alpha-linolenic acid

Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.

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Introduction

To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with alpha-linolenic acid?

alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid

MeSH term MeSH ID Detail
Diabetic Angiopathies D003925 20 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Edema D004487 152 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Endomyocardial Fibrosis D004719 4 associated lipids
Epilepsy D004827 35 associated lipids
Mental Fatigue D005222 3 associated lipids
Fatty Liver D005234 48 associated lipids
Hearing Loss, High-Frequency D006316 1 associated lipids
Heart Failure D006333 36 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with alpha-linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with alpha-linolenic acid?

Related references are published most in these journals:

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What functions are associated with alpha-linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with alpha-linolenic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with alpha-linolenic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with alpha-linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with alpha-linolenic acid

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Authors Title Published Journal PubMed Link
Guelzim N et al. A role for PPARα in the regulation of arginine metabolism and nitric oxide synthesis. 2011 Amino Acids pmid:21063737
Kim CH et al. Effects of emulsified octadecanic acids on gas production and cellulolysis by the rumen anaerobic fungus, Piromyces communis M014. 2008 Anaerobe pmid:17996466
Wang YL et al. LC-DAD-APCI-MS-based screening and analysis of the absorption and metabolite components in plasma from a rabbit administered an oral solution of danggui. 2005 Anal Bioanal Chem pmid:16132135
Molkentin J and Giesemann A Differentiation of organically and conventionally produced milk by stable isotope and fatty acid analysis. 2007 Anal Bioanal Chem pmid:17393158
Martin CA et al. Trans polyunsaturated fatty acid contents in Brazilian refined soybean oil. 2006 Anal Sci pmid:16760612
Degousée N et al. Measurement of thermally produced volatile alkanes: an assay for plant hydroperoxy fatty acid evaluation. 1995 Anal. Biochem. pmid:7733454
Schneider C et al. Enantiomeric separation of hydroxy eicosanoids by chiral column chromatography: effect of the alcohol modifier. 2000 Anal. Biochem. pmid:11078601
Oliw EH et al. Payne rearrangement during analysis of epoxyalcohols of linoleic and alpha-linolenic acids by normal phase liquid chromatography with tandem mass spectrometry. 2006 Anal. Biochem. pmid:16712763
Hejazi L et al. Determination of the composition of fatty acid mixtures using GC x FI-MS: a comprehensive two-dimensional separation approach. 2009 Anal. Chem. pmid:19146461
Yoo HJ and HÃ¥kansson K Determination of double bond location in fatty acids by manganese adduction and electron induced dissociation. 2010 Anal. Chem. pmid:20704384
Gómez-Cortés P et al. Production of isotopically labeled standards from a uniformly labeled precursor for quantitative volatile metabolomic studies. 2012 Anal. Chem. pmid:22662968
Wu D et al. Determination of alpha-linolenic acid and linoleic acid in edible oils using near-infrared spectroscopy improved by wavelet transform and uninformative variable elimination. 2009 Anal. Chim. Acta pmid:19185115
Moodley R et al. Elemental composition and fatty acid profile of the edible fruits of Amatungula (Carissa macrocarpa) and impact of soil quality on chemical characteristics. 2012 Anal. Chim. Acta pmid:22632042
Huang YQ et al. Use of isotope mass probes for metabolic analysis of the jasmonate biosynthetic pathway. 2011 Analyst pmid:21331428
HILDITCH TP and SHRIVASTAVA RK The spectrophotometric determination of small proportions of linolenic acid in fats. 1947 Analyst pmid:18901122
Tavilani H et al. Decreased polyunsaturated and increased saturated fatty acid concentration in spermatozoa from asthenozoospermic males as compared with normozoospermic males. 2006 Andrologia pmid:16961570
Heller AR et al. Omega-3 alpha linolenic acid does not reflect the entire omega-3 fatty acid family. 2006 Anesth. Analg. pmid:16551943
Paschos GK et al. Apolipoprotein E genotype in dyslipidemic patients and response of blood lipids and inflammatory markers to alpha-linolenic Acid. 2005 Jan-Feb Angiology pmid:15678256
Kaka A et al. α-Linolenic acid supplementation in BioXcell® extender can improve the quality of post-cooling and frozen-thawed bovine sperm. 2015 Anim. Reprod. Sci. pmid:25544152
Mattioli S et al. Performance and egg quality of laying hens fed flaxseed: highlights on n-3 fatty acids, cholesterol, lignans and isoflavones. 2017 Animal pmid:27819218
Yang YX et al. Effects of duodenal infusion of free α-linolenic acid on the plasma and milk proteome of lactating dairy cows. 2013 Animal pmid:23031206
Smink W et al. Linoleic and α-linolenic acid as precursor and inhibitor for the synthesis of long-chain polyunsaturated fatty acids in liver and brain of growing pigs. 2012 Animal pmid:22436184
Chen W et al. Effect of flaxseed on the fatty acid profile of egg yolk and antioxidant status of their neonatal offspring in Huoyan geese. 2015 Animal pmid:26173627
Budowski P et al. [Protective effect of alpha-linolenic acid in encephalomalacia in chickens]. 1980 Ann Nutr Aliment pmid:6254420
François M et al. [Effects of a dietary deficiency of alpha-linolenic acid in the rat]. 1980 Ann Nutr Aliment pmid:6254422
Shi X et al. Efficacy of taurine based compounds as hydroxyl radical scavengers in silica induced peroxidation. 1997 Sep-Oct Ann. Clin. Lab. Sci. pmid:9303176
Kankaanpää P et al. Dietary fatty acids and allergy. 1999 Ann. Med. pmid:10480759
Babu US et al. Impact of in vitro fatty acid uptake on nitric oxide production and antilisterial activity of WEHI-3 cells. 1996 Ann. N. Y. Acad. Sci. pmid:8993386
Kim JY et al. Growth-inhibitory and proapoptotic effects of alpha-linolenic acid on estrogen-positive breast cancer cells. 2009 Ann. N. Y. Acad. Sci. pmid:19723055
Yu JH et al. Effects of omega-3 fatty acids on apoptosis of human gastric epithelial cells exposed to silica-immobilized glucose oxidase. 2009 Ann. N. Y. Acad. Sci. pmid:19723076
Park KS et al. Inhibitory mechanism of omega-3 fatty acids in pancreatic inflammation and apoptosis. 2009 Ann. N. Y. Acad. Sci. pmid:19723085
Egert S et al. Effects of dietary alpha-linolenic acid, eicosapentaenoic acid or docosahexaenoic acid on parameters of glucose metabolism in healthy volunteers. 2008 Ann. Nutr. Metab. pmid:19011281
Ikeda A and Sugano M Interaction of dietary protein and alpha-linolenic acid on polyunsaturated fatty acid composition of liver microsomal phospholipids and eicosanoid production in streptozotocin-induced diabetic rats. 1993 Ann. Nutr. Metab. pmid:8103979
Choi YS and Sugano M Effects of dietary alpha- and gamma-linolenic acid on lipid metabolism in young and adult rats. 1988 Ann. Nutr. Metab. pmid:2903713
Saito M Effect of dietary alpha-linolenic, eicosapentaenoic and docosahexaenoic acids on liver microsomal mixed-function oxidases in rats. 1994 Ann. Nutr. Metab. pmid:7702359
Seppänen-Laakso T et al. Replacement of margarine on bread by rapeseed and olive oils: effects on plasma fatty acid composition and serum cholesterol. 1993 Ann. Nutr. Metab. pmid:8105749
Fuhrmann H and Sallmann HP Alpha-tocopherol and phospholipase A2 in liver and brain of chicks posthatching: the influence of dietary fat and vitamin E. 1995 Ann. Nutr. Metab. pmid:8585700
Santos MJ et al. Influence of dietary supplementation with fish on plasma fatty acid composition in coronary heart disease patients. 1995 Ann. Nutr. Metab. pmid:7872656
Lohner S et al. Gender differences in the long-chain polyunsaturated fatty acid status: systematic review of 51 publications. 2013 Ann. Nutr. Metab. pmid:23327902
Becker W et al. Uptake of radiolabelled alpha-linolenic, arachidonic and oleic acid in tissues of normal and essential fatty acid-deficient rats--an autoradiographic study. 1985 Ann. Nutr. Metab. pmid:2859826
Andersen G et al. Dietary eicosapentaenoic acid and docosahexaenoic acid are more effective than alpha-linolenic acid in improving insulin sensitivity in rats. 2008 Ann. Nutr. Metab. pmid:18562792
Wenger FA et al. Does dietary alpha-linolenic acid promote liver metastases in pancreatic carcinoma initiated by BOP in Syrian hamster? 1999 Ann. Nutr. Metab. pmid:10436311
Roth HP and Kirchgessner M [Effect of various unsaturated fatty acids on the stability of the erythrocyte membrane in the rat]. 1992 Ann. Nutr. Metab. pmid:1354951
Aziz AA et al. Increasing Dietary alpha-linolenic acid enhances tissue levels of long-chain n-3 PUFA when linoleic acid intake is low in hamsters. 2010 Ann. Nutr. Metab. pmid:20714137
Crawford M et al. Role of plant-derived omega-3 fatty acids in human nutrition. 2000 Ann. Nutr. Metab. pmid:11146334
Xiang M et al. Diet and gene expression: delta-5 and delta-6 desaturases in healthy Chinese and European subjects. 2006 Ann. Nutr. Metab. pmid:16988497
Barre DE Potential of evening primrose, borage, black currant, and fungal oils in human health. 2001 Ann. Nutr. Metab. pmid:11359029
Inui K et al. The nutritional effect of a-linolenic acid-rich emulsion with total parenteral nutrition in a rat model with inflammatory bowel disease. 1996 Ann. Nutr. Metab. pmid:8886251
Leat WM et al. Retinal function in rats and guinea-pigs reared on diets low in essential fatty acids and supplemented with linoleic or linolenic acids. 1986 Ann. Nutr. Metab. pmid:2872851
Sanders TA and Rana SK Comparison of the metabolism of linoleic and linolenic acids in the fetal rat. 1987 Ann. Nutr. Metab. pmid:2892461