alpha-linolenic acid

Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.

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Introduction

To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with alpha-linolenic acid?

alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid

MeSH term MeSH ID Detail
Urinary Bladder Neoplasms D001749 7 associated lipids
Body Weight D001835 333 associated lipids
Breast Neoplasms D001943 24 associated lipids
Bronchial Spasm D001986 18 associated lipids
Cat Diseases D002371 12 associated lipids
Cattle Diseases D002418 24 associated lipids
Brain Ischemia D002545 89 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Conjunctivitis, Allergic D003233 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with alpha-linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with alpha-linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with alpha-linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with alpha-linolenic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with alpha-linolenic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with alpha-linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with alpha-linolenic acid

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Authors Title Published Journal PubMed Link
Guo Q et al. Highly sensitive method for the quantification of trans-linolenic acid isomers in trilinolenin of edible oils using an ionic liquid capillary column. 2017 J. Sci. Food Agric. pmid:28369919
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Yadav S et al. Comparative efficacy of alpha-linolenic acid and gamma-linolenic acid to attenuate valproic acid-induced autism-like features. 2017 J. Physiol. Biochem. pmid:27878518
Mao Y et al. Chemical Composition Analysis, Sensory, and Feasibility Study of Tree Peony Seed. 2017 J. Food Sci. pmid:28135396
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Zheng JS et al. Genetic Risk Score of Nine Type 2 Diabetes Risk Variants that Interact with Erythrocyte Phospholipid Alpha-Linolenic Acid for Type 2 Diabetes in Chinese Hans: A Case-Control Study. 2017 Nutrients pmid:28398239
Lodolini EM et al. Oil Characteristics of Four Palestinian Olive Varieties. 2017 J Oleo Sci pmid:28381771
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Marmon S et al. Two Acyltransferases Contribute Differently to Linolenic Acid Levels in Seed Oil. 2017 Plant Physiol. pmid:28235891
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Du H et al. Extraction and the Fatty Acid Profile of Rosa acicularis Seed Oil. 2017 J Oleo Sci pmid:29129896
Park H et al. Towards the development of a sustainable soya bean-based feedstock for aquaculture. 2017 Plant Biotechnol. J. pmid:27496594
Wang XH et al. High Fat Diet-Induced Hepatic 18-Carbon Fatty Acids Accumulation Up-Regulates CYP2A5/CYP2A6 via NF-E2-Related Factor 2. 2017 Front Pharmacol pmid:28555106
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Leroy C et al. Fatty acid-binding protein3 expression in BeWo cells, a human placental choriocarcinoma cell line. 2017 Prostaglandins Leukot. Essent. Fatty Acids pmid:28515017
Li T et al. Defense priming by non-jasmonate producing fatty acids in maize (Zea mays). 2016 Plant Signal Behav pmid:27763804
Yamanaka N et al. Alpha-Linolenic Acid-Enriched Diacylglycerol Oil Suppresses the Postprandial Serum Triglyceride Level-A Randomized, Double-Blind, Placebo-Controlled, Crossover Study. 2016 J. Nutr. Sci. Vitaminol. pmid:28202845
Kjær MA et al. Regulation of the Omega-3 Fatty Acid Biosynthetic Pathway in Atlantic Salmon Hepatocytes. 2016 PLoS ONE pmid:27973547
Cao X et al. Transcriptional Responses and Gentiopicroside Biosynthesis in Methyl Jasmonate-Treated Gentiana macrophylla Seedlings. 2016 PLoS ONE pmid:27851826
Wolters M et al. Associations of Whole Blood n-3 and n-6 Polyunsaturated Fatty Acids with Blood Pressure in Children and Adolescents - Results from the IDEFICS/I.Family Cohort. 2016 PLoS ONE pmid:27806134
Demorest ZL et al. Direct stacking of sequence-specific nuclease-induced mutations to produce high oleic and low linolenic soybean oil. 2016 BMC Plant Biol. pmid:27733139
Li XZ et al. Dietary linseed oil with or without malate increases conjugated linoleic acid and oleic acid in milk fat and and gene expression in mammary gland and milk somatic cells of lactating goats. 2016 J. Anim. Sci. pmid:27695785
Lee Y et al. Alpha-linolenic acid treatment during oocyte maturation enhances embryonic development by influencing mitogen-activated protein kinase activity and intraoocyte glutathione content in pigs. 2016 J. Anim. Sci. pmid:27695771
Bork CS et al. Dietary intake and adipose tissue content of α-linolenic acid and risk of myocardial infarction: a Danish cohort study. 2016 Am. J. Clin. Nutr. pmid:27169831
Esquivel-Hernández DA et al. Supercritical Carbon Dioxide and Microwave-Assisted Extraction of Functional Lipophilic Compounds from Arthrospira platensis. 2016 Int J Mol Sci pmid:27164081
Campidonico L et al. Fatty acid composition of ruminal digesta and longissimus muscle from lambs fed silage mixtures including red clover, sainfoin, and timothy. 2016 J. Anim. Sci. pmid:27136014
Bourourou M et al. Alpha-linolenic acid given as enteral or parenteral nutritional intervention against sensorimotor and cognitive deficits in a mouse model of ischemic stroke. 2016 Neuropharmacology pmid:27133376
Tian Y et al. Perilla Oil Has Similar Protective Effects of Fish Oil on High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease and Gut Dysbiosis. 2016 Biomed Res Int pmid:27051672
Duscharla D et al. Prostate Cancer Associated Lipid Signatures in Serum Studied by ESI-Tandem Mass Spectrometryas Potential New Biomarkers. 2016 PLoS ONE pmid:26958841
Jablonická V et al. Identification of a secretory phospholipase A2 from Papaver somniferum L. that transforms membrane phospholipids. 2016 Phytochemistry pmid:27473012
Minihane AM Impact of Genotype on EPA and DHA Status and Responsiveness to Increased Intakes. 2016 Nutrients pmid:26950146
Carotenuto F et al. Dietary Flaxseed Mitigates Impaired Skeletal Muscle Regeneration: in Vivo, in Vitro and in Silico Studies. 2016 Int J Med Sci pmid:26941581
Dote S et al. Effects of Triacylglycerol Molecular Species on the Oxidation Behavior of Oils Containing α-Linolenic Acid. 2016 J Oleo Sci pmid:26935948
Heskey CE et al. Adipose tissue α-linolenic acid is inversely associated with insulin resistance in adults. 2016 Am. J. Clin. Nutr. pmid:26912497
Zhao N et al. α-Linolenic acid increases the G0/G1 switch gene 2 mRNA expression in peripheral blood mononuclear cells from obese patients: a pilot study. 2016 Lipids Health Dis pmid:26912161
Taha AY et al. Threshold changes in rat brain docosahexaenoic acid incorporation and concentration following graded reductions in dietary alpha-linolenic acid. 2016 Prostaglandins Leukot. Essent. Fatty Acids pmid:26869088
Moriyama R et al. Long-chain unsaturated fatty acids reduce the transcriptional activity of the rat follicle-stimulating hormone β-subunit gene. 2016 J. Reprod. Dev. pmid:26853521
Deng Q et al. Single frequency intake of α-linolenic acid rich phytosterol esters attenuates atherosclerosis risk factors in hamsters fed a high fat diet. 2016 Lipids Health Dis pmid:26843021
Garsetti M et al. Fat composition of vegetable oil spreads and margarines in the USA in 2013: a national marketplace analysis. 2016 Int J Food Sci Nutr pmid:27046021
Wang JJ et al. Two ω-3 FADs Are Associated with Peach Fruit Volatile Formation. 2016 Int J Mol Sci pmid:27043529