Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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There are no associated biomedical information in the current reference collection.
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Kastner DW and Van Wagoner DR | Diet and atrial fibrillation: does α-linolenic acid, a plant derived essential fatty acid, have an impact? | 2013 | J Am Heart Assoc | pmid:23525415 |
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Kälber T et al. | Effect of feeding buckwheat and chicory silages on fatty acid profile and cheese-making properties of milk from dairy cows. | 2013 | J. Dairy Res. | pmid:23253429 |
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Gillingham LG et al. | Dietary oils and FADS1-FADS2 genetic variants modulate [13C]α-linolenic acid metabolism and plasma fatty acid composition. | 2013 | Am. J. Clin. Nutr. | pmid:23221573 |
Liu M et al. | Characterization and biological effects of di-hydroxylated compounds deriving from the lipoxygenation of ALA. | 2013 | J. Lipid Res. | pmid:23740966 |
Gage SH et al. | Functionalization of monodisperse iron oxide NPs and their properties as magnetically recoverable catalysts. | 2013 | Langmuir | pmid:23234434 |
Lohner S et al. | Gender differences in the long-chain polyunsaturated fatty acid status: systematic review of 51 publications. | 2013 | Ann. Nutr. Metab. | pmid:23327902 |
MacIntosh BA et al. | Low-n-6 and low-n-6 plus high-n-3 diets for use in clinical research. | 2013 | Br. J. Nutr. | pmid:23328113 |
Carey AN et al. | The ability of walnut extract and fatty acids to protect against the deleterious effects of oxidative stress and inflammation in hippocampal cells. | 2013 | Nutr Neurosci | pmid:23321679 |
Hoque M et al. | Oleic acid may be the key contributor in the BAMLET-induced erythrocyte hemolysis and tumoricidal action. | 2013 | PLoS ONE | pmid:24039698 |
Moallem U et al. | Dietary α-linolenic acid from flaxseed oil improved folliculogenesis and IVF performance in dairy cows, similar to eicosapentaenoic and docosahexaenoic acids from fish oil. | 2013 | Reproduction | pmid:24062566 |
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Carotenuto F et al. | A diet supplemented with ALA-rich flaxseed prevents cardiomyocyte apoptosis by regulating caveolin-3 expression. | 2013 | Cardiovasc. Res. | pmid:24042018 |
Zhang W et al. | Alpha-linolenic acid exerts an endothelial protective effect against high glucose injury via PI3K/Akt pathway. | 2013 | PLoS ONE | pmid:23861910 |
Randall KM et al. | Effects of dietary supplementation of coriander oil, in canola oil diets, on the metabolism of [1-(14)C] 18:3n-3 and [1-(14)C] 18:2n-6 in rainbow trout hepatocytes. | 2013 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:23867781 |
Oliva ME et al. | Dietary Salba (Salvia hispanica L) seed rich in α-linolenic acid improves adipose tissue dysfunction and the altered skeletal muscle glucose and lipid metabolism in dyslipidemic insulin-resistant rats. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24120122 |
Coles L et al. | A model to predict the ATP equivalents of macronutrients absorbed from food. | 2013 | Food Funct | pmid:23233079 |
Shen JH et al. | Effect of α-linolenic acid on streptozotocin-induced diabetic retinopathy indices in vivo. | 2013 | Arch. Med. Res. | pmid:24120388 |
Végner L et al. | Experimental confirmation of new drug-target interactions predicted by Drug Profile Matching. | 2013 | J. Med. Chem. | pmid:24088053 |
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Ogata F et al. | Study on analysis of waste edible oil with deterioration and removal of acid value, carbonyl value, and free fatty acid by a food additive (calcium silicate). | 2013 | J Oleo Sci | pmid:23391535 |
Arm JP et al. | Impact of botanical oils on polyunsaturated fatty acid metabolism and leukotriene generation in mild asthmatics. | 2013 | Lipids Health Dis | pmid:24088297 |
Zhang W et al. | Alpha-linolenic acid intake prevents endothelial dysfunction in high-fat diet-fed streptozotocin rats and underlying mechanisms. | 2013 | VASA | pmid:24220118 |
Rodriguez-Leyva D et al. | Potent antihypertensive action of dietary flaxseed in hypertensive patients. | 2013 | Hypertension | pmid:24126178 |
Hoffmann I and Oliw EH | Discovery of a linoleate 9S-dioxygenase and an allene oxide synthase in a fusion protein of Fusarium oxysporum. | 2013 | J. Lipid Res. | pmid:24082064 |
Al-Bishri WM | Favorable effects of flaxseed supplemented diet on liver and kidney functions in hypertensive Wistar rats. | 2013 | J Oleo Sci | pmid:24005015 |
Alhazzaa R et al. | Bioconversion of α-linolenic acid into n-3 long-chain polyunsaturated fatty acid in hepatocytes and ad hoc cell culture optimisation. | 2013 | PLoS ONE | pmid:24040040 |
Caligiuri SP et al. | Dietary linoleic acid and α-linolenic acid differentially affect renal oxylipins and phospholipid fatty acids in diet-induced obese rats. | 2013 | J. Nutr. | pmid:23902961 |
Botsoglou E et al. | Olive leaves (Olea europea L.) and α-tocopheryl acetate as feed antioxidants for improving the oxidative stability of α-linolenic acid-enriched eggs. | 2013 | J Anim Physiol Anim Nutr (Berl) | pmid:22716021 |