alpha-linolenic acid

Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.

Cross Reference

Introduction

To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with alpha-linolenic acid?

alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid

MeSH term MeSH ID Detail
Inflammation D007249 119 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Cattle Diseases D002418 24 associated lipids
Fatty Liver D005234 48 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 50 100 | Total 104

PubChem Associated disorders and diseases

What pathways are associated with alpha-linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with alpha-linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with alpha-linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with alpha-linolenic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with alpha-linolenic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with alpha-linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with alpha-linolenic acid

Download all related citations
Per page 10 20 50 100 | Total 2471
Authors Title Published Journal PubMed Link
Pedersen JI [Does alpha-linolenic acid prevent cardiac death?]. 2006 Tidsskr. Nor. Laegeforen. pmid:17086215
Sánchez-Hernández C et al. Reduced levels of volatile emissions in jasmonate-deficient spr2 tomato mutants favour oviposition by insect herbivores. 2006 Plant Cell Environ. pmid:17080606
Pankiewicz E et al. Maternal adipose tissue, maternal and cord blood essential fatty acids and their long-chain polyunsaturated derivatives composition after elective caesarean section. 2007 Early Hum. Dev. pmid:17059872
Ander BP et al. Differential sensitivities of the NCX1.1 and NCX1.3 isoforms of the Na+-Ca2+ exchanger to alpha-linolenic acid. 2007 Cardiovasc. Res. pmid:17059813
de Lorgeril M and Salen P The Mediterranean diet in secondary prevention of coronary heart disease. 2006 Clin Invest Med pmid:17058434
Harper CR et al. Flaxseed oil supplementation does not affect plasma lipoprotein concentration or particle size in human subjects. 2006 J. Nutr. pmid:17056811
Alessandri C et al. Alpha-linolenic acid-rich wheat germ oil decreases oxidative stress and CD40 ligand in patients with mild hypercholesterolemia. 2006 Arterioscler. Thromb. Vasc. Biol. pmid:17053175
Igarashi M et al. Upregulated liver conversion of alpha-linolenic acid to docosahexaenoic acid in rats on a 15 week n-3 PUFA-deficient diet. 2007 J. Lipid Res. pmid:17050905
Matta JA et al. TRPV1 is a novel target for omega-3 polyunsaturated fatty acids. 2007 J. Physiol. (Lond.) pmid:17038422
Moore CS et al. Oily fish reduces plasma triacylglycerols: a primary prevention study in overweight men and women. 2006 Nutrition pmid:17027436
Villarroel M et al. [Development of an optimized formulation of flaxseed (Linum usitatissimum) mousse]. 2006 Arch Latinoam Nutr pmid:17024965
Nannicini F et al. Alpha-linolenic acid and cardiovascular diseases omega-3 fatty acids beyond eicosapentaenoic acid and docosahexaenoic acid. 2006 Minerva Cardioangiol pmid:17016414
Lorenzi V et al. Purification, product characterization and kinetic properties of lipoxygenase from olive fruit (Olea europaea L.). 2006 Jul-Sep Plant Physiol. Biochem. pmid:17011785
Marangoni F et al. Levels of the n-3 fatty acid eicosapentaenoic acid in addition to those of alpha linolenic acid are significantly raised in blood lipids by the intake of four walnuts a day in humans. 2007 Nutr Metab Cardiovasc Dis pmid:17008073
Xiang M et al. Diet and gene expression: delta-5 and delta-6 desaturases in healthy Chinese and European subjects. 2006 Ann. Nutr. Metab. pmid:16988497
Erkkilä AT et al. Higher plasma docosahexaenoic acid is associated with reduced progression of coronary atherosclerosis in women with CAD. 2006 J. Lipid Res. pmid:16983146
Yao HT et al. The inhibitory effect of polyunsaturated fatty acids on human CYP enzymes. 2006 Life Sci. pmid:16978661
Egert S et al. Influence of three rapeseed oil-rich diets, fortified with alpha-linolenic acid, eicosapentaenoic acid or docosahexaenoic acid on the composition and oxidizability of low-density lipoproteins: results of a controlled study in healthy volunteers. 2007 Eur J Clin Nutr pmid:16969378
Tavilani H et al. Decreased polyunsaturated and increased saturated fatty acid concentration in spermatozoa from asthenozoospermic males as compared with normozoospermic males. 2006 Andrologia pmid:16961570
Sawada Y et al. Absolute configuration of volicitin from the regurgitant of lepidopteran caterpillars and biological activity of volicitin-related compounds. 2006 Biosci. Biotechnol. Biochem. pmid:16960380
Sanders TA et al. Effect of varying the ratio of n-6 to n-3 fatty acids by increasing the dietary intake of alpha-linolenic acid, eicosapentaenoic and docosahexaenoic acid, or both on fibrinogen and clotting factors VII and XII in persons aged 45-70 y: the OPTILIP study. 2006 Am. J. Clin. Nutr. pmid:16960164
Chuang CY et al. Fractionation and identification of 9c, 11t, 13t-conjugated linolenic acid as an activator of PPARalpha in bitter gourd (Momordica charantia L.). 2006 J. Biomed. Sci. pmid:16955349
Sebei K et al. Evolution of phosphoenolpyruvate carboxylase activity and lipid content during seed maturation of two spring rapeseed cultivars (Brassica napus L.). 2006 C. R. Biol. pmid:16945838
Leone A et al. Lipoxygenase involvement in ripening strawberry. 2006 J. Agric. Food Chem. pmid:16939347
Levant B et al. Differential effects of modulation of docosahexaenoic acid content during development in specific regions of rat brain. 2006 Lipids pmid:16933785
Dabadie H et al. Variations in daily intakes of myristic and alpha-linolenic acids in sn-2 position modify lipid profile and red blood cell membrane fluidity. 2006 Br. J. Nutr. pmid:16923222
Bere E Wild berries: a good source of omega-3. 2007 Eur J Clin Nutr pmid:16900081
Yasui Y et al. Troglitazone and 9cis,11trans,13trans-conjugated linolenic acid: comparison of their antiproliferative and apoptosis-inducing effects on different colon cancer cell lines. 2006 Chemotherapy pmid:16899971
Uauy R and Hoffman DR Essential fatty acid requirements for normal eye and brain development. 1991 Semin. Perinatol. pmid:1687090
Maillard V et al. Dietary beta-carotene inhibits mammary carcinogenesis in rats depending on dietary alpha-linolenic acid content. 2006 Br. J. Nutr. pmid:16869986
Langdon JH Has an aquatic diet been necessary for hominin brain evolution and functional development? 2006 Br. J. Nutr. pmid:16869985
Wainwright PE Alpha-linolenic acid, long-chain n-3 fatty acids, and neonatal brain development. 1991 Nov-Dec Nutrition pmid:1686983
Cook HW Brain metabolism of alpha-linolenic acid during development. 1991 Nov-Dec Nutrition pmid:1686982
Cunnane SC et al. Alpha-linolenic acid in humans: direct functional role or dietary precursor? 1991 Nov-Dec Nutrition pmid:1686981
Szachowicz-Petelska B et al. Altered membrane free unsaturated fatty acid composition in human colorectal cancer tissue. 2007 Mol. Cell. Biochem. pmid:16858511
Levant B et al. Diet (n-3) polyunsaturated fatty acid content and parity interact to alter maternal rat brain phospholipid fatty acid composition. 2006 J. Nutr. pmid:16857847
Tsuzuki T et al. Conjugated linolenic acid is slowly absorbed in rat intestine, but quickly converted to conjugated linoleic acid. 2006 J. Nutr. pmid:16857834
Delion S et al. Chronic dietary alpha-linolenic acid deficiency alters dopaminergic and serotoninergic neurotransmission in rats. 1994 J. Nutr. pmid:16856329
Carlson SE et al. Long-term feeding of formulas high in linolenic acid and marine oil to very low birth weight infants: phospholipid fatty acids. 1991 Pediatr. Res. pmid:1684416
Breslow JL n-3 fatty acids and cardiovascular disease. 2006 Am. J. Clin. Nutr. pmid:16841857
Arterburn LM et al. Distribution, interconversion, and dose response of n-3 fatty acids in humans. 2006 Am. J. Clin. Nutr. pmid:16841856
Ambrose DJ et al. Lower pregnancy losses in lactating dairy cows fed a diet enriched in alpha-linolenic acid. 2006 J. Dairy Sci. pmid:16840624
Galli C and Marangoni F N-3 fatty acids in the Mediterranean diet. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16837180
Narisawa T et al. Inhibitory effect of dietary perilla oil rich in the n-3 polyunsaturated fatty acid alpha-linolenic acid on colon carcinogenesis in rats. 1991 Jpn. J. Cancer Res. pmid:1683347
Burdge GC Metabolism of alpha-linolenic acid in humans. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16828546
Wang Q et al. [Determination of alpha-linolenic acid in perilla oil by reversed-phase high performance liquid chromatography coupled with evaporative light-scattering detector]. 2006 Se Pu pmid:16827313
Goyens PL et al. Conversion of alpha-linolenic acid in humans is influenced by the absolute amounts of alpha-linolenic acid and linoleic acid in the diet and not by their ratio. 2006 Am. J. Clin. Nutr. pmid:16825680
Wang C et al. n-3 Fatty acids from fish or fish-oil supplements, but not alpha-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: a systematic review. 2006 Am. J. Clin. Nutr. pmid:16825676
Kainou K et al. Isolation of Delta12 and omega3-fatty acid desaturase genes from the yeast Kluyveromyces lactis and their heterologous expression to produce linoleic and alpha-linolenic acids in Saccharomyces cerevisiae. 2006 Yeast pmid:16823888
Sakai K and Okuyama H Effects of a high alpha-linolenate and high linoleate diet on hemolysis and lipid peroxidation of rat erythrocytes. 1991 Chem. Pharm. Bull. pmid:1682062
Rhodes PG et al. Effects of different levels of intravenous alpha-linolenic acid and supplemental breast milk on red blood cell docosahexaenoic acid in very low birth-weight infants. 1991 J. Pediatr. Gastroenterol. Nutr. pmid:1681044
Djoussé L et al. Influence of saturated fat and linolenic acid on the association between intake of dairy products and blood pressure. 2006 Hypertension pmid:16801477
Papies B et al. Ischemic myocardial damage in spontaneously hypertensive rats (SHR) is enhanced after long-term feeding of an alpha-linolenic acid enriched diet. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:1679554
Horii T et al. Effect of dietary alpha-linolenate on platelet-activating factor production in rat peritoneal polymorphonuclear leukocytes. 1991 J. Immunol. pmid:1679081
Taha AY et al. Lack of benefit of linoleic and alpha-linolenic polyunsaturated fatty acids on seizure latency, duration, severity or incidence in rats. 2006 Epilepsy Res. pmid:16787740
Hamada T et al. Reduction of trienoic fatty acid content by expression of a double-stranded RNA of a plastid omega-3 fatty acid desaturase gene in transgenic tobacco. 2006 Biotechnol. Lett. pmid:16786241
Koralek DO et al. A prospective study of dietary alpha-linolenic acid and the risk of prostate cancer (United States). 2006 Cancer Causes Control pmid:16783606
Hasler CM et al. Inhibition of gap junction-mediated intercellular communication by alpha-linolenate. 1991 Am. J. Physiol. pmid:1677533
Kwon JS et al. Effects of diets high in saturated fatty acids, canola oil, or safflower oil on platelet function, thromboxane B2 formation, and fatty acid composition of platelet phospholipids. 1991 Am. J. Clin. Nutr. pmid:1677525
Bauer JE et al. Docosahexaenoic acid accumulates in plasma of canine puppies raised on alpha-linolenic acid-rich milk during suckling but not when fed alpha-linolenic acid-rich diets after weaning. 2006 J. Nutr. pmid:16772507
Hu X et al. Mapping of the loci controlling oleic and linolenic acid contents and development of fad2 and fad3 allele-specific markers in canola (Brassica napus L.). 2006 Theor. Appl. Genet. pmid:16767448
McClead RE et al. The effect of three intravenous fat emulsions containing different concentrations of linoleic and alpha-linolenic acids on the plasma total fatty acid profile of neonates. 1991 J. Pediatr. Gastroenterol. Nutr. pmid:1676411
Martin CA et al. Trans polyunsaturated fatty acid contents in Brazilian refined soybean oil. 2006 Anal Sci pmid:16760612
Morris DD et al. Effect of dietary alpha-linolenic acid on endotoxin-induced production of tumor necrosis factor by peritoneal macrophages in horses. 1991 Am. J. Vet. Res. pmid:1675843
Henry MM et al. Influence of an omega-3 fatty acid-enriched ration on in vivo responses of horses to endotoxin. 1991 Am. J. Vet. Res. pmid:1675842
Bjerve KS Omega 3 fatty acid deficiency in man: implications for the requirement of alpha-linolenic acid and long-chain omega 3 fatty acids. 1991 World Rev Nutr Diet pmid:1675825
Cancelo Hidalgo MJ et al. Effect of a compound containing isoflavones, primrose oil and vitamin E in two different doses on climacteric symptoms. 2006 J Obstet Gynaecol pmid:16753687
Biagi PL et al. Gamma-linolenic acid dietary supplementation can reverse the aging influence on rat liver microsome delta 6-desaturase activity. 1991 Biochim. Biophys. Acta pmid:1674661
Dyer JR and Greenwood CE Neural 22-carbon fatty acids in the weanling rat respond rapidly and specifically to a range of dietary linoleic to alpha-linolenic fatty acid ratios. 1991 J. Neurochem. pmid:1673995
Cave WT Dietary n-3 (omega-3) polyunsaturated fatty acid effects on animal tumorigenesis. 1991 FASEB J. pmid:1673664
Chan JK et al. Dietary alpha-linolenic acid is as effective as oleic acid and linoleic acid in lowering blood cholesterol in normolipidemic men. 1991 Am. J. Clin. Nutr. pmid:1673589
Vanden Heuvel JP et al. Differential activation of nuclear receptors by perfluorinated fatty acid analogs and natural fatty acids: a comparison of human, mouse, and rat peroxisome proliferator-activated receptor-alpha, -beta, and -gamma, liver X receptor-beta, and retinoid X receptor-alpha. 2006 Toxicol. Sci. pmid:16731579
Choi YH et al. NMR metabolomics to revisit the tobacco mosaic virus infection in Nicotiana tabacum leaves. 2006 J. Nat. Prod. pmid:16724833
Hamberg M Transformations of alpha-linolenic acid in leaves of corn (Zea mays L.). 1991 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:1671803
Li D et al. Omega 6 to omega 3 fatty acid imbalance early in life leads to persistent reductions in DHA levels in glycerophospholipids in rat hypothalamus even after long-term omega 3 fatty acid repletion. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16716580
Lemaitre RN et al. Trans-fatty acids and sudden cardiac death. 2006 Atheroscler Suppl pmid:16713398
Oliw EH et al. Payne rearrangement during analysis of epoxyalcohols of linoleic and alpha-linolenic acids by normal phase liquid chromatography with tandem mass spectrometry. 2006 Anal. Biochem. pmid:16712763
Li D et al. Alpha-linolenic acid content of commonly available nuts in Hangzhou. 2006 Int J Vitam Nutr Res pmid:16711652
Zhou D et al. Vitamin A deficiency enhances docosahexaenoic and osbond acids in liver of rats fed an alpha linolenic acid-adequate diet. 2006 Lipids pmid:16711595
Marotta F et al. Liver exposure to xenobiotics: the aging factor and potentials for functional foods. 2006 Rejuvenation Res pmid:16706665
Kelley DS et al. Dietary alpha-linolenic acid and immunocompetence in humans. 1991 Am. J. Clin. Nutr. pmid:1670594
Igarashi M et al. Low liver conversion rate of alpha-linolenic to docosahexaenoic acid in awake rats on a high-docosahexaenoate-containing diet. 2006 J. Lipid Res. pmid:16687661
Blanco M et al. Ischemic preconditioning: a novel target for neuroprotective therapy. 2006 Cerebrovasc. Dis. pmid:16651813
King VR et al. Omega-3 fatty acids improve recovery, whereas omega-6 fatty acids worsen outcome, after spinal cord injury in the adult rat. 2006 J. Neurosci. pmid:16641248
Cristea M and Oliw EH A G316A mutation of manganese lipoxygenase augments hydroperoxide isomerase activity: mechanism of biosynthesis of epoxyalcohols. 2006 J. Biol. Chem. pmid:16641090
Cornejo V et al. [Lipids composition diet in phenylketonuric children with early diagnosis]. 2005 Arch Latinoam Nutr pmid:16640195
Shanker KS et al. Isolation and characterization of neutral lipids of desilked eri silkworm pupae grown on castor and tapioca leaves. 2006 J. Agric. Food Chem. pmid:16637689
Murayama SY et al. Construction and functional analysis of fatty acid desaturase gene disruptants in Candida albicans. 2006 Microbiology (Reading, Engl.) pmid:16622072
MandaÅŸescu S et al. Flaxseed supplementation in hyperlipidemic patients. 2005 Jul-Sep Rev Med Chir Soc Med Nat Iasi pmid:16607740
Aldámiz-Echevarría L et al. Effect of docosahexaenoic acid administration on plasma lipid profile and metabolic parameters of children with methylmalonic acidaemia. 2006 J. Inherit. Metab. Dis. pmid:16601869
Bretillon L et al. In vivo oxidation of [9-14C] cyclic fatty acids derived from linolenic acid in the rat. 2006 Mar-Apr Reprod. Nutr. Dev. pmid:16597424
Knudsen VK et al. Fish oil in various doses or flax oil in pregnancy and timing of spontaneous delivery: a randomised controlled trial. 2006 BJOG pmid:16579802
Zhang HT et al. [Functional expression of an omega-3 fatty acid desaturase gene from Glycine max in Saccharomyces cerevisiae]. 2006 Sheng Wu Gong Cheng Xue Bao pmid:16572837
Djoussé L et al. Dietary linolenic acid and fasting glucose and insulin: the National Heart, Lung, and Blood Institute Family Heart Study. 2006 Obesity (Silver Spring) pmid:16571856
Turpeinen AM et al. Effects of conjugated linoleic acid on linoleic and linolenic acid metabolism in man. 2006 Br. J. Nutr. pmid:16571152
Heller AR et al. Omega-3 alpha linolenic acid does not reflect the entire omega-3 fatty acid family. 2006 Anesth. Analg. pmid:16551943
I take ground flaxseed to help control my cholesterol. But I read that the alpha-linoleic acid (ALA) in flax increases the risk of prostate cancer. Is this true? Does the risk differ between ground flaxseed and concentrated flaxseed oil in capsules? 2006 Johns Hopkins Med Lett Health After 50 pmid:16548073
Hoffman DR et al. Docosahexaenoic acid in red blood cells of term infants receiving two levels of long-chain polyunsaturated fatty acids. 2006 J. Pediatr. Gastroenterol. Nutr. pmid:16540798
Usami M et al. Phospholipid fatty acid composition and diamine oxidase activity of intestinal mucosa from rats treated with irinotecan hydrochloride (CPT-11) under vegetable oil-enriched diets: comparison between perilla oil and corn oil. 2006 Mar-Apr JPEN J Parenter Enteral Nutr pmid:16517957
DeFilippis AP and Sperling LS Understanding omega-3's. 2006 Am. Heart J. pmid:16504616