Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Uauy R and Hoffman DR | Essential fatty acid requirements for normal eye and brain development. | 1991 | Semin. Perinatol. | pmid:1687090 |
Kelley DS et al. | Dietary alpha-linolenic acid and immunocompetence in humans. | 1991 | Am. J. Clin. Nutr. | pmid:1670594 |
Hamberg M | Transformations of alpha-linolenic acid in leaves of corn (Zea mays L.). | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1671803 |
Cave WT | Dietary n-3 (omega-3) polyunsaturated fatty acid effects on animal tumorigenesis. | 1991 | FASEB J. | pmid:1673664 |
Bjerve KS | Omega 3 fatty acid deficiency in man: implications for the requirement of alpha-linolenic acid and long-chain omega 3 fatty acids. | 1991 | World Rev Nutr Diet | pmid:1675825 |
Henry MM et al. | Influence of an omega-3 fatty acid-enriched ration on in vivo responses of horses to endotoxin. | 1991 | Am. J. Vet. Res. | pmid:1675842 |
Morris DD et al. | Effect of dietary alpha-linolenic acid on endotoxin-induced production of tumor necrosis factor by peritoneal macrophages in horses. | 1991 | Am. J. Vet. Res. | pmid:1675843 |
Hasler CM et al. | Inhibition of gap junction-mediated intercellular communication by alpha-linolenate. | 1991 | Am. J. Physiol. | pmid:1677533 |
Horii T et al. | Effect of dietary alpha-linolenate on platelet-activating factor production in rat peritoneal polymorphonuclear leukocytes. | 1991 | J. Immunol. | pmid:1679081 |
Papies B et al. | Ischemic myocardial damage in spontaneously hypertensive rats (SHR) is enhanced after long-term feeding of an alpha-linolenic acid enriched diet. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1679554 |
Rhodes PG et al. | Effects of different levels of intravenous alpha-linolenic acid and supplemental breast milk on red blood cell docosahexaenoic acid in very low birth-weight infants. | 1991 | J. Pediatr. Gastroenterol. Nutr. | pmid:1681044 |
Sakai K and Okuyama H | Effects of a high alpha-linolenate and high linoleate diet on hemolysis and lipid peroxidation of rat erythrocytes. | 1991 | Chem. Pharm. Bull. | pmid:1682062 |
Narisawa T et al. | Inhibitory effect of dietary perilla oil rich in the n-3 polyunsaturated fatty acid alpha-linolenic acid on colon carcinogenesis in rats. | 1991 | Jpn. J. Cancer Res. | pmid:1683347 |
Hunter JE | n-3 fatty acids from vegetable oils. | 1990 | Am. J. Clin. Nutr. | pmid:1970702 |
Berger A and German JB | Phospholipid fatty acid composition of various mouse tissues after feeding alpha-linolenate (18:3n-3) or eicosatrienoate (20:3n-3). | 1990 | Lipids | pmid:1977067 |
Uauy R | Are omega-3 fatty acids required for normal eye and brain development in the human? | 1990 | J. Pediatr. Gastroenterol. Nutr. | pmid:1978859 |
Hirose M et al. | Effects of dietary perilla oil, soybean oil and safflower oil on 7,12-dimethylbenz[a]anthracene (DMBA) and 1,2-dimethyl-hydrazine (DMH)-induced mammary gland and colon carcinogenesis in female SD rats. | 1990 | Carcinogenesis | pmid:2110511 |
Chapkin RS and Carmichael SL | Effect of dietary blackcurrant seed oil on mouse macrophage subclasses of choline and ethanolamine glycerophospholipids. | 1990 | J. Nutr. | pmid:1974284 |
Bourre JM et al. | Nutritional fatty acids control. Composition and function of cerebral membranes. | 1990 | Bibl Nutr Dieta | pmid:1980414 |
Henry MM et al. | Effect of dietary alpha-linolenic acid on equine monocyte procoagulant activity and eicosanoid synthesis. | 1990 | Circ. Shock | pmid:1979759 |
Fritsche KL and Johnston PV | Effect of dietary alpha-linolenic acid on growth, metastasis, fatty acid profile and prostaglandin production of two murine mammary adenocarcinomas. | 1990 | J. Nutr. | pmid:1979807 |
Kestin M et al. | n-3 fatty acids of marine origin lower systolic blood pressure and triglycerides but raise LDL cholesterol compared with n-3 and n-6 fatty acids from plants. | 1990 | Am. J. Clin. Nutr. | pmid:1971991 |
Oxholm A et al. | Abnormal essential fatty acid metabolism in Darier's disease. | 1990 | Arch Dermatol | pmid:1977367 |
Buffière F et al. | Purification and characterization of monoclonal antibodies to alpha-linolenic acid. | 1989 Mar-Apr | J Lipid Mediat | pmid:2485142 |
Simopoulos AP | Summary of the NATO advanced research workshop on dietary omega 3 and omega 6 fatty acids: biological effects and nutritional essentiality. | 1989 | J. Nutr. | pmid:2564887 |
Bjerve KS | n-3 fatty acid deficiency in man. | 1989 | J Intern Med Suppl | pmid:2565114 |
Sprecher H | Interactions between the metabolism of n-3 and n-6 fatty acids. | 1989 | J Intern Med Suppl | pmid:2565115 |
Schöneich C et al. | Thiyl radical attack on polyunsaturated fatty acids: a possible route to lipid peroxidation. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2567162 |
Fritsche KL and Johnston PV | Modulation of eicosanoid production and cell-mediated cytotoxicity by dietary alpha-linolenic acid in BALB/c mice. | 1989 | Lipids | pmid:2569149 |
Garg ML et al. | Dietary saturated fat level alters the competition between alpha-linolenic and linoleic acid. | 1989 | Lipids | pmid:2569150 |
Sok DE and Kim MR | The possible role of 9(S)-hydroperoxyoctadecatrienoic acid as a suicide substrate of soybean lipoxygenase. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2569867 |
Hashimoto Y et al. | Effect of black-pigmented Bacteroides gingivalis on cytotoxic activity of linolenic acid against mouse macrophages. | 1989 | Kitasato Arch. Exp. Med. | pmid:2570177 |
Sharov VS et al. | Selective sensitization of chemiluminescence resulted from lipid and oxygen radical reactions. | 1989 | Free Radic. Biol. Med. | pmid:2570736 |
Olaf A | Effects of linoleic and alpha linolenic acids intake on blood pressure in man. | 1989 | Prog. Clin. Biol. Res. | pmid:2571995 |
Bourre JM et al. | The effects of dietary alpha-linolenic acid on the composition of nerve membranes, enzymatic activity, amplitude of electrophysiological parameters, resistance to poisons and performance of learning tasks in rats. | 1989 | J. Nutr. | pmid:2576038 |
Bourre JM | [Nature, origin and role of fatty acids of the nervous system: an essential fatty acid, an alpha-linolenic acid, changing the structure and the cerebral function]. | 1989 | Bull. Acad. Natl. Med. | pmid:2576722 |
Biliński T et al. | Superoxide dismutase deficiency and the toxicity of the products of autooxidation of polyunsaturated fatty acids in yeast. | 1989 | Biochim. Biophys. Acta | pmid:2563227 |
Bourre JM et al. | Brain cell and tissue recovery in rats made deficient in n-3 fatty acids by alteration of dietary fat. | 1989 | J. Nutr. | pmid:2563284 |
Bjerve KS et al. | alpha-Linolenic acid and long-chain omega-3 fatty acid supplementation in three patients with omega-3 fatty acid deficiency: effect on lymphocyte function, plasma and red cell lipids, and prostanoid formation. | 1989 | Am. J. Clin. Nutr. | pmid:2563625 |
Hagve TA and Sprecher H | Metabolism of long-chain polyunsaturated fatty acids in isolated cardiac myocytes. | 1989 | Biochim. Biophys. Acta | pmid:2563660 |
Romans JR | Alpha-linolenic acid. | 1989 | Lancet | pmid:2563803 |
Hennig B and Watkins BA | Linoleic acid and linolenic acid: effect on permeability properties of cultured endothelial cell monolayers. | 1989 | Am. J. Clin. Nutr. | pmid:2563626 |
D'Aquino M et al. | Vitamin A and glutathione-mediated free radical damage: competing reactions with polyunsaturated fatty acids and vitamin C. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2568114 |
Hrelia S et al. | Age-related changes in linoleate and alpha-linolenate desaturation by rat liver microsomes. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2570573 |
Choi YS and Sugano M | Effects of dietary alpha- and gamma-linolenic acid on lipid metabolism in young and adult rats. | 1988 | Ann. Nutr. Metab. | pmid:2903713 |
Hashimoto A et al. | Effect of the dietary alpha-linolenate/linoleate balance on leukotriene production and histamine release in rats. | 1988 | Prostaglandins | pmid:2459732 |
Urano S et al. | Membrane-stabilizing effect of vitamin E: effect of alpha-tocopherol and its model compounds on fluidity of lecithin liposomes. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2892491 |
Hwang DH et al. | Dietary linolenic acid and longer-chain n-3 fatty acids: comparison of effects on arachidonic acid metabolism in rats. | 1988 | J. Nutr. | pmid:2895804 |
Arthur JR | Effects of selenium and vitamin E status on plasma creatine kinase activity in calves. | 1988 | J. Nutr. | pmid:2897437 |
Guesnet P et al. | Effects of dietary alpha-linolenic acid deficiency during pregnancy and lactation on lipid fatty acid composition of liver and serum in the rat. | 1988 | Reprod Nutr Dev | pmid:2897705 |
Koletzko B and Cunnane S | Human alpha-linolenic acid deficiency. | 1988 | Am. J. Clin. Nutr. | pmid:2897782 |
Homayoun P et al. | Alteration in fatty acid composition of adult rat brain capillaries and choroid plexus induced by a diet deficient in n-3 fatty acids: slow recovery after substitution with a nondeficient diet. | 1988 | J. Neurochem. | pmid:2898007 |
Fan WX | [Alpha-linolenic acid and its metabolites EPA and DHA]. | 1988 | Sheng Li Ke Xue Jin Zhan | pmid:2901141 |
Garg ML et al. | Dietary cholesterol and/or n-3 fatty acid modulate delta 9-desaturase activity in rat liver microsomes. | 1988 | Biochim. Biophys. Acta | pmid:2901857 |
Khokher MA and Dandona P | The effect of polyunsaturated fatty acids on rat adipocyte lipogenesis: the role of protein kinase C, calcium and calmodulin. | 1988 | Diabetes Res. | pmid:2906578 |
Blasig IE et al. | Effect of troxerutin and methionine on spin trapping of free oxy-radicals. | 1988 | Biomed. Biochim. Acta | pmid:2907855 |
Yamamoto N et al. | Effect of the dietary alpha-linolenate/linoleate balance on lipid compositions and learning ability of rats. II. Discrimination process, extinction process, and glycolipid compositions. | 1988 | J. Lipid Res. | pmid:2903207 |
Whitcomb RW et al. | Effects of long-chain, saturated fatty acids on membrane microviscosity and adrenocorticotropin responsiveness of human adrenocortical cells in vitro. | 1988 | J. Clin. Invest. | pmid:2891726 |
Chander A and Fisher AB | Choline-phosphate cytidyltransferase activity and phosphatidylcholine synthesis in rat granular pneumocytes are increased with exogenous fatty acids. | 1988 | Biochim. Biophys. Acta | pmid:2893643 |
Sebokova E et al. | Modulation of receptor-mediated gonadotropin action in rat testes by dietary fat. | 1988 | Am. J. Physiol. | pmid:2897795 |
Jones DB et al. | Glucose, insulin and platelet fatty acids following myocardial infarction: an association with infarct size. | 1987 Jul-Aug | Diabete Metab | pmid:3315767 |
Bjerve KS et al. | Alpha-linolenic acid deficiency in patients on long-term gastric-tube feeding: estimation of linolenic acid and long-chain unsaturated n-3 fatty acid requirement in man. | 1987 | Am. J. Clin. Nutr. | pmid:2879436 |
Warden JT and Csatorday K | On the mechanism of linolenic acid inhibition in Photosystem II. | 1987 | Biochim. Biophys. Acta | pmid:2879567 |
Gutteridge JM | The antioxidant activity of haptoglobin towards haemoglobin-stimulated lipid peroxidation. | 1987 | Biochim. Biophys. Acta | pmid:2879568 |
Bjerve KS | Alpha-linolenic acid deficiency in adult women. | 1987 | Nutr. Rev. | pmid:2881237 |
McDonald GB and Weidman M | Partitioning of polar fatty acids into lymph and portal vein after intestinal absorption in the rat. | 1987 | Q J Exp Physiol | pmid:2884690 |
Bursztyn P | Does dietary linolenic acid influence blood pressure? | 1987 | Am. J. Clin. Nutr. | pmid:2884863 |
Singer P et al. | Changes of N-6 and N-3 fatty acids in liver from spontaneously hypertensive (SHR) and normotensive rats after diets supplemented with alpha-linolenic or eicosapentaenoic acids. | 1987 | Prostaglandins Leukot Med | pmid:2888133 |
Bjerve KS et al. | Alpha-linolenic acid deficiency in man: effect of essential fatty acids on fatty acid composition. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2890285 |
Vrignaud P and Robert J | Free fatty acid uptake is increased in doxorubicin-resistant rat glioblastoma cells. | 1987 | Biochim. Biophys. Acta | pmid:2886153 |
Astorg PO and Chevalier J | Polyunsaturated fatty acids in tissues of rats fed trielaidin and high or low levels of linolenic acid. | 1987 | Lipids | pmid:2897610 |
Huang YS et al. | Selective incorporation of n-3 and n-6 fatty acids in essential fatty acid deficient rats in response to short-term oil feeding. | 1987 | Biochem. Int. | pmid:2898942 |
Yamamoto N et al. | Effect of dietary alpha-linolenate/linoleate balance on brain lipid compositions and learning ability of rats. | 1987 | J. Lipid Res. | pmid:2883248 |
Hasegawa J et al. | Lipid requirement for mu opioid receptor binding. | 1987 | J. Neurochem. | pmid:2887631 |
Takahashi R et al. | Impaired platelet aggregation and thromboxane generation in essential fatty acid-deficient rats. | 1987 | J. Nutr. | pmid:2888839 |
Coté GG and Brody S | Circadian rhythms in Neurospora crassa: a clock mutant, prd-1, is altered in membrane fatty acid composition. | 1987 | Biochim. Biophys. Acta | pmid:2889471 |
Sanders TA and Rana SK | Comparison of the metabolism of linoleic and linolenic acids in the fetal rat. | 1987 | Ann. Nutr. Metab. | pmid:2892461 |
Betteridge J | Nutrition and platelet function in atherogenesis. | 1987 | Proc Nutr Soc | pmid:2893383 |
Novo C et al. | Altered fatty acid membrane composition modifies lymphocyte localization in vivo. | 1987 | Cell. Immunol. | pmid:2882861 |
Gotoh K et al. | Effects of unsaturated fatty acids on the peroxisomal enzyme activities of Tetrahymena pyriformis. | 1986 | J. Biochem. | pmid:2880840 |
Hiltunen JK et al. | beta-Oxidation of polyunsaturated fatty acids by rat liver peroxisomes. A role for 2,4-dienoyl-coenzyme A reductase in peroxisomal beta-oxidation. | 1986 | J. Biol. Chem. | pmid:2877988 |
Hansson A et al. | Activation of protein kinase C by lipoxin A and other eicosanoids. Intracellular action of oxygenation products of arachidonic acid. | 1986 | Biochem. Biophys. Res. Commun. | pmid:2418836 |
Pisanti FA et al. | Effects of bonellin on lipids. | 1986 | Life Sci. | pmid:2869393 |
Hagve TA et al. | Desaturation and chain elongation of essential fatty acids in isolated liver cells from rat and rainbow trout. | 1986 | Lipids | pmid:2871473 |
Takahashi K et al. | Polyethylene glycol-modified hemin having peroxidase activity in organic solvents. | 1986 | Biochem. Biophys. Res. Commun. | pmid:2874801 |
Berry EM and Hirsch J | Does dietary linolenic acid influence blood pressure? | 1986 | Am. J. Clin. Nutr. | pmid:2875645 |
Nouvelot A et al. | Hepatic metabolism of dietary alpha-linolenic acid in suckling rats, and its possible importance in polyunsaturated fatty acid uptake by the brain. | 1986 | Ann. Nutr. Metab. | pmid:2875687 |
Nakamoto S et al. | Lipid peroxidation and cytotoxicity of Ehrlich ascites tumor cells by ferric nitrilotriacetate. | 1986 | Biochim. Biophys. Acta | pmid:2876731 |
Acosta PB and Stepnick-Gropper S | Problems related to diet management of maternal phenylketonuria. | 1986 | J. Inherit. Metab. Dis. | pmid:2877116 |
Guesnet P et al. | Dietary alpha-linolenic acid deficiency in the rat. I. Effects on reproduction and postnatal growth. | 1986 | Reprod Nutr Dev | pmid:2877477 |
Nutrition classics. Lipids, June 1979 Volume 14, No. 6: Reproduction and survival of rainbow trout (Salmo gairdneri) fed linolenic acid as the only source of essential fatty acids. By T.C. Yu, R.O. Sinnhuber, and J.D. Hendricks. | 1986 | Nutr. Rev. | pmid:2878402 | |
Johnston PV and Fritsche KL | Linolenate metabolism. | 1986 | Nutr. Rev. | pmid:2878403 |
Holman RT | Nutritional and functional requirements for essential fatty acids. | 1986 | Prog. Clin. Biol. Res. | pmid:2878441 |
Anding RH and Hwang DH | Effects of dietary linolenate on the fatty acid composition of brain lipids in rats. | 1986 | Lipids | pmid:2879208 |
Sato M et al. | [Experimental cerebral ischemia effects of fatty acid in Mongolian gerbils]. | 1986 | Rinsho Shinkeigaku | pmid:2879661 |
Bjerve KS et al. | [Essential linolenic fatty acid deficiency. Patients on long-term gastric tube feeding]. | 1986 | Tidsskr. Nor. Laegeforen. | pmid:2880408 |
Zöllner N | Dietary linolenic acid in man--an overview. | 1986 | Prog. Lipid Res. | pmid:2892211 |
Leat WM et al. | Retinal function in rats and guinea-pigs reared on diets low in essential fatty acids and supplemented with linoleic or linolenic acids. | 1986 | Ann. Nutr. Metab. | pmid:2872851 |
Siegel I et al. | Inhibition of sperm motility and agglutination of sperm cells by free fatty acids in whole semen. | 1986 | Fertil. Steril. | pmid:2868925 |
Tabachnick M and Korcek L | Effect of long-chain fatty acids on the binding of thyroxine and triiodothyronine to human thyroxine-binding globulin. | 1986 | Biochim. Biophys. Acta | pmid:2869786 |