Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
KORN ED and GREENBLATT CL | SYNTHESIS OF ALPHA-LINOLENIC ACID BY LEISHMANIA ENRIETTII. | 1963 | Science | pmid:14074842 |
MOHRHAUER H and HOLMAN RT | EFFECT OF LINOLENIC ACID UPON THE METABOLISM OF LINOLEIC ACID. | 1963 | J. Nutr. | pmid:14061405 |
WARAVDEKAR VS et al. | HEPATIC CHANGES INDUCED BY AN AQUEOUS EXTRACT OF ULTRAVIOLET-IRRADIATED LINOLENIC ACID. | 1964 | Am. J. Pathol. | pmid:14234476 |
RAHM JJ and HOLMAN RT | EFFECT OF LINOLEIC ACID UPON THE METABOLISM OF LINOLENIC ACID. | 1964 | J. Nutr. | pmid:14210015 |
Kanazawa A et al. | Relationship between essential fatty acid requirements of aquatic animals and the capacity for bioconversion of linolenic acid to highly unsaturated fatty acids. | 1979 | Comp. Biochem. Physiol., B | pmid:233802 |
Ayala S and Brenner RR | Effect of polyunsaturated fatty acids of the alpha-linolenic series in the lipid composition of rat testicles during development. | 1980 | Acta Physiol Lat Am | pmid:6287807 |
Budowski P et al. | [Protective effect of alpha-linolenic acid in encephalomalacia in chickens]. | 1980 | Ann Nutr Aliment | pmid:6254420 |
François M et al. | [Effects of a dietary deficiency of alpha-linolenic acid in the rat]. | 1980 | Ann Nutr Aliment | pmid:6254422 |
Vergroesen AJ et al. | Cardiovascular effects of linoleic acid. | 1980 | Prog Food Nutr Sci | pmid:6256818 |
Volpe JJ and Obert KA | Coordinate regulation of cholesterol synthesis and 3-hydroxy-3-methylglutaryl coenzyme A synthase but not 3-hydroxy-3-methylglutaryl coenzyme A reductase in C-6 glia. | 1981 | Arch. Biochem. Biophys. | pmid:6118099 |
Cowey CB et al. | Tissue distribution, uptake, and requirement for alpha-tocopherol of rainbow trout (Salmo gairdneri) fed diets with a minimal content of unsaturated fatty acids. | 1981 | J. Nutr. | pmid:6268765 |
Yoshino M and Murakami K | Effect of spermine on the inhibition by fatty acid on AMP deaminase reaction as a control system of the adenylate energy charge in yeast. | 1981 | Biochem. Biophys. Res. Commun. | pmid:6272814 |
Quadt JF and ten Hoor F | Effects of dietary alpha-linolenic acid on the production of a PGI-like substance of the isolated pulsatingly perfused rat aorta. | 1981 | Prog. Lipid Res. | pmid:6281803 |
Marshall LA and Johnston PV | alpha-Linolenic and linoleic acids and the immune response. | 1981 | Prog. Lipid Res. | pmid:6281806 |
Dusting GJ et al. | Increased conversion of arachidonic acid to vasodilator prostanoids in spontaneously hypertensive rats. | 1981 Sep-Oct | Clin. Exp. Pharmacol. Physiol. | pmid:6276057 |
Tinoco J | Dietary requirements and functions of alpha-linolenic acid in animals. | 1982 | Prog. Lipid Res. | pmid:6287500 |
Bozian RC and Moussavian SN | Human linolenic acid deficiency. | 1982 | Am. J. Clin. Nutr. | pmid:6293298 |
Yoshino M and Murakami K | The regulatory role of spermine and fatty acid in the interaction of AMP deaminase with phosphofructokinase. | 1982 | Biochim. Biophys. Acta | pmid:6295506 |
Byrne WJ | Intralipid or Liposyn--comparable products? | 1982 | J. Pediatr. Gastroenterol. Nutr. | pmid:6310073 |
Rosenthal MD and Whitehurst MC | Selective utilization of omega 6 and omega 3 polyunsaturated fatty acids by human skin fibroblasts. | 1982 | J. Cell. Physiol. | pmid:6294123 |
Torinuki W et al. | Chemiluminescence of UV-irradiated linolenic acid and squalene. | 1982 | Tohoku J. Exp. Med. | pmid:6280339 |
Scherhag R et al. | Dietary administration of eicosapentaenoic and linolenic acid increases arterial blood pressure and suppresses vascular prostacyclin synthesis in the rat. | 1982 | Prostaglandins | pmid:6285420 |
Yoshino M and Murakami K | AMP deaminase as a control system of glycolysis in yeast. Mechanism of the inhibition of glycolysis by fatty acid and citrate. | 1982 | J. Biol. Chem. | pmid:6286666 |
Rosenthal MD and Whitehurst MC | Fatty acyl delta 6 desaturation activity of cultured human endothelial cells. Modulation by fetal bovine serum. | 1983 | Biochim. Biophys. Acta | pmid:6297606 |
Oliw EH | Oxygenation of linolenic and linoleic acid to novel vicinal dihydroxy acids by hepatic microsomes of the rabbit. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6301473 |
Nicholson T and Omer SA | The application of cumulative sum analysis to the investigation of reticulum motility in ruminant animals. | 1983 | Zentralbl Veterinarmed A | pmid:6318476 |
Sanders TA | Dietary fat and platelet function. | 1983 | Clin. Sci. | pmid:6309463 |
Magrum LJ and Johnston PV | Modulation of prostaglandin synthesis in rat peritoneal macrophages with omega-3 fatty acids. | 1983 | Lipids | pmid:6312240 |
Marshall LA et al. | Dietary alpha-linolenic acid and prostaglandin synthesis: a time course study. | 1983 | Am. J. Clin. Nutr. | pmid:6316775 |
Hansen HS and Jensen B | Urinary prostaglandin E2 and vasopressin excretion in essential fatty acid-deficient rats: effect of linolenic acid supplementation. | 1983 | Lipids | pmid:6318006 |
Marshall LA and Johnston PV | The effect of dietary alpha-linolenic acid in the rat on fatty acid profiles of immunocompetent cell populations. | 1983 | Lipids | pmid:6318008 |
Gutteridge JM et al. | Superoxide-dependent lipid peroxidation. Problems with the use of catalase as a specific probe for fenton-derived hydroxyl radicals. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6320819 |
Frankel EN | Volatile lipid oxidation products. | 1983 | Prog. Lipid Res. | pmid:6306693 |
Renaud S and Nordøy A | "Small is beautiful": alpha-linolenic acid and eicosapentaenoic acid in man. | 1983 | Lancet | pmid:6133188 |
Poisson JP and Blond JP | [Effect of supplementation with gamma-linolenic acid on the fatty acid composition of lipids from the liver and plasma in the diabetic rat]. | 1983 | Arch. Int. Physiol. Biochim. | pmid:6204605 |
Brush MG et al. | Abnormal essential fatty acid levels in plasma of women with premenstrual syndrome. | 1984 | Am. J. Obstet. Gynecol. | pmid:6091462 |
Codde JP et al. | Dissociation of effects of dietary fatty acids on blood pressure and prostanoid metabolism in Goldblatt hypertensive rats. | 1984 | J. Hypertens. | pmid:6099384 |
Frankel EN | Chemistry of free radical and singlet oxidation of lipids. | 1984 | Prog. Lipid Res. | pmid:6100997 |
Manku MS et al. | Essential fatty acids in the plasma phospholipids of patients with atopic eczema. | 1984 | Br. J. Dermatol. | pmid:6329254 |
Furukawa M et al. | Studies on arachidonate 5-lipoxygenase of rat basophilic leukemia cells. | 1984 | Biochim. Biophys. Acta | pmid:6089906 |
Neuringer M et al. | Dietary omega-3 fatty acid deficiency and visual loss in infant rhesus monkeys. | 1984 | J. Clin. Invest. | pmid:6317716 |
McCarty MF | Hormonal and nutritional enhancement of Na+-K+-ATPase activity may aid the prevention and treatment of essential hypertension. | 1984 | Med. Hypotheses | pmid:6328233 |
Bolton-Smith C et al. | Comparative aspects of omega-3 and omega-6 polyunsaturated fatty acids in rabbits and rats: effects on platelet function, thromboxane and prostacyclin generation, tissue phospholipid fatty acids and membrane fluidity. | 1984 | Br J Clin Pract Suppl | pmid:6091719 |
Golbeck JH and Warden JT | Interaction of linolenic acid with bound quinone molecules in Photosystem II. Time-resolved optical and electron spin resonance studies. | 1984 | Biochim. Biophys. Acta | pmid:6093871 |
Cocchi M et al. | Effect of C 18:3 (n-3) dietary supplementation on the fatty acid composition of the rat brain. | 1984 | Acta Vitaminol. Enzymol. | pmid:6098183 |
Hagve TA and Christophersen BO | Effect of dietary fats on arachidonic acid and eicosapentaenoic acid biosynthesis and conversion to C22 fatty acids in isolated rat liver cells. | 1984 | Biochim. Biophys. Acta | pmid:6093889 |
Osipov AN et al. | [Study of radicals formed in the interaction of organic hydroperoxides with ferric ions using the spin trap method]. | 1984 Jul-Aug | Biofizika | pmid:6091781 |
Morisaki N et al. | Metabolism of n-3 polyunsaturated fatty acids and modification of phospholipids in cultured rabbit aortic smooth muscle cells. | 1985 | J. Lipid Res. | pmid:2864379 |
Stymne S and Stobart AK | Involvement of acyl exchange between acyl-CoA and phosphatidylcholine in the remodelling of phosphatidylcholine in microsomal preparations of rat lung. | 1985 | Biochim. Biophys. Acta | pmid:2865978 |
Booyens J et al. | Chronic arachidonic acid eicosanoid imbalance: a common feature in coronary artery disease, hypercholesterolemia, cancer and other important diseases. Significance of desaturase enzyme inhibition and of the arachidonic acid desaturase-independent pathway. | 1985 | Med. Hypotheses | pmid:2866439 |
Becker W et al. | Uptake of radiolabelled alpha-linolenic, arachidonic and oleic acid in tissues of normal and essential fatty acid-deficient rats--an autoradiographic study. | 1985 | Ann. Nutr. Metab. | pmid:2859826 |
Das UN | Antibiotic-like action of essential fatty acids. | 1985 | Can Med Assoc J | pmid:2860965 |
Carlin G | Peroxidation of linolenic acid promoted by human polymorphonuclear leucocytes. | 1985 | J Free Radic Biol Med | pmid:2873164 |
Towell JF | An animated graphics program depicting the steps in lipid peroxidation. | 1985 | J Free Radic Biol Med | pmid:2875091 |
McClead RE et al. | Comparison of the clinical and biochemical effect of increased alpha-linolenic acid in a safflower oil intravenous fat emulsion. | 1985 | J. Pediatr. Gastroenterol. Nutr. | pmid:2859362 |
Nakamura T | Red pigment-forming substances from autoxidized linolenate: identification of prostaglandin-like substances. | 1985 | Lipids | pmid:2859511 |
Piconneaux A et al. | [Identification of an atypical polyunsaturated fatty acid present in the liver of rats after the ingestion of heated linseed oil]. | 1985 | C. R. Acad. Sci. III, Sci. Vie | pmid:2859918 |
Gutteridge JM et al. | Aluminium salts accelerate peroxidation of membrane lipids stimulated by iron salts. | 1985 | Biochim. Biophys. Acta | pmid:2861853 |
Nordøy A et al. | Effect of dietary (n--3) fatty acids on platelet function and lipid metabolism in rats. | 1985 | Biochim. Biophys. Acta | pmid:2861854 |
Budowski P and Crawford MA | a-Linolenic acid as a regulator of the metabolism of arachidonic acid: dietary implications of the ratio, n-6:n-3 fatty acids. | 1985 | Proc Nutr Soc | pmid:2864692 |
Crutchley DJ | Hydroxyeicosatetraenoic acids and other unsaturated fatty acids inhibit endotoxin-induced thromboplastin activity in human monocytes. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2865954 |
Johnston NW | Chronic degenerative radiculomyelopathy therapy. | 1985 Dec 21-28 | Vet. Rec. | pmid:2869606 |
Azizova OA et al. | [Initiation of nonenzymatic lipid peroxidation in a Fe2+-ascorbate-linolenate system]. | 1985 Jan-Feb | Biofizika | pmid:2858224 |
Gotoh K et al. | Effects of unsaturated fatty acids on the peroxisomal enzyme activities of Tetrahymena pyriformis. | 1986 | J. Biochem. | pmid:2880840 |
Hiltunen JK et al. | beta-Oxidation of polyunsaturated fatty acids by rat liver peroxisomes. A role for 2,4-dienoyl-coenzyme A reductase in peroxisomal beta-oxidation. | 1986 | J. Biol. Chem. | pmid:2877988 |
Hansson A et al. | Activation of protein kinase C by lipoxin A and other eicosanoids. Intracellular action of oxygenation products of arachidonic acid. | 1986 | Biochem. Biophys. Res. Commun. | pmid:2418836 |
Pisanti FA et al. | Effects of bonellin on lipids. | 1986 | Life Sci. | pmid:2869393 |
Hagve TA et al. | Desaturation and chain elongation of essential fatty acids in isolated liver cells from rat and rainbow trout. | 1986 | Lipids | pmid:2871473 |
Dyerberg J | Linolenate-derived polyunsaturated fatty acids and prevention of atherosclerosis. | 1986 | Nutr. Rev. | pmid:2872640 |
Cholesterol metabolism and omega-3 polyenes in fish oils. | 1986 | Nutr. Rev. | pmid:2872641 | |
Meadows J et al. | Uric acid protects membranes and linolenic acid from ozone-induced oxidation. | 1986 | Biochem. Biophys. Res. Commun. | pmid:2872893 |
Adam O et al. | Effect of alpha-linolenic acid in the human diet on linoleic acid metabolism and prostaglandin biosynthesis. | 1986 | J. Lipid Res. | pmid:2873197 |
Takahashi K et al. | Polyethylene glycol-modified hemin having peroxidase activity in organic solvents. | 1986 | Biochem. Biophys. Res. Commun. | pmid:2874801 |
Berry EM and Hirsch J | Does dietary linolenic acid influence blood pressure? | 1986 | Am. J. Clin. Nutr. | pmid:2875645 |
Nouvelot A et al. | Hepatic metabolism of dietary alpha-linolenic acid in suckling rats, and its possible importance in polyunsaturated fatty acid uptake by the brain. | 1986 | Ann. Nutr. Metab. | pmid:2875687 |
Nakamoto S et al. | Lipid peroxidation and cytotoxicity of Ehrlich ascites tumor cells by ferric nitrilotriacetate. | 1986 | Biochim. Biophys. Acta | pmid:2876731 |
Acosta PB and Stepnick-Gropper S | Problems related to diet management of maternal phenylketonuria. | 1986 | J. Inherit. Metab. Dis. | pmid:2877116 |
Guesnet P et al. | Dietary alpha-linolenic acid deficiency in the rat. I. Effects on reproduction and postnatal growth. | 1986 | Reprod Nutr Dev | pmid:2877477 |
Nutrition classics. Lipids, June 1979 Volume 14, No. 6: Reproduction and survival of rainbow trout (Salmo gairdneri) fed linolenic acid as the only source of essential fatty acids. By T.C. Yu, R.O. Sinnhuber, and J.D. Hendricks. | 1986 | Nutr. Rev. | pmid:2878402 | |
Johnston PV and Fritsche KL | Linolenate metabolism. | 1986 | Nutr. Rev. | pmid:2878403 |
Holman RT | Nutritional and functional requirements for essential fatty acids. | 1986 | Prog. Clin. Biol. Res. | pmid:2878441 |
Anding RH and Hwang DH | Effects of dietary linolenate on the fatty acid composition of brain lipids in rats. | 1986 | Lipids | pmid:2879208 |
Sato M et al. | [Experimental cerebral ischemia effects of fatty acid in Mongolian gerbils]. | 1986 | Rinsho Shinkeigaku | pmid:2879661 |
Bjerve KS et al. | [Essential linolenic fatty acid deficiency. Patients on long-term gastric tube feeding]. | 1986 | Tidsskr. Nor. Laegeforen. | pmid:2880408 |
Zöllner N | Dietary linolenic acid in man--an overview. | 1986 | Prog. Lipid Res. | pmid:2892211 |
Leikin AI and Brenner RR | Regulation of linoleic acid delta 6-desaturation by a cytosolic lipoprotein-like fraction in isolated rat liver microsomes. | 1986 | Biochim. Biophys. Acta | pmid:2869785 |
Carlson SE et al. | High fat diets varying in ratios of polyunsaturated to saturated fatty acid and linoleic to linolenic acid: a comparison of rat neural and red cell membrane phospholipids. | 1986 | J. Nutr. | pmid:2871142 |
Leat WM et al. | Retinal function in rats and guinea-pigs reared on diets low in essential fatty acids and supplemented with linoleic or linolenic acids. | 1986 | Ann. Nutr. Metab. | pmid:2872851 |
Jenkins KJ and Kramer JK | Influence of low linoleic and linolenic acids in milk replacer on calf performance and lipids in blood plasma, heart, and liver. | 1986 | J. Dairy Sci. | pmid:2873158 |
Morson LA and Clandinin MT | Diets varying in linoleic and linolenic acid content alter liver plasma membrane lipid composition and glucagon-stimulated adenylate cyclase activity. | 1986 | J. Nutr. | pmid:2879899 |
Siegel I et al. | Inhibition of sperm motility and agglutination of sperm cells by free fatty acids in whole semen. | 1986 | Fertil. Steril. | pmid:2868925 |
Tabachnick M and Korcek L | Effect of long-chain fatty acids on the binding of thyroxine and triiodothyronine to human thyroxine-binding globulin. | 1986 | Biochim. Biophys. Acta | pmid:2869786 |
Bjerve KS et al. | Alpha-linolenic acid deficiency in patients on long-term gastric-tube feeding: estimation of linolenic acid and long-chain unsaturated n-3 fatty acid requirement in man. | 1987 | Am. J. Clin. Nutr. | pmid:2879436 |
Warden JT and Csatorday K | On the mechanism of linolenic acid inhibition in Photosystem II. | 1987 | Biochim. Biophys. Acta | pmid:2879567 |
Huang YS et al. | Selective incorporation of n-3 and n-6 fatty acids in essential fatty acid deficient rats in response to short-term oil feeding. | 1987 | Biochem. Int. | pmid:2898942 |
Yamamoto N et al. | Effect of dietary alpha-linolenate/linoleate balance on brain lipid compositions and learning ability of rats. | 1987 | J. Lipid Res. | pmid:2883248 |
Hasegawa J et al. | Lipid requirement for mu opioid receptor binding. | 1987 | J. Neurochem. | pmid:2887631 |
Coté GG and Brody S | Circadian rhythms in Neurospora crassa: a clock mutant, prd-1, is altered in membrane fatty acid composition. | 1987 | Biochim. Biophys. Acta | pmid:2889471 |
Sanders TA and Rana SK | Comparison of the metabolism of linoleic and linolenic acids in the fetal rat. | 1987 | Ann. Nutr. Metab. | pmid:2892461 |
Betteridge J | Nutrition and platelet function in atherogenesis. | 1987 | Proc Nutr Soc | pmid:2893383 |