alpha-linolenic acid

Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.

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Introduction

To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with alpha-linolenic acid?

alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid

MeSH term MeSH ID Detail
Irritable Bowel Syndrome D043183 8 associated lipids
Overweight D050177 11 associated lipids
Atherosclerosis D050197 85 associated lipids
Carcinogenesis D063646 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with alpha-linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with alpha-linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with alpha-linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with alpha-linolenic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with alpha-linolenic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with alpha-linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with alpha-linolenic acid

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Authors Title Published Journal PubMed Link
Childs CE et al. Increased dietary α-linolenic acid has sex-specific effects upon eicosapentaenoic acid status in humans: re-examination of data from a randomised, placebo-controlled, parallel study. 2014 Nutr J pmid:25496415
Thamphiwatana S et al. In vivo treatment of Helicobacter pylori infection with liposomal linolenic acid reduces colonization and ameliorates inflammation. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:25422427
Alvarado-Gilis CA et al. Effects of feeding diets rich in α-linolenic acid and copper on performance, carcass characteristics, and fatty acid profiles of feedlot heifers. 2014 J. Anim. Sci. pmid:25414107
Rajaram S Health benefits of plant-derived α-linolenic acid. 2014 Am. J. Clin. Nutr. pmid:24898228
Høstmark AT and Haug A The inverse association between relative abundances of oleic acid and arachidonic acid is related to alpha -linolenic acid. 2014 Lipids Health Dis pmid:24885640
He F et al. Perinatal α-linolenic acid availability alters the expression of genes related to memory and to epigenetic machinery, and the Mecp2 DNA methylation in the whole brain of mouse offspring. 2014 Int. J. Dev. Neurosci. pmid:24866706
Howard TD et al. DNA methylation in an enhancer region of the FADS cluster is associated with FADS activity in human liver. 2014 PLoS ONE pmid:24842322
Tian E et al. Detection and molecular characterization of two FAD3 genes controlling linolenic acid content and development of allele-specific markers in yellow mustard (Sinapis alba). 2014 PLoS ONE pmid:24823372
Zhu G et al. Enhanced production of docosahexaenoic acid in mammalian cells. 2014 PLoS ONE pmid:24788769
Enos RT et al. Reducing the dietary omega-6:omega-3 utilizing α-linolenic acid; not a sufficient therapy for attenuating high-fat-diet-induced obesity development nor related detrimental metabolic and adipose tissue inflammatory outcomes. 2014 PLoS ONE pmid:24733548
Papanikolaou Y et al. U.S. adults are not meeting recommended levels for fish and omega-3 fatty acid intake: results of an analysis using observational data from NHANES 2003-2008. 2014 Nutr J pmid:24694001
Burns-Whitmore B et al. Effects of supplementing n-3 fatty acid enriched eggs and walnuts on cardiovascular disease risk markers in healthy free-living lacto-ovo-vegetarians: a randomized, crossover, free-living intervention study. 2014 Nutr J pmid:24673793
Qin G et al. Evolution of the aroma volatiles of pear fruits supplemented with fatty acid metabolic precursors. 2014 Molecules pmid:25474290
Hudson BD et al. The molecular basis of ligand interaction at free fatty acid receptor 4 (FFA4/GPR120). 2014 J. Biol. Chem. pmid:24860101
Gorina SS et al. Detection and molecular cloning of CYP74Q1 gene: identification of Ranunculus acris leaf divinyl ether synthase. 2014 Biochim. Biophys. Acta pmid:24863619
Soto-Cerda BJ et al. Association mapping of seed quality traits using the Canadian flax (Linum usitatissimum L.) core collection. 2014 Theor. Appl. Genet. pmid:24463785
Petzinger C et al. Conversion of α-linolenic acid to long-chain omega-3 fatty acid derivatives and alterations of HDL density subfractions and plasma lipids with dietary polyunsaturated fatty acids in Monk parrots (Myiopsitta monachus). 2014 J Anim Physiol Anim Nutr (Berl) pmid:23600588
Yavin E et al. Metabolic conversion of intra-amniotically-injected deuterium-labeled essential fatty acids by fetal rats following maternal n-3 fatty acid deficiency. 2014 Biochim. Biophys. Acta pmid:24960100
Khodadoust S et al. Identification and determination of the fatty acid composition of Quercus brantii growing in southwestern Iran by GC-MS. 2014 Nat. Prod. Res. pmid:24499169
Canetti L et al. Linoleic and alpha linolenic acids ameliorate streptozotocin-induced diabetes in mice. 2014 Arch. Physiol. Biochem. pmid:24320056