alpha-linolenic acid

Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.

Cross Reference

Introduction

To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with alpha-linolenic acid?

alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid

MeSH term MeSH ID Detail
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Aging, Premature D019588 1 associated lipids
Depression, Postpartum D019052 3 associated lipids
Carcinoma, Ductal, Breast D018270 19 associated lipids
Community-Acquired Infections D017714 8 associated lipids
Tachycardia, Ventricular D017180 9 associated lipids
Malaria, Falciparum D016778 22 associated lipids
Death, Sudden, Cardiac D016757 12 associated lipids
Torsades de Pointes D016171 2 associated lipids
Weight Gain D015430 101 associated lipids
Per page 10 20 50 100 | Total 104

PubChem Associated disorders and diseases

What pathways are associated with alpha-linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with alpha-linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with alpha-linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with alpha-linolenic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with alpha-linolenic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with alpha-linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with alpha-linolenic acid

Download all related citations
Per page 10 20 50 100 | Total 2471
Authors Title Published Journal PubMed Link
Ivan M et al. Rumen fermentation and microbial population in lactating dairy cows receiving diets containing oilseeds rich in C-18 fatty acids. 2013 Br. J. Nutr. pmid:22850225
Zhao ML et al. Enzymatic production of zero-trans plastic fat rich in α-linolenic acid and medium-chain fatty acids from highly hydrogenated soybean oil, Cinnamomum camphora seed oil, and perilla oil by lipozyme TL IM. 2013 J. Agric. Food Chem. pmid:23350869
Nozue T et al. Effects of statins on serum n-3 to n-6 polyunsaturated fatty acid ratios in patients with coronary artery disease. 2013 J. Cardiovasc. Pharmacol. Ther. pmid:23324995
Yan W et al. Reply to manuscript IJC-D-12-04197 entitled "Does alpha-lipoic acid treatment play a role on oxidative stress and insulin resistance in overweight/obese patients?" by MD Turgay Ulas. 2013 Int. J. Cardiol. pmid:23313466
Yan W et al. Effect of oral ALA supplementation on oxidative stress and insulin sensitivity among overweight/obese adults: a double-blinded, randomized, controlled, cross-over intervention trial. 2013 Int. J. Cardiol. pmid:23102606
Walker CG et al. Stearidonic acid as a supplemental source of ω-3 polyunsaturated fatty acids to enhance status for improved human health. 2013 Nutrition pmid:23102888
Kim Y et al. Synergism of α-linolenic acid, conjugated linoleic acid and calcium in decreasing adipocyte and increasing osteoblast cell growth. 2013 Lipids pmid:23757205
Lai YH et al. Association of dietary omega-3 fatty acids with prevalence of metabolic syndrome: the National Heart, Lung, and Blood Institute Family Heart Study. 2013 Clin Nutr pmid:23711994
Sun L et al. The neuroprotective effects of Coccomyxa gloeobotrydiformis on the ischemic stroke in a rat model. 2013 Int. J. Biol. Sci. pmid:23983614
Kwon TY et al. Headspace-solid phase microextraction-gas chromatography-tandem mass spectrometry (HS-SPME-GC-MS2) method for the determination of pyrazines in perilla seed oils: impact of roasting on the pyrazines in perilla seed oils. 2013 J. Agric. Food Chem. pmid:23968142
Lund AS et al. N-3 polyunsaturated fatty acids, body fat and inflammation. 2013 Obes Facts pmid:23970146
Lagunas B et al. A temporal regulatory mechanism controls the different contribution of endoplasmic reticulum and plastidial ω-3 desaturases to trienoic fatty acid content during leaf development in soybean (Glycine max cv Volania). 2013 Phytochemistry pmid:23928132
Coles L et al. A model to predict the ATP equivalents of macronutrients absorbed from food. 2013 Food Funct pmid:23233079
Yang Z and Huffman SL Modelling linoleic acid and α-linolenic acid requirements for infants and young children in developing countries. 2013 Matern Child Nutr pmid:23167585
Khaw KT Dietary fats and breast cancer risk. 2013 BMJ pmid:23861431
Ghisolfi J et al. Nutrient intakes of children aged 1-2 years as a function of milk consumption, cows' milk or growing-up milk. 2013 Public Health Nutr pmid:23098567
Katrangi W et al. Interactions of linoleic and alpha-linolenic acids in the development of fatty acid alterations in cystic fibrosis. 2013 Lipids pmid:23440519
Yi LT et al. Essential oil of Perilla frutescens-induced change in hippocampal expression of brain-derived neurotrophic factor in chronic unpredictable mild stress in mice. 2013 J Ethnopharmacol pmid:23506995
Gao F et al. Aging decreases rate of docosahexaenoic acid synthesis-secretion from circulating unesterified α-linolenic acid by rat liver. 2013 Age (Dordr) pmid:22388930
Kiernan M et al. The effect of the in vitro supplementation of exogenous long-chain fatty acids on bovine sperm cell function. 2013 Reprod. Fertil. Dev. pmid:23036717
Delplanque B et al. A dairy fat matrix providing alpha-linolenic acid (ALA) is better than a vegetable fat mixture to increase brain DHA accretion in young rats. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22884780
Gladine C et al. Optimized rapeseed oil enriched with healthy micronutrients: a relevant nutritional approach to prevent cardiovascular diseases. Results of the Optim'Oils randomized intervention trial. 2013 J. Nutr. Biochem. pmid:22784432
Turk HF et al. Inhibitory effects of omega-3 fatty acids on injury-induced epidermal growth factor receptor transactivation contribute to delayed wound healing. 2013 Am. J. Physiol., Cell Physiol. pmid:23426968
Kartikasari LR et al. Dietary alpha-linolenic acid enhances omega-3 long chain polyunsaturated fatty acid levels in chicken tissues. 2012 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:22925778
Tsuzuki W Inconsistencies in a highly polar capillary gas chromatography column and necessity of column performance checks for trans fatty acid measurement. 2012 Nov-Dec J AOAC Int pmid:23451392
Hofacer R et al. Omega-3 fatty acid deficiency increases stearoyl-CoA desaturase expression and activity indices in rat liver: positive association with non-fasting plasma triglyceride levels. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22047910
Harland DR et al. Acute effects of prostaglandin E1 and E2 on vascular reactivity and blood flow in situ in the chick chorioallantoic membrane. 2012 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:22858445
Pany S et al. PKC activation by resveratrol derivatives with unsaturated aliphatic chain. 2012 PLoS ONE pmid:23285216
Botsoglou E et al. Effect of supplementation of the laying hen diet with olive leaves (Olea europea L.) on lipid oxidation and fatty acid profile of α-linolenic acid enriched eggs during storage. 2012 Br. Poult. Sci. pmid:23130586
Zhao T et al. Impact of roasting on the chemical composition and oxidative stability of perilla oil. 2012 J. Food Sci. pmid:23140339
Wang Z et al. De novo characterization of the banana root transcriptome and analysis of gene expression under Fusarium oxysporum f. sp. Cubense tropical race 4 infection. 2012 BMC Genomics pmid:23170772
Astiz M et al. Exogenous arachidonate restores the dimethoate-induced inhibition of steroidogenesis in rat interstitial cells. 2012 Lipids pmid:22476691
Macášek J et al. Plasma fatty acid composition in patients with pancreatic cancer: correlations to clinical parameters. 2012 Nutr Cancer pmid:23061902
Vanden Heuvel JP et al. Mechanistic examination of walnuts in prevention of breast cancer. 2012 Nutr Cancer pmid:23061909
Vedtofte MS et al. The role of essential fatty acids in the control of coronary heart disease. 2012 Curr Opin Clin Nutr Metab Care pmid:23037902
Kim DH et al. Gamma linolenic acid exerts anti-inflammatory and anti-fibrotic effects in diabetic nephropathy. 2012 Yonsei Med. J. pmid:23074118
Pan A et al. α-Linolenic acid and risk of cardiovascular disease: a systematic review and meta-analysis. 2012 Am. J. Clin. Nutr. pmid:23076616
Hennessy AA et al. The production of conjugated α-linolenic, γ-linolenic and stearidonic acids by strains of bifidobacteria and propionibacteria. 2012 Lipids pmid:22160449
Msika O et al. NGF blocks polyunsaturated fatty acids biosynthesis in n-3 fatty acid-supplemented PC12 cells. 2012 Biochim. Biophys. Acta pmid:22564256
Moodley R et al. Elemental composition and fatty acid profile of the edible fruits of Amatungula (Carissa macrocarpa) and impact of soil quality on chemical characteristics. 2012 Anal. Chim. Acta pmid:22632042
Lakshmanan V et al. Metabolomic analysis of patient plasma yields evidence of plant-like α-linolenic acid metabolism in Plasmodium falciparum. 2012 J. Infect. Dis. pmid:22566569
Shimpukade B et al. Discovery of a potent and selective GPR120 agonist. 2012 J. Med. Chem. pmid:22519963
Shinohara N et al. Jacaric acid, a linolenic acid isomer with a conjugated triene system, has a strong antitumor effect in vitro and in vivo. 2012 Biochim. Biophys. Acta pmid:22521763
Valentine CJ Maternal dietary DHA supplementation to improve inflammatory outcomes in the preterm infant. 2012 Adv Nutr pmid:22585914
González-Mañán D et al. Bioconversion of α-linolenic acid to n-3 LCPUFA and expression of PPAR-alpha, acyl Coenzyme A oxidase 1 and carnitine acyl transferase I are incremented after feeding rats with α-linolenic acid-rich oils. 2012 Food Funct pmid:22588205
Vecchio AJ et al. Investigating substrate promiscuity in cyclooxygenase-2: the role of Arg-120 and residues lining the hydrophobic groove. 2012 J. Biol. Chem. pmid:22637474
Jiang M et al. [Protective effect of ALA on high glucose induced cellular injury of LLC-PK1 cell]. 2012 Wei Sheng Yan Jiu pmid:22611923
Ngaki MN et al. Evolution of the chalcone-isomerase fold from fatty-acid binding to stereospecific catalysis. 2012 Nature pmid:22622584
Yang Q et al. Identification of FAD2 and FAD3 genes in Brassica napus genome and development of allele-specific markers for high oleic and low linolenic acid contents. 2012 Theor. Appl. Genet. pmid:22534790
von Berlepsch S et al. The acyl-acyl carrier protein synthetase from Synechocystis sp. PCC 6803 mediates fatty acid import. 2012 Plant Physiol. pmid:22535424
Tyagi A et al. Attenuation of colonic inflammation by partial replacement of dietary linoleic acid with α-linolenic acid in a rat model of inflammatory bowel disease. 2012 Br. J. Nutr. pmid:22243775
Thomas T et al. The effect of a 1-year multiple micronutrient or n-3 fatty acid fortified food intervention on morbidity in Indian school children. 2012 Eur J Clin Nutr pmid:22009072
Alessandri JM et al. Influence of gender on DHA synthesis: the response of rat liver to low dietary α-linolenic acid evidences higher ω3 ∆4-desaturation index in females. 2012 Eur J Nutr pmid:21647669
Raatz SK et al. Total dietary fat and fatty acid content modifies plasma phospholipid fatty acids, desaturase activity indices, and urinary prostaglandin E in women. 2012 Nutr Res pmid:22260857
Zhang J et al. Alpha-linolenic acid increases cholesterol efflux in macrophage-derived foam cells by decreasing stearoyl CoA desaturase 1 expression: evidence for a farnesoid-X-receptor mechanism of action. 2012 J. Nutr. Biochem. pmid:21658928
Poudyal H et al. Lipid redistribution by α-linolenic acid-rich chia seed inhibits stearoyl-CoA desaturase-1 and induces cardiac and hepatic protection in diet-induced obese rats. 2012 J. Nutr. Biochem. pmid:21429727
Regensburger J et al. Fatty acids and vitamins generate singlet oxygen under UVB irradiation. 2012 Exp. Dermatol. pmid:22229443
Gaquerel E et al. Nicotiana attenuata α-DIOXYGENASE1 through its production of 2-hydroxylinolenic acid is required for intact plant defense expression against attack from Manduca sexta larvae. 2012 New Phytol. pmid:22937952
Padilla MN et al. Molecular cloning, functional characterization and transcriptional regulation of a 9-lipoxygenase gene from olive. 2012 Phytochemistry pmid:22169502
Lerch S et al. Rapeseed or linseed in grass-based diets: effects on conjugated linoleic and conjugated linolenic acid isomers in milk fat from Holstein cows over 2 consecutive lactations. 2012 J. Dairy Sci. pmid:22999291
Levitan EB et al. α-Linolenic acid, linoleic acid and heart failure in women. 2012 Br. J. Nutr. pmid:22172525
Wilk JB et al. Plasma and dietary omega-3 fatty acids, fish intake, and heart failure risk in the Physicians' Health Study. 2012 Am. J. Clin. Nutr. pmid:22952185
Moallem U et al. Transfer rate of α-linolenic acid from abomasally infused flaxseed oil into milk fat and the effects on milk fatty acid composition in dairy cows. 2012 J. Dairy Sci. pmid:22916932
Yang G et al. Duodenal infusion of α-linolenic acid affects fatty acid metabolism in the mammary gland of lactating dairy cows. 2012 J. Dairy Sci. pmid:22921622
Umesha SS and Naidu KA Vegetable oil blends with α-linolenic acid rich Garden cress oil modulate lipid metabolism in experimental rats. 2012 Food Chem pmid:22980881
Gupta R and Prabhune AA Structural determination and chemical esterification of the sophorolipids produced by Candida bombicola grown on glucose and α-linolenic acid. 2012 Biotechnol. Lett. pmid:22167634
Poudel-Tandukar K et al. Relationship of serum fatty acid composition and desaturase activity to C-reactive protein in Japanese men and women. 2012 Atherosclerosis pmid:22153152
Zheng MM et al. Immobilization of Candida rugosa lipase on hydrophobic/strong cation-exchange functional silica particles for biocatalytic synthesis of phytosterol esters. 2012 Bioresour. Technol. pmid:22209442
Ogawa N et al. Intestinal fatty acid infusion modulates food preference as well as calorie intake via the vagal nerve and midbrain-hypothalamic neural pathways in rats. 2012 Metab. Clin. Exp. pmid:22445513
Chiu CC et al. Associations between n-3 PUFA concentrations and cognitive function after recovery from late-life depression. 2012 Am. J. Clin. Nutr. pmid:22218153
Lemaitre RN et al. Circulating and dietary α-linolenic acid and incidence of congestive heart failure in older adults: the Cardiovascular Health Study. 2012 Am. J. Clin. Nutr. pmid:22743310
Zhang L et al. Quantitative genomics of 30 complex phenotypes in Wagyu x Angus F₁ progeny. 2012 Int. J. Biol. Sci. pmid:22745575
Kuhns EH et al. A lepidopteran aminoacylase (L-ACY-1) in Heliothis virescens (Lepidoptera: Noctuidae) gut lumen hydrolyzes fatty acid-amino acid conjugates, elicitors of plant defense. 2012 Insect Biochem. Mol. Biol. pmid:22056272
Mitra K et al. Studies of reaction variables for lipase-catalyzed production of alpha-linolenic acid enriched structured lipid and oxidative stability with antioxidants. 2012 J. Food Sci. pmid:22122200
Couëdelo L et al. The fraction of α-linolenic acid present in the sn-2 position of structured triacylglycerols decreases in lymph chylomicrons and plasma triacylglycerols during the course of lipid absorption in rats. 2012 J. Nutr. pmid:22131546
Nwaru BI et al. Maternal intake of fatty acids during pregnancy and allergies in the offspring. 2012 Br. J. Nutr. pmid:22067943
Pal M and Ghosh M Studies on comparative efficacy of α-linolenic acid and α-eleostearic acid on prevention of organic mercury-induced oxidative stress in kidney and liver of rat. 2012 Food Chem. Toxicol. pmid:22269903
Pal M and Ghosh M Prophylactic effect of α-linolenic acid and α-eleostearic acid against MeHg induced oxidative stress, DNA damage and structural changes in RBC membrane. 2012 Food Chem. Toxicol. pmid:22683484
Kowalska A et al. Impact of diets with different proportions of linseed and sunflower oils on the growth, liver histology, immunological and chemical blood parameters, and proximate composition of pikeperch Sander lucioperca (L.). 2012 Fish Physiol. Biochem. pmid:21656178
Arsenault D et al. Chronic dietary intake of α-linolenic acid does not replicate the effects of DHA on passive properties of entorhinal cortex neurons. 2012 Br. J. Nutr. pmid:21851757
Ling PR et al. Purified fish oil eliminating linoleic and alpha linolenic acid meets essential fatty acid requirements in rats. 2012 Metab. Clin. Exp. pmid:22512821
Zhang LH et al. [Effects of alpha-linolenic acid on inflammation and oxidative stress in the diabetic rats]. 2012 Zhongguo Ying Yong Sheng Li Xue Za Zhi pmid:22493899
Smink W et al. Linoleic and α-linolenic acid as precursor and inhibitor for the synthesis of long-chain polyunsaturated fatty acids in liver and brain of growing pigs. 2012 Animal pmid:22436184
Luo ZM et al. A new norisoprenoid and other compounds from Fuzhuan brick tea. 2012 Molecules pmid:22430120
Baars T et al. Experimental improvement of cow milk fatty acid composition in organic winter diets. 2012 J. Sci. Food Agric. pmid:22173628
Ibrahim A et al. Dietary α-linolenic acid-rich formula reduces adhesion molecules in rats with experimental colitis. 2012 Nutrition pmid:22261574
Zhang H et al. A mechanism underlying the effects of polyunsaturated fatty acids on breast cancer. 2012 Int. J. Mol. Med. pmid:22692672
Kronberg SL et al. Treatment of flaxseed to reduce biohydrogenation of α-linolenic acid by ruminal microbes in sheep and cattle, and increase n-3 fatty acid concentrations in red meat. 2012 J. Anim. Sci. pmid:22696616
Turchini GM et al. Jumping on the omega-3 bandwagon: distinguishing the role of long-chain and short-chain omega-3 fatty acids. 2012 Crit Rev Food Sci Nutr pmid:22698270
Passos PP et al. Dopaminergic cell populations of the rat substantia nigra are differentially affected by essential fatty acid dietary restriction over two generations. 2012 J. Chem. Neuroanat. pmid:22687395
Botsoglou E et al. Lipid and protein oxidation of α-linolenic acid-enriched pork during refrigerated storage as influenced by diet supplementation with olive leaves (Olea europea L.) or α-tocopheryl acetate. 2012 Meat Sci. pmid:22710099
Erdinest N et al. Anti-inflammatory effects of alpha linolenic acid on human corneal epithelial cells. 2012 Invest. Ophthalmol. Vis. Sci. pmid:22669722
Chen CY and Inui A What kind of polyunsaturated fatty acid should we eat to stay healthy? 2012 Nutrition pmid:22658641
Gómez-Cortés P et al. Production of isotopically labeled standards from a uniformly labeled precursor for quantitative volatile metabolomic studies. 2012 Anal. Chem. pmid:22662968
Jin F et al. Supplementation of milled chia seeds increases plasma ALA and EPA in postmenopausal women. 2012 Plant Foods Hum Nutr pmid:22538527
Gerber M Omega-3 fatty acids and cancers: a systematic update review of epidemiological studies. 2012 Br. J. Nutr. pmid:22591896
Tu WC et al. An alternative n-3 fatty acid elongation pathway utilising 18:3n-3 in barramundi (Lates calcarifer). 2012 Biochem. Biophys. Res. Commun. pmid:22640739
Vyncke KE et al. Dietary fatty acid intake, its food sources and determinants in European adolescents: the HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) Study. 2012 Br. J. Nutr. pmid:22370331
Park HG et al. Production of a conjugated fatty acid by Bifidobacterium breve LMC520 from α-linolenic acid: conjugated linolenic acid (CLnA). 2012 J. Agric. Food Chem. pmid:22372442
Liu HL et al. Identification and evaluation of ω-3 fatty acid desaturase genes for hyperfortifying α-linolenic acid in transgenic rice seed. 2012 J. Exp. Bot. pmid:22378946