alpha-linolenic acid

Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.

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Introduction

To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with alpha-linolenic acid?

alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid

MeSH term MeSH ID Detail
Inflammation D007249 119 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Cattle Diseases D002418 24 associated lipids
Fatty Liver D005234 48 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 50 100 | Total 104

PubChem Associated disorders and diseases

What pathways are associated with alpha-linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with alpha-linolenic acid?

Related references are published most in these journals:

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What functions are associated with alpha-linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with alpha-linolenic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with alpha-linolenic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with alpha-linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with alpha-linolenic acid

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Authors Title Published Journal PubMed Link
Sugasini D and Lokesh BR Uptake of α-linolenic acid and its conversion to long chain omega-3 fatty acids in rats fed microemulsions of linseed oil. 2012 Lipids pmid:23104428
Jung DM et al. Chemical properties and oxidative stability of perilla oils obtained from roasted perilla seeds as affected by extraction methods. 2012 J. Food Sci. pmid:23106331
Pereira H et al. Polyunsaturated Fatty acids of marine macroalgae: potential for nutritional and pharmaceutical applications. 2012 Mar Drugs pmid:23118712
Barrett E et al. Bifidobacterium breve with α-linolenic acid and linoleic acid alters fatty acid metabolism in the maternal separation model of irritable bowel syndrome. 2012 PLoS ONE pmid:23185248
Fang XL et al. Roles of α-linolenic acid on IGF-I secretion and GH/IGF system gene expression in porcine primary hepatocytes. 2012 Mol. Biol. Rep. pmid:23053988
He ML et al. Triticale dried distillers' grain increases alpha-linolenic acid in subcutaneous fat of beef cattle fed oilseeds. 2012 Lipids pmid:23054550
Msika O et al. NGF blocks polyunsaturated fatty acids biosynthesis in n-3 fatty acid-supplemented PC12 cells. 2012 Biochim. Biophys. Acta pmid:22564256
Moodley R et al. Elemental composition and fatty acid profile of the edible fruits of Amatungula (Carissa macrocarpa) and impact of soil quality on chemical characteristics. 2012 Anal. Chim. Acta pmid:22632042
Saha SS et al. Synergistic effect of conjugated linolenic acid isomers against induced oxidative stress, inflammation and erythrocyte membrane disintegrity in rat model. 2012 Biochim. Biophys. Acta pmid:22967758
Kim N and Choe E Singlet oxygen-related photooxidative stability and antioxidant changes of diacylglycerol-rich oil derived from mixture of olive and perilla oil. 2012 J. Food Sci. pmid:23057833
Georgiadi A et al. Detailed transcriptomics analysis of the effect of dietary fatty acids on gene expression in the heart. 2012 Physiol. Genomics pmid:22274564
He ML et al. Feeding flaxseed in grass hay and barley silage diets to beef cows increases alpha-linolenic acid and its biohydrogenation intermediates in subcutaneous fat. 2012 J. Anim. Sci. pmid:22274861
Sun T et al. Meat fatty acid and cholesterol level of free-range broilers fed on grasshoppers on alpine rangeland in the Tibetan Plateau. 2012 J. Sci. Food Agric. pmid:22318921
Deckelbaum RJ and Torrejon C The omega-3 fatty acid nutritional landscape: health benefits and sources. 2012 J. Nutr. pmid:22323763
Larsen MK et al. Fatty acid, tocopherol and carotenoid content in herbage and milk affected by sward composition and season of grazing. 2012 J. Sci. Food Agric. pmid:22337263
Pirat C et al. Targeting peroxisome proliferator-activated receptors (PPARs): development of modulators. 2012 J. Med. Chem. pmid:22260081
Huang T et al. Effect of n-3 polyunsaturated fatty acid on gene expression of the critical enzymes involved in homocysteine metabolism. 2012 Nutr J pmid:22260268
Hughes BH et al. Oxidative stability and consumer acceptance of fish oil fortified nutrition bars. 2012 J. Food Sci. pmid:22957916
Aliani M et al. Effect of flax addition on the flavor profile and acceptability of bagels. 2012 J. Food Sci. pmid:22260132
Janssen S et al. Sensing of fatty acids for octanoylation of ghrelin involves a gustatory G-protein. 2012 PLoS ONE pmid:22768248
Reinders I et al. Association of serum n-3 polyunsaturated fatty acids with C-reactive protein in men. 2012 Eur J Clin Nutr pmid:22113248
Shen J et al. Effect of essential fatty acids on glucose-induced cytotoxicity to retinal vascular endothelial cells. 2012 Lipids Health Dis pmid:22781401
Rosa DD et al. Fish oil improves the lipid profile and reduces inflammatory cytokines in Wistar rats with precancerous colon lesions. 2012 Nutr Cancer pmid:22483364
Karppi J et al. Serum β-carotene in relation to risk of prostate cancer: the Kuopio Ischaemic Heart Disease Risk Factor study. 2012 Nutr Cancer pmid:22420939
Pal M and Ghosh M Prophylactic effect of α-linolenic acid and α-eleostearic acid against MeHg induced oxidative stress, DNA damage and structural changes in RBC membrane. 2012 Food Chem. Toxicol. pmid:22683484
Zhang G et al. Erythrocyte n-3 fatty acids and metabolic syndrome in middle-aged and older Chinese. 2012 J. Clin. Endocrinol. Metab. pmid:22456621
Ishida Y et al. Validation of thermally assisted hydrolysis and methylation-gas chromatography using a vertical microfurnace pyrolyzer for the compositional analysis of Fatty Acid components in microalgae. 2012 J. Agric. Food Chem. pmid:22458968
Mirmiran P et al. Association between interaction and ratio of ω-3 and ω-6 polyunsaturated fatty acid and the metabolic syndrome in adults. 2012 Nutrition pmid:22459553
Maqbool A et al. Relation between dietary fat intake type and serum fatty acid status in children with cystic fibrosis. 2012 J. Pediatr. Gastroenterol. Nutr. pmid:22699835
Du Q et al. Dairy fat blends high in α-linolenic acid are superior to n-3 fatty-acid-enriched palm oil blends for increasing DHA levels in the brains of young rats. 2012 J. Nutr. Biochem. pmid:22445803
Ling PR et al. Purified fish oil eliminating linoleic and alpha linolenic acid meets essential fatty acid requirements in rats. 2012 Metab. Clin. Exp. pmid:22512821
Miyake Y et al. Dietary meat and fat intake and prevalence of rhinoconjunctivitis in pregnant Japanese women: baseline data from the Kyushu Okinawa Maternal and Child Health Study. 2012 Nutr J pmid:22449171
Nakamura YK et al. Modulation of oxidative stress by γ-glutamylcysteine (GGC) and conjugated linoleic acid (CLA) isomer mixture in human umbilical vein endothelial cells. 2012 Food Chem. Toxicol. pmid:22490668
Fatima T et al. Fatty acid composition of developing sea buckthorn (Hippophae rhamnoides L.) berry and the transcriptome of the mature seed. 2012 PLoS ONE pmid:22558083
Passos PP et al. Dopaminergic cell populations of the rat substantia nigra are differentially affected by essential fatty acid dietary restriction over two generations. 2012 J. Chem. Neuroanat. pmid:22687395
Longvah T et al. Eri silkworm: a source of edible oil with a high content of α-linolenic acid and of significant nutritional value. 2012 J. Sci. Food Agric. pmid:22290445
de Freitas JM et al. Influence of cellular fatty acid composition on the response of Saccharomyces cerevisiae to hydrostatic pressure stress. 2012 FEMS Yeast Res. pmid:22846157
Monteiro J et al. Menhaden oil, but not safflower or soybean oil, aids in restoring the polyunsaturated fatty acid profile in the novel delta-6-desaturase null mouse. 2012 Lipids Health Dis pmid:22642787
Nam KH and Yoshihara T Interactions among LOX metabolites regulate temperature-mediated flower bud formation in morning glory (Pharbitis nil). 2012 J. Plant Physiol. pmid:22902207
Evans SJ et al. Association of plasma ω-3 and ω-6 lipids with burden of disease measures in bipolar subjects. 2012 J Psychiatr Res pmid:22884424
Castro LF et al. Functional desaturase Fads1 (Δ5) and Fads2 (Δ6) orthologues evolved before the origin of jawed vertebrates. 2012 PLoS ONE pmid:22384110
Pan H et al. Alpha-linolenic acid is a potent neuroprotective agent against soman-induced neuropathology. 2012 Neurotoxicology pmid:22884490
Huan M et al. In vivo anti-tumor activity of a new doxorubicin conjugate via α-linolenic acid. 2012 Biosci. Biotechnol. Biochem. pmid:22878199
Zhang G et al. [Effects of fatty acids on proliferation and differentiation of myoblast]. 2012 Wei Sheng Yan Jiu pmid:23424861
Harland DR et al. Acute effects of prostaglandin E1 and E2 on vascular reactivity and blood flow in situ in the chick chorioallantoic membrane. 2012 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:22858445
Hofacer R et al. Omega-3 fatty acid deficiency increases stearoyl-CoA desaturase expression and activity indices in rat liver: positive association with non-fasting plasma triglyceride levels. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22047910
Tsuzuki W Inconsistencies in a highly polar capillary gas chromatography column and necessity of column performance checks for trans fatty acid measurement. 2012 Nov-Dec J AOAC Int pmid:23451392
Kartikasari LR et al. Dietary alpha-linolenic acid enhances omega-3 long chain polyunsaturated fatty acid levels in chicken tissues. 2012 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:22925778
Zheng JS et al. Intake of fish and marine n-3 polyunsaturated fatty acids and risk of breast cancer: meta-analysis of data from 21 independent prospective cohort studies. 2013 BMJ pmid:23814120
Almario RU and Karakas SE Lignan content of the flaxseed influences its biological effects in healthy men and women. 2013 J Am Coll Nutr pmid:23885993
Stivala S et al. Dietary α-linolenic acid increases the platelet count in ApoE-/- mice by reducing clearance. 2013 Blood pmid:23801636
Pan X et al. Identification of a pair of phospholipid:diacylglycerol acyltransferases from developing flax (Linum usitatissimum L.) seed catalyzing the selective production of trilinolenin. 2013 J. Biol. Chem. pmid:23824186
Nakashima R et al. Exposure to DEHP decreased four fatty acid levels in plasma of prepartum mice. 2013 Toxicology pmid:23619606
Wang DQ et al. [Alpha-linolenic acid improves insulin sensitivity in obese patients]. 2013 Zhonghua Yi Xue Za Zhi pmid:23648351
Oh HJ et al. Production of 10-hydroxy-12,15(Z,Z)-octadecadienoic acid from α-linolenic acid by permeabilized cells of recombinant Escherichia coli expressing the oleate hydratase gene of Stenotrophomonas maltophilia. 2013 Biotechnol. Lett. pmid:23690042
Schuchardt JP et al. Comparison of free serum oxylipin concentrations in hyper- vs. normolipidemic men. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23694766
Sengupta A and Ghosh M Protective effect of eicosapentaenoic acid-docosahexaenoic acid and alpha-linolenic acid rich phytosterol ester on brain antioxidant status and brain lipid composition in hypercholesterolemic rats. 2013 Indian J. Exp. Biol. pmid:23678545
Rao CV et al. Prevention of familial adenomatous polyp development in APC min mice and azoxymethane-induced colon carcinogenesis in F344 Rats by ω-3 fatty acid rich perilla oil. 2013 Nutr Cancer pmid:23682783
Stamey Lanier J et al. Mammary uptake of fatty acids supplied by intravenous triacylglycerol infusion to lactating dairy cows. 2013 Lipids pmid:23504269
Saubeau G et al. Differential induction of oxylipin pathway in potato and tobacco cells by bacterial and oomycete elicitors. 2013 Plant Cell Rep. pmid:23479199
Cao AH et al. Composition of long chain polyunsaturated fatty acids (LC-PUFAs) in different encephalic regions and its association with behavior in spontaneous hypertensive rat (SHR). 2013 Brain Res. pmid:23811335
Moloney AP et al. Colour of fat, and colour, fatty acid composition and sensory characteristics of muscle from heifers offered alternative forages to grass silage in a finishing ration. 2013 Meat Sci. pmid:23806853
Zong G et al. Effects of flaxseed supplementation on erythrocyte fatty acids and multiple cardiometabolic biomarkers among Chinese with risk factors of metabolic syndrome. 2013 Eur J Nutr pmid:23179200
Lagarde M et al. Lipidomics of essential fatty acids and oxygenated metabolites. 2013 Mol Nutr Food Res pmid:23818385
Perga ME et al. Are cyanobacterial blooms trophic dead ends? 2013 Oecologia pmid:23129401
Gregory MK et al. Functional characterization of the chicken fatty acid elongases. 2013 J. Nutr. pmid:23173174
Tu WC et al. Dietary alpha-linolenic acid does not enhance accumulation of omega-3 long-chain polyunsaturated fatty acids in barramundi (Lates calcarifer). 2013 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:23085323
Van Ba H et al. Significant influence of particular unsaturated fatty acids and pH on the volatile compounds in meat-like model systems. 2013 Meat Sci. pmid:23632107
Poudyal H et al. Effects of ALA, EPA and DHA in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats. 2013 J. Nutr. Biochem. pmid:23026492
Yang YX et al. Effects of duodenal infusion of free α-linolenic acid on the plasma and milk proteome of lactating dairy cows. 2013 Animal pmid:23031206
Kälber T et al. Effect of feeding buckwheat and chicory silages on fatty acid profile and cheese-making properties of milk from dairy cows. 2013 J. Dairy Res. pmid:23253429
Yu X et al. α-Linolenic acid attenuates doxorubicin-induced cardiotoxicity in rats through suppression of oxidative stress and apoptosis. 2013 Acta Biochim. Biophys. Sin. (Shanghai) pmid:23896563
Egusa Saiga A and Nishimura T Antioxidative properties of peptides obtained from porcine myofibrillar proteins by a protease treatment in an Fe (II)-induced aqueous lipid peroxidation system. 2013 Biosci. Biotechnol. Biochem. pmid:24200778
Grindel A et al. Cheek cell fatty acids reflect n-3 PUFA in blood fractions during linseed oil supplementation: a controlled human intervention study. 2013 Lipids Health Dis pmid:24229084
Afitlhile M et al. A mutant of the Arabidopsis thaliana TOC159 gene accumulates reduced levels of linolenic acid and monogalactosyldiacylglycerol. 2013 Plant Physiol. Biochem. pmid:24184455
Ma T et al. Effect of droplet size on autoxidation rates of methyl linoleate and α-linolenate in an oil-in-water emulsion. 2013 J Oleo Sci pmid:24292352
Carey AN et al. The ability of walnut extract and fatty acids to protect against the deleterious effects of oxidative stress and inflammation in hippocampal cells. 2013 Nutr Neurosci pmid:23321679
Lau BY et al. Investigating the role of polyunsaturated fatty acids in bone development using animal models. 2013 Molecules pmid:24248147
Sonne DP and Knop FK Cardiovascular effects of alpha-linolenic acid--a possible role of glucagon-like peptide-1. 2013 Exp. Biol. Med. (Maywood) pmid:24174423
Hoque M et al. Oleic acid may be the key contributor in the BAMLET-induced erythrocyte hemolysis and tumoricidal action. 2013 PLoS ONE pmid:24039698
Moallem U et al. Dietary α-linolenic acid from flaxseed oil improved folliculogenesis and IVF performance in dairy cows, similar to eicosapentaenoic and docosahexaenoic acids from fish oil. 2013 Reproduction pmid:24062566
Tu WC et al. Correlations between blood and tissue omega-3 LCPUFA status following dietary ALA intervention in rats. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22521090
Arm JP et al. Impact of botanical oils on polyunsaturated fatty acid metabolism and leukotriene generation in mild asthmatics. 2013 Lipids Health Dis pmid:24088297
Meijerink J et al. N-Acyl amines of docosahexaenoic acid and other n-3 polyunsatured fatty acids - from fishy endocannabinoids to potential leads. 2013 Br. J. Pharmacol. pmid:23088259
Chechetkin IR et al. Isolation and structure elucidation of linolipins C and D, complex oxylipins from flax leaves. 2013 Phytochemistry pmid:24042063
Vaezi R et al. Identification and functional characterization of genes encoding omega-3 polyunsaturated fatty acid biosynthetic activities from unicellular microalgae. 2013 Mar Drugs pmid:24351909
Brouwer IA et al. Effect of alpha linolenic acid supplementation on serum prostate specific antigen (PSA): results from the alpha omega trial. 2013 PLoS ONE pmid:24349086
Zhang W et al. Alpha-linolenic acid intake prevents endothelial dysfunction in high-fat diet-fed streptozotocin rats and underlying mechanisms. 2013 VASA pmid:24220118
Al-Bishri WM Favorable effects of flaxseed supplemented diet on liver and kidney functions in hypertensive Wistar rats. 2013 J Oleo Sci pmid:24005015
Niculescu MD et al. Perinatal manipulation of α-linolenic acid intake induces epigenetic changes in maternal and offspring livers. 2013 FASEB J. pmid:22997227
Meyer BJ et al. Assessing long-chain ω-3 polyunsaturated fatty acids: a tailored food-frequency questionnaire is better. 2013 Nutrition pmid:22929186
Shin JA et al. Preparation of recombined milk using modified butterfats containing α-linolenic acid. 2013 J. Food Sci. pmid:23278855
Yang D et al. Antioxidative activities of Ginkgo biloba extract on oil/water emulsion system prepared from an enzymatically modified lipid containing alpha-linolenic acid. 2013 J. Food Sci. pmid:23278764
Shibata E et al. Free fatty acids inhibit protein tyrosine phosphatase 1B and activate Akt. 2013 Cell. Physiol. Biochem. pmid:24107614
Smink W et al. Effect of intake of linoleic acid and α-linolenic acid levels on conversion into long-chain polyunsaturated fatty acids in backfat and in intramuscular fat of growing pigs. 2013 J Anim Physiol Anim Nutr (Berl) pmid:22463497
Benbrook CM et al. Organic production enhances milk nutritional quality by shifting fatty acid composition: a United States-wide, 18-month study. 2013 PLoS ONE pmid:24349282
de Oliveira Otto MC et al. Circulating and dietary omega-3 and omega-6 polyunsaturated fatty acids and incidence of CVD in the Multi-Ethnic Study of Atherosclerosis. 2013 J Am Heart Assoc pmid:24351702
Rahman H et al. Development of low-linolenic acid Brassica oleracea lines through seed mutagenesis and molecular characterization of mutants. 2013 Theor. Appl. Genet. pmid:23475317
Wei M et al. Perilla oil and exercise decrease expressions of tumor necrosis factor-alpha, plasminogen activator inhibitor-1 and highly sensitive C-reactive protein in patients with hyperlipidemia. 2013 J Tradit Chin Med pmid:23789212
Esselburn KM et al. Intake of specific fatty acids and fat alters growth, health, and titers following vaccination in dairy calves. 2013 J. Dairy Sci. pmid:23810586