Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Crastes de Paulet A et al. | [Biological effects on premature neonates of a milk formula enriched with alpha-linolenic acid: a multicenter study]. | 1994 | Bull. Acad. Natl. Med. | pmid:7913655 |
Makrides M et al. | Fatty acid composition of brain, retina, and erythrocytes in breast- and formula-fed infants. | 1994 | Am. J. Clin. Nutr. | pmid:7913291 |
Yang X and Dick TA | Dietary alpha-linolenic and linoleic acids competitively affect metabolism of polyunsaturated fatty acids in Arctic charr (Salvelinus alpinus). | 1994 | J. Nutr. | pmid:7913126 |
Lapenna D et al. | Hypochlorous acid-induced zinc release from thiolate bonds: a potential protective mechanism towards biomolecules oxidant damage during inflammation. | 1994 | Free Radic. Res. | pmid:7912612 |
Caffieri S et al. | Psoralen-fatty acid cycloadducts activate protein kinase C (PKC) in human platelets. | 1994 | J. Photochem. Photobiol. B, Biol. | pmid:7912265 |
Chen Q and Nilsson A | Interconversion of alpha-linolenic acid in rat intestinal mucosa: studies in vivo and in isolated villus and crypt cells. | 1994 | J. Lipid Res. | pmid:7911819 |
Yehuda S et al. | Essential fatty acid preparation (SR-3) raises the seizure threshold in rats. | 1994 | Eur. J. Pharmacol. | pmid:7911428 |
de Lorgeril M et al. | Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease. | 1994 | Lancet | pmid:7911176 |
McKeigue P | Diets for secondary prevention of coronary heart disease: can linolenic acid substitute for oily fish? | 1994 | Lancet | pmid:7911171 |
Anderson GJ and Connor WE | Accretion of n-3 fatty acids in the brain and retina of chicks fed a low-linolenic acid diet supplemented with docosahexaenoic acid. | 1994 | Am. J. Clin. Nutr. | pmid:7911000 |
Mantzioris E et al. | Dietary substitution with an alpha-linolenic acid-rich vegetable oil increases eicosapentaenoic acid concentrations in tissues. | 1994 | Am. J. Clin. Nutr. | pmid:7910999 |
Huang YS et al. | Differences in the metabolism of 18:2n-6 and 18:3n-6 by the liver and kidney may explain the anti-hypertensive effect of 18:3n-6. | 1994 | Biochem. Med. Metab. Biol. | pmid:7910749 |
Franke AA et al. | Effects of micronutrients and antioxidants on lipid peroxidation in human plasma and in cell culture. | 1994 | Cancer Lett. | pmid:7910514 |
Ohta S et al. | Anti methicillin-resistant Staphylococcus aureus (MRSA) activity by linolenic acid isolated from the marine microalga Chlorococcum HS-101. | 1994 | Bull Environ Contam Toxicol | pmid:7910498 |
Laethem RM et al. | Epoxidation of arachidonic acid as an active-site probe of cytochrome P-450 2B isoforms. | 1994 | Biochim. Biophys. Acta | pmid:7910485 |
Grandgirard A et al. | Incorporation of trans long-chain n-3 polyunsaturated fatty acids in rat brain structures and retina. | 1994 | Lipids | pmid:7909911 |
Zakhariv OIa and Ianovych VH | [Use of [1-14C]linolenic acid in lipid synthesis in ruminant tissues during the prenatal and postnatal periods of development in vitro]. | 1993 Sep-Oct | Ukr. Biokhim. Zh. | pmid:7909179 |
Mibu H et al. | A study on lipid peroxide-induced lens damage in vitro. | 1994 | Exp. Eye Res. | pmid:7908884 |
Narisawa T et al. | Colon cancer prevention with a small amount of dietary perilla oil high in alpha-linolenic acid in an animal model. | 1994 | Cancer | pmid:7908858 |
Mourente G and Tocher DR | In vivo metabolism of [1-14C]linolenic acid (18:3(n-3)) and [1-14C]eicosapentaenoic acid (20:5(n-3)) in a marine fish: time-course of the desaturation/elongation pathway. | 1994 | Biochim. Biophys. Acta | pmid:7908832 |
Uauy R et al. | Safety and efficacy of omega-3 fatty acids in the nutrition of very low birth weight infants: soy oil and marine oil supplementation of formula. | 1994 | J. Pediatr. | pmid:7908693 |
Lockwood K et al. | Partial and complete regression of breast cancer in patients in relation to dosage of coenzyme Q10. | 1994 | Biochem. Biophys. Res. Commun. | pmid:7908519 |
Okuley J et al. | Arabidopsis FAD2 gene encodes the enzyme that is essential for polyunsaturated lipid synthesis. | 1994 | Plant Cell | pmid:7907506 |
Saad Aida MA et al. | Role of dietary lipids and butylated hydroxy anisol (BHA) administration on albino rats. Part I. Serum unsaturated fatty acids. | 1993 | Nahrung | pmid:7907168 |
Jiang Z and Sim JS | Consumption of n-3 polyunsaturated fatty acid-enriched eggs and changes in plasma lipids of human subjects. | 1993 Nov-Dec | Nutrition | pmid:7906572 |
Regdel D et al. | On the reaction specificity of the lipoxygenase from tomato fruits. | 1994 | Biochim. Biophys. Acta | pmid:7905748 |
Green P and Yavin E | Elongation, desaturation, and esterification of essential fatty acids by fetal rat brain in vivo. | 1993 | J. Lipid Res. | pmid:7905509 |
Tang AB et al. | Preferential reduction in adipose tissue alpha-linolenic acid (18:3 omega 3) during very low calorie dieting despite supplementation with 18:3 omega 3. | 1993 | Lipids | pmid:7904040 |
Carter J | Flax seed as a source of alpha linolenic acid. | 1993 | J Am Coll Nutr | pmid:7903325 |
Bierenbaum ML et al. | Reducing atherogenic risk in hyperlipemic humans with flax seed supplementation: a preliminary report. | 1993 | J Am Coll Nutr | pmid:7903324 |
Cao J et al. | Inhibition of fatty acid delta 6- and delta 5-desaturation by cyclopropene fatty acids in rat liver microsomes. | 1993 | Biochim. Biophys. Acta | pmid:7903050 |
Wang N and Anderson RE | Synthesis of docosahexaenoic acid by retina and retinal pigment epithelium. | 1993 | Biochemistry | pmid:7903049 |
Yehuda S and Carasso RL | Modulation of learning, pain thresholds, and thermoregulation in the rat by preparations of free purified alpha-linolenic and linoleic acids: determination of the optimal omega 3-to-omega 6 ratio. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7901853 |
Kardinaal AF et al. | Relations between antioxidant vitamins in adipose tissue, plasma, and diet. | 1995 | Am. J. Epidemiol. | pmid:7879788 |
Santos MJ et al. | Influence of dietary supplementation with fish on plasma fatty acid composition in coronary heart disease patients. | 1995 | Ann. Nutr. Metab. | pmid:7872656 |
Moore SA | Local synthesis and targeting of essential fatty acids at the cellular interface between blood and brain: a role for cerebral endothelium and astrocytes in the accretion of CNS docosahexaenoic acid. | 1994 | World Rev Nutr Diet | pmid:7871814 |
Pawlosky R et al. | Essential fatty acid metabolism in the feline: relationship between liver and brain production of long-chain polyunsaturated fatty acids. | 1994 | J. Lipid Res. | pmid:7868981 |
Lawrence JF et al. | An incident of elevated levels of unsaturated free fatty acids in mussels from Nova Scotia and their toxic effect in mice after intraperitoneal injection. | 1994 | Nat. Toxins | pmid:7866668 |
Chen ZY et al. | Moderate, selective depletion of linoleate and alpha-linolenate in weight-cycled rats. | 1995 | Am. J. Physiol. | pmid:7864247 |
Goré J et al. | Linoleic acid uptake by isolated enterocytes: influence of alpha-linolenic acid on absorption. | 1994 | Lipids | pmid:7861937 |
Kojima S et al. | Antioxidative activity of benzylideneascorbate and its effect on adriamycin-induced cardiotoxicity. | 1994 Sep-Oct | Anticancer Res. | pmid:7847820 |
Ingram AJ et al. | Effects of flaxseed and flax oil diets in a rat-5/6 renal ablation model. | 1995 | Am. J. Kidney Dis. | pmid:7847360 |
Yuasa H et al. | Gastric emptying-limited oral absorption of alpha-linolenic acid administered as a milk fat-globule membrane (MFGM) emulsion in rats. | 1994 | Biol. Pharm. Bull. | pmid:7841950 |
Ghafoorunissa | Dietary lipids and heart disease--the Indian context. | 1994 Nov-Dec | Natl Med J India | pmid:7841878 |
Mantzioris E et al. | Differences exist in the relationships between dietary linoleic and alpha-linolenic acids and their respective long-chain metabolites. | 1995 | Am. J. Clin. Nutr. | pmid:7840069 |
Oulhaj H et al. | [Utilization of linoleate and alpha-linolenate in peritubular cells and Sertoli cells in culture]. | 1994 | C. R. Seances Soc. Biol. Fil. | pmid:7834508 |
Cunnane SC et al. | Nutritional attributes of traditional flaxseed in healthy young adults. | 1995 | Am. J. Clin. Nutr. | pmid:7825540 |
Kirmani ZA et al. | Effects of supplemented omega-3 and omega-6 fatty acid rich oils on the cardiovascular system of thermally injured rabbits: changes in plasma and platelet fatty acids. | 1995 Mar-Apr | J Burn Care Rehabil | pmid:7775514 |
Kumar GS and Das UN | Free radical-dependent suppression of growth of mouse myeloma cells by alpha-linolenic and eicosapentaenoic acids in vitro. | 1995 | Cancer Lett. | pmid:7757958 |
Numata M | [Antitumor effects of alpha-linolenic acid on the human tumor transplanted in nude mice and on the metastasis of Vx-7 tumor in rabbit]. | 1995 | Hokkaido Igaku Zasshi | pmid:7744366 |
Decsi T et al. | Essential fatty acids in full term infants fed breast milk or formula. | 1995 | Arch. Dis. Child. Fetal Neonatal Ed. | pmid:7743279 |
Uauy-Dagach R et al. | Essential fatty acid metabolism and requirements for LBW infants. | 1994 | Acta Paediatr Suppl | pmid:7734797 |
Degousée N et al. | Measurement of thermally produced volatile alkanes: an assay for plant hydroperoxy fatty acid evaluation. | 1995 | Anal. Biochem. | pmid:7733454 |
Kang JX et al. | Free, long-chain, polyunsaturated fatty acids reduce membrane electrical excitability in neonatal rat cardiac myocytes. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7732020 |
Saradhi PP et al. | Proline accumulates in plants exposed to UV radiation and protects them against UV induced peroxidation. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7726821 |
Smuts CM et al. | The effect of iron fortification on the fatty acid composition of plasma and erythrocyte membranes in primary school children with and without iron deficiency. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7708822 |
Saito M | Effect of dietary alpha-linolenic, eicosapentaenoic and docosahexaenoic acids on liver microsomal mixed-function oxidases in rats. | 1994 | Ann. Nutr. Metab. | pmid:7702359 |
Grechkin AN et al. | The lipoxygenase pathway in garlic (Allium sativum L.) bulbs: detection of the novel divinyl ether oxylipins. | 1995 | FEBS Lett. | pmid:7672118 |
Sheaff RC et al. | Conversion of alpha-linolenate to docosahexaenoate is not depressed by high dietary levels of linoleate in young rats: tracer evidence using high precision mass spectrometry. | 1995 | J. Lipid Res. | pmid:7658170 |
Tezabwala BU et al. | Immunotoxicity of polyunsaturated fatty acids in serum-free medium. | 1995 | Immunopharmacol Immunotoxicol | pmid:7650296 |
Guo W and Hamilton JA | Phase behavior and crystalline structures of cholesteryl ester mixtures: a C-13 MASNMR study. | 1995 | Biophys. J. | pmid:7647242 |
Weisinger HS et al. | Dietary manipulation of long-chain polyunsaturated fatty acids in the retina and brain of guinea pigs. | 1995 | Lipids | pmid:7637569 |
Emmison N et al. | Linoleic and linolenic acids are selectively secreted in triacylglycerol by hepatocytes from neonatal rats. | 1995 | Am. J. Physiol. | pmid:7631907 |
Krugliak M et al. | Antimalarial effects of C18 fatty acids on Plasmodium falciparum in culture and on Plasmodium vinckei petteri and Plasmodium yoelii nigeriensis in vivo. | 1995 | Exp. Parasitol. | pmid:7628573 |
Sugihara N et al. | High susceptibility to paraquat-driven lipid peroxidation of cultured hepatocytes loaded with linolenic acid. | 1995 | J. Pharmacol. Exp. Ther. | pmid:7616398 |
Lok E et al. | The effect of different levels of dietary alpha-linolenic and other fatty acids on mammary gland ductular cell proliferation in female Swiss Webster mice. | 1995 | Cancer Lett. | pmid:7600535 |
Ferrier LK et al. | alpha-Linolenic acid- and docosahexaenoic acid-enriched eggs from hens fed flaxseed: influence on blood lipids and platelet phospholipid fatty acids in humans. | 1995 | Am. J. Clin. Nutr. | pmid:7598070 |
Nordström DC et al. | Alpha-linolenic acid in the treatment of rheumatoid arthritis. A double-blind, placebo-controlled and randomized study: flaxseed vs. safflower seed. | 1995 | Rheumatol. Int. | pmid:7597378 |
Wijkander J et al. | 5-Lipoxygenase products modulate the activity of the 85-kDa phospholipase A2 in human neutrophils. | 1995 | J. Biol. Chem. | pmid:7592874 |
Romans JR et al. | Effects of ground flaxseed in swine diets on pig performance and on physical and sensory characteristics and omega-3 fatty acid content of pork: I. Dietary level of flaxseed. | 1995 | J. Anim. Sci. | pmid:7592082 |
Mantzioris E et al. | Nutritional attributes of dietary flaxseed oil. | 1995 | Am. J. Clin. Nutr. | pmid:7572718 |
Fujiyama-Fujiwara Y et al. | Effects of sesamin on the fatty acid composition of the liver of rats fed N-6 and N-3 fatty acid-rich diet. | 1995 | J. Nutr. Sci. Vitaminol. | pmid:7562115 |
Larsson-Backström C et al. | Effects of dietary alpha- and gamma-linolenic acids on liver fatty acids, lipid metabolism, and survival in sepsis. | 1995 | Shock | pmid:7552772 |
Kawasaki M et al. | Effect of alpha-linolenic acid on the metabolism of omega-3 and omega-6 polyunsaturated fatty acids and histamine release in RBL-2H3 cells. | 1994 | Biol. Pharm. Bull. | pmid:7533019 |
Ahn DU et al. | Effects of dietary alpha-linolenic acid and strain of hen on the fatty acid composition, storage stability, and flavor characteristics of chicken eggs. | 1995 | Poult. Sci. | pmid:7501600 |
Hartman IS | alpha-Linolenic acid: a preventive in secondary coronary events? | 1995 | Nutr. Rev. | pmid:7494621 |
Tsutsumi T et al. | Effect of a high alpha-linolenate and high linoleate diet on membrane-associated enzyme activities in rat brain--modulation of Na+, K+- ATPase activity at suboptimal concentrations of ATP. | 1995 | Biol. Pharm. Bull. | pmid:7492979 |
Muñoz SF et al. | Protective capability of dietary Zizyphus mistol seed oil, rich in 18:3, n-3, on the development of two murine mammary gland adenocarcinomas with high or low metastatic potential. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7480075 |
Francès H et al. | Effects of dietary alpha-linolenic acid deficiency on neuromuscular and cognitive functions in mice. | 1995 | Life Sci. | pmid:7475943 |
Watanabe T et al. | Immobilization of lipases on polyethylene and application to perilla oil hydrolysis for production of alpha-linolenic acid. | 1995 | J. Nutr. Sci. Vitaminol. | pmid:7472675 |
Manku MS et al. | Essential fatty acids in the plasma phospholipids of patients with atopic eczema. | 1984 | Br. J. Dermatol. | pmid:6329254 |
McCarty MF | Hormonal and nutritional enhancement of Na+-K+-ATPase activity may aid the prevention and treatment of essential hypertension. | 1984 | Med. Hypotheses | pmid:6328233 |
Gutteridge JM et al. | Superoxide-dependent lipid peroxidation. Problems with the use of catalase as a specific probe for fenton-derived hydroxyl radicals. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6320819 |
Nicholson T and Omer SA | The application of cumulative sum analysis to the investigation of reticulum motility in ruminant animals. | 1983 | Zentralbl Veterinarmed A | pmid:6318476 |
Marshall LA and Johnston PV | The effect of dietary alpha-linolenic acid in the rat on fatty acid profiles of immunocompetent cell populations. | 1983 | Lipids | pmid:6318008 |
Hansen HS and Jensen B | Urinary prostaglandin E2 and vasopressin excretion in essential fatty acid-deficient rats: effect of linolenic acid supplementation. | 1983 | Lipids | pmid:6318006 |
Neuringer M et al. | Dietary omega-3 fatty acid deficiency and visual loss in infant rhesus monkeys. | 1984 | J. Clin. Invest. | pmid:6317716 |
Marshall LA et al. | Dietary alpha-linolenic acid and prostaglandin synthesis: a time course study. | 1983 | Am. J. Clin. Nutr. | pmid:6316775 |
Magrum LJ and Johnston PV | Modulation of prostaglandin synthesis in rat peritoneal macrophages with omega-3 fatty acids. | 1983 | Lipids | pmid:6312240 |
Byrne WJ | Intralipid or Liposyn--comparable products? | 1982 | J. Pediatr. Gastroenterol. Nutr. | pmid:6310073 |
Sanders TA | Dietary fat and platelet function. | 1983 | Clin. Sci. | pmid:6309463 |
Frankel EN | Volatile lipid oxidation products. | 1983 | Prog. Lipid Res. | pmid:6306693 |
Oliw EH | Oxygenation of linolenic and linoleic acid to novel vicinal dihydroxy acids by hepatic microsomes of the rabbit. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6301473 |
Rosenthal MD and Whitehurst MC | Fatty acyl delta 6 desaturation activity of cultured human endothelial cells. Modulation by fetal bovine serum. | 1983 | Biochim. Biophys. Acta | pmid:6297606 |
Yoshino M and Murakami K | The regulatory role of spermine and fatty acid in the interaction of AMP deaminase with phosphofructokinase. | 1982 | Biochim. Biophys. Acta | pmid:6295506 |
Rosenthal MD and Whitehurst MC | Selective utilization of omega 6 and omega 3 polyunsaturated fatty acids by human skin fibroblasts. | 1982 | J. Cell. Physiol. | pmid:6294123 |
Bozian RC and Moussavian SN | Human linolenic acid deficiency. | 1982 | Am. J. Clin. Nutr. | pmid:6293298 |
Ayala S and Brenner RR | Effect of polyunsaturated fatty acids of the alpha-linolenic series in the lipid composition of rat testicles during development. | 1980 | Acta Physiol Lat Am | pmid:6287807 |
Tinoco J | Dietary requirements and functions of alpha-linolenic acid in animals. | 1982 | Prog. Lipid Res. | pmid:6287500 |
Yoshino M and Murakami K | AMP deaminase as a control system of glycolysis in yeast. Mechanism of the inhibition of glycolysis by fatty acid and citrate. | 1982 | J. Biol. Chem. | pmid:6286666 |