| MeSH term | MeSH ID | Detail |
|---|---|---|
| Irritable Bowel Syndrome | D043183 | 8 associated lipids |
| Overweight | D050177 | 11 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Carcinogenesis | D063646 | 3 associated lipids |
alpha-linolenic acid
Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
Cross Reference
Introduction
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with alpha-linolenic acid?
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
PubChem Associated disorders and diseases
What pathways are associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with alpha-linolenic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with alpha-linolenic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with alpha-linolenic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Grechkin AN et al. | Lipoxygenase pathway in tulip: biosynthesis of ketols. | 2000 | Biochem. Soc. Trans. | pmid:11171230 |
| Nuñez A et al. | Anaerobic lipoxygenase activity from Chlorella pyrenoidosa. | 2000 | Biochem. Soc. Trans. | pmid:11171268 |
| Kaushik N and Agnihotri A | GLC analysis of Indian rapeseed-mustard to study the variability of fatty acid composition. | 2000 | Biochem. Soc. Trans. | pmid:11171132 |
| Cheon SH et al. | Effect of dietary linoleate/alpha-linolenate balance on the brain lipid composition, reproductive outcome and behavior of rats during their prenatal and postnatal development. | 2000 | Biosci. Biotechnol. Biochem. | pmid:11193394 |
| Loï C et al. | Incorporation and metabolism of dietary trans isomers of linolenic acid alter the fatty acid profile of rat tissues. | 2000 | J. Nutr. | pmid:11015488 |
| MarÃn MC et al. | Dietary long-chain fatty acids and visual response in malnourished nursing infants. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11133176 |
| Harbige LS et al. | The protective effects of omega-6 fatty acids in experimental autoimmune encephalomyelitis (EAE) in relation to transforming growth factor-beta 1 (TGF-beta1) up-regulation and increased prostaglandin E2 (PGE2) production. | 2000 | Clin. Exp. Immunol. | pmid:11122253 |
| Granot E et al. | Breast-fed and formula-fed infants do not differ in immunocompetent cell cytokine production despite differences in cell membrane fatty acid composition. | 2000 | Am. J. Clin. Nutr. | pmid:11063450 |
| Richieri GV et al. | Fatty acid binding proteins from different tissues show distinct patterns of fatty acid interactions. | 2000 | Biochemistry | pmid:10852718 |
| Larqué E et al. | Dietary trans fatty acids affect docosahexaenoic acid concentrations in plasma and liver but not brain of pregnant and fetal rats. | 2000 | Pediatr. Res. | pmid:10674359 |
| Dobson G | Leaf lipids of Ribes nigrum: a plant containing 16:3, alpha-18:3, gamma-18:3 and 18:4 fatty acids. | 2000 | Biochem. Soc. Trans. | pmid:11171133 |
| Okolo SN et al. | The fatty acid composition of human milk in northern Nigeria. | 2000 | J Hum Lact | pmid:11138221 |
| Utsunomiya T et al. | Correspondence re: M. Kondo et al., Increased expression of COX-2 in nontumor liver tissue is associated with shorter disease-free survival in patients with hepatocellular carcinoma. Clin. Cancer Res., 5: 4005-4012, 1999. | 2000 | Clin. Cancer Res. | pmid:11156258 |
| Makrides M et al. | A randomized trial of different ratios of linoleic to alpha-linolenic acid in the diet of term infants: effects on visual function and growth. | 2000 | Am. J. Clin. Nutr. | pmid:10617956 |
| Connor WE | Importance of n-3 fatty acids in health and disease. | 2000 | Am. J. Clin. Nutr. | pmid:10617967 |
| Ide T | Effect of dietary alpha-linolenic acid on the activity and gene expression of hepatic fatty acid oxidation enzymes. | 2000 | Biofactors | pmid:11237206 |
| Auestad N and Innis SM | Dietary n-3 fatty acid restriction during gestation in rats: neuronal cell body and growth-cone fatty acids. | 2000 | Am. J. Clin. Nutr. | pmid:10617988 |
| James MJ et al. | Dietary polyunsaturated fatty acids and inflammatory mediator production. | 2000 | Am. J. Clin. Nutr. | pmid:10617994 |
| Crawford M et al. | Role of plant-derived omega-3 fatty acids in human nutrition. | 2000 | Ann. Nutr. Metab. | pmid:11146334 |
| Berghaus TM et al. | Essential fatty acids and their long-chain polyunsaturated metabolites in maternal and cord plasma triglycerides during late gestation. | 2000 | Biol. Neonate | pmid:10657686 |
| Charnock JS | Gamma-linolenic acid provides additional protection against ventricular fibrillation in aged rats fed linoleic acid rich diets. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10780878 |
| Ikemoto A et al. | Lysosomal enzyme activities are decreased in the retina and their circadian rhythms are different from those in the pineal gland of rats fed an alpha-linolenic acid-restricted diet. | 2000 | J. Nutr. | pmid:11110869 |
| Babin F et al. | Alpha linolenic acid in cholesterol esters: a marker of alphalinolenic acid intake in newborns. | 2000 | Eur J Clin Nutr | pmid:11114678 |
| Punchard NA et al. | Analysis of the intestinal absorption of essential fatty acids in vivo in the rat. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10765976 |
| Ikemoto A et al. | Diurnal rhythms of retinal phospholipid synthetic enzymes are retained but their activities are decreased in rats under alpha-linolenic acid deficiency. | 2000 | Arch. Biochem. Biophys. | pmid:11097182 |
| Gonzalez-Esquerra R and Leeson S | Effects of menhaden oil and flaxseed in broiler diets on sensory quality and lipid composition of poultry meat. | 2000 | Br. Poult. Sci. | pmid:11128390 |
| Contreras MA et al. | Nutritional deprivation of alpha-linolenic acid decreases but does not abolish turnover and availability of unacylated docosahexaenoic acid and docosahexaenoyl-CoA in rat brain. | 2000 | J. Neurochem. | pmid:11080190 |
| Frey M et al. | An herbivore elicitor activates the gene for indole emission in maize. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11106389 |
| Colditz GA | Changing dietary patterns and cancer prevention: alpha-linolenic acid health risks and benefits. | 2000 | Cancer Causes Control | pmid:11065003 |
| McCarty MF | Activation of PPARgamma may mediate a portion of the anticancer activity of conjugated linoleic acid. | 2000 | Med. Hypotheses | pmid:10985906 |
| Petrik MB et al. | Highly unsaturated (n-3) fatty acids, but not alpha-linolenic, conjugated linoleic or gamma-linolenic acids, reduce tumorigenesis in Apc(Min/+) mice. | 2000 | J. Nutr. | pmid:11015469 |
| Zamora R et al. | Contribution of pyrrole formation and polymerization to the nonenzymatic browning produced by amino-carbonyl reactions. | 2000 | J. Agric. Food Chem. | pmid:10956084 |
| Sea MM et al. | Weight cycling-induced alteration in fatty acid metabolism. | 2000 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:10956277 |
| Sauer LA et al. | Mechanism for the antitumor and anticachectic effects of n-3 fatty acids. | 2000 | Cancer Res. | pmid:11016660 |
| Simopoulos AP | Human requirement for N-3 polyunsaturated fatty acids. | 2000 | Poult. Sci. | pmid:10901194 |
| de la Presa Owens S and Innis SM | Diverse, region-specific effects of addition of arachidonic and docosahexanoic acids to formula with low or adequate linoleic and alpha-linolenic acids on piglet brain monoaminergic neurotransmitters. | 2000 | Pediatr. Res. | pmid:10879811 |
| Bartsch H and Nair J | New DNA-based biomarkers for oxidative stress and cancer chemoprevention studies. | 2000 | Eur. J. Cancer | pmid:10882861 |
| McCarty MF | Toward practical prevention of type 2 diabetes. | 2000 | Med. Hypotheses | pmid:10859688 |
| Mantzioris E et al. | Biochemical effects of a diet containing foods enriched with n-3 fatty acids. | 2000 | Am. J. Clin. Nutr. | pmid:10871559 |
| Fein A and Cavar S | Divergent mechanisms for phototransduction of invertebrate microvillar photoreceptors. | 2000 Nov-Dec | Vis. Neurosci. | pmid:11193107 |
| Innis SM | The role of dietary n-6 and n-3 fatty acids in the developing brain. | 2000 Sep-Dec | Dev. Neurosci. | pmid:11111165 |
| Tijet N et al. | Biogenesis of volatile aldehydes from fatty acid hydroperoxides: molecular cloning of a hydroperoxide lyase (CYP74C) with specificity for both the 9- and 13-hydroperoxides of linoleic and linolenic acids. | 2001 | Arch. Biochem. Biophys. | pmid:11368353 |
| Bretillon L et al. | Isomerization increases the postprandial oxidation of linoleic acid but not alpha-linolenic acid in men. | 2001 | J. Lipid Res. | pmid:11369808 |
| Schaller F | Enzymes of the biosynthesis of octadecanoid-derived signalling molecules. | 2001 | J. Exp. Bot. | pmid:11181709 |
| Nomura T et al. | A long-lasting facilitation of hippocampal neurotransmission via a phospholipase A2 signaling pathway. | 2001 | Life Sci. | pmid:11432454 |
| Vancassel S et al. | Plasma fatty acid levels in autistic children. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11487301 |
| Sijben JW et al. | Interactions and antigen dependence of dietary n-3 and n-6 polyunsaturated fatty acids on antibody responsiveness in growing layer hens. | 2001 | Poult. Sci. | pmid:11469650 |
| Moriguchi T et al. | Reversal of docosahexaenoic acid deficiency in the rat brain, retina, liver, and serum. | 2001 | J. Lipid Res. | pmid:11254754 |
| Cho E et al. | Prospective study of dietary fat and the risk of age-related macular degeneration. | 2001 | Am. J. Clin. Nutr. | pmid:11157315 |
| Zien CA et al. | In vivo substrates and the contribution of the common phospholipase D, PLDalpha, to wound-induced metabolism of lipids in Arabidopsis. | 2001 | Biochim. Biophys. Acta | pmid:11239826 |
| Tocher DR and Dick JR | Effects of essential fatty acid deficiency and supplementation with docosahexaenoic acid (DHA; 22:6n-3) on cellular fatty acid compositions and fatty acyl desaturation in a cell culture model. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11161581 |
| Agatha G et al. | Fatty acid composition of lymphocyte membrane phospholipids in children with acute leukemia. | 2001 | Cancer Lett. | pmid:11597788 |
| Wiesenfeld PW et al. | Effect of long-chain fatty acids in the culture medium on fatty acid composition of WEHI-3 and J774A.1 cells. | 2001 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:11163311 |
| Son BW et al. | New galactolipids from the marine bacillariophycean microalga Nitzschia sp. | 2001 | Nat Prod Lett | pmid:11841113 |
| Xian M et al. | Production of gamma-linolenic acid by Mortierella isabellina grown on hexadecanol. | 2001 | Lett. Appl. Microbiol. | pmid:11696098 |
| Harper CR and Jacobson TA | The fats of life: the role of omega-3 fatty acids in the prevention of coronary heart disease. | 2001 | Arch. Intern. Med. | pmid:11575974 |
| Yamaguchi S et al. | Identification of a component that induces flowering of Lemna among the reaction products of alpha-ketol linolenic acid (FIF) and norepinephrine. | 2001 | Plant Cell Physiol. | pmid:11726704 |
| Pereira C et al. | The alpha-linolenic acid content of green vegetables commonly available in Australia. | 2001 | Int J Vitam Nutr Res | pmid:11582857 |
| Dobos G and Michalsen A | [Comment on the contribution by G. Keyser, "Are there reliable dietary recommendations for patients with rheumatoid arthritis?"]. | 2001 | Z Rheumatol | pmid:11584725 |
| Oomen CM et al. | alpha-Linolenic acid intake is not beneficially associated with 10-y risk of coronary artery disease incidence: the Zutphen Elderly Study. | 2001 | Am. J. Clin. Nutr. | pmid:11566643 |
| Kaku S et al. | Interactions of dietary fats and proteins on fatty acid composition of immune cells and LTB4 production by peritoneal exudate cells of rats. | 2001 | Biosci. Biotechnol. Biochem. | pmid:11302164 |
| Pawlosky RJ et al. | Physiological compartmental analysis of alpha-linolenic acid metabolism in adult humans. | 2001 | J. Lipid Res. | pmid:11483627 |
| Kim E et al. | Effects of gamma-irradiated fats on plasma lipid concentrations and hepatic cholesterol metabolism in rats. | 2001 | Ann. Nutr. Metab. | pmid:11463998 |
| Cherian G and Sim JS | Maternal dietary alpha-linolenic acid (18:3n-3) alters n-3 polyunsaturated fatty acid metabolism and liver enzyme activity in hatched chicks. | 2001 | Poult. Sci. | pmid:11469652 |
| Sharma R et al. | Mulberry moracins: scavengers of UV stress-generated free radicals. | 2001 | Biosci. Biotechnol. Biochem. | pmid:11471743 |
| Renaud SC | Diet and stroke. | 2001 | J Nutr Health Aging | pmid:11458287 |
| Hrelia S et al. | Role of gamma-linolenic acid in counteracting doxorubicin-induced damage in cultured rat cardiomyocytes. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11334548 |
| Lanzmann-Petithory D | Alpha-linolenic acid and cardiovascular diseases. | 2001 | J Nutr Health Aging | pmid:11458289 |
| Hoffman DR et al. | Impaired synthesis of DHA in patients with X-linked retinitis pigmentosa. | 2001 | J. Lipid Res. | pmid:11518758 |
| Barre DE | Potential of evening primrose, borage, black currant, and fungal oils in human health. | 2001 | Ann. Nutr. Metab. | pmid:11359029 |
| De Vriese SR et al. | Estimation of dietary fat intake of Belgian pregnant women. Comparison of two methods. | 2001 | Ann. Nutr. Metab. | pmid:11786650 |
| Thies F et al. | Dietary supplementation with gamma-linolenic acid or fish oil decreases T lymphocyte proliferation in healthy older humans. | 2001 | J. Nutr. | pmid:11435508 |
| Kim HK and Choi H | Dietary alpha-linolenic acid lowers postprandial lipid levels with increase of eicosapentaenoic and docosahexaenoic acid contents in rat hepatic membrane. | 2001 | Lipids | pmid:11834085 |
| Randich A et al. | Jejunal or portal vein infusions of lipids increase hepatic vagal afferent activity. | 2001 | Neuroreport | pmid:11568645 |
| Wróbel A | Decrease in 2,2,6,6-tetramethyl-piperidine-1-oxyl (TEMPO) EPR signal in peroxynitrite-treated erythrocyte membranes. | 2001 | Cell. Mol. Biol. Lett. | pmid:11753439 |
| Hatakeyama Y and Scarpace PJ | Transcriptional regulation of uncoupling protein-2 gene expression in L6 myotubes. | 2001 | Int. J. Obes. Relat. Metab. Disord. | pmid:11753581 |
| Glew RH et al. | Fatty acid composition of the milk lipids of Nepalese women: correlation between fatty acid composition of serum phospholipids and melting point. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11728165 |
| Djoussé L et al. | Relation between dietary linolenic acid and coronary artery disease in the National Heart, Lung, and Blood Institute Family Heart Study. | 2001 | Am. J. Clin. Nutr. | pmid:11684529 |
| Vermunt SH et al. | Dietary trans alpha-linolenic acid from deodorised rapeseed oil and plasma lipids and lipoproteins in healthy men: the TransLinE Study. | 2001 | Br. J. Nutr. | pmid:11299084 |
| Kawamoto S et al. | Lack of effect of the abnormal fatty acid metabolism in NC/Nga mice on their atopic dermatitis. | 2001 | Biosci. Biotechnol. Biochem. | pmid:11302182 |
| Watkins SM et al. | Unique phospholipid metabolism in mouse heart in response to dietary docosahexaenoic or alpha-linolenic acids. | 2001 | Lipids | pmid:11337979 |
| Karlsson S et al. | Reactivity of Trametes laccases with fatty and resin acids. | 2001 | Appl. Microbiol. Biotechnol. | pmid:11341313 |
| Almario RU et al. | Effects of walnut consumption on plasma fatty acids and lipoproteins in combined hyperlipidemia. | 2001 | Am. J. Clin. Nutr. | pmid:11451720 |
| Murase T et al. | Abundant expression of uncoupling protein-2 in the small intestine: up-regulation by dietary fish oil and fibrates. | 2001 | Biochim. Biophys. Acta | pmid:11341955 |
| Trommer H et al. | The examination of skin lipid model systems stressed by ultraviolet irradiation in the presence of transition metal ions. | 2001 | Eur J Pharm Biopharm | pmid:11343884 |
| Robertson RM and Smaha L | Can a Mediterranean-style diet reduce heart disease? | 2001 | Circulation | pmid:11282917 |
| Kris-Etherton P et al. | AHA Science Advisory: Lyon Diet Heart Study. Benefits of a Mediterranean-style, National Cholesterol Education Program/American Heart Association Step I Dietary Pattern on Cardiovascular Disease. | 2001 | Circulation | pmid:11282918 |
| Marmunti M and Catalá A | Incorporation of 1-(14)C linoleic acid in rat liver nuclei and chromatin fractions. | 2001 | Int. J. Biochem. Cell Biol. | pmid:11311857 |
| Dyer JM et al. | Chilling-sensitive, post-transcriptional regulation of a plant fatty acid desaturase expressed in yeast. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11352654 |
| Johnson LK et al. | [Diet and secondary prevention of coronary heart disease--are our recommendations good enough?]. | 2001 | Tidsskr. Nor. Laegeforen. | pmid:11354888 |
| Williard DE et al. | Identification of a fatty acid delta6-desaturase deficiency in human skin fibroblasts. | 2001 | J. Lipid Res. | pmid:11290821 |
| Su HM et al. | Fetal baboons convert 18:3n-3 to 22:6n-3 in vivo. A stable isotope tracer study. | 2001 | J. Lipid Res. | pmid:11290830 |
| Elias SL and Innis SM | Infant plasma trans, n-6, and n-3 fatty acids and conjugated linoleic acids are related to maternal plasma fatty acids, length of gestation, and birth weight and length. | 2001 | Am. J. Clin. Nutr. | pmid:11273857 |
| Choi SB et al. | Transcriptional expression characteristics and subcellular localization of ADP-glucose pyrophosphorylase in the oil plant Perilla frutescens. | 2001 | Plant Cell Physiol. | pmid:11230568 |
| Wolff RL et al. | Alpha-linolenic acid and its delta5-desaturation product, coniferonic acid, in the seed lipids of Tsuga and Hesperopeuce as a taxonomic means to differentiate the two genera. | 2001 | Lipids | pmid:11269703 |
| Blondeau N et al. | Activation of the nuclear factor-kappaB is a key event in brain tolerance. | 2001 | J. Neurosci. | pmid:11425894 |
| Avery AM and Avery SV | Saccharomyces cerevisiae expresses three phospholipid hydroperoxide glutathione peroxidases. | 2001 | J. Biol. Chem. | pmid:11445588 |
| Liu L et al. | [Expression of delta 6-fatty acid desaturase gene from Mortierella alpina in Saccharomyces cerevisiae]. | 2001 | Sheng Wu Gong Cheng Xue Bao | pmid:11411223 |
| Kelder B et al. | Expression of fungal desaturase genes in cultured mammalian cells. | 2001 | Mol. Cell. Biochem. | pmid:11354256 |
| Inouye S et al. | In-vitro and in-vivo anti-Trichophyton activity of essential oils by vapour contact. | 2001 | Mycoses | pmid:11413931 |