| MeSH term | MeSH ID | Detail |
|---|---|---|
| Stomatitis, Aphthous | D013281 | 1 associated lipids |
| Endomyocardial Fibrosis | D004719 | 4 associated lipids |
| Conjunctivitis, Allergic | D003233 | 1 associated lipids |
| Carcinogenesis | D063646 | 3 associated lipids |
alpha-linolenic acid
Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
Cross Reference
Introduction
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with alpha-linolenic acid?
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
PubChem Associated disorders and diseases
What pathways are associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with alpha-linolenic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with alpha-linolenic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with alpha-linolenic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Pany S et al. | PKC activation by resveratrol derivatives with unsaturated aliphatic chain. | 2012 | PLoS ONE | pmid:23285216 |
| Macášek J et al. | Plasma fatty acid composition in patients with pancreatic cancer: correlations to clinical parameters. | 2012 | Nutr Cancer | pmid:23061902 |
| Vanden Heuvel JP et al. | Mechanistic examination of walnuts in prevention of breast cancer. | 2012 | Nutr Cancer | pmid:23061909 |
| Vedtofte MS et al. | The role of essential fatty acids in the control of coronary heart disease. | 2012 | Curr Opin Clin Nutr Metab Care | pmid:23037902 |
| Kim DH et al. | Gamma linolenic acid exerts anti-inflammatory and anti-fibrotic effects in diabetic nephropathy. | 2012 | Yonsei Med. J. | pmid:23074118 |
| Pan A et al. | α-Linolenic acid and risk of cardiovascular disease: a systematic review and meta-analysis. | 2012 | Am. J. Clin. Nutr. | pmid:23076616 |
| Msika O et al. | NGF blocks polyunsaturated fatty acids biosynthesis in n-3 fatty acid-supplemented PC12 cells. | 2012 | Biochim. Biophys. Acta | pmid:22564256 |
| Moodley R et al. | Elemental composition and fatty acid profile of the edible fruits of Amatungula (Carissa macrocarpa) and impact of soil quality on chemical characteristics. | 2012 | Anal. Chim. Acta | pmid:22632042 |
| Jiang M et al. | [Protective effect of ALA on high glucose induced cellular injury of LLC-PK1 cell]. | 2012 | Wei Sheng Yan Jiu | pmid:22611923 |
| Ngaki MN et al. | Evolution of the chalcone-isomerase fold from fatty-acid binding to stereospecific catalysis. | 2012 | Nature | pmid:22622584 |
| Yang Q et al. | Identification of FAD2 and FAD3 genes in Brassica napus genome and development of allele-specific markers for high oleic and low linolenic acid contents. | 2012 | Theor. Appl. Genet. | pmid:22534790 |
| von Berlepsch S et al. | The acyl-acyl carrier protein synthetase from Synechocystis sp. PCC 6803 mediates fatty acid import. | 2012 | Plant Physiol. | pmid:22535424 |
| Thomas T et al. | The effect of a 1-year multiple micronutrient or n-3 fatty acid fortified food intervention on morbidity in Indian school children. | 2012 | Eur J Clin Nutr | pmid:22009072 |
| Zhang J et al. | Alpha-linolenic acid increases cholesterol efflux in macrophage-derived foam cells by decreasing stearoyl CoA desaturase 1 expression: evidence for a farnesoid-X-receptor mechanism of action. | 2012 | J. Nutr. Biochem. | pmid:21658928 |
| Poudyal H et al. | Lipid redistribution by α-linolenic acid-rich chia seed inhibits stearoyl-CoA desaturase-1 and induces cardiac and hepatic protection in diet-induced obese rats. | 2012 | J. Nutr. Biochem. | pmid:21429727 |
| Angulo J et al. | Nutritional evaluation of fruit and vegetable waste as feedstuff for diets of lactating Holstein cows. | 2012 | J. Environ. Manage. | pmid:21784573 |
| Umesha SS and Naidu KA | Vegetable oil blends with α-linolenic acid rich Garden cress oil modulate lipid metabolism in experimental rats. | 2012 | Food Chem | pmid:22980881 |
| Gupta R and Prabhune AA | Structural determination and chemical esterification of the sophorolipids produced by Candida bombicola grown on glucose and α-linolenic acid. | 2012 | Biotechnol. Lett. | pmid:22167634 |
| Poudel-Tandukar K et al. | Relationship of serum fatty acid composition and desaturase activity to C-reactive protein in Japanese men and women. | 2012 | Atherosclerosis | pmid:22153152 |
| Zheng MM et al. | Immobilization of Candida rugosa lipase on hydrophobic/strong cation-exchange functional silica particles for biocatalytic synthesis of phytosterol esters. | 2012 | Bioresour. Technol. | pmid:22209442 |
| Chiu CC et al. | Associations between n-3 PUFA concentrations and cognitive function after recovery from late-life depression. | 2012 | Am. J. Clin. Nutr. | pmid:22218153 |
| Lemaitre RN et al. | Circulating and dietary α-linolenic acid and incidence of congestive heart failure in older adults: the Cardiovascular Health Study. | 2012 | Am. J. Clin. Nutr. | pmid:22743310 |
| Zhang L et al. | Quantitative genomics of 30 complex phenotypes in Wagyu x Angus Fâ‚ progeny. | 2012 | Int. J. Biol. Sci. | pmid:22745575 |
| Fink BD et al. | Endothelial cell and platelet bioenergetics: effect of glucose and nutrient composition. | 2012 | PLoS ONE | pmid:22745753 |
| Egert S et al. | Margarines fortified with α-linolenic acid, eicosapentaenoic acid, or docosahexaenoic acid alter the fatty acid composition of erythrocytes but do not affect the antioxidant status of healthy adults. | 2012 | J. Nutr. | pmid:22810989 |
| Pal M and Ghosh M | Studies on comparative efficacy of α-linolenic acid and α-eleostearic acid on prevention of organic mercury-induced oxidative stress in kidney and liver of rat. | 2012 | Food Chem. Toxicol. | pmid:22269903 |
| Pal M and Ghosh M | Prophylactic effect of α-linolenic acid and α-eleostearic acid against MeHg induced oxidative stress, DNA damage and structural changes in RBC membrane. | 2012 | Food Chem. Toxicol. | pmid:22683484 |
| Arsenault D et al. | Chronic dietary intake of α-linolenic acid does not replicate the effects of DHA on passive properties of entorhinal cortex neurons. | 2012 | Br. J. Nutr. | pmid:21851757 |
| Ling PR et al. | Purified fish oil eliminating linoleic and alpha linolenic acid meets essential fatty acid requirements in rats. | 2012 | Metab. Clin. Exp. | pmid:22512821 |
| Bocianowski J et al. | Determination of fatty acid composition in seed oil of rapeseed (Brassica napus L.) by mutated alleles of the FAD3 desaturase genes. | 2012 | J. Appl. Genet. | pmid:21912934 |
| Marei WF et al. | Differential effects of linoleic and alpha-linolenic fatty acids on spatial and temporal mitochondrial distribution and activity in bovine oocytes. | 2012 | Reprod. Fertil. Dev. | pmid:22697118 |
| Passos PP et al. | Dopaminergic cell populations of the rat substantia nigra are differentially affected by essential fatty acid dietary restriction over two generations. | 2012 | J. Chem. Neuroanat. | pmid:22687395 |
| Chen CY and Inui A | What kind of polyunsaturated fatty acid should we eat to stay healthy? | 2012 | Nutrition | pmid:22658641 |
| Gómez-Cortés P et al. | Production of isotopically labeled standards from a uniformly labeled precursor for quantitative volatile metabolomic studies. | 2012 | Anal. Chem. | pmid:22662968 |
| Jin F et al. | Supplementation of milled chia seeds increases plasma ALA and EPA in postmenopausal women. | 2012 | Plant Foods Hum Nutr | pmid:22538527 |
| Gerber M | Omega-3 fatty acids and cancers: a systematic update review of epidemiological studies. | 2012 | Br. J. Nutr. | pmid:22591896 |
| Tu WC et al. | An alternative n-3 fatty acid elongation pathway utilising 18:3n-3 in barramundi (Lates calcarifer). | 2012 | Biochem. Biophys. Res. Commun. | pmid:22640739 |
| Vyncke KE et al. | Dietary fatty acid intake, its food sources and determinants in European adolescents: the HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) Study. | 2012 | Br. J. Nutr. | pmid:22370331 |
| Park HG et al. | Production of a conjugated fatty acid by Bifidobacterium breve LMC520 from α-linolenic acid: conjugated linolenic acid (CLnA). | 2012 | J. Agric. Food Chem. | pmid:22372442 |
| Liu HL et al. | Identification and evaluation of ω-3 fatty acid desaturase genes for hyperfortifying α-linolenic acid in transgenic rice seed. | 2012 | J. Exp. Bot. | pmid:22378946 |
| Tu WC et al. | Barramundi (Lates calcarifer) desaturase with Δ6/Δ8 dual activities. | 2012 | Biotechnol. Lett. | pmid:22391738 |
| Caspar-Bauguil S et al. | Anorexia nervosa patients display a deficit in membrane long chain poly-unsaturated fatty acids. | 2012 | Clin Nutr | pmid:22385730 |
| Gorissen L et al. | Conjugated linoleic and linolenic acid production kinetics by bifidobacteria differ among strains. | 2012 | Int. J. Food Microbiol. | pmid:22405353 |
| Santos FS et al. | Status of cis and trans fatty acids in Brazilian adolescent mothers and their newborns. | 2012 | J Pediatr Adolesc Gynecol | pmid:22840939 |
| Harland DR et al. | Acute effects of prostaglandin E1 and E2 on vascular reactivity and blood flow in situ in the chick chorioallantoic membrane. | 2012 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22858445 |
| Hofacer R et al. | Omega-3 fatty acid deficiency increases stearoyl-CoA desaturase expression and activity indices in rat liver: positive association with non-fasting plasma triglyceride levels. | 2012 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22047910 |
| Tsuzuki W | Inconsistencies in a highly polar capillary gas chromatography column and necessity of column performance checks for trans fatty acid measurement. | 2012 Nov-Dec | J AOAC Int | pmid:23451392 |
| Kartikasari LR et al. | Dietary alpha-linolenic acid enhances omega-3 long chain polyunsaturated fatty acid levels in chicken tissues. | 2012 Oct-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22925778 |
| Zheng JS et al. | Intake of fish and marine n-3 polyunsaturated fatty acids and risk of breast cancer: meta-analysis of data from 21 independent prospective cohort studies. | 2013 | BMJ | pmid:23814120 |
| Molkentin J | Applicability of organic milk indicators to the authentication of processed products. | 2013 | Food Chem | pmid:23199986 |
| Ulas T et al. | Does α-lipoic acid treatment play a role on oxidative stress and insulin resistance in overweight/obese patients? | 2013 | Int. J. Cardiol. | pmid:23200266 |
| Zhao ML et al. | Enzymatic production of zero-trans plastic fat rich in α-linolenic acid and medium-chain fatty acids from highly hydrogenated soybean oil, Cinnamomum camphora seed oil, and perilla oil by lipozyme TL IM. | 2013 | J. Agric. Food Chem. | pmid:23350869 |
| Stamey Lanier J et al. | Mammary uptake of fatty acids supplied by intravenous triacylglycerol infusion to lactating dairy cows. | 2013 | Lipids | pmid:23504269 |
| Saubeau G et al. | Differential induction of oxylipin pathway in potato and tobacco cells by bacterial and oomycete elicitors. | 2013 | Plant Cell Rep. | pmid:23479199 |
| Nozue T et al. | Effects of statins on serum n-3 to n-6 polyunsaturated fatty acid ratios in patients with coronary artery disease. | 2013 | J. Cardiovasc. Pharmacol. Ther. | pmid:23324995 |
| Yan W et al. | Reply to manuscript IJC-D-12-04197 entitled "Does alpha-lipoic acid treatment play a role on oxidative stress and insulin resistance in overweight/obese patients?" by MD Turgay Ulas. | 2013 | Int. J. Cardiol. | pmid:23313466 |
| Yan W et al. | Effect of oral ALA supplementation on oxidative stress and insulin sensitivity among overweight/obese adults: a double-blinded, randomized, controlled, cross-over intervention trial. | 2013 | Int. J. Cardiol. | pmid:23102606 |
| Walker CG et al. | Stearidonic acid as a supplemental source of ω-3 polyunsaturated fatty acids to enhance status for improved human health. | 2013 | Nutrition | pmid:23102888 |
| Cao AH et al. | Composition of long chain polyunsaturated fatty acids (LC-PUFAs) in different encephalic regions and its association with behavior in spontaneous hypertensive rat (SHR). | 2013 | Brain Res. | pmid:23811335 |
| Moloney AP et al. | Colour of fat, and colour, fatty acid composition and sensory characteristics of muscle from heifers offered alternative forages to grass silage in a finishing ration. | 2013 | Meat Sci. | pmid:23806853 |
| Zong G et al. | Effects of flaxseed supplementation on erythrocyte fatty acids and multiple cardiometabolic biomarkers among Chinese with risk factors of metabolic syndrome. | 2013 | Eur J Nutr | pmid:23179200 |
| Lagarde M et al. | Lipidomics of essential fatty acids and oxygenated metabolites. | 2013 | Mol Nutr Food Res | pmid:23818385 |
| Perga ME et al. | Are cyanobacterial blooms trophic dead ends? | 2013 | Oecologia | pmid:23129401 |
| Van Ba H et al. | Significant influence of particular unsaturated fatty acids and pH on the volatile compounds in meat-like model systems. | 2013 | Meat Sci. | pmid:23632107 |
| Cedernaes J et al. | Adipose tissue stearoyl-CoA desaturase 1 index is increased and linoleic acid is decreased in obesity-prone rats fed a high-fat diet. | 2013 | Lipids Health Dis | pmid:23298201 |
| Fretts AM et al. | Associations of plasma phospholipid and dietary alpha linolenic acid with incident atrial fibrillation in older adults: the Cardiovascular Health Study. | 2013 | J Am Heart Assoc | pmid:23525429 |
| Kälber T et al. | Effect of feeding buckwheat and chicory silages on fatty acid profile and cheese-making properties of milk from dairy cows. | 2013 | J. Dairy Res. | pmid:23253429 |
| Monteiro J et al. | Oils rich in α-linolenic acid independently protect against characteristics of fatty liver disease in the Δ6-desaturase null mouse. | 2013 | Can. J. Physiol. Pharmacol. | pmid:23746194 |
| Gillingham LG et al. | Dietary oils and FADS1-FADS2 genetic variants modulate [13C]α-linolenic acid metabolism and plasma fatty acid composition. | 2013 | Am. J. Clin. Nutr. | pmid:23221573 |
| Liu M et al. | Characterization and biological effects of di-hydroxylated compounds deriving from the lipoxygenation of ALA. | 2013 | J. Lipid Res. | pmid:23740966 |
| Kim Y et al. | Synergism of α-linolenic acid, conjugated linoleic acid and calcium in decreasing adipocyte and increasing osteoblast cell growth. | 2013 | Lipids | pmid:23757205 |
| Lai YH et al. | Association of dietary omega-3 fatty acids with prevalence of metabolic syndrome: the National Heart, Lung, and Blood Institute Family Heart Study. | 2013 | Clin Nutr | pmid:23711994 |
| Gage SH et al. | Functionalization of monodisperse iron oxide NPs and their properties as magnetically recoverable catalysts. | 2013 | Langmuir | pmid:23234434 |
| Sun L et al. | The neuroprotective effects of Coccomyxa gloeobotrydiformis on the ischemic stroke in a rat model. | 2013 | Int. J. Biol. Sci. | pmid:23983614 |
| Kwon TY et al. | Headspace-solid phase microextraction-gas chromatography-tandem mass spectrometry (HS-SPME-GC-MS2) method for the determination of pyrazines in perilla seed oils: impact of roasting on the pyrazines in perilla seed oils. | 2013 | J. Agric. Food Chem. | pmid:23968142 |
| Lund AS et al. | N-3 polyunsaturated fatty acids, body fat and inflammation. | 2013 | Obes Facts | pmid:23970146 |
| Lagunas B et al. | A temporal regulatory mechanism controls the different contribution of endoplasmic reticulum and plastidial ω-3 desaturases to trienoic fatty acid content during leaf development in soybean (Glycine max cv Volania). | 2013 | Phytochemistry | pmid:23928132 |
| Yu X et al. | α-Linolenic acid attenuates doxorubicin-induced cardiotoxicity in rats through suppression of oxidative stress and apoptosis. | 2013 | Acta Biochim. Biophys. Sin. (Shanghai) | pmid:23896563 |
| Egusa Saiga A and Nishimura T | Antioxidative properties of peptides obtained from porcine myofibrillar proteins by a protease treatment in an Fe (II)-induced aqueous lipid peroxidation system. | 2013 | Biosci. Biotechnol. Biochem. | pmid:24200778 |
| Grindel A et al. | Cheek cell fatty acids reflect n-3 PUFA in blood fractions during linseed oil supplementation: a controlled human intervention study. | 2013 | Lipids Health Dis | pmid:24229084 |
| Carey AN et al. | The ability of walnut extract and fatty acids to protect against the deleterious effects of oxidative stress and inflammation in hippocampal cells. | 2013 | Nutr Neurosci | pmid:23321679 |
| Coles L et al. | A model to predict the ATP equivalents of macronutrients absorbed from food. | 2013 | Food Funct | pmid:23233079 |
| Végner L et al. | Experimental confirmation of new drug-target interactions predicted by Drug Profile Matching. | 2013 | J. Med. Chem. | pmid:24088053 |
| Yang Z and Huffman SL | Modelling linoleic acid and α-linolenic acid requirements for infants and young children in developing countries. | 2013 | Matern Child Nutr | pmid:23167585 |
| Khaw KT | Dietary fats and breast cancer risk. | 2013 | BMJ | pmid:23861431 |
| Katrangi W et al. | Interactions of linoleic and alpha-linolenic acids in the development of fatty acid alterations in cystic fibrosis. | 2013 | Lipids | pmid:23440519 |
| Tu WC et al. | Correlations between blood and tissue omega-3 LCPUFA status following dietary ALA intervention in rats. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22521090 |
| Yi LT et al. | Essential oil of Perilla frutescens-induced change in hippocampal expression of brain-derived neurotrophic factor in chronic unpredictable mild stress in mice. | 2013 | J Ethnopharmacol | pmid:23506995 |
| Gao F et al. | Aging decreases rate of docosahexaenoic acid synthesis-secretion from circulating unesterified α-linolenic acid by rat liver. | 2013 | Age (Dordr) | pmid:22388930 |
| Meijerink J et al. | N-Acyl amines of docosahexaenoic acid and other n-3 polyunsatured fatty acids - from fishy endocannabinoids to potential leads. | 2013 | Br. J. Pharmacol. | pmid:23088259 |
| Chechetkin IR et al. | Isolation and structure elucidation of linolipins C and D, complex oxylipins from flax leaves. | 2013 | Phytochemistry | pmid:24042063 |
| Niculescu MD et al. | Perinatal manipulation of α-linolenic acid intake induces epigenetic changes in maternal and offspring livers. | 2013 | FASEB J. | pmid:22997227 |
| Botsoglou E et al. | Olive leaves (Olea europea L.) and α-tocopheryl acetate as feed antioxidants for improving the oxidative stability of α-linolenic acid-enriched eggs. | 2013 | J Anim Physiol Anim Nutr (Berl) | pmid:22716021 |
| Smink W et al. | Effect of intake of linoleic acid and α-linolenic acid levels on conversion into long-chain polyunsaturated fatty acids in backfat and in intramuscular fat of growing pigs. | 2013 | J Anim Physiol Anim Nutr (Berl) | pmid:22463497 |
| Delplanque B et al. | A dairy fat matrix providing alpha-linolenic acid (ALA) is better than a vegetable fat mixture to increase brain DHA accretion in young rats. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22884780 |
| Gladine C et al. | Optimized rapeseed oil enriched with healthy micronutrients: a relevant nutritional approach to prevent cardiovascular diseases. Results of the Optim'Oils randomized intervention trial. | 2013 | J. Nutr. Biochem. | pmid:22784432 |
| Turk HF et al. | Inhibitory effects of omega-3 fatty acids on injury-induced epidermal growth factor receptor transactivation contribute to delayed wound healing. | 2013 | Am. J. Physiol., Cell Physiol. | pmid:23426968 |
| Rahman H et al. | Development of low-linolenic acid Brassica oleracea lines through seed mutagenesis and molecular characterization of mutants. | 2013 | Theor. Appl. Genet. | pmid:23475317 |
| Wei M et al. | Perilla oil and exercise decrease expressions of tumor necrosis factor-alpha, plasminogen activator inhibitor-1 and highly sensitive C-reactive protein in patients with hyperlipidemia. | 2013 | J Tradit Chin Med | pmid:23789212 |
| Esselburn KM et al. | Intake of specific fatty acids and fat alters growth, health, and titers following vaccination in dairy calves. | 2013 | J. Dairy Sci. | pmid:23810586 |