alpha-linolenic acid
Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
Cross Reference
Introduction
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with alpha-linolenic acid?
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
PubChem Associated disorders and diseases
What pathways are associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with alpha-linolenic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with alpha-linolenic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with alpha-linolenic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Herdmann A et al. | Effect of dietary n-3 and n-6 PUFA on lipid composition of different tissues of German Holstein bulls and the fate of bioactive fatty acids during processing. | 2010 | J. Agric. Food Chem. | pmid:20597504 |
| Beezhold BL et al. | Vegetarian diets are associated with healthy mood states: a cross-sectional study in seventh day adventist adults. | 2010 | Nutr J | pmid:20515497 |
| Wien M et al. | Decreasing the linoleic acid to alpha-linolenic acid diet ratio increases eicosapentaenoic acid in erythrocytes in adults. | 2010 | Lipids | pmid:20496049 |
| Sartorelli DS et al. | Dietary omega-3 fatty acid and omega-3: omega-6 fatty acid ratio predict improvement in glucose disturbances in Japanese Brazilians. | 2010 | Nutrition | pmid:19647413 |
| Even P et al. | Postprandial effects of a lipid-rich meal in the rat are modulated by the degree of unsaturation of 18C fatty acids. | 2010 | Metab. Clin. Exp. | pmid:19775712 |
| Ben Youssef N et al. | Effect of olive ripeness on chemical properties and phenolic composition of Chétoui virgin olive oil. | 2010 | J. Sci. Food Agric. | pmid:20355031 |
| Namiranian K et al. | Cerebrovascular responses in mice deficient in the potassium channel, TREK-1. | 2010 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:20357027 |
| Adkins Y and Kelley DS | Mechanisms underlying the cardioprotective effects of omega-3 polyunsaturated fatty acids. | 2010 | J. Nutr. Biochem. | pmid:20382009 |
| Field CJ et al. | Effect of feeding a formula supplemented with long-chain polyunsaturated fatty acids for 14 weeks improves the ex vivo response to a mitogen and reduces the response to a soy protein in infants at low risk for allergy. | 2010 | J. Pediatr. Gastroenterol. Nutr. | pmid:20386325 |
| Gracious BL et al. | Randomized, placebo-controlled trial of flax oil in pediatric bipolar disorder. | 2010 | Bipolar Disord | pmid:20402707 |
| Wall R et al. | Impact of administered bifidobacterium on murine host fatty acid composition. | 2010 | Lipids | pmid:20405232 |
| Mazer LM et al. | Docosahexaenoic acid status in females of reproductive age with maple syrup urine disease. | 2010 | J. Inherit. Metab. Dis. | pmid:20217236 |
| Carayol M et al. | Prospective studies of dietary alpha-linolenic acid intake and prostate cancer risk: a meta-analysis. | 2010 | Cancer Causes Control | pmid:19921446 |
| Ander BP et al. | Distribution of omega-3 fatty acids in tissues of rabbits fed a flaxseed-supplemented diet. | 2010 | Metab. Clin. Exp. | pmid:19913851 |
| Legrand P et al. | The consumption of food products from linseed-fed animals maintains erythrocyte omega-3 fatty acids in obese humans. | 2010 | Lipids | pmid:20012223 |
| Zhu H et al. | Dietary fish oil n-3 polyunsaturated fatty acids and alpha-linolenic acid differently affect brain accretion of docosahexaenoic acid and expression of desaturases and sterol regulatory element-binding protein 1 in mice. | 2010 | J. Nutr. Biochem. | pmid:19954955 |
| Niewitetzki O et al. | A new near-infrared reflectance spectroscopy method for high-throughput analysis of oleic acid and linolenic acid content of single seeds in oilseed rape (Brassica napus L.). | 2010 | J. Agric. Food Chem. | pmid:19961144 |
| Christensen KB et al. | Activation of the nuclear receptor PPARγ by metabolites isolated from sage (Salvia officinalis L.). | 2010 | J Ethnopharmacol | pmid:20696231 |
| Davis PF et al. | Dopamine receptor alterations in female rats with diet-induced decreased brain docosahexaenoic acid (DHA): interactions with reproductive status. | 2010 | Nutr Neurosci | pmid:20670471 |
| Talahalli RR et al. | Lower efficacy in the utilization of dietary ALA as compared to preformed EPA + DHA on long chain n-3 PUFA levels in rats. | 2010 | Lipids | pmid:20734237 |
| Levant B et al. | Developmental effects of dietary n-3 fatty acids on activity and response to novelty. | 2010 | Physiol. Behav. | pmid:20457171 |
| Stumpe M et al. | The moss Physcomitrella patens contains cyclopentenones but no jasmonates: mutations in allene oxide cyclase lead to reduced fertility and altered sporophyte morphology. | 2010 | New Phytol. | pmid:20704658 |
| Begg DP et al. | Hypertension induced by omega-3 polyunsaturated fatty acid deficiency is alleviated by alpha-linolenic acid regardless of dietary source. | 2010 | Hypertens. Res. | pmid:20520615 |
| Szalai G et al. | Effect of nitrogen source in the fertilizing solution on nutritional quality of three members of the Portulaca oleracea aggregate. | 2010 | J. Sci. Food Agric. | pmid:20572061 |
| Broughton KS et al. | High α-linolenic acid and fish oil ingestion promotes ovulation to the same extent in rats. | 2010 | Nutr Res | pmid:21056289 |
| Seltmann MA et al. | Jasmonates during senescence: signals or products of metabolism? | 2010 | Plant Signal Behav | pmid:21057217 |
| Brand A et al. | Retailoring docosahexaenoic acid-containing phospholipid species during impaired neurogenesis following omega-3 alpha-linolenic acid deprivation. | 2010 | J. Neurochem. | pmid:20557429 |
| Lin YH et al. | Compartmental analyses of 2H5-alpha-linolenic acid and C-U-eicosapentaenoic acid toward synthesis of plasma labeled 22:6n-3 in newborn term infants. | 2010 | Am. J. Clin. Nutr. | pmid:20534748 |
| Muller-Delp JM | The role of TREK-1 in cerebrovascular regulation remains elusive: focus on "Cerebrovascular responses in mice deficient in the potassium channel, TREK-1". | 2010 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:20484697 |
| Degirolamo C et al. | Dietary n-3 LCPUFA from fish oil but not alpha-linolenic acid-derived LCPUFA confers atheroprotection in mice. | 2010 | J. Lipid Res. | pmid:20154006 |
| Fekete K and Decsi T | Long-chain polyunsaturated fatty acids in inborn errors of metabolism. | 2010 | Nutrients | pmid:22254065 |
| Seo PJ et al. | Proteolytic processing of an Arabidopsis membrane-bound NAC transcription factor is triggered by cold-induced changes in membrane fluidity. | 2010 | Biochem. J. | pmid:20156199 |
| Rajwade AV et al. | Relatedness of Indian flax genotypes (Linum usitatissimum L.): an inter-simple sequence repeat (ISSR) primer assay. | 2010 | Mol. Biotechnol. | pmid:20195799 |
| Zhou J et al. | Trans-membrane uptake and intracellular metabolism of fatty acids in Atlantic salmon (Salmo salar L.) hepatocytes. | 2010 | Lipids | pmid:20186497 |
| Liu Q et al. | Influence of linolenic acid content on the oxidation of milk fat. | 2010 | J. Agric. Food Chem. | pmid:20175540 |
| Bharadwaj AS et al. | Dietary source of stearidonic acid promotes higher muscle DHA concentrations than linolenic acid in hybrid striped bass. | 2010 | Lipids | pmid:20049582 |
| Eckert GP et al. | Plant derived omega-3-fatty acids protect mitochondrial function in the brain. | 2010 | Pharmacol. Res. | pmid:20079842 |
| Nguemeni C et al. | Dietary supplementation of alpha-linolenic acid in an enriched rapeseed oil diet protects from stroke. | 2010 | Pharmacol. Res. | pmid:20036742 |
| Aziz AA et al. | Increasing Dietary alpha-linolenic acid enhances tissue levels of long-chain n-3 PUFA when linoleic acid intake is low in hamsters. | 2010 | Ann. Nutr. Metab. | pmid:20714137 |
| Mason JE | By the way, doctor. I am confused about omega-3 fats Are the different types equally good for you? | 2010 | Harv Health Lett | pmid:20821857 |
| Ruiz-Rodriguez A et al. | Recent trends in the advanced analysis of bioactive fatty acids. | 2010 | J Pharm Biomed Anal | pmid:19525080 |
| Wu TC et al. | Fatty acid composition of Taiwanese human milk. | 2010 | J Chin Med Assoc | pmid:21093826 |
| Steinritz D et al. | Effect of N-acetyl cysteine and alpha-linolenic acid on sulfur mustard caused impairment of in vitro endothelial tube formation. | 2010 | Toxicol. Sci. | pmid:20833707 |
| Miyazawa D et al. | Regional differences of the mouse brain in response to an α-linolenic acid-restricted diet: Neurotrophin content and protein kinase activity. | 2010 | Life Sci. | pmid:20837030 |
| Safarinejad MR et al. | Relationship of omega-3 and omega-6 fatty acids with semen characteristics, and anti-oxidant status of seminal plasma: a comparison between fertile and infertile men. | 2010 | Clin Nutr | pmid:19666200 |
| Kishino S et al. | Microbial production of conjugated gamma-linolenic acid from gamma-linolenic acid by Lactobacillus plantarum AKU 1009a. | 2010 | J. Appl. Microbiol. | pmid:19919619 |
| Welch AA et al. | Dietary intake and status of n-3 polyunsaturated fatty acids in a population of fish-eating and non-fish-eating meat-eaters, vegetarians, and vegans and the product-precursor ratio [corrected] of α-linolenic acid to long-chain n-3 polyunsaturated fatty acids: results from the EPIC-Norfolk cohort. | 2010 | Am. J. Clin. Nutr. | pmid:20861171 |
| Kromhout D et al. | n-3 fatty acids and cardiovascular events after myocardial infarction. | 2010 | N. Engl. J. Med. | pmid:20929341 |
| Tsukada K et al. | Biosynthesis of jasmonic acid in a plant pathogenic fungus, Lasiodiplodia theobromae. | 2010 | Phytochemistry | pmid:20952041 |
| West SG et al. | Effects of diets high in walnuts and flax oil on hemodynamic responses to stress and vascular endothelial function. | 2010 | J Am Coll Nutr | pmid:21677123 |
| Kim M et al. | Erythrocyte α-linolenic acid is associated with the risk for mild dementia in Korean elderly. | 2010 | Nutr Res | pmid:21130294 |
| Sun P et al. | Effects of different doses of free alpha-linolenic acid infused to the duodenum on the immune function of lactating dairy cows. | 2010 | Arch Anim Nutr | pmid:21214022 |
| Berthelot V et al. | Utilization of extruded linseed to modify fatty composition of intensively-reared lamb meat: effect of associated cereals (wheat vs. corn) and linoleic acid content of the diet. | 2010 | Meat Sci. | pmid:20374762 |
| Chen T et al. | Analytical characterization of Hempseed (seed of Cannabis sativa L.) oil from eight regions in China. | 2010 | J Diet Suppl | pmid:22435611 |
| Rodriguez-Leyva D et al. | The cardiovascular effects of flaxseed and its omega-3 fatty acid, alpha-linolenic acid. | 2010 | Can J Cardiol | pmid:21076723 |
| Georgiadi A et al. | Induction of cardiac Angptl4 by dietary fatty acids is mediated by peroxisome proliferator-activated receptor beta/delta and protects against fatty acid-induced oxidative stress. | 2010 | Circ. Res. | pmid:20378851 |
| DomÃnguez T et al. | Increasing omega-3 desaturase expression in tomato results in altered aroma profile and enhanced resistance to cold stress. | 2010 | Plant Physiol. | pmid:20382895 |
| Yoo HJ and HÃ¥kansson K | Determination of double bond location in fatty acids by manganese adduction and electron induced dissociation. | 2010 | Anal. Chem. | pmid:20704384 |
| Lau BY et al. | Influence of high-fat diet from differential dietary sources on bone mineral density, bone strength, and bone fatty acid composition in rats. | 2010 | Appl Physiol Nutr Metab | pmid:20962915 |
| Khiaosa-Ard R et al. | Transfer of linoleic and linolenic acid from feed to milk in cows fed isoenergetic diets differing in proportion and origin of concentrates and roughages. | 2010 | J. Dairy Res. | pmid:20482940 |
| Campoy C et al. | [Update of knowledge, recommendations and full consensus about the role of long chain polyunsaturated fatty acids in pregnancy, lactating period and first year of life.Asociación Española de PediatrÃa. Sociedad Española de GinecologÃa y Obstetricia. Sociedad Española de Nutrición Comunitaria. Academia Española deNutrición y Ciencias de la Alimentación]. | 2010 | Med Clin (Barc) | pmid:20434734 |
| Rapoport SI et al. | Quantitative contributions of diet and liver synthesis to docosahexaenoic acid homeostasis. | 2010 Apr-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20226642 |
| Hurst S et al. | Dietary fatty acids and arthritis. | 2010 Apr-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20189789 |
| McCusker MM and Grant-Kels JM | Healing fats of the skin: the structural and immunologic roles of the omega-6 and omega-3 fatty acids. | 2010 Jul-Aug | Clin. Dermatol. | pmid:20620762 |
| Muramatsu T et al. | Higher dietary intake of alpha-linolenic acid is associated with lower insulin resistance in middle-aged Japanese. | 2010 May-Jun | Prev Med | pmid:20211645 |
| Childs CE et al. | Maternal diet during pregnancy has tissue-specific effects upon fetal fatty acid composition and alters fetal immune parameters. | 2010 Oct-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20817424 |
| McNamara RK et al. | Omega-3 fatty acid deficiency increases constitutive pro-inflammatory cytokine production in rats: relationship with central serotonin turnover. | 2010 Oct-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20817496 |
| Berkov S et al. | Changes in apolar metabolites during in vitro organogenesis of Pancratium maritimum. | 2010 Oct-Nov | Plant Physiol. Biochem. | pmid:20702100 |
| Anadon A et al. | A 4-week repeated oral dose toxicity study of dairy fat naturally enriched in vaccenic, rumenic and α-linolenic acids in rats. | 2011 | J. Agric. Food Chem. | pmid:21678997 |
| O'Sullivan TA et al. | Dietary intake and food sources of fatty acids in Australian adolescents. | 2011 | Nutrition | pmid:20338727 |
| Lebold KM et al. | Vitamin E deficiency decreases long-chain PUFA in zebrafish (Danio rerio). | 2011 | J. Nutr. | pmid:22013196 |
| Guelzim N et al. | A role for PPARα in the regulation of arginine metabolism and nitric oxide synthesis. | 2011 | Amino Acids | pmid:21063737 |
| Legrand P et al. | Update of French nutritional recommendations for fatty acids. | 2011 | World Rev Nutr Diet | pmid:21865827 |
| Guesnet P et al. | α-Linolenate reduces the dietary requirement for linoleate in the growing rat. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21880475 |
| Bradbury J | Docosahexaenoic acid (DHA): an ancient nutrient for the modern human brain. | 2011 | Nutrients | pmid:22254110 |
| Degen C et al. | Metabolic and growth inhibitory effects of conjugated fatty acids in the cell line HT-29 with special regard to the conversion of t11,t13-CLA. | 2011 | Biochim. Biophys. Acta | pmid:21889998 |
| Jung DM et al. | A gas chromatography-tandem quadrupole mass spectrometric analysis of policosanols in commercial vegetable oils. | 2011 | J. Food Sci. | pmid:22417487 |
| Decsi T and Kennedy K | Sex-specific differences in essential fatty acid metabolism. | 2011 | Am. J. Clin. Nutr. | pmid:22089435 |
| Nudda A et al. | Documentation of fatty acid profiles in lamb meat and lamb-based infant foods. | 2011 | J. Food Sci. | pmid:21535766 |
| Gorissen L et al. | Conjugated linoleic acid and conjugated linolenic acid production by bifidobacteria. | 2011 | Commun. Agric. Appl. Biol. Sci. | pmid:21539185 |
| Farina EK et al. | Dietary intakes of arachidonic acid and alpha-linolenic acid are associated with reduced risk of hip fracture in older adults. | 2011 | J. Nutr. | pmid:21508210 |
| Diwakar BT et al. | Modulatory effect of α-linolenic acid-rich garden cress (Lepidium sativum L.) seed oil on inflammatory mediators in adult albino rats. | 2011 | Br. J. Nutr. | pmid:21521541 |
| de Goede J et al. | Alpha-linolenic acid intake and 10-year incidence of coronary heart disease and stroke in 20,000 middle-aged men and women in the Netherlands. | 2011 | PLoS ONE | pmid:21464993 |
| Moltó-Puigmartà C et al. | Additional data from our study on fatty acids variations during lactation: correlations between n-3 and n-6 PUFAs in human colostrum, transitional, and mature milk. | 2011 | Clin Nutr | pmid:21470725 |
| Huang YQ et al. | Use of isotope mass probes for metabolic analysis of the jasmonate biosynthetic pathway. | 2011 | Analyst | pmid:21331428 |
| Lucas M et al. | Dietary intake of n-3 and n-6 fatty acids and the risk of clinical depression in women: a 10-y prospective follow-up study. | 2011 | Am. J. Clin. Nutr. | pmid:21471279 |
| Kapich AN et al. | Comparative evaluation of manganese peroxidase- and Mn(III)-initiated peroxidation of C18 unsaturated fatty acids by different methods. | 2011 | Enzyme Microb. Technol. | pmid:22112267 |
| Han Y et al. | Dynamic QTL analysis of linolenic acid content in different developmental stages of soybean seed. | 2011 | Theor. Appl. Genet. | pmid:21344183 |
| Gong J et al. | Genetic variation in stearoyl-CoA desaturase 1 is associated with metabolic syndrome prevalence in Costa Rican adults. | 2011 | J. Nutr. | pmid:22049297 |
| Lenka SK et al. | Comparative analysis of drought-responsive transcriptome in Indica rice genotypes with contrasting drought tolerance. | 2011 | Plant Biotechnol. J. | pmid:20809928 |
| Holy EW et al. | Dietary α-linolenic acid inhibits arterial thrombus formation, tissue factor expression, and platelet activation. | 2011 | Arterioscler. Thromb. Vasc. Biol. | pmid:21571683 |
| Belin RJ et al. | Fish intake and the risk of incident heart failure: the Women's Health Initiative. | 2011 | Circ Heart Fail | pmid:21610249 |
| Leyva DR et al. | The effect of dietary flaxseed on improving symptoms of cardiovascular disease in patients with peripheral artery disease: rationale and design of the FLAX-PAD randomized controlled trial. | 2011 | Contemp Clin Trials | pmid:21616170 |
| Qiu L et al. | Coenzyme Q10 production by Sphingomonas sp. ZUTE03 with novel precursors isolated from tobacco waste in a two-phase conversion system. | 2011 | J. Microbiol. Biotechnol. | pmid:21617346 |
| Ash MM et al. | Unrefined and refined black raspberry seed oils significantly lower triglycerides and moderately affect cholesterol metabolism in male Syrian hamsters. | 2011 | J Med Food | pmid:21548801 |
| Kasuli EG | Are alternative supplements effective treatment for diabetes mellitus? | 2011 | Nutr Clin Pract | pmid:21586420 |
| Dumont J et al. | FADS1 genetic variability interacts with dietary α-linolenic acid intake to affect serum non-HDL-cholesterol concentrations in European adolescents. | 2011 | J. Nutr. | pmid:21593353 |
| Xie N et al. | α-Linolenic acid intake attenuates myocardial ischemia/reperfusion injury through anti-inflammatory and anti-oxidative stress effects in diabetic but not normal rats. | 2011 | Arch. Med. Res. | pmid:21722811 |
| Wong WT et al. | Relative contribution of individual oxidized components in ox-LDL to inhibition on endothelium-dependent relaxation in rat aorta. | 2011 | Nutr Metab Cardiovasc Dis | pmid:20005687 |
| Ding BJ et al. | Terminal fatty-acyl-CoA desaturase involved in sex pheromone biosynthesis in the winter moth (Operophtera brumata). | 2011 | Insect Biochem. Mol. Biol. | pmid:21651981 |