alpha-linolenic acid

Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.

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Introduction

To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with alpha-linolenic acid?

alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid

MeSH term MeSH ID Detail
Diabetic Angiopathies D003925 20 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Edema D004487 152 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Endomyocardial Fibrosis D004719 4 associated lipids
Epilepsy D004827 35 associated lipids
Mental Fatigue D005222 3 associated lipids
Fatty Liver D005234 48 associated lipids
Hearing Loss, High-Frequency D006316 1 associated lipids
Heart Failure D006333 36 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with alpha-linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with alpha-linolenic acid?

Related references are published most in these journals:

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What functions are associated with alpha-linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with alpha-linolenic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with alpha-linolenic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with alpha-linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with alpha-linolenic acid

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Authors Title Published Journal PubMed Link
Decsi T et al. Polyunsaturated fatty acids in plasma and erythrocyte membrane lipids of diabetic children. 2002 Prostaglandins Leukot. Essent. Fatty Acids pmid:12401433
Kratz M et al. The impact of dietary fat composition on serum leptin concentrations in healthy nonobese men and women. 2002 J. Clin. Endocrinol. Metab. pmid:12414865
Bowen RA and Clandinin MT Dietary low linolenic acid compared with docosahexaenoic acid alter synaptic plasma membrane phospholipid fatty acid composition and sodium-potassium ATPase kinetics in developing rats. 2002 J. Neurochem. pmid:12421348
Sanderson P et al. UK Food Standards Agency alpha-linolenic acid workshop report. 2002 Br. J. Nutr. pmid:12425738
Kris-Etherton PM et al. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. 2002 Circulation pmid:12438303
Lanzmann-Petithory D et al. Primary prevention of cardiovascular diseases by alpha-linolenic acid. 2002 Am. J. Clin. Nutr. pmid:12450919
Acar N et al. FA composition of plasma, red blood cell, and liver phospholipids of newborn piglets fed trans isomers of alpha-linolenic acid. 2002 Lipids pmid:12458619
Simopoulos AP Omega-3 fatty acids in inflammation and autoimmune diseases. 2002 J Am Coll Nutr pmid:12480795
Fisher AJ et al. The biochemical origin of pentenol emissions from wounded leaves. 2003 Phytochemistry pmid:12482451
Maillard V et al. Interaction of dietary beta-carotene and alpha-linolenic acid: effect on promotion of experimental mammary tumours. 2002 IARC Sci. Publ. pmid:12484221
López-López A et al. Fatty acid and sn-2 fatty acid composition in human milk from Granada (Spain) and in infant formulas. 2002 Eur J Clin Nutr pmid:12494309
Briscoe CP et al. The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids. 2003 J. Biol. Chem. pmid:12496284
Liu YC and Wu SN Block of erg current by linoleoylamide, a sleep-inducing agent, in pituitary GH3 cells. 2003 Eur. J. Pharmacol. pmid:12498905
Takemura N et al. Dietary, but not topical, alpha-linolenic acid suppresses UVB-induced skin injury in hairless mice when compared with linoleic acids. 2002 Photochem. Photobiol. pmid:12511046
Scorolli L et al. [Photodynamic therapy for age related macular degeneration with and without antioxidants]. 2002 Can. J. Ophthalmol. pmid:12518724
Lemaitre RN et al. n-3 Polyunsaturated fatty acids, fatal ischemic heart disease, and nonfatal myocardial infarction in older adults: the Cardiovascular Health Study. 2003 Am. J. Clin. Nutr. pmid:12540389
Innis SM and Elias SL Intakes of essential n-6 and n-3 polyunsaturated fatty acids among pregnant Canadian women. 2003 Am. J. Clin. Nutr. pmid:12540410
Vos E and Cunnane SC Alpha-linolenic acid, linoleic acid, coronary artery disease, and overall mortality. 2003 Am. J. Clin. Nutr. pmid:12540417
Suzuki M et al. Endogenous alpha-ketol linolenic acid levels in short day-induced cotyledons are closely related to flower induction in Pharbitis nil. 2003 Plant Cell Physiol. pmid:12552145
Ghafoorunissa A et al. Effects of dietary alpha-linolenic acid from blended oils on biochemical indices of coronary heart disease in Indians. 2002 Lipids pmid:12558058
Kotarsky K et al. A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs. 2003 Biochem. Biophys. Res. Commun. pmid:12565875
Ascherio A Epidemiologic studies on dietary fats and coronary heart disease. 2002 Am. J. Med. pmid:12566133
Castelli F et al. Biomimesis of linolenic acid transport through model lipidic membranes by differential scanning calorimetry. 2003 J. Agric. Food Chem. pmid:12568537
Saito M and Kubo K Relationship between tissue lipid peroxidation and peroxidizability index after alpha-linolenic, eicosapentaenoic, or docosahexaenoic acid intake in rats. 2003 Br. J. Nutr. pmid:12568661
Tan X et al. [Supercritical-CO2 fluid extraction of fatty oils from Perilla frutescens seeds and pharmacological study]. 1999 Zhong Yao Cai pmid:12571915
von Schacky C The role of omega-3 fatty acids in cardiovascular disease. 2003 Curr Atheroscler Rep pmid:12573200
Bazinet RP et al. Whole-body beta-oxidation of 18:2omega6 and 18:3omega3 in the pig varies markedly with weaning strategy and dietary 18:3omega3. 2003 J. Lipid Res. pmid:12576513
Chen J et al. Dietary flaxseed inhibits human breast cancer growth and metastasis and downregulates expression of insulin-like growth factor and epidermal growth factor receptor. 2002 Nutr Cancer pmid:12588699
Tsydendambaev VD and Vereshchagin AG Changes in triacylglycerol composition during ripening of sea buckthorn (Hippophaë rhamnoides L.) seeds. 2003 J. Agric. Food Chem. pmid:12590468
Kurowska EM et al. Bioavailability of omega-3 essential fatty acids from perilla seed oil. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12591004
Araseki M et al. Oxidative stability of polyunsaturated fatty acid in phosphatidylcholine liposomes. 2002 Biosci. Biotechnol. Biochem. pmid:12596850
Yang X et al. [Effects of silkworm pupa oil on serum lipids level and platelet function in rats]. 2002 Wei Sheng Yan Jiu pmid:12600031
Pawlosky RJ et al. Effects of beef- and fish-based diets on the kinetics of n-3 fatty acid metabolism in human subjects. 2003 Am. J. Clin. Nutr. pmid:12600844
Sinclair AJ et al. What is the role of alpha-linolenic acid for mammals? 2002 Lipids pmid:12617463
Wolff RL Are trans isomers of alpha-linolenic acid of nutritional significance for certain populations? 2002 Lipids pmid:12617467
Suresh Y and Das UN Long-chain polyunsaturated fatty acids and chemically induced diabetes mellitus. Effect of omega-3 fatty acids. 2003 Nutrition pmid:12620523
Itoh Y et al. Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40. 2003 Nature pmid:12629551
Adlof RO and List GR Synthesis and analysis of symmetrical and nonsymmetrical disaturated/monounsaturated triacylglycerols. 2003 J. Agric. Food Chem. pmid:12643679
Tanaka A and Nishizaki T The newly synthesized linoleic acid derivative FR236924 induces a long-lasting facilitation of hippocampal neurotransmission by targeting nicotinic acetylcholine receptors. 2003 Bioorg. Med. Chem. Lett. pmid:12643906
Acar N et al. Modification of the dopaminergic neurotransmitters in striatum, frontal cortex and hippocampus of rats fed for 21 months with trans isomers of alpha-linolenic acid. 2003 Neurosci. Res. pmid:12657450
Finnegan YE et al. Plant- and marine-derived n-3 polyunsaturated fatty acids have differential effects on fasting and postprandial blood lipid concentrations and on the susceptibility of LDL to oxidative modification in moderately hyperlipidemic subjects. 2003 Am. J. Clin. Nutr. pmid:12663273
Djoussé L et al. Dietary linolenic acid and carotid atherosclerosis: the National Heart, Lung, and Blood Institute Family Heart Study. 2003 Am. J. Clin. Nutr. pmid:12663278
Baylin A et al. Adipose tissue alpha-linolenic acid and nonfatal acute myocardial infarction in Costa Rica. 2003 Circulation pmid:12668490
Bakshi A et al. Gamma-linolenic acid therapy of human gliomas. 2003 Nutrition pmid:12679162
Eynard AR Potential of essential fatty acids as natural therapeutic products for human tumors. 2003 Nutrition pmid:12679177
AbuGhazaleh AA et al. Milk conjugated linoleic acid response to fish oil supplementation of diets differing in fatty acid profiles. 2003 J. Dairy Sci. pmid:12703631
Ichihara K and Suda Y Lipid biosynthesis in developing perilla seeds. 2003 Phytochemistry pmid:12711134
Gueck T et al. Effects of essential fatty acids on mediators of mast cells in culture. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12711248
Steer P et al. Endothelial vasodilatory function is related to the proportions of saturated fatty acids and alpha-linolenic acid in young men, but not in women. 2003 Eur. J. Clin. Invest. pmid:12713452
James MJ et al. Metabolism of stearidonic acid in human subjects: comparison with the metabolism of other n-3 fatty acids. 2003 Am. J. Clin. Nutr. pmid:12716664
Kew S et al. Lack of effect of foods enriched with plant- or marine-derived n-3 fatty acids on human immune function. 2003 Am. J. Clin. Nutr. pmid:12716684
Wallace FA et al. Comparison of the effects of linseed oil and different doses of fish oil on mononuclear cell function in healthy human subjects. 2003 Br. J. Nutr. pmid:12720588
Inagaki K et al. Evidence of isozymes for delta6 fatty acid desaturase in rat hepatocytes. 2003 Biosci. Biotechnol. Biochem. pmid:12729021
Steer P et al. Vitamin C, diclophenac, and L-arginine protect endothelium-dependent vasodilation against elevated circulating fatty acid levels in humans. 2003 Atherosclerosis pmid:12732388
Pratt DA et al. Theoretical calculations of carbon-oxygen bond dissociation enthalpies of peroxyl radicals formed in the autoxidation of lipids. 2003 J. Am. Chem. Soc. pmid:12733921
Wiesenfeld PW et al. Flaxseed increased alpha-linolenic and eicosapentaenoic acid and decreased arachidonic acid in serum and tissues of rat dams and offspring. 2003 Food Chem. Toxicol. pmid:12738189
Babu US et al. Impact of high flaxseed diet on mitogen-induced proliferation, IL-2 production, cell subsets and fatty acid composition of spleen cells from pregnant and F1 generation Sprague-Dawley rats. 2003 Food Chem. Toxicol. pmid:12738196
Mashek DG and Grummer RR Short communication: Net uptake of nonesterified long chain fatty acids by the perfused caudate lobe of the caprine liver. 2003 J. Dairy Sci. pmid:12741546
Gorinstein S et al. Comparison of the contents of the main biochemical compounds and the antioxidant activity of some Spanish olive oils as determined by four different radical scavenging tests. 2003 J. Nutr. Biochem. pmid:12742543
Buckner JS and Hagen MM Triacylglycerol and phospholipid fatty acids of the silverleaf whitefly: composition and biosynthesis. 2003 Arch. Insect Biochem. Physiol. pmid:12761874
Dai CC et al. [Comparative studies on the fatty acids contained in four species of medicinal plants from family Euphorbiaceae and their endophytic fungi]. 2001 Zhongguo Zhong Yao Za Zhi pmid:12776425
Ward AT et al. Fresh forage and solin supplementation on conjugated linoleic acid levels in plasma and milk. 2003 J. Dairy Sci. pmid:12778585
Barceló-Coblijn G et al. Gene expression and molecular composition of phospholipids in rat brain in relation to dietary n-6 to n-3 fatty acid ratio. 2003 Biochim. Biophys. Acta pmid:12782153
Kim H et al. Suppression of fatty acid synthase by dietary polyunsaturated fatty acids is mediated by fat itself, not by peroxidative mechanism. 2003 J. Biochem. Mol. Biol. pmid:12787479
Rodriguez A et al. Preterm infant formula supplementation with alpha linolenic acid and docosahexaenoic acid. 2003 Eur J Clin Nutr pmid:12792656
Park WS et al. Torilin from Torilis japonica, as a new inhibitor of testosterone 5 alpha-reductase. 2003 Planta Med. pmid:12802730
Erkkilä AT et al. n-3 Fatty acids and 5-y risks of death and cardiovascular disease events in patients with coronary artery disease. 2003 Am. J. Clin. Nutr. pmid:12816772
Rallidis LS et al. Dietary alpha-linolenic acid decreases C-reactive protein, serum amyloid A and interleukin-6 in dyslipidaemic patients. 2003 Atherosclerosis pmid:12818406
Qian SY et al. Identification of spin trapped carbon-centered radicals in soybean lipoxygenase-dependent peroxidations of omega-3 polyunsaturated fatty acids by LC/ESR, LC/MS, and tandem MS. 2003 Free Radic. Biol. Med. pmid:12826254
Laoteng K et al. A Mucor rouxii mutant with high accumulation of an unusual trans-linoleic acid (9c,12t-C18:2). 2003 FEMS Microbiol. Lett. pmid:12829281
Shirasaka N et al. Microbial synthesis of trans isomer of eicosapentaenoic acid (EPA) from the chemically synthesized trans isomer of linolenic acid by a delta12 desaturase-defective mutant of Mortierella alpina 1S-4. 2003 Biosci. Biotechnol. Biochem. pmid:12834302
Mori N et al. Identification of volicitin-related compounds from the regurgitant of lepidopteran caterpillars. 2003 Biosci. Biotechnol. Biochem. pmid:12834303
Hosokawa M et al. Production of novel tetrahydroxyfuranyl fatty acids from alpha-linolenic acid by Clavibacter sp. strain ALA2. 2003 Appl. Environ. Microbiol. pmid:12839755
Gavino VC et al. Kinetic analysis of the selectivity of acylcarnitine synthesis in rat mitochondria. 2003 Lipids pmid:12848298
Daligault F et al. Mechanistic characterization of omega-3 desaturation in the green alga Chlorella vulgaris. 2003 Phytochemistry pmid:12877913
Ratnayake WM and Gilani GS Protective effects of flax meal against hypercholesterolemia and hypertriglyceridemia in rats. 2003 J Am Coll Nutr pmid:12897048
Mulder C et al. Decreased lysophosphatidylcholine/phosphatidylcholine ratio in cerebrospinal fluid in Alzheimer's disease. 2003 J Neural Transm pmid:12898349
Miyazawa D et al. Dietary alpha-linolenic acid suppresses the formation of lysophosphatidic acid, a lipid mediator, in rat platelets compared with linoleic acid. 2003 Life Sci. pmid:12899931
Mashek DG and Grummer RR Effects of long chain fatty acids on lipid and glucose metabolism in monolayer cultures of bovine hepatocytes. 2003 J. Dairy Sci. pmid:12906057
Burdge GC and Wootton SA Conversion of alpha-linolenic acid to palmitic, palmitoleic, stearic and oleic acids in men and women. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12907139
Ravindra PV and Narayan MS Antioxidant activity of the anthocyanin from carrot (Daucus carota) callus culture. 2003 Int J Food Sci Nutr pmid:12907406
Trommer H et al. Mass spectrometric examinations of stratum corneum lipid models exposed to ultraviolet irradiation. 2003 Sep-Oct Skin Pharmacol. Appl. Skin Physiol. pmid:12907834
Burdge GC et al. Effect of altered dietary n-3 fatty acid intake upon plasma lipid fatty acid composition, conversion of [13C]alpha-linolenic acid to longer-chain fatty acids and partitioning towards beta-oxidation in older men. 2003 Br. J. Nutr. pmid:12908891
Damiani E et al. Comparison of antioxidant activity between aromatic indolinonic nitroxides and natural and synthetic antioxidants. 2003 Free Radic. Res. pmid:12911269
Kouba M et al. Effect of a high-linolenic acid diet on lipogenic enzyme activities, fatty acid composition, and meat quality in the growing pig. 2003 J. Anim. Sci. pmid:12926779
Glocker TM [Pathology of placenta of rats induced by fatty acid deficiency]. 2000 Rev Fac Cien Med Univ Nac Cordoba pmid:12934235
Li Y et al. Impact of dietary n-3 FA deficiency on rat bone tissue FA composition. 2003 Lipids pmid:12934680
Looking for the number-one omega-3. All three varieties are probably good for you, but evidence for the EPA and DHA in fish is the strongest. 2003 Harv Health Lett pmid:12936877
Dewhurst RJ et al. Comparison of grass and legume silages for milk production. 2. In vivo and in sacco evaluations of rumen function. 2003 J. Dairy Sci. pmid:12939085
Lang-Lazdunski L et al. Linolenic acid prevents neuronal cell death and paraplegia after transient spinal cord ischemia in rats. 2003 J. Vasc. Surg. pmid:12947278
Morel C et al. Isoflavones as potentiators of antibacterial activity. 2003 J. Agric. Food Chem. pmid:12952418
Schmelz EA et al. Nitrogen deficiency increases volicitin-induced volatile emission, jasmonic acid accumulation, and ethylene sensitivity in maize. 2003 Plant Physiol. pmid:12970495
Langelier B et al. Docosahexaenoic acid membrane content and mRNA expression of acyl-CoA oxidase and of peroxisome proliferator-activated receptor-delta are modulated in Y79 retinoblastoma cells differently by low and high doses of alpha-linolenic acid. 2003 J. Neurosci. Res. pmid:13130515
pmid:13272072
STEINBERG G et al. Metabolism of essential fatty acids. V. Metabolic pathway of linolenic acid. 1957 J. Biol. Chem. pmid:13405913
Cunnane S Cholesterol lowering by alpha-linolenic acid. 1992 Am. J. Clin. Nutr. pmid:1345883
Yamazaki K et al. Comparison of the conversion rates of alpha-linolenic acid (18:3(n - 3)) and stearidonic acid (18:4(n - 3)) to longer polyunsaturated fatty acids in rats. 1992 Biochim. Biophys. Acta pmid:1346092
Bourre JM et al. Dietary alpha-linolenic acid deficiency in adult rats for 7 months does not alter brain docosahexaenoic acid content, in contrast to liver, heart and testes. 1992 Biochim. Biophys. Acta pmid:1347458
FISHER H and LEVEILLE GA Observations on the cholesterol, linoleic and linolenic acid content of eggs as influenced by dietary fats. 1957 J. Nutr. pmid:13476240
Arbuckle LD and Innis SM Docosahexaenoic acid in developing brain and retina of piglets fed high or low alpha-linolenate formula with and without fish oil. 1992 Lipids pmid:1349717