alpha-linolenic acid

Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.

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Introduction

To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with alpha-linolenic acid?

alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Tuberculosis D014376 20 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Neoplasms D009369 13 associated lipids
Pain D010146 64 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Cattle Diseases D002418 24 associated lipids
Fatty Liver D005234 48 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Precancerous Conditions D011230 48 associated lipids
Arthritis D001168 41 associated lipids
Amyloidosis D000686 4 associated lipids
Heart Failure D006333 36 associated lipids
Coronary Disease D003327 70 associated lipids
Liver Diseases D008107 31 associated lipids
Hypersensitivity D006967 22 associated lipids
Weight Gain D015430 101 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Thrombosis D013927 49 associated lipids
Myocardial Infarction D009203 21 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Urinary Bladder Neoplasms D001749 7 associated lipids
Prostatic Hyperplasia D011470 20 associated lipids
Arteriosclerosis D001161 86 associated lipids
Neuroblastoma D009447 66 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Colorectal Neoplasms D015179 10 associated lipids
Carcinoma, Ductal, Breast D018270 19 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Pancytopenia D010198 6 associated lipids
Pseudomonas Infections D011552 25 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Stroke D020521 32 associated lipids
Brain Ischemia D002545 89 associated lipids
Epilepsy D004827 35 associated lipids
Seizures D012640 87 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with alpha-linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with alpha-linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with alpha-linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with alpha-linolenic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with alpha-linolenic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with alpha-linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with alpha-linolenic acid

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Per page 10 20 50 100 | Total 2471
Authors Title Published Journal PubMed Link
Rao CV et al. Prevention of familial adenomatous polyp development in APC min mice and azoxymethane-induced colon carcinogenesis in F344 Rats by ω-3 fatty acid rich perilla oil. 2013 Nutr Cancer pmid:23682783
Kasuli EG Are alternative supplements effective treatment for diabetes mellitus? 2011 Nutr Clin Pract pmid:21586420
Hadjighassem M et al. Oral consumption of α-linolenic acid increases serum BDNF levels in healthy adult humans. 2015 Nutr J pmid:25889793
Childs CE et al. Increased dietary α-linolenic acid has sex-specific effects upon eicosapentaenoic acid status in humans: re-examination of data from a randomised, placebo-controlled, parallel study. 2014 Nutr J pmid:25496415
Beezhold BL et al. Vegetarian diets are associated with healthy mood states: a cross-sectional study in seventh day adventist adults. 2010 Nutr J pmid:20515497
Griel AE et al. An increase in dietary n-3 fatty acids decreases a marker of bone resorption in humans. 2007 Nutr J pmid:17227589
Papanikolaou Y et al. U.S. adults are not meeting recommended levels for fish and omega-3 fatty acid intake: results of an analysis using observational data from NHANES 2003-2008. 2014 Nutr J pmid:24694001
Burns-Whitmore B et al. Effects of supplementing n-3 fatty acid enriched eggs and walnuts on cardiovascular disease risk markers in healthy free-living lacto-ovo-vegetarians: a randomized, crossover, free-living intervention study. 2014 Nutr J pmid:24673793
Bermudez OI et al. Dietary intakes and food sources of fat and fatty acids in Guatemalan schoolchildren: a cross-sectional study. 2010 Nutr J pmid:20416064
Huang T et al. Effect of n-3 polyunsaturated fatty acid on gene expression of the critical enzymes involved in homocysteine metabolism. 2012 Nutr J pmid:22260268
Garneau V et al. Omega-3 fatty acids status in human subjects estimated using a food frequency questionnaire and plasma phospholipids levels. 2012 Nutr J pmid:22775977
Miyake Y et al. Dietary meat and fat intake and prevalence of rhinoconjunctivitis in pregnant Japanese women: baseline data from the Kyushu Okinawa Maternal and Child Health Study. 2012 Nutr J pmid:22449171
Kim H et al. Association between maternal intake of n-6 to n-3 fatty acid ratio during pregnancy and infant neurodevelopment at 6 months of age: results of the MOCEH cohort study. 2017 Nutr J pmid:28420388
Kawakami Y et al. Flaxseed oil intake reduces serum small dense low-density lipoprotein concentrations in Japanese men: a randomized, double blind, crossover study. 2015 Nutr J pmid:25896182
de Lorgeril M and Salen P Alpha-linolenic acid and coronary heart disease. 2004 Nutr Metab Cardiovasc Dis pmid:15330276
Marangoni F et al. Levels of the n-3 fatty acid eicosapentaenoic acid in addition to those of alpha linolenic acid are significantly raised in blood lipids by the intake of four walnuts a day in humans. 2007 Nutr Metab Cardiovasc Dis pmid:17008073
Warensjö E et al. Effects of saturated and unsaturated fatty acids on estimated desaturase activities during a controlled dietary intervention. 2008 Nutr Metab Cardiovasc Dis pmid:18367385
Christensen JH et al. Alpha-linolenic acid and heart rate variability in women examined for coronary artery disease. 2005 Nutr Metab Cardiovasc Dis pmid:16216720
Bordoni A et al. Hypoxia/reoxygenation alters essential fatty acids metabolism in cultured rat cardiomyocytes: protection by antioxidants. 2005 Nutr Metab Cardiovasc Dis pmid:15955464
Nenseter MS et al. Effect of Norwegian fish powder on risk factors for coronary heart disease among hypercholesterolemic individuals. 2000 Nutr Metab Cardiovasc Dis pmid:11302007
Wong WT et al. Relative contribution of individual oxidized components in ox-LDL to inhibition on endothelium-dependent relaxation in rat aorta. 2011 Nutr Metab Cardiovasc Dis pmid:20005687
Christensen JH et al. Alpha-linolenic acid and heart rate variability. 2000 Nutr Metab Cardiovasc Dis pmid:10919169
Carrié I et al. Docosahexaenoic acid-rich phospholipid supplementation: effect on behavior, learning ability, and retinal function in control and n-3 polyunsaturated fatty acid deficient old mice. 2002 Nutr Neurosci pmid:11929197
Carey AN et al. The ability of walnut extract and fatty acids to protect against the deleterious effects of oxidative stress and inflammation in hippocampal cells. 2013 Nutr Neurosci pmid:23321679
Davis PF et al. Dopamine receptor alterations in female rats with diet-induced decreased brain docosahexaenoic acid (DHA): interactions with reproductive status. 2010 Nutr Neurosci pmid:20670471
Yehuda S et al. Mixture of essential fatty acids lowers test anxiety. 2005 Nutr Neurosci pmid:16491653
Hutchins AM et al. Daily flaxseed consumption improves glycemic control in obese men and women with pre-diabetes: a randomized study. 2013 Nutr Res pmid:23684438
Nieman DC et al. Chia seed does not promote weight loss or alter disease risk factors in overweight adults. 2009 Nutr Res pmid:19628108
Broughton KS et al. High α-linolenic acid and fish oil ingestion promotes ovulation to the same extent in rats. 2010 Nutr Res pmid:21056289
Raatz SK et al. Total dietary fat and fatty acid content modifies plasma phospholipid fatty acids, desaturase activity indices, and urinary prostaglandin E in women. 2012 Nutr Res pmid:22260857
Lora KR et al. Validity and reliability of an omega-3 fatty acid food frequency questionnaire for first-generation Midwestern Latinas. 2010 Nutr Res pmid:20851309
Poudel-Tandukar K et al. Dietary intakes of alpha-linolenic and linoleic acids are inversely associated with serum C-reactive protein levels among Japanese men. 2009 Nutr Res pmid:19628101
Kim M et al. Erythrocyte α-linolenic acid is associated with the risk for mild dementia in Korean elderly. 2010 Nutr Res pmid:21130294
Stark AH et al. Update on alpha-linolenic acid. 2008 Nutr. Rev. pmid:18522621
Dyerberg J Linolenate-derived polyunsaturated fatty acids and prevention of atherosclerosis. 1986 Nutr. Rev. pmid:2872640
Cholesterol metabolism and omega-3 polyenes in fish oils. 1986 Nutr. Rev. pmid:2872641
Bloedon LT and Szapary PO Flaxseed and cardiovascular risk. 2004 Nutr. Rev. pmid:14995053
Nutrition classics. Lipids, June 1979 Volume 14, No. 6: Reproduction and survival of rainbow trout (Salmo gairdneri) fed linolenic acid as the only source of essential fatty acids. By T.C. Yu, R.O. Sinnhuber, and J.D. Hendricks. 1986 Nutr. Rev. pmid:2878402
Johnston PV and Fritsche KL Linolenate metabolism. 1986 Nutr. Rev. pmid:2878403
Bjerve KS Alpha-linolenic acid deficiency in adult women. 1987 Nutr. Rev. pmid:2881237
Hartman IS alpha-Linolenic acid: a preventive in secondary coronary events? 1995 Nutr. Rev. pmid:7494621
Liu J and Ma DW The role of n-3 polyunsaturated fatty acids in the prevention and treatment of breast cancer. 2014 Nutrients pmid:25412153
De Mel D and Suphioglu C Fishy business: effect of omega-3 fatty acids on zinc transporters and free zinc availability in human neuronal cells. 2014 Nutrients pmid:25195602
Valenzuela R et al. Modification of Docosahexaenoic Acid Composition of Milk from Nursing Women Who Received Alpha Linolenic Acid from Chia Oil during Gestation and Nursing. 2015 Nutrients pmid:26247968
Ebrahimi M et al. Effects of oils rich in linoleic and α-linolenic acids on fatty acid profile and gene expression in goat meat. 2014 Nutrients pmid:25255382
Fekete K and Decsi T Long-chain polyunsaturated fatty acids in inborn errors of metabolism. 2010 Nutrients pmid:22254065
Bradbury J Docosahexaenoic acid (DHA): an ancient nutrient for the modern human brain. 2011 Nutrients pmid:22254110
Veselinovic M et al. Clinical Benefits of n-3 PUFA and ɤ-Linolenic Acid in Patients with Rheumatoid Arthritis. 2017 Nutrients pmid:28346333
Zheng JS et al. Genetic Risk Score of Nine Type 2 Diabetes Risk Variants that Interact with Erythrocyte Phospholipid Alpha-Linolenic Acid for Type 2 Diabetes in Chinese Hans: A Case-Control Study. 2017 Nutrients pmid:28398239
Lefort N et al. Dietary Buglossoides Arvensis Oil Increases Circulating n-3 Polyunsaturated Fatty Acids in a Dose-Dependent Manner and Enhances Lipopolysaccharide-Stimulated Whole Blood Interleukin-10-A Randomized Placebo-Controlled Trial. 2017 Nutrients pmid:28287415
Senftleber NK et al. Marine Oil Supplements for Arthritis Pain: A Systematic Review and Meta-Analysis of Randomized Trials. 2017 Nutrients pmid:28067815
Minihane AM Impact of Genotype on EPA and DHA Status and Responsiveness to Increased Intakes. 2016 Nutrients pmid:26950146
Cinelli G et al. Influence of Maternal Obesity and Gestational Weight Gain on Maternal and Foetal Lipid Profile. 2016 Nutrients pmid:27314385
Nieman DC et al. No positive influence of ingesting chia seed oil on human running performance. 2015 Nutrients pmid:25988762
Machado AM et al. Effects of brown and golden flaxseed on the lipid profile, glycemia, inflammatory biomarkers, blood pressure and body composition in overweight adolescents. 2015 Nutrition pmid:25441591
Cunnane SC et al. Alpha-linolenic acid in humans: direct functional role or dietary precursor? 1991 Nov-Dec Nutrition pmid:1686981
Cook HW Brain metabolism of alpha-linolenic acid during development. 1991 Nov-Dec Nutrition pmid:1686982
Wainwright PE Alpha-linolenic acid, long-chain n-3 fatty acids, and neonatal brain development. 1991 Nov-Dec Nutrition pmid:1686983
Schubert R et al. Influence of low-dose polyunsaturated fatty acids supplementation on the inflammatory response of healthy adults. 2007 Nutrition pmid:17664057
Monge-Rojas R et al. Changes in dietary intake and food sources of saturated and cis and trans unsaturated fatty acids in Costa Rican adolescents: 1996 versus 2006. 2013 Nutrition pmid:23298971
Gatchalian-Yee M et al. Soybean protein lowers serum cholesterol levels in hamsters: effect of debittered undigested fraction. 1997 Jul-Aug Nutrition pmid:9263255
Walker CG et al. Stearidonic acid as a supplemental source of ω-3 polyunsaturated fatty acids to enhance status for improved human health. 2013 Nutrition pmid:23102888
Zhang W et al. Alpha-linolenic acid attenuates high glucose-induced apoptosis in cultured human umbilical vein endothelial cells via PI3K/Akt/eNOS pathway. 2007 Nutrition pmid:17716867
Sartorelli DS et al. Dietary omega-3 fatty acid and omega-3: omega-6 fatty acid ratio predict improvement in glucose disturbances in Japanese Brazilians. 2010 Nutrition pmid:19647413
Burke PA et al. Conditionally essential fatty acid deficiencies in end-stage liver disease. 1999 Nutrition pmid:10319364
Bakshi A et al. Gamma-linolenic acid therapy of human gliomas. 2003 Nutrition pmid:12679162
Eynard AR Potential of essential fatty acids as natural therapeutic products for human tumors. 2003 Nutrition pmid:12679177
O'Sullivan TA et al. Dietary intake and food sources of fatty acids in Australian adolescents. 2011 Nutrition pmid:20338727
Ikeda A et al. Effects of intravenous perilla oil emulsion on nutritional status, polyunsaturated fatty acid composition of tissue phospholipids, and thromboxane A2 production in streptozotocin-induced diabetic rats. 1995 Sep-Oct Nutrition pmid:8748197
Manav M et al. Omega-3 fatty acids and selenium as coronary heart disease risk modifying factors in Asian Indian and Chinese males. 2004 Nov-Dec Nutrition pmid:15561485
Muñoz SE et al. Differential effects of dietary Oenothera, Zizyphus mistol, and corn oils, and essential fatty acid deficiency on the progression of a murine mammary gland adenocarcinoma. 1999 Nutrition pmid:10198915
Suresh Y and Das UN Long-chain polyunsaturated fatty acids and chemically induced diabetes mellitus. Effect of omega-3 fatty acids. 2003 Nutrition pmid:12620523
Jiang Z and Sim JS Consumption of n-3 polyunsaturated fatty acid-enriched eggs and changes in plasma lipids of human subjects. 1993 Nov-Dec Nutrition pmid:7906572
Moore CS et al. Oily fish reduces plasma triacylglycerols: a primary prevention study in overweight men and women. 2006 Nutrition pmid:17027436
Meyer BJ et al. Assessing long-chain ω-3 polyunsaturated fatty acids: a tailored food-frequency questionnaire is better. 2013 Nutrition pmid:22929186
O'Callaghan N et al. Telomere shortening in elderly individuals with mild cognitive impairment may be attenuated with ω-3 fatty acid supplementation: a randomized controlled pilot study. 2014 Nutrition pmid:24342530
Bjerve KS et al. Clinical studies with alpha-linolenic acid and long-chain n-3 fatty acids. 1992 Mar-Apr Nutrition pmid:1350473
Singer P Alpha-linolenic acid vs. long-chain n-3 fatty acids in hypertension and hyperlipidemia. 1992 Mar-Apr Nutrition pmid:1350474
Holub BJ and Celi B Relationships of alpha-linolenic acid to platelet fatty acid composition and trans content of cholesterol-free foods. 1992 Mar-Apr Nutrition pmid:1350475
Mirmiran P et al. Association between interaction and ratio of ω-3 and ω-6 polyunsaturated fatty acid and the metabolic syndrome in adults. 2012 Nutrition pmid:22459553
Garg ML and Clandinin MT Alpha-linolenic acid and metabolism of cholesterol and long-chain fatty acids. 1992 May-Jun Nutrition pmid:1356032
Boudreau MD et al. Alpha-linolenic acid and prostaglandin synthesis. 1992 May-Jun Nutrition pmid:1356033
Emken EA et al. Human metabolic studies with deuterated alpha-linolenic acid. 1992 May-Jun Nutrition pmid:1356034
Kelley DS Alpha-linolenic acid and immune response. 1992 May-Jun Nutrition pmid:1356035
Dick TA and Yang X Alpha-linolenic acid metabolism in fish. 1992 May-Jun Nutrition pmid:1356036
Sim JS et al. Alpha-linolenic acid metabolism: the chicken and the egg. 1992 May-Jun Nutrition pmid:1356037
Ibrahim A et al. Dietary α-linolenic acid-rich formula reduces adhesion molecules in rats with experimental colitis. 2012 Nutrition pmid:22261574
Kim Y and Ilich JZ Implications of dietary α-linolenic acid in bone health. 2011 Nov-Dec Nutrition pmid:21726979
Chen CY and Inui A What kind of polyunsaturated fatty acid should we eat to stay healthy? 2012 Nutrition pmid:22658641
Decsi T and Koletzko B Effects of protein-energy malnutrition and human immunodeficiency virus-1 infection on essential fatty acid metabolism in children. 2000 Nutrition pmid:10869902
Hamazaki K et al. Effects of cooking plant oils on recurrent aphthous stomatitis: a randomized, placebo-controlled, double-blind trial. 2006 Nutrition pmid:16472981
Lund AS et al. N-3 polyunsaturated fatty acids, body fat and inflammation. 2013 Obes Facts pmid:23970146
Faintuch J et al. Systemic inflammation in morbidly obese subjects: response to oral supplementation with alpha-linolenic acid. 2007 Obes Surg pmid:17546842
Djoussé L et al. Dietary linolenic acid and fasting glucose and insulin: the National Heart, Lung, and Blood Institute Family Heart Study. 2006 Obesity (Silver Spring) pmid:16571856
Perga ME et al. Are cyanobacterial blooms trophic dead ends? 2013 Oecologia pmid:23129401
Celik A et al. Enantioselective epoxidation of linolenic acid catalysed by cytochrome P450(BM3) from Bacillus megaterium. 2005 Org. Biomol. Chem. pmid:16032346
Nonaka H et al. Stereoselective synthesis of epi-jasmonic acid, tuberonic acid, and 12-oxo-PDA. 2010 Org. Biomol. Chem. pmid:20844792
Lohner S et al. [Dietary supplementation of obese children with 1000 mg alpha-linolenic acid per day: a placebo-controlled double blind study]. 2007 Orv Hetil pmid:17675277
Varga Z [Omega-3 polyunsaturated fatty acids in the prevention of atherosclerosis]. 2008 Orv Hetil pmid:18375362
Han H et al. Flaxseed Oil Containing α -Linolenic Acid Ester of Plant Sterol Improved Atherosclerosis in ApoE Deficient Mice. 2015 Oxid Med Cell Longev pmid:26180602