |
| Blondeau N et al. | Activation of the nuclear factor-kappaB is a key event in brain tolerance. | 2001 | J. Neurosci. | pmid:11425894 |
| Nomura T et al. | A long-lasting facilitation of hippocampal neurotransmission via a phospholipase A2 signaling pathway. | 2001 | Life Sci. | pmid:11432454 |
| Thies F et al. | Dietary supplementation with gamma-linolenic acid or fish oil decreases T lymphocyte proliferation in healthy older humans. | 2001 | J. Nutr. | pmid:11435508 |
| Avery AM and Avery SV | Saccharomyces cerevisiae expresses three phospholipid hydroperoxide glutathione peroxidases. | 2001 | J. Biol. Chem. | pmid:11445588 |
| Almario RU et al. | Effects of walnut consumption on plasma fatty acids and lipoproteins in combined hyperlipidemia. | 2001 | Am. J. Clin. Nutr. | pmid:11451720 |
| Renaud SC | Diet and stroke. | 2001 | J Nutr Health Aging | pmid:11458287 |
| Lanzmann-Petithory D | Alpha-linolenic acid and cardiovascular diseases. | 2001 | J Nutr Health Aging | pmid:11458289 |
| Kim E et al. | Effects of gamma-irradiated fats on plasma lipid concentrations and hepatic cholesterol metabolism in rats. | 2001 | Ann. Nutr. Metab. | pmid:11463998 |
| Sijben JW et al. | Interactions and antigen dependence of dietary n-3 and n-6 polyunsaturated fatty acids on antibody responsiveness in growing layer hens. | 2001 | Poult. Sci. | pmid:11469650 |
| Cherian G and Sim JS | Maternal dietary alpha-linolenic acid (18:3n-3) alters n-3 polyunsaturated fatty acid metabolism and liver enzyme activity in hatched chicks. | 2001 | Poult. Sci. | pmid:11469652 |
| Sharma R et al. | Mulberry moracins: scavengers of UV stress-generated free radicals. | 2001 | Biosci. Biotechnol. Biochem. | pmid:11471743 |