alpha-linolenic acid

Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.

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Introduction

To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with alpha-linolenic acid?

alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid

MeSH term MeSH ID Detail
Liver Diseases D008107 31 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Learning Disorders D007859 11 associated lipids
Insulin Resistance D007333 99 associated lipids
Insect Bites and Stings D007299 4 associated lipids
Inflammation D007249 119 associated lipids
Hypertension D006973 115 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Hypersensitivity D006967 22 associated lipids
Hyperlipidemia, Familial Combined D006950 9 associated lipids
Hyperlipidemias D006949 73 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hemolysis D006461 131 associated lipids
Heart Failure D006333 36 associated lipids
Hearing Loss, High-Frequency D006316 1 associated lipids
Fatty Liver D005234 48 associated lipids
Mental Fatigue D005222 3 associated lipids
Epilepsy D004827 35 associated lipids
Endomyocardial Fibrosis D004719 4 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Edema D004487 152 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Diabetic Angiopathies D003925 20 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Dermatitis D003872 30 associated lipids
Deficiency Diseases D003677 12 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Coronary Disease D003327 70 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Conjunctivitis, Allergic D003233 1 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Colitis D003092 69 associated lipids
Brain Ischemia D002545 89 associated lipids
Cattle Diseases D002418 24 associated lipids
Cat Diseases D002371 12 associated lipids
Bronchial Spasm D001986 18 associated lipids
Breast Neoplasms D001943 24 associated lipids
Body Weight D001835 333 associated lipids
Urinary Bladder Neoplasms D001749 7 associated lipids
Birth Weight D001724 23 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Atrial Fibrillation D001281 16 associated lipids
Arthritis D001168 41 associated lipids
Arteriosclerosis D001161 86 associated lipids
Aortic Diseases D001018 11 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with alpha-linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with alpha-linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with alpha-linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with alpha-linolenic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with alpha-linolenic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with alpha-linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with alpha-linolenic acid

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Authors Title Published Journal PubMed Link
Perumalsamy H et al. Larvicidal activity and possible mode of action of four flavonoids and two fatty acids identified in Millettia pinnata seed toward three mosquito species. 2015 Parasit Vectors pmid:25928224
Llanos A et al. Infants with intrauterine growth restriction have impaired formation of docosahexaenoic acid in early neonatal life: a stable isotope study. 2005 Pediatr. Res. pmid:16189202
Woods J et al. Is docosahexaenoic acid necessary in infant formula? Evaluation of high linolenate diets in the neonatal rat. 1996 Pediatr. Res. pmid:8910933
Bongiovanni KD et al. Neonatal growth rate and development of mice raised on milk transgenically enriched with omega-3 fatty acids. 2007 Pediatr. Res. pmid:17667849
Greiner RC et al. Brain docosahexaenoate accretion in fetal baboons: bioequivalence of dietary alpha-linolenic and docosahexaenoic acids. 1997 Pediatr. Res. pmid:9396565
Lefkowitz W et al. Where does the developing brain obtain its docosahexaenoic acid? Relative contributions of dietary alpha-linolenic acid, docosahexaenoic acid, and body stores in the developing rat. 2005 Pediatr. Res. pmid:15531740
Su HM et al. Bioequivalence of dietary alpha-linolenic and docosahexaenoic acids as sources of docosahexaenoate accretion in brain and associated organs of neonatal baboons. 1999 Pediatr. Res. pmid:9890614
Larqué E et al. Dietary trans fatty acids affect docosahexaenoic acid concentrations in plasma and liver but not brain of pregnant and fetal rats. 2000 Pediatr. Res. pmid:10674359
Bowen RA et al. Does increasing dietary linolenic acid content increase the docosahexaenoic acid content of phospholipids in neuronal cells of neonatal rats? 1999 Pediatr. Res. pmid:10367771
Anderson GJ et al. Can prenatal N-3 fatty acid deficiency be completely reversed after birth? Effects on retinal and brain biochemistry and visual function in rhesus monkeys. 2005 Pediatr. Res. pmid:16257925
Cunnane SC et al. Suckling rats actively recycle carbon from alpha-linolenate into newly synthesized lipids even during extreme dietary deficiency of n-3 polyunsaturates. 2006 Pediatr. Res. pmid:16326997
Carlson SE et al. Long-term feeding of formulas high in linolenic acid and marine oil to very low birth weight infants: phospholipid fatty acids. 1991 Pediatr. Res. pmid:1684416
Mayes C et al. Variation in [U-13C] alpha linolenic acid absorption, beta-oxidation and conversion to docosahexaenoic acid in the pre-term infant fed a DHA-enriched formula. 2006 Pediatr. Res. pmid:16439591
de la Presa Owens S and Innis SM Diverse, region-specific effects of addition of arachidonic and docosahexanoic acids to formula with low or adequate linoleic and alpha-linolenic acids on piglet brain monoaminergic neurotransmitters. 2000 Pediatr. Res. pmid:10879811
Carnielli VP et al. The very low birth weight premature infant is capable of synthesizing arachidonic and docosahexaenoic acids from linoleic and linolenic acids. 1996 Pediatr. Res. pmid:8798265
Fu Z and Sinclair AJ Novel pathway of metabolism of alpha-linolenic acid in the guinea pig. 2000 Pediatr. Res. pmid:10709744
Yehuda S et al. Fatty acids and brain peptides. 1998 Peptides pmid:9493877
Tattersall AL and Wilkins RJ Effects of hexosamines and omega-3/omega-6 fatty acids on pH regulation by interleukin 1-treated isolated bovine articular chondrocytes. 2008 Pflugers Arch. pmid:18204856
Rastogi SK and Singh J Effect of chemical penetration enhancer and iontophoresis on the in vitro percutaneous absorption enhancement of insulin through porcine epidermis. 2005 Pharm Dev Technol pmid:15776817
Yehuda S Possible anti-Parkinson properties of N-(alpha-linolenoyl) tyrosine: a new molecule. 2002 Pharmacol. Biochem. Behav. pmid:11900763
Eckert GP et al. Plant derived omega-3-fatty acids protect mitochondrial function in the brain. 2010 Pharmacol. Res. pmid:20079842
Nguemeni C et al. Dietary supplementation of alpha-linolenic acid in an enriched rapeseed oil diet protects from stroke. 2010 Pharmacol. Res. pmid:20036742
Furuno K et al. Lipid peroxidation induced by adriamycin in linolenic acid-loaded cultured hepatocytes. 1998 Pharmacol. Toxicol. pmid:9820879
Brown RO et al. Comparison of specialized and standard enteral formulas in trauma patients. 1994 May-Jun Pharmacotherapy pmid:7937272
Takemura N et al. Dietary, but not topical, alpha-linolenic acid suppresses UVB-induced skin injury in hairless mice when compared with linoleic acids. 2002 Photochem. Photobiol. pmid:12511046
Anthony FA et al. Psoralen-fatty acid adducts activate melanocyte protein kinase C: a proposed mechanism for melanogenesis induced by 8-methoxypsoralen and ultraviolet A light. 1997 Feb-Apr Photodermatol Photoimmunol Photomed pmid:9361122
Paré PW et al. Elicitors and priming agents initiate plant defense responses. 2005 Photosyn. Res. pmid:16075316
Sampels S et al. Fatty acid transfer from sow to piglet differs for different polyunsaturated fatty acids (PUFA). 2011 Physiol Res pmid:20945951
Levant B et al. Developmental effects of dietary n-3 fatty acids on activity and response to novelty. 2010 Physiol. Behav. pmid:20457171
Georgiadi A et al. Detailed transcriptomics analysis of the effect of dietary fatty acids on gene expression in the heart. 2012 Physiol. Genomics pmid:22274564
House RL et al. Functional genomic characterization of delipidation elicited by trans-10, cis-12-conjugated linoleic acid (t10c12-CLA) in a polygenic obese line of mice. 2005 Physiol. Genomics pmid:15888570
Salazar MO et al. A thin-layer chromatography autographic method for the detection of inhibitors of the Salmonella PhoP-PhoQ regulatory system. 2014 Mar-Apr Phytochem Anal pmid:24185747
Qu WX et al. Analysis of fatty acids in A. szechenyianum Gay. by microwave-assisted extraction and gas chromatography-mass spectrometry. 2011 May-Jun Phytochem Anal pmid:20848395
Williams M and Harwood JL Characterisation of lipoxygenase isoforms from olive callus cultures. 2008 Phytochemistry pmid:18790508
Lagunas B et al. A temporal regulatory mechanism controls the different contribution of endoplasmic reticulum and plastidial ω-3 desaturases to trienoic fatty acid content during leaf development in soybean (Glycine max cv Volania). 2013 Phytochemistry pmid:23928132
Ichihara K and Suda Y Lipid biosynthesis in developing perilla seeds. 2003 Phytochemistry pmid:12711134
Frey M et al. Transcriptional activation of Igl, the gene for indole formation in Zea mays: a structure-activity study with elicitor-active N-acyl glutamines from insects. 2004 Phytochemistry pmid:15110684
Fisher AJ et al. The biochemical origin of pentenol emissions from wounded leaves. 2003 Phytochemistry pmid:12482451
Chechetkin IR et al. Isolation and structure elucidation of linolipins C and D, complex oxylipins from flax leaves. 2013 Phytochemistry pmid:24042063
Daligault F et al. Mechanistic characterization of omega-3 desaturation in the green alga Chlorella vulgaris. 2003 Phytochemistry pmid:12877913
Padilla MN et al. Molecular cloning, functional characterization and transcriptional regulation of a 9-lipoxygenase gene from olive. 2012 Phytochemistry pmid:22169502
Tsukada K et al. Biosynthesis of jasmonic acid in a plant pathogenic fungus, Lasiodiplodia theobromae. 2010 Phytochemistry pmid:20952041
Jablonická V et al. Identification of a secretory phospholipase A2 from Papaver somniferum L. that transforms membrane phospholipids. 2016 Phytochemistry pmid:27473012
Shinohara R et al. Evaluation of antilipid peroxidative action of propolis ethanol extract. 2002 Phytother Res pmid:12112290
Jäger AK et al. Isolation of linoleic and alpha-linolenic acids as COX-1 and -2 inhibitors in rose hip. 2008 Phytother Res pmid:18389471
Chou YC et al. Bioassay-guided purification and identification of PPARalpha/gamma agonists from Chlorella sorokiniana. 2008 Phytother Res pmid:18398904
Christensen KB et al. Identification of bioactive compounds from flowers of black elder (Sambucus nigra L.) that activate the human peroxisome proliferator-activated receptor (PPAR) gamma. 2010 Phytother Res pmid:20222152
Demchenko K et al. Analysis of the subcellular localisation of lipoxygenase in legume and actinorhizal nodules. 2012 Plant Biol (Stuttg) pmid:21973171
Ruiz-López N et al. The synthesis and accumulation of stearidonic acid in transgenic plants: a novel source of 'heart-healthy' omega-3 fatty acids. 2009 Plant Biotechnol. J. pmid:19702757
Park H et al. Towards the development of a sustainable soya bean-based feedstock for aquaculture. 2017 Plant Biotechnol. J. pmid:27496594
Lenka SK et al. Comparative analysis of drought-responsive transcriptome in Indica rice genotypes with contrasting drought tolerance. 2011 Plant Biotechnol. J. pmid:20809928
Maeda H et al. Tocopherols modulate extraplastidic polyunsaturated fatty acid metabolism in Arabidopsis at low temperature. 2008 Plant Cell pmid:18314499
Truitt CL et al. A plasma membrane protein from Zea mays binds with the herbivore elicitor volicitin. 2004 Plant Cell pmid:14729912
Kunz HH et al. The ABC transporter PXA1 and peroxisomal beta-oxidation are vital for metabolism in mature leaves of Arabidopsis during extended darkness. 2009 Plant Cell pmid:19794119
Okuley J et al. Arabidopsis FAD2 gene encodes the enzyme that is essential for polyunsaturated lipid synthesis. 1994 Plant Cell pmid:7907506
Howe GA et al. An octadecanoid pathway mutant (JL5) of tomato is compromised in signaling for defense against insect attack. 1996 Plant Cell pmid:8953771
Sánchez-Hernández C et al. Reduced levels of volatile emissions in jasmonate-deficient spr2 tomato mutants favour oviposition by insect herbivores. 2006 Plant Cell Environ. pmid:17080606
Yara A et al. Disease resistance against Magnaporthe grisea is enhanced in transgenic rice with suppression of omega-3 fatty acid desaturases. 2007 Plant Cell Physiol. pmid:17716996
Suzuki M et al. Endogenous alpha-ketol linolenic acid levels in short day-induced cotyledons are closely related to flower induction in Pharbitis nil. 2003 Plant Cell Physiol. pmid:12552145
Yamaguchi S et al. Identification of a component that induces flowering of Lemna among the reaction products of alpha-ketol linolenic acid (FIF) and norepinephrine. 2001 Plant Cell Physiol. pmid:11726704
Yokoyama M et al. Stress-induced factor involved in flower formation of Lemna is an alpha-ketol derivative of linolenic acid. 2000 Plant Cell Physiol. pmid:10750715
Küpper FC et al. Free Fatty Acids and Methyl Jasmonate Trigger Defense Reactions in Laminaria digitata. 2009 Plant Cell Physiol. pmid:19213737
Choi SB et al. Transcriptional expression characteristics and subcellular localization of ADP-glucose pyrophosphorylase in the oil plant Perilla frutescens. 2001 Plant Cell Physiol. pmid:11230568
Saubeau G et al. Differential induction of oxylipin pathway in potato and tobacco cells by bacterial and oomycete elicitors. 2013 Plant Cell Rep. pmid:23479199
Freiberger CE et al. Nutrient content of the edible leaves of seven wild plants from Niger. 1998 Plant Foods Hum Nutr pmid:10890758
Jin F et al. Supplementation of milled chia seeds increases plasma ALA and EPA in postmenopausal women. 2012 Plant Foods Hum Nutr pmid:22538527
Rao MS et al. Yield, protein, and oil quality of soybean genotypes selected for tofu production. 1998 Plant Foods Hum Nutr pmid:9950085
Baudouin E et al. Short communication: unsaturated fatty acids inhibit MP2C, a protein phosphatase 2C involved in the wound-induced MAP kinase pathway regulation. 1999 Plant J. pmid:10571894
O'Neill CM et al. Two high linolenic mutants of Arabidopsis thaliana contain megabase-scale genome duplications encompassing the FAD3 locus. 2011 Plant J. pmid:21848868
Kajikawa M et al. Isolation and characterization of delta(6)-desaturase, an ELO-like enzyme and delta(5)-desaturase from the liverwort Marchantia polymorpha and production of arachidonic and eicosapentaenoic acids in the methylotrophic yeast Pichia pastoris. 2004 Plant Mol. Biol. pmid:15284491
Mariutto M et al. Reprogramming of fatty acid and oxylipin synthesis in rhizobacteria-induced systemic resistance in tomato. 2014 Plant Mol. Biol. pmid:24146221
Kaup MT et al. A role for diacylglycerol acyltransferase during leaf senescence. 2002 Plant Physiol. pmid:12177474
Schmelz EA et al. Nitrogen deficiency increases volicitin-induced volatile emission, jasmonic acid accumulation, and ethylene sensitivity in maize. 2003 Plant Physiol. pmid:12970495
Fraser TC et al. Expression of the Isochrysis C18-delta9 polyunsaturated fatty acid specific elongase component alters Arabidopsis glycerolipid profiles. 2004 Plant Physiol. pmid:15173563
Koch T et al. Differential induction of plant volatile biosynthesis in the lima bean by early and late intermediates of the octadecanoid-signaling pathway. 1999 Plant Physiol. pmid:10482670
Maffei M et al. Effects of feeding Spodoptera littoralis on lima bean leaves. I. Membrane potentials, intracellular calcium variations, oral secretions, and regurgitate components. 2004 Plant Physiol. pmid:15051862
Shimada TL et al. Leaf oil body functions as a subcellular factory for the production of a phytoalexin in Arabidopsis. 2014 Plant Physiol. pmid:24214535
von Berlepsch S et al. The acyl-acyl carrier protein synthetase from Synechocystis sp. PCC 6803 mediates fatty acid import. 2012 Plant Physiol. pmid:22535424
Clemente TE and Cahoon EB Soybean oil: genetic approaches for modification of functionality and total content. 2009 Plant Physiol. pmid:19783644
Qi J et al. The chloroplast-localized phospholipases D α4 and α5 regulate herbivore-induced direct and indirect defenses in rice. 2011 Plant Physiol. pmid:21984727
Cahoon EB et al. Transgenic production of epoxy fatty acids by expression of a cytochrome P450 enzyme from Euphorbia lagascae seed. 2002 Plant Physiol. pmid:11842164
Vrinten P et al. Two FAD3 desaturase genes control the level of linolenic acid in flax seed. 2005 Plant Physiol. pmid:16113219
Marmon S et al. Two Acyltransferases Contribute Differently to Linolenic Acid Levels in Seed Oil. 2017 Plant Physiol. pmid:28235891
Vigeolas H et al. Nonsymbiotic hemoglobin-2 leads to an elevated energy state and to a combined increase in polyunsaturated fatty acids and total oil content when overexpressed in developing seeds of transgenic Arabidopsis plants. 2011 Plant Physiol. pmid:21205621
Domínguez T et al. Increasing omega-3 desaturase expression in tomato results in altered aroma profile and enhanced resistance to cold stress. 2010 Plant Physiol. pmid:20382895
Mata-Pérez C et al. Nitro-Fatty Acids in Plant Signaling: Nitro-Linolenic Acid Induces the Molecular Chaperone Network in Arabidopsis. 2016 Plant Physiol. pmid:26628746
Norton G et al. Characterisation of recombinant Hevea brasiliensis allene oxide synthase: effects of cycloxygenase inhibitors, lipoxygenase inhibitors and salicylates on enzyme activity. 2007 Plant Physiol. Biochem. pmid:17344058
Zhang HY et al. Isolation and functional assessment of a tomato proteinase inhibitor II gene. 2004 Plant Physiol. Biochem. pmid:15191748
Afitlhile M et al. A mutant of the Arabidopsis thaliana TOC159 gene accumulates reduced levels of linolenic acid and monogalactosyldiacylglycerol. 2013 Plant Physiol. Biochem. pmid:24184455
Yamauchi Y et al. Malondialdehyde generated from peroxidized linolenic acid causes protein modification in heat-stressed plants. 2008 Aug-Sep Plant Physiol. Biochem. pmid:18538576
Chua AC et al. Characterization of oil bodies in jelly fig achenes. 2008 May-Jun Plant Physiol. Biochem. pmid:18434174
Berkov S et al. Changes in apolar metabolites during in vitro organogenesis of Pancratium maritimum. 2010 Oct-Nov Plant Physiol. Biochem. pmid:20702100
Lorenzi V et al. Purification, product characterization and kinetic properties of lipoxygenase from olive fruit (Olea europaea L.). 2006 Jul-Sep Plant Physiol. Biochem. pmid:17011785
Venegas-Calerón M et al. Effect of the ferredoxin electron donor on sunflower (Helianthus annuus) desaturases. 2009 Plant Physiol. Biochem. pmid:19342250
Li T et al. Defense priming by non-jasmonate producing fatty acids in maize (Zea mays). 2016 Plant Signal Behav pmid:27763804
Seltmann MA et al. Jasmonates during senescence: signals or products of metabolism? 2010 Plant Signal Behav pmid:21057217
Truitt CL and Paré PW In situ translocation of volicitin by beet armyworm larvae to maize and systemic immobility of the herbivore elicitor in planta. 2004 Planta pmid:14685859
Schmelz EA et al. The influence of intact-plant and excised-leaf bioassay designs on volicitin- and jasmonic acid-induced sesquiterpene volatile release in Zea mays. 2001 Planta pmid:11800380
Deng YM et al. Anti-asthmatic effects of Perilla seed oil in the guinea pig in vitro and in vivo. 2007 Planta Med. pmid:17315310
Park WS et al. Torilin from Torilis japonica, as a new inhibitor of testosterone 5 alpha-reductase. 2003 Planta Med. pmid:12802730