alpha-linolenic acid
Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
Cross Reference
Introduction
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with alpha-linolenic acid?
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
PubChem Associated disorders and diseases
What pathways are associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with alpha-linolenic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with alpha-linolenic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with alpha-linolenic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Vos E et al. | alpha-Linolenic acid and fish oil n-3 fatty acids and cardiovascular disease risk. | 2007 | Am. J. Clin. Nutr. | pmid:17344517 |
| Kelley DS et al. | Dietary alpha-linolenic acid and immunocompetence in humans. | 1991 | Am. J. Clin. Nutr. | pmid:1670594 |
| Djoussé L et al. | Dietary linolenic acid and carotid atherosclerosis: the National Heart, Lung, and Blood Institute Family Heart Study. | 2003 | Am. J. Clin. Nutr. | pmid:12663278 |
| Innis SM and Elias SL | Intakes of essential n-6 and n-3 polyunsaturated fatty acids among pregnant Canadian women. | 2003 | Am. J. Clin. Nutr. | pmid:12540410 |
| Vos E and Cunnane SC | Alpha-linolenic acid, linoleic acid, coronary artery disease, and overall mortality. | 2003 | Am. J. Clin. Nutr. | pmid:12540417 |
| Finnegan YE et al. | Plant- and marine-derived n-3 polyunsaturated fatty acids have differential effects on fasting and postprandial blood lipid concentrations and on the susceptibility of LDL to oxidative modification in moderately hyperlipidemic subjects. | 2003 | Am. J. Clin. Nutr. | pmid:12663273 |
| Vedtofte MS et al. | Dietary α-linolenic acid, linoleic acid, and n-3 long-chain PUFA and risk of ischemic heart disease. | 2011 | Am. J. Clin. Nutr. | pmid:21865326 |
| Carlson SE et al. | Effect of long-chain n-3 fatty acid supplementation on visual acuity and growth of preterm infants with and without bronchopulmonary dysplasia. | 1996 | Am. J. Clin. Nutr. | pmid:8615350 |
| Connor WE | Alpha-linolenic acid in health and disease. | 1999 | Am. J. Clin. Nutr. | pmid:10232618 |
| Bursztyn P | Does dietary linolenic acid influence blood pressure? | 1987 | Am. J. Clin. Nutr. | pmid:2884863 |
| Decsi T and Kennedy K | Sex-specific differences in essential fatty acid metabolism. | 2011 | Am. J. Clin. Nutr. | pmid:22089435 |
| Dutta-Roy AK | Transport mechanisms for long-chain polyunsaturated fatty acids in the human placenta. | 2000 | Am. J. Clin. Nutr. | pmid:10617989 |
| Horrobin DF | Essential fatty acid metabolism and its modification in atopic eczema. | 2000 | Am. J. Clin. Nutr. | pmid:10617999 |
| Lucas M et al. | Dietary intake of n-3 and n-6 fatty acids and the risk of clinical depression in women: a 10-y prospective follow-up study. | 2011 | Am. J. Clin. Nutr. | pmid:21471279 |
| Oomen CM et al. | alpha-Linolenic acid intake is not beneficially associated with 10-y risk of coronary artery disease incidence: the Zutphen Elderly Study. | 2001 | Am. J. Clin. Nutr. | pmid:11566643 |
| Heskey CE et al. | Adipose tissue α-linolenic acid is inversely associated with insulin resistance in adults. | 2016 | Am. J. Clin. Nutr. | pmid:26912497 |
| Kardinaal AF et al. | Relations between antioxidant vitamins in adipose tissue, plasma, and diet. | 1995 | Am. J. Epidemiol. | pmid:7879788 |
| Ingram AJ et al. | Effects of flaxseed and flax oil diets in a rat-5/6 renal ablation model. | 1995 | Am. J. Kidney Dis. | pmid:7847360 |
| Ascherio A | Epidemiologic studies on dietary fats and coronary heart disease. | 2002 | Am. J. Med. | pmid:12566133 |
| De Lorgeril M and Salen P | Fish and N-3 fatty acids for the prevention and treatment of coronary heart disease: nutrition is not pharmacology. | 2002 | Am. J. Med. | pmid:11893373 |
| JORDAN GL et al. | The effect of linoleic and linolenic acid, estradiol valerate and beta sitosterol upon experimentally induced hypercholesterolemia and the development of lipid changes in the aorta of dogs. | 1961 | Am. J. Med. Sci. | pmid:13790676 |
| Brush MG et al. | Abnormal essential fatty acid levels in plasma of women with premenstrual syndrome. | 1984 | Am. J. Obstet. Gynecol. | pmid:6091462 |
| WARAVDEKAR VS et al. | HEPATIC CHANGES INDUCED BY AN AQUEOUS EXTRACT OF ULTRAVIOLET-IRRADIATED LINOLENIC ACID. | 1964 | Am. J. Pathol. | pmid:14234476 |
| Fiaccavento R et al. | Alpha-linolenic acid-enriched diet prevents myocardial damage and expands longevity in cardiomyopathic hamsters. | 2006 | Am. J. Pathol. | pmid:17148657 |
| Hasler CM et al. | Inhibition of gap junction-mediated intercellular communication by alpha-linolenate. | 1991 | Am. J. Physiol. | pmid:1677533 |
| Emmison N et al. | Linoleic and linolenic acids are selectively secreted in triacylglycerol by hepatocytes from neonatal rats. | 1995 | Am. J. Physiol. | pmid:7631907 |
| Oe H et al. | Calcium overload and cardiac myocyte cell damage induced by arachidonate lipoxygenation. | 1994 | Am. J. Physiol. | pmid:7943384 |
| Chen ZY et al. | Moderate, selective depletion of linoleate and alpha-linolenate in weight-cycled rats. | 1995 | Am. J. Physiol. | pmid:7864247 |
| Sebokova E et al. | Modulation of receptor-mediated gonadotropin action in rat testes by dietary fat. | 1988 | Am. J. Physiol. | pmid:2897795 |
| López-Luna P et al. | Fate of orally administered radioactive fatty acids in the late-pregnant rat. | 2016 | Am. J. Physiol. Endocrinol. Metab. | pmid:26714850 |
| Bessesen DH et al. | Trafficking of dietary oleic, linolenic, and stearic acids in fasted or fed lean rats. | 2000 | Am. J. Physiol. Endocrinol. Metab. | pmid:10827016 |
| Matravadia S et al. | Both linoleic and α-linolenic acid prevent insulin resistance but have divergent impacts on skeletal muscle mitochondrial bioenergetics in obese Zucker rats. | 2014 | Am. J. Physiol. Endocrinol. Metab. | pmid:24844257 |
| Gong Z et al. | G protein-coupled receptor 120 signaling regulates ghrelin secretion in vivo and in vitro. | 2014 | Am. J. Physiol. Endocrinol. Metab. | pmid:24222669 |
| Running CA and Mattes RD | Humans are more sensitive to the taste of linoleic and α-linolenic than oleic acid. | 2015 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:25540234 |
| Friesen R and Innis SM | Maternal dietary fat alters amniotic fluid and fetal intestinal membrane essential n-6 and n-3 fatty acids in the rat. | 2006 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:16282365 |
| McHowat J and Creer MH | Selective plasmalogen substrate utilization by thrombin-stimulated Ca(2+)-independent PLA(2) in cardiomyocytes. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:10843891 |
| Bassett CM et al. | The α-linolenic acid content of flaxseed can prevent the atherogenic effects of dietary trans fat. | 2011 | Am. J. Physiol. Heart Circ. Physiol. | pmid:21963840 |
| Ayalew-Pervanchon A et al. | Long-term effect of dietary {alpha}-linolenic acid or decosahexaenoic acid on incorporation of decosahexaenoic acid in membranes and its influence on rat heart in vivo. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17526653 |
| Matravadia S et al. | LA and ALA prevent glucose intolerance in obese male rats without reducing reactive lipid content, but cause tissue-specific changes in fatty acid composition. | 2016 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:26764053 |
| Namiranian K et al. | Cerebrovascular responses in mice deficient in the potassium channel, TREK-1. | 2010 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:20357027 |
| Muller-Delp JM | The role of TREK-1 in cerebrovascular regulation remains elusive: focus on "Cerebrovascular responses in mice deficient in the potassium channel, TREK-1". | 2010 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:20484697 |
| Conde-Sieira M et al. | Hypothalamic fatty acid sensing in Senegalese sole (Solea senegalensis): response to long-chain saturated, monounsaturated, and polyunsaturated (n-3) fatty acids. | 2015 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:26468264 |
| Al-Khalifa A et al. | Effect of dietary hempseed intake on cardiac ischemia-reperfusion injury. | 2007 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:17122327 |
| Sea MM et al. | Weight cycling-induced alteration in fatty acid metabolism. | 2000 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:10956277 |
| Turk HF et al. | Inhibitory effects of omega-3 fatty acids on injury-induced epidermal growth factor receptor transactivation contribute to delayed wound healing. | 2013 | Am. J. Physiol., Cell Physiol. | pmid:23426968 |
| Reiner WB et al. | Fatty acids in mountain gorilla diets: implications for primate nutrition and health. | 2014 | Am. J. Primatol. | pmid:24243235 |
| Henry MM et al. | Influence of an omega-3 fatty acid-enriched ration on in vivo responses of horses to endotoxin. | 1991 | Am. J. Vet. Res. | pmid:1675842 |
| Morris DD et al. | Effect of dietary alpha-linolenic acid on endotoxin-induced production of tumor necrosis factor by peritoneal macrophages in horses. | 1991 | Am. J. Vet. Res. | pmid:1675843 |
| Munsterman AS et al. | Effects of the omega-3 fatty acid, alpha-linolenic acid, on lipopolysaccharide-challenged synovial explants from horses. | 2005 | Am. J. Vet. Res. | pmid:16261822 |
| Mazaki-Tovi M et al. | Effect of omega-3 fatty acids on serum concentrations of adipokines in healthy cats. | 2011 | Am. J. Vet. Res. | pmid:21879986 |
| Guelzim N et al. | A role for PPARα in the regulation of arginine metabolism and nitric oxide synthesis. | 2011 | Amino Acids | pmid:21063737 |
| Kim CH et al. | Effects of emulsified octadecanic acids on gas production and cellulolysis by the rumen anaerobic fungus, Piromyces communis M014. | 2008 | Anaerobe | pmid:17996466 |
| Wang YL et al. | LC-DAD-APCI-MS-based screening and analysis of the absorption and metabolite components in plasma from a rabbit administered an oral solution of danggui. | 2005 | Anal Bioanal Chem | pmid:16132135 |
| Molkentin J and Giesemann A | Differentiation of organically and conventionally produced milk by stable isotope and fatty acid analysis. | 2007 | Anal Bioanal Chem | pmid:17393158 |
| Martin CA et al. | Trans polyunsaturated fatty acid contents in Brazilian refined soybean oil. | 2006 | Anal Sci | pmid:16760612 |
| Degousée N et al. | Measurement of thermally produced volatile alkanes: an assay for plant hydroperoxy fatty acid evaluation. | 1995 | Anal. Biochem. | pmid:7733454 |
| Schneider C et al. | Enantiomeric separation of hydroxy eicosanoids by chiral column chromatography: effect of the alcohol modifier. | 2000 | Anal. Biochem. | pmid:11078601 |
| Oliw EH et al. | Payne rearrangement during analysis of epoxyalcohols of linoleic and alpha-linolenic acids by normal phase liquid chromatography with tandem mass spectrometry. | 2006 | Anal. Biochem. | pmid:16712763 |
| Hejazi L et al. | Determination of the composition of fatty acid mixtures using GC x FI-MS: a comprehensive two-dimensional separation approach. | 2009 | Anal. Chem. | pmid:19146461 |
| Yoo HJ and HÃ¥kansson K | Determination of double bond location in fatty acids by manganese adduction and electron induced dissociation. | 2010 | Anal. Chem. | pmid:20704384 |
| Gómez-Cortés P et al. | Production of isotopically labeled standards from a uniformly labeled precursor for quantitative volatile metabolomic studies. | 2012 | Anal. Chem. | pmid:22662968 |
| Wu D et al. | Determination of alpha-linolenic acid and linoleic acid in edible oils using near-infrared spectroscopy improved by wavelet transform and uninformative variable elimination. | 2009 | Anal. Chim. Acta | pmid:19185115 |
| Moodley R et al. | Elemental composition and fatty acid profile of the edible fruits of Amatungula (Carissa macrocarpa) and impact of soil quality on chemical characteristics. | 2012 | Anal. Chim. Acta | pmid:22632042 |
| Huang YQ et al. | Use of isotope mass probes for metabolic analysis of the jasmonate biosynthetic pathway. | 2011 | Analyst | pmid:21331428 |
| HILDITCH TP and SHRIVASTAVA RK | The spectrophotometric determination of small proportions of linolenic acid in fats. | 1947 | Analyst | pmid:18901122 |
| Tavilani H et al. | Decreased polyunsaturated and increased saturated fatty acid concentration in spermatozoa from asthenozoospermic males as compared with normozoospermic males. | 2006 | Andrologia | pmid:16961570 |
| Heller AR et al. | Omega-3 alpha linolenic acid does not reflect the entire omega-3 fatty acid family. | 2006 | Anesth. Analg. | pmid:16551943 |
| Paschos GK et al. | Apolipoprotein E genotype in dyslipidemic patients and response of blood lipids and inflammatory markers to alpha-linolenic Acid. | 2005 Jan-Feb | Angiology | pmid:15678256 |
| Kaka A et al. | α-Linolenic acid supplementation in BioXcell® extender can improve the quality of post-cooling and frozen-thawed bovine sperm. | 2015 | Anim. Reprod. Sci. | pmid:25544152 |
| Mattioli S et al. | Performance and egg quality of laying hens fed flaxseed: highlights on n-3 fatty acids, cholesterol, lignans and isoflavones. | 2017 | Animal | pmid:27819218 |
| Yang YX et al. | Effects of duodenal infusion of free α-linolenic acid on the plasma and milk proteome of lactating dairy cows. | 2013 | Animal | pmid:23031206 |
| Smink W et al. | Linoleic and α-linolenic acid as precursor and inhibitor for the synthesis of long-chain polyunsaturated fatty acids in liver and brain of growing pigs. | 2012 | Animal | pmid:22436184 |
| Chen W et al. | Effect of flaxseed on the fatty acid profile of egg yolk and antioxidant status of their neonatal offspring in Huoyan geese. | 2015 | Animal | pmid:26173627 |
| Budowski P et al. | [Protective effect of alpha-linolenic acid in encephalomalacia in chickens]. | 1980 | Ann Nutr Aliment | pmid:6254420 |
| François M et al. | [Effects of a dietary deficiency of alpha-linolenic acid in the rat]. | 1980 | Ann Nutr Aliment | pmid:6254422 |
| Shi X et al. | Efficacy of taurine based compounds as hydroxyl radical scavengers in silica induced peroxidation. | 1997 Sep-Oct | Ann. Clin. Lab. Sci. | pmid:9303176 |
| Kankaanpää P et al. | Dietary fatty acids and allergy. | 1999 | Ann. Med. | pmid:10480759 |
| Babu US et al. | Impact of in vitro fatty acid uptake on nitric oxide production and antilisterial activity of WEHI-3 cells. | 1996 | Ann. N. Y. Acad. Sci. | pmid:8993386 |
| Kim JY et al. | Growth-inhibitory and proapoptotic effects of alpha-linolenic acid on estrogen-positive breast cancer cells. | 2009 | Ann. N. Y. Acad. Sci. | pmid:19723055 |
| Yu JH et al. | Effects of omega-3 fatty acids on apoptosis of human gastric epithelial cells exposed to silica-immobilized glucose oxidase. | 2009 | Ann. N. Y. Acad. Sci. | pmid:19723076 |
| Park KS et al. | Inhibitory mechanism of omega-3 fatty acids in pancreatic inflammation and apoptosis. | 2009 | Ann. N. Y. Acad. Sci. | pmid:19723085 |
| Brenna JT and Lapillonne A | Background paper on fat and fatty acid requirements during pregnancy and lactation. | 2009 | Ann. Nutr. Metab. | pmid:19752538 |
| Galli C and Calder PC | Effects of fat and fatty acid intake on inflammatory and immune responses: a critical review. | 2009 | Ann. Nutr. Metab. | pmid:19752539 |
| Egert S et al. | Effects of dietary alpha-linolenic acid, eicosapentaenoic acid or docosahexaenoic acid on parameters of glucose metabolism in healthy volunteers. | 2008 | Ann. Nutr. Metab. | pmid:19011281 |
| Ikeda A and Sugano M | Interaction of dietary protein and alpha-linolenic acid on polyunsaturated fatty acid composition of liver microsomal phospholipids and eicosanoid production in streptozotocin-induced diabetic rats. | 1993 | Ann. Nutr. Metab. | pmid:8103979 |
| Valenzuela A et al. | Supplementation of female rats with alpha-linolenic acid or docosahexaenoic acid leads to the same omega-6/omega-3 LC-PUFA accretion in mother tissues and in fetal and newborn brains. | 2004 | Ann. Nutr. Metab. | pmid:14639043 |
| Fuhrmann H and Sallmann HP | Alpha-tocopherol and phospholipase A2 in liver and brain of chicks posthatching: the influence of dietary fat and vitamin E. | 1995 | Ann. Nutr. Metab. | pmid:8585700 |
| Santos MJ et al. | Influence of dietary supplementation with fish on plasma fatty acid composition in coronary heart disease patients. | 1995 | Ann. Nutr. Metab. | pmid:7872656 |
| Lohner S et al. | Gender differences in the long-chain polyunsaturated fatty acid status: systematic review of 51 publications. | 2013 | Ann. Nutr. Metab. | pmid:23327902 |
| Bourre JM et al. | Fatty acid alterations in liver peroxisomes from n-3-deficient mice. | 2006 | Ann. Nutr. Metab. | pmid:16407648 |
| Nouvelot A et al. | Hepatic metabolism of dietary alpha-linolenic acid in suckling rats, and its possible importance in polyunsaturated fatty acid uptake by the brain. | 1986 | Ann. Nutr. Metab. | pmid:2875687 |
| Roth HP and Kirchgessner M | [Effect of various unsaturated fatty acids on the stability of the erythrocyte membrane in the rat]. | 1992 | Ann. Nutr. Metab. | pmid:1354951 |
| Aziz AA et al. | Increasing Dietary alpha-linolenic acid enhances tissue levels of long-chain n-3 PUFA when linoleic acid intake is low in hamsters. | 2010 | Ann. Nutr. Metab. | pmid:20714137 |
| Xiang M et al. | Diet and gene expression: delta-5 and delta-6 desaturases in healthy Chinese and European subjects. | 2006 | Ann. Nutr. Metab. | pmid:16988497 |
| Kim E et al. | Effects of gamma-irradiated fats on plasma lipid concentrations and hepatic cholesterol metabolism in rats. | 2001 | Ann. Nutr. Metab. | pmid:11463998 |
| Barre DE | Potential of evening primrose, borage, black currant, and fungal oils in human health. | 2001 | Ann. Nutr. Metab. | pmid:11359029 |
| De Vriese SR et al. | Estimation of dietary fat intake of Belgian pregnant women. Comparison of two methods. | 2001 | Ann. Nutr. Metab. | pmid:11786650 |
| Inui K et al. | The nutritional effect of a-linolenic acid-rich emulsion with total parenteral nutrition in a rat model with inflammatory bowel disease. | 1996 | Ann. Nutr. Metab. | pmid:8886251 |
| Inui K et al. | The effect of alpha-linolenic acid-rich emulsion on fatty acid metabolism and leukotriene generation of the colon in a rat model with inflammatory bowel disease. | 1996 | Ann. Nutr. Metab. | pmid:8862700 |
| Ayerza R and Coates W | Effect of dietary alpha-linolenic fatty acid derived from chia when fed as ground seed, whole seed and oil on lipid content and fatty acid composition of rat plasma. | 2007 | Ann. Nutr. Metab. | pmid:17356263 |