| MeSH term | MeSH ID | Detail |
|---|---|---|
| Edema | D004487 | 152 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Amyloidosis | D000686 | 4 associated lipids |
| Heart Failure | D006333 | 36 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
| Hypersensitivity | D006967 | 22 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
alpha-linolenic acid
Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
Cross Reference
Introduction
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with alpha-linolenic acid?
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
PubChem Associated disorders and diseases
What pathways are associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with alpha-linolenic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with alpha-linolenic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with alpha-linolenic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Monge-Rojas R et al. | Changes in dietary intake and food sources of saturated and cis and trans unsaturated fatty acids in Costa Rican adolescents: 1996 versus 2006. | 2013 | Nutrition | pmid:23298971 |
| Molkentin J | Applicability of organic milk indicators to the authentication of processed products. | 2013 | Food Chem | pmid:23199986 |
| Ulas T et al. | Does α-lipoic acid treatment play a role on oxidative stress and insulin resistance in overweight/obese patients? | 2013 | Int. J. Cardiol. | pmid:23200266 |
| Zhao ML et al. | Enzymatic production of zero-trans plastic fat rich in α-linolenic acid and medium-chain fatty acids from highly hydrogenated soybean oil, Cinnamomum camphora seed oil, and perilla oil by lipozyme TL IM. | 2013 | J. Agric. Food Chem. | pmid:23350869 |
| Nozue T et al. | Effects of statins on serum n-3 to n-6 polyunsaturated fatty acid ratios in patients with coronary artery disease. | 2013 | J. Cardiovasc. Pharmacol. Ther. | pmid:23324995 |
| Cedernaes J et al. | Adipose tissue stearoyl-CoA desaturase 1 index is increased and linoleic acid is decreased in obesity-prone rats fed a high-fat diet. | 2013 | Lipids Health Dis | pmid:23298201 |
| Kastner DW and Van Wagoner DR | Diet and atrial fibrillation: does α-linolenic acid, a plant derived essential fatty acid, have an impact? | 2013 | J Am Heart Assoc | pmid:23525415 |
| Fretts AM et al. | Associations of plasma phospholipid and dietary alpha linolenic acid with incident atrial fibrillation in older adults: the Cardiovascular Health Study. | 2013 | J Am Heart Assoc | pmid:23525429 |
| Kälber T et al. | Effect of feeding buckwheat and chicory silages on fatty acid profile and cheese-making properties of milk from dairy cows. | 2013 | J. Dairy Res. | pmid:23253429 |
| Monteiro J et al. | Oils rich in α-linolenic acid independently protect against characteristics of fatty liver disease in the Δ6-desaturase null mouse. | 2013 | Can. J. Physiol. Pharmacol. | pmid:23746194 |
| Gillingham LG et al. | Dietary oils and FADS1-FADS2 genetic variants modulate [13C]α-linolenic acid metabolism and plasma fatty acid composition. | 2013 | Am. J. Clin. Nutr. | pmid:23221573 |
| Liu M et al. | Characterization and biological effects of di-hydroxylated compounds deriving from the lipoxygenation of ALA. | 2013 | J. Lipid Res. | pmid:23740966 |
| Kim Y et al. | Synergism of α-linolenic acid, conjugated linoleic acid and calcium in decreasing adipocyte and increasing osteoblast cell growth. | 2013 | Lipids | pmid:23757205 |
| Lai YH et al. | Association of dietary omega-3 fatty acids with prevalence of metabolic syndrome: the National Heart, Lung, and Blood Institute Family Heart Study. | 2013 | Clin Nutr | pmid:23711994 |
| Gage SH et al. | Functionalization of monodisperse iron oxide NPs and their properties as magnetically recoverable catalysts. | 2013 | Langmuir | pmid:23234434 |
| Lohner S et al. | Gender differences in the long-chain polyunsaturated fatty acid status: systematic review of 51 publications. | 2013 | Ann. Nutr. Metab. | pmid:23327902 |
| Carey AN et al. | The ability of walnut extract and fatty acids to protect against the deleterious effects of oxidative stress and inflammation in hippocampal cells. | 2013 | Nutr Neurosci | pmid:23321679 |
| Coles L et al. | A model to predict the ATP equivalents of macronutrients absorbed from food. | 2013 | Food Funct | pmid:23233079 |
| Shen JH et al. | Effect of α-linolenic acid on streptozotocin-induced diabetic retinopathy indices in vivo. | 2013 | Arch. Med. Res. | pmid:24120388 |
| Végner L et al. | Experimental confirmation of new drug-target interactions predicted by Drug Profile Matching. | 2013 | J. Med. Chem. | pmid:24088053 |
| Yang Z and Huffman SL | Modelling linoleic acid and α-linolenic acid requirements for infants and young children in developing countries. | 2013 | Matern Child Nutr | pmid:23167585 |
| Alhazzaa R et al. | Bioconversion of α-linolenic acid into n-3 long-chain polyunsaturated fatty acid in hepatocytes and ad hoc cell culture optimisation. | 2013 | PLoS ONE | pmid:24040040 |
| Botsoglou E et al. | Olive leaves (Olea europea L.) and α-tocopheryl acetate as feed antioxidants for improving the oxidative stability of α-linolenic acid-enriched eggs. | 2013 | J Anim Physiol Anim Nutr (Berl) | pmid:22716021 |
| Kartikasari LR et al. | Dietary alpha-linolenic acid enhances omega-3 long chain polyunsaturated fatty acid levels in chicken tissues. | 2012 Oct-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22925778 |
| Tsuzuki W | Inconsistencies in a highly polar capillary gas chromatography column and necessity of column performance checks for trans fatty acid measurement. | 2012 Nov-Dec | J AOAC Int | pmid:23451392 |
| Hofacer R et al. | Omega-3 fatty acid deficiency increases stearoyl-CoA desaturase expression and activity indices in rat liver: positive association with non-fasting plasma triglyceride levels. | 2012 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22047910 |
| Harland DR et al. | Acute effects of prostaglandin E1 and E2 on vascular reactivity and blood flow in situ in the chick chorioallantoic membrane. | 2012 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22858445 |
| Sugasini D and Lokesh BR | Uptake of α-linolenic acid and its conversion to long chain omega-3 fatty acids in rats fed microemulsions of linseed oil. | 2012 | Lipids | pmid:23104428 |
| Jung DM et al. | Chemical properties and oxidative stability of perilla oils obtained from roasted perilla seeds as affected by extraction methods. | 2012 | J. Food Sci. | pmid:23106331 |
| Pereira H et al. | Polyunsaturated Fatty acids of marine macroalgae: potential for nutritional and pharmaceutical applications. | 2012 | Mar Drugs | pmid:23118712 |
| Botsoglou E et al. | Effect of supplementation of the laying hen diet with olive leaves (Olea europea L.) on lipid oxidation and fatty acid profile of α-linolenic acid enriched eggs during storage. | 2012 | Br. Poult. Sci. | pmid:23130586 |
| Zhao T et al. | Impact of roasting on the chemical composition and oxidative stability of perilla oil. | 2012 | J. Food Sci. | pmid:23140339 |
| Wang Z et al. | De novo characterization of the banana root transcriptome and analysis of gene expression under Fusarium oxysporum f. sp. Cubense tropical race 4 infection. | 2012 | BMC Genomics | pmid:23170772 |
| Astiz M et al. | Exogenous arachidonate restores the dimethoate-induced inhibition of steroidogenesis in rat interstitial cells. | 2012 | Lipids | pmid:22476691 |
| Fang XL et al. | Roles of α-linolenic acid on IGF-I secretion and GH/IGF system gene expression in porcine primary hepatocytes. | 2012 | Mol. Biol. Rep. | pmid:23053988 |
| He ML et al. | Triticale dried distillers' grain increases alpha-linolenic acid in subcutaneous fat of beef cattle fed oilseeds. | 2012 | Lipids | pmid:23054550 |
| Msika O et al. | NGF blocks polyunsaturated fatty acids biosynthesis in n-3 fatty acid-supplemented PC12 cells. | 2012 | Biochim. Biophys. Acta | pmid:22564256 |
| Garcia CV et al. | Characterisation of bound volatile compounds of a low flavour kiwifruit species: Actinidia eriantha. | 2012 | Food Chem | pmid:23107675 |
| Moodley R et al. | Elemental composition and fatty acid profile of the edible fruits of Amatungula (Carissa macrocarpa) and impact of soil quality on chemical characteristics. | 2012 | Anal. Chim. Acta | pmid:22632042 |
| Lakshmanan V et al. | Metabolomic analysis of patient plasma yields evidence of plant-like α-linolenic acid metabolism in Plasmodium falciparum. | 2012 | J. Infect. Dis. | pmid:22566569 |
| Saha SS et al. | Synergistic effect of conjugated linolenic acid isomers against induced oxidative stress, inflammation and erythrocyte membrane disintegrity in rat model. | 2012 | Biochim. Biophys. Acta | pmid:22967758 |
| Shimpukade B et al. | Discovery of a potent and selective GPR120 agonist. | 2012 | J. Med. Chem. | pmid:22519963 |
| Shinohara N et al. | Jacaric acid, a linolenic acid isomer with a conjugated triene system, has a strong antitumor effect in vitro and in vivo. | 2012 | Biochim. Biophys. Acta | pmid:22521763 |
| Valentine CJ | Maternal dietary DHA supplementation to improve inflammatory outcomes in the preterm infant. | 2012 | Adv Nutr | pmid:22585914 |
| González-Mañán D et al. | Bioconversion of α-linolenic acid to n-3 LCPUFA and expression of PPAR-alpha, acyl Coenzyme A oxidase 1 and carnitine acyl transferase I are incremented after feeding rats with α-linolenic acid-rich oils. | 2012 | Food Funct | pmid:22588205 |
| Kim N and Choe E | Singlet oxygen-related photooxidative stability and antioxidant changes of diacylglycerol-rich oil derived from mixture of olive and perilla oil. | 2012 | J. Food Sci. | pmid:23057833 |
| Vecchio AJ et al. | Investigating substrate promiscuity in cyclooxygenase-2: the role of Arg-120 and residues lining the hydrophobic groove. | 2012 | J. Biol. Chem. | pmid:22637474 |
| Jiang M et al. | [Protective effect of ALA on high glucose induced cellular injury of LLC-PK1 cell]. | 2012 | Wei Sheng Yan Jiu | pmid:22611923 |
| Georgiadi A et al. | Detailed transcriptomics analysis of the effect of dietary fatty acids on gene expression in the heart. | 2012 | Physiol. Genomics | pmid:22274564 |
| Alessandri JM et al. | Influence of gender on DHA synthesis: the response of rat liver to low dietary α-linolenic acid evidences higher ω3 ∆4-desaturation index in females. | 2012 | Eur J Nutr | pmid:21647669 |
| de Batlle J et al. | Association between Ω3 and Ω6 fatty acid intakes and serum inflammatory markers in COPD. | 2012 | J. Nutr. Biochem. | pmid:21889886 |
| Sun T et al. | Meat fatty acid and cholesterol level of free-range broilers fed on grasshoppers on alpine rangeland in the Tibetan Plateau. | 2012 | J. Sci. Food Agric. | pmid:22318921 |
| Deckelbaum RJ and Torrejon C | The omega-3 fatty acid nutritional landscape: health benefits and sources. | 2012 | J. Nutr. | pmid:22323763 |
| Larsen MK et al. | Fatty acid, tocopherol and carotenoid content in herbage and milk affected by sward composition and season of grazing. | 2012 | J. Sci. Food Agric. | pmid:22337263 |
| Angulo J et al. | Nutritional evaluation of fruit and vegetable waste as feedstuff for diets of lactating Holstein cows. | 2012 | J. Environ. Manage. | pmid:21784573 |
| Pirat C et al. | Targeting peroxisome proliferator-activated receptors (PPARs): development of modulators. | 2012 | J. Med. Chem. | pmid:22260081 |
| Huang T et al. | Effect of n-3 polyunsaturated fatty acid on gene expression of the critical enzymes involved in homocysteine metabolism. | 2012 | Nutr J | pmid:22260268 |
| Gaquerel E et al. | Nicotiana attenuata α-DIOXYGENASE1 through its production of 2-hydroxylinolenic acid is required for intact plant defense expression against attack from Manduca sexta larvae. | 2012 | New Phytol. | pmid:22937952 |
| Hughes BH et al. | Oxidative stability and consumer acceptance of fish oil fortified nutrition bars. | 2012 | J. Food Sci. | pmid:22957916 |
| Aliani M et al. | Effect of flax addition on the flavor profile and acceptability of bagels. | 2012 | J. Food Sci. | pmid:22260132 |
| Lerch S et al. | Rapeseed or linseed in grass-based diets: effects on conjugated linoleic and conjugated linolenic acid isomers in milk fat from Holstein cows over 2 consecutive lactations. | 2012 | J. Dairy Sci. | pmid:22999291 |
| Wilk JB et al. | Plasma and dietary omega-3 fatty acids, fish intake, and heart failure risk in the Physicians' Health Study. | 2012 | Am. J. Clin. Nutr. | pmid:22952185 |
| Moallem U et al. | Transfer rate of α-linolenic acid from abomasally infused flaxseed oil into milk fat and the effects on milk fatty acid composition in dairy cows. | 2012 | J. Dairy Sci. | pmid:22916932 |
| Yang G et al. | Duodenal infusion of α-linolenic acid affects fatty acid metabolism in the mammary gland of lactating dairy cows. | 2012 | J. Dairy Sci. | pmid:22921622 |
| Umesha SS and Naidu KA | Vegetable oil blends with α-linolenic acid rich Garden cress oil modulate lipid metabolism in experimental rats. | 2012 | Food Chem | pmid:22980881 |
| Janssen S et al. | Sensing of fatty acids for octanoylation of ghrelin involves a gustatory G-protein. | 2012 | PLoS ONE | pmid:22768248 |
| Reinders I et al. | Association of serum n-3 polyunsaturated fatty acids with C-reactive protein in men. | 2012 | Eur J Clin Nutr | pmid:22113248 |
| Kuhns EH et al. | A lepidopteran aminoacylase (L-ACY-1) in Heliothis virescens (Lepidoptera: Noctuidae) gut lumen hydrolyzes fatty acid-amino acid conjugates, elicitors of plant defense. | 2012 | Insect Biochem. Mol. Biol. | pmid:22056272 |
| Mitra K et al. | Studies of reaction variables for lipase-catalyzed production of alpha-linolenic acid enriched structured lipid and oxidative stability with antioxidants. | 2012 | J. Food Sci. | pmid:22122200 |
| Couëdelo L et al. | The fraction of α-linolenic acid present in the sn-2 position of structured triacylglycerols decreases in lymph chylomicrons and plasma triacylglycerols during the course of lipid absorption in rats. | 2012 | J. Nutr. | pmid:22131546 |
| Nwaru BI et al. | Maternal intake of fatty acids during pregnancy and allergies in the offspring. | 2012 | Br. J. Nutr. | pmid:22067943 |
| Pal M and Ghosh M | Studies on comparative efficacy of α-linolenic acid and α-eleostearic acid on prevention of organic mercury-induced oxidative stress in kidney and liver of rat. | 2012 | Food Chem. Toxicol. | pmid:22269903 |
| Pal M and Ghosh M | Prophylactic effect of α-linolenic acid and α-eleostearic acid against MeHg induced oxidative stress, DNA damage and structural changes in RBC membrane. | 2012 | Food Chem. Toxicol. | pmid:22683484 |
| Zhang G et al. | Erythrocyte n-3 fatty acids and metabolic syndrome in middle-aged and older Chinese. | 2012 | J. Clin. Endocrinol. Metab. | pmid:22456621 |
| Kowalska A et al. | Impact of diets with different proportions of linseed and sunflower oils on the growth, liver histology, immunological and chemical blood parameters, and proximate composition of pikeperch Sander lucioperca (L.). | 2012 | Fish Physiol. Biochem. | pmid:21656178 |
| Ishida Y et al. | Validation of thermally assisted hydrolysis and methylation-gas chromatography using a vertical microfurnace pyrolyzer for the compositional analysis of Fatty Acid components in microalgae. | 2012 | J. Agric. Food Chem. | pmid:22458968 |
| Mirmiran P et al. | Association between interaction and ratio of ω-3 and ω-6 polyunsaturated fatty acid and the metabolic syndrome in adults. | 2012 | Nutrition | pmid:22459553 |
| Maqbool A et al. | Relation between dietary fat intake type and serum fatty acid status in children with cystic fibrosis. | 2012 | J. Pediatr. Gastroenterol. Nutr. | pmid:22699835 |
| Du Q et al. | Dairy fat blends high in α-linolenic acid are superior to n-3 fatty-acid-enriched palm oil blends for increasing DHA levels in the brains of young rats. | 2012 | J. Nutr. Biochem. | pmid:22445803 |
| Ling PR et al. | Purified fish oil eliminating linoleic and alpha linolenic acid meets essential fatty acid requirements in rats. | 2012 | Metab. Clin. Exp. | pmid:22512821 |
| Miyake Y et al. | Dietary meat and fat intake and prevalence of rhinoconjunctivitis in pregnant Japanese women: baseline data from the Kyushu Okinawa Maternal and Child Health Study. | 2012 | Nutr J | pmid:22449171 |
| Nakamura YK et al. | Modulation of oxidative stress by γ-glutamylcysteine (GGC) and conjugated linoleic acid (CLA) isomer mixture in human umbilical vein endothelial cells. | 2012 | Food Chem. Toxicol. | pmid:22490668 |
| Zhang LH et al. | [Effects of alpha-linolenic acid on inflammation and oxidative stress in the diabetic rats]. | 2012 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:22493899 |
| Fatima T et al. | Fatty acid composition of developing sea buckthorn (Hippophae rhamnoides L.) berry and the transcriptome of the mature seed. | 2012 | PLoS ONE | pmid:22558083 |
| Luo ZM et al. | A new norisoprenoid and other compounds from Fuzhuan brick tea. | 2012 | Molecules | pmid:22430120 |
| Ibrahim A et al. | Dietary α-linolenic acid-rich formula reduces adhesion molecules in rats with experimental colitis. | 2012 | Nutrition | pmid:22261574 |
| Zhang H et al. | A mechanism underlying the effects of polyunsaturated fatty acids on breast cancer. | 2012 | Int. J. Mol. Med. | pmid:22692672 |
| Marei WF et al. | Differential effects of linoleic and alpha-linolenic fatty acids on spatial and temporal mitochondrial distribution and activity in bovine oocytes. | 2012 | Reprod. Fertil. Dev. | pmid:22697118 |
| Kronberg SL et al. | Treatment of flaxseed to reduce biohydrogenation of α-linolenic acid by ruminal microbes in sheep and cattle, and increase n-3 fatty acid concentrations in red meat. | 2012 | J. Anim. Sci. | pmid:22696616 |
| Turchini GM et al. | Jumping on the omega-3 bandwagon: distinguishing the role of long-chain and short-chain omega-3 fatty acids. | 2012 | Crit Rev Food Sci Nutr | pmid:22698270 |
| Passos PP et al. | Dopaminergic cell populations of the rat substantia nigra are differentially affected by essential fatty acid dietary restriction over two generations. | 2012 | J. Chem. Neuroanat. | pmid:22687395 |
| Botsoglou E et al. | Lipid and protein oxidation of α-linolenic acid-enriched pork during refrigerated storage as influenced by diet supplementation with olive leaves (Olea europea L.) or α-tocopheryl acetate. | 2012 | Meat Sci. | pmid:22710099 |
| Erdinest N et al. | Anti-inflammatory effects of alpha linolenic acid on human corneal epithelial cells. | 2012 | Invest. Ophthalmol. Vis. Sci. | pmid:22669722 |
| Longvah T et al. | Eri silkworm: a source of edible oil with a high content of α-linolenic acid and of significant nutritional value. | 2012 | J. Sci. Food Agric. | pmid:22290445 |
| Monteiro J et al. | Menhaden oil, but not safflower or soybean oil, aids in restoring the polyunsaturated fatty acid profile in the novel delta-6-desaturase null mouse. | 2012 | Lipids Health Dis | pmid:22642787 |
| Castro LF et al. | Functional desaturase Fads1 (Δ5) and Fads2 (Δ6) orthologues evolved before the origin of jawed vertebrates. | 2012 | PLoS ONE | pmid:22384110 |
| Pan H et al. | Alpha-linolenic acid is a potent neuroprotective agent against soman-induced neuropathology. | 2012 | Neurotoxicology | pmid:22884490 |
| Huan M et al. | In vivo anti-tumor activity of a new doxorubicin conjugate via α-linolenic acid. | 2012 | Biosci. Biotechnol. Biochem. | pmid:22878199 |
| Zhang G et al. | [Effects of fatty acids on proliferation and differentiation of myoblast]. | 2012 | Wei Sheng Yan Jiu | pmid:23424861 |
| Santos FS et al. | Status of cis and trans fatty acids in Brazilian adolescent mothers and their newborns. | 2012 | J Pediatr Adolesc Gynecol | pmid:22840939 |