alpha-linolenic acid

Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.

Cross Reference

Introduction

To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with alpha-linolenic acid?

alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid

MeSH term MeSH ID Detail
Liver Diseases D008107 31 associated lipids
Stroke D020521 32 associated lipids
Neurotoxicity Syndromes D020258 34 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Epilepsy D004827 35 associated lipids
Heart Failure D006333 36 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Adenoma D000236 40 associated lipids
Arthritis D001168 41 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Precancerous Conditions D011230 48 associated lipids
Fatty Liver D005234 48 associated lipids
Thrombosis D013927 49 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Pain D010146 64 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Per page 10 20 50 100 | Total 104

PubChem Associated disorders and diseases

What pathways are associated with alpha-linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with alpha-linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with alpha-linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with alpha-linolenic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with alpha-linolenic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with alpha-linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with alpha-linolenic acid

Download all related citations
Per page 10 20 50 100 | Total 2471
Authors Title Published Journal PubMed Link
McClead RE et al. The effect of three intravenous fat emulsions containing different concentrations of linoleic and alpha-linolenic acids on the plasma total fatty acid profile of neonates. 1991 J. Pediatr. Gastroenterol. Nutr. pmid:1676411
Kelley DS et al. Dietary alpha-linolenic acid and immunocompetence in humans. 1991 Am. J. Clin. Nutr. pmid:1670594
Hamberg M Transformations of alpha-linolenic acid in leaves of corn (Zea mays L.). 1991 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:1671803
Cave WT Dietary n-3 (omega-3) polyunsaturated fatty acid effects on animal tumorigenesis. 1991 FASEB J. pmid:1673664
Bjerve KS Omega 3 fatty acid deficiency in man: implications for the requirement of alpha-linolenic acid and long-chain omega 3 fatty acids. 1991 World Rev Nutr Diet pmid:1675825
Henry MM et al. Influence of an omega-3 fatty acid-enriched ration on in vivo responses of horses to endotoxin. 1991 Am. J. Vet. Res. pmid:1675842
Morris DD et al. Effect of dietary alpha-linolenic acid on endotoxin-induced production of tumor necrosis factor by peritoneal macrophages in horses. 1991 Am. J. Vet. Res. pmid:1675843
Hasler CM et al. Inhibition of gap junction-mediated intercellular communication by alpha-linolenate. 1991 Am. J. Physiol. pmid:1677533
Carlson SE et al. Long-term feeding of formulas high in linolenic acid and marine oil to very low birth weight infants: phospholipid fatty acids. 1991 Pediatr. Res. pmid:1684416
Kwon JS et al. Effects of diets high in saturated fatty acids, canola oil, or safflower oil on platelet function, thromboxane B2 formation, and fatty acid composition of platelet phospholipids. 1991 Am. J. Clin. Nutr. pmid:1677525
Chan JK et al. Dietary alpha-linolenic acid is as effective as oleic acid and linoleic acid in lowering blood cholesterol in normolipidemic men. 1991 Am. J. Clin. Nutr. pmid:1673589
Dyer JR and Greenwood CE Neural 22-carbon fatty acids in the weanling rat respond rapidly and specifically to a range of dietary linoleic to alpha-linolenic fatty acid ratios. 1991 J. Neurochem. pmid:1673995
Biagi PL et al. Gamma-linolenic acid dietary supplementation can reverse the aging influence on rat liver microsome delta 6-desaturase activity. 1991 Biochim. Biophys. Acta pmid:1674661
Hunter JE n-3 fatty acids from vegetable oils. 1990 Am. J. Clin. Nutr. pmid:1970702
Berger A and German JB Phospholipid fatty acid composition of various mouse tissues after feeding alpha-linolenate (18:3n-3) or eicosatrienoate (20:3n-3). 1990 Lipids pmid:1977067
Uauy R Are omega-3 fatty acids required for normal eye and brain development in the human? 1990 J. Pediatr. Gastroenterol. Nutr. pmid:1978859
Hirose M et al. Effects of dietary perilla oil, soybean oil and safflower oil on 7,12-dimethylbenz[a]anthracene (DMBA) and 1,2-dimethyl-hydrazine (DMH)-induced mammary gland and colon carcinogenesis in female SD rats. 1990 Carcinogenesis pmid:2110511
Chapkin RS and Carmichael SL Effect of dietary blackcurrant seed oil on mouse macrophage subclasses of choline and ethanolamine glycerophospholipids. 1990 J. Nutr. pmid:1974284
Bourre JM et al. Nutritional fatty acids control. Composition and function of cerebral membranes. 1990 Bibl Nutr Dieta pmid:1980414
Henry MM et al. Effect of dietary alpha-linolenic acid on equine monocyte procoagulant activity and eicosanoid synthesis. 1990 Circ. Shock pmid:1979759
Fritsche KL and Johnston PV Effect of dietary alpha-linolenic acid on growth, metastasis, fatty acid profile and prostaglandin production of two murine mammary adenocarcinomas. 1990 J. Nutr. pmid:1979807
Kestin M et al. n-3 fatty acids of marine origin lower systolic blood pressure and triglycerides but raise LDL cholesterol compared with n-3 and n-6 fatty acids from plants. 1990 Am. J. Clin. Nutr. pmid:1971991
Oxholm A et al. Abnormal essential fatty acid metabolism in Darier's disease. 1990 Arch Dermatol pmid:1977367
Buffière F et al. Purification and characterization of monoclonal antibodies to alpha-linolenic acid. 1989 Mar-Apr J Lipid Mediat pmid:2485142
Simopoulos AP Summary of the NATO advanced research workshop on dietary omega 3 and omega 6 fatty acids: biological effects and nutritional essentiality. 1989 J. Nutr. pmid:2564887
Bjerve KS n-3 fatty acid deficiency in man. 1989 J Intern Med Suppl pmid:2565114
Sprecher H Interactions between the metabolism of n-3 and n-6 fatty acids. 1989 J Intern Med Suppl pmid:2565115
Schöneich C et al. Thiyl radical attack on polyunsaturated fatty acids: a possible route to lipid peroxidation. 1989 Biochem. Biophys. Res. Commun. pmid:2567162
Fritsche KL and Johnston PV Modulation of eicosanoid production and cell-mediated cytotoxicity by dietary alpha-linolenic acid in BALB/c mice. 1989 Lipids pmid:2569149
Garg ML et al. Dietary saturated fat level alters the competition between alpha-linolenic and linoleic acid. 1989 Lipids pmid:2569150
Sok DE and Kim MR The possible role of 9(S)-hydroperoxyoctadecatrienoic acid as a suicide substrate of soybean lipoxygenase. 1989 Biochem. Biophys. Res. Commun. pmid:2569867
Hashimoto Y et al. Effect of black-pigmented Bacteroides gingivalis on cytotoxic activity of linolenic acid against mouse macrophages. 1989 Kitasato Arch. Exp. Med. pmid:2570177
Sharov VS et al. Selective sensitization of chemiluminescence resulted from lipid and oxygen radical reactions. 1989 Free Radic. Biol. Med. pmid:2570736
Olaf A Effects of linoleic and alpha linolenic acids intake on blood pressure in man. 1989 Prog. Clin. Biol. Res. pmid:2571995
Bourre JM et al. The effects of dietary alpha-linolenic acid on the composition of nerve membranes, enzymatic activity, amplitude of electrophysiological parameters, resistance to poisons and performance of learning tasks in rats. 1989 J. Nutr. pmid:2576038
Bourre JM [Nature, origin and role of fatty acids of the nervous system: an essential fatty acid, an alpha-linolenic acid, changing the structure and the cerebral function]. 1989 Bull. Acad. Natl. Med. pmid:2576722
Biliński T et al. Superoxide dismutase deficiency and the toxicity of the products of autooxidation of polyunsaturated fatty acids in yeast. 1989 Biochim. Biophys. Acta pmid:2563227
Bourre JM et al. Brain cell and tissue recovery in rats made deficient in n-3 fatty acids by alteration of dietary fat. 1989 J. Nutr. pmid:2563284
Bjerve KS et al. alpha-Linolenic acid and long-chain omega-3 fatty acid supplementation in three patients with omega-3 fatty acid deficiency: effect on lymphocyte function, plasma and red cell lipids, and prostanoid formation. 1989 Am. J. Clin. Nutr. pmid:2563625
Hagve TA and Sprecher H Metabolism of long-chain polyunsaturated fatty acids in isolated cardiac myocytes. 1989 Biochim. Biophys. Acta pmid:2563660
Romans JR Alpha-linolenic acid. 1989 Lancet pmid:2563803
Hennig B and Watkins BA Linoleic acid and linolenic acid: effect on permeability properties of cultured endothelial cell monolayers. 1989 Am. J. Clin. Nutr. pmid:2563626
D'Aquino M et al. Vitamin A and glutathione-mediated free radical damage: competing reactions with polyunsaturated fatty acids and vitamin C. 1989 Biochem. Biophys. Res. Commun. pmid:2568114
Hrelia S et al. Age-related changes in linoleate and alpha-linolenate desaturation by rat liver microsomes. 1989 Biochem. Biophys. Res. Commun. pmid:2570573
Choi YS and Sugano M Effects of dietary alpha- and gamma-linolenic acid on lipid metabolism in young and adult rats. 1988 Ann. Nutr. Metab. pmid:2903713
Hashimoto A et al. Effect of the dietary alpha-linolenate/linoleate balance on leukotriene production and histamine release in rats. 1988 Prostaglandins pmid:2459732
Urano S et al. Membrane-stabilizing effect of vitamin E: effect of alpha-tocopherol and its model compounds on fluidity of lecithin liposomes. 1988 Biochem. Biophys. Res. Commun. pmid:2892491
Hwang DH et al. Dietary linolenic acid and longer-chain n-3 fatty acids: comparison of effects on arachidonic acid metabolism in rats. 1988 J. Nutr. pmid:2895804
Arthur JR Effects of selenium and vitamin E status on plasma creatine kinase activity in calves. 1988 J. Nutr. pmid:2897437
Guesnet P et al. Effects of dietary alpha-linolenic acid deficiency during pregnancy and lactation on lipid fatty acid composition of liver and serum in the rat. 1988 Reprod Nutr Dev pmid:2897705
Koletzko B and Cunnane S Human alpha-linolenic acid deficiency. 1988 Am. J. Clin. Nutr. pmid:2897782
Homayoun P et al. Alteration in fatty acid composition of adult rat brain capillaries and choroid plexus induced by a diet deficient in n-3 fatty acids: slow recovery after substitution with a nondeficient diet. 1988 J. Neurochem. pmid:2898007
Fan WX [Alpha-linolenic acid and its metabolites EPA and DHA]. 1988 Sheng Li Ke Xue Jin Zhan pmid:2901141
Garg ML et al. Dietary cholesterol and/or n-3 fatty acid modulate delta 9-desaturase activity in rat liver microsomes. 1988 Biochim. Biophys. Acta pmid:2901857
Khokher MA and Dandona P The effect of polyunsaturated fatty acids on rat adipocyte lipogenesis: the role of protein kinase C, calcium and calmodulin. 1988 Diabetes Res. pmid:2906578
Blasig IE et al. Effect of troxerutin and methionine on spin trapping of free oxy-radicals. 1988 Biomed. Biochim. Acta pmid:2907855
Yamamoto N et al. Effect of the dietary alpha-linolenate/linoleate balance on lipid compositions and learning ability of rats. II. Discrimination process, extinction process, and glycolipid compositions. 1988 J. Lipid Res. pmid:2903207
Whitcomb RW et al. Effects of long-chain, saturated fatty acids on membrane microviscosity and adrenocorticotropin responsiveness of human adrenocortical cells in vitro. 1988 J. Clin. Invest. pmid:2891726
Chander A and Fisher AB Choline-phosphate cytidyltransferase activity and phosphatidylcholine synthesis in rat granular pneumocytes are increased with exogenous fatty acids. 1988 Biochim. Biophys. Acta pmid:2893643
Sebokova E et al. Modulation of receptor-mediated gonadotropin action in rat testes by dietary fat. 1988 Am. J. Physiol. pmid:2897795
Jones DB et al. Glucose, insulin and platelet fatty acids following myocardial infarction: an association with infarct size. 1987 Jul-Aug Diabete Metab pmid:3315767
Bjerve KS et al. Alpha-linolenic acid deficiency in patients on long-term gastric-tube feeding: estimation of linolenic acid and long-chain unsaturated n-3 fatty acid requirement in man. 1987 Am. J. Clin. Nutr. pmid:2879436
Warden JT and Csatorday K On the mechanism of linolenic acid inhibition in Photosystem II. 1987 Biochim. Biophys. Acta pmid:2879567
Gutteridge JM The antioxidant activity of haptoglobin towards haemoglobin-stimulated lipid peroxidation. 1987 Biochim. Biophys. Acta pmid:2879568
Bjerve KS Alpha-linolenic acid deficiency in adult women. 1987 Nutr. Rev. pmid:2881237
McDonald GB and Weidman M Partitioning of polar fatty acids into lymph and portal vein after intestinal absorption in the rat. 1987 Q J Exp Physiol pmid:2884690
Bursztyn P Does dietary linolenic acid influence blood pressure? 1987 Am. J. Clin. Nutr. pmid:2884863
Singer P et al. Changes of N-6 and N-3 fatty acids in liver from spontaneously hypertensive (SHR) and normotensive rats after diets supplemented with alpha-linolenic or eicosapentaenoic acids. 1987 Prostaglandins Leukot Med pmid:2888133
Bjerve KS et al. Alpha-linolenic acid deficiency in man: effect of essential fatty acids on fatty acid composition. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2890285
Vrignaud P and Robert J Free fatty acid uptake is increased in doxorubicin-resistant rat glioblastoma cells. 1987 Biochim. Biophys. Acta pmid:2886153
Astorg PO and Chevalier J Polyunsaturated fatty acids in tissues of rats fed trielaidin and high or low levels of linolenic acid. 1987 Lipids pmid:2897610
Huang YS et al. Selective incorporation of n-3 and n-6 fatty acids in essential fatty acid deficient rats in response to short-term oil feeding. 1987 Biochem. Int. pmid:2898942
Yamamoto N et al. Effect of dietary alpha-linolenate/linoleate balance on brain lipid compositions and learning ability of rats. 1987 J. Lipid Res. pmid:2883248
Hasegawa J et al. Lipid requirement for mu opioid receptor binding. 1987 J. Neurochem. pmid:2887631
Takahashi R et al. Impaired platelet aggregation and thromboxane generation in essential fatty acid-deficient rats. 1987 J. Nutr. pmid:2888839
Coté GG and Brody S Circadian rhythms in Neurospora crassa: a clock mutant, prd-1, is altered in membrane fatty acid composition. 1987 Biochim. Biophys. Acta pmid:2889471
Sanders TA and Rana SK Comparison of the metabolism of linoleic and linolenic acids in the fetal rat. 1987 Ann. Nutr. Metab. pmid:2892461
Betteridge J Nutrition and platelet function in atherogenesis. 1987 Proc Nutr Soc pmid:2893383
Novo C et al. Altered fatty acid membrane composition modifies lymphocyte localization in vivo. 1987 Cell. Immunol. pmid:2882861
Pisanti FA et al. Effects of bonellin on lipids. 1986 Life Sci. pmid:2869393
Hagve TA et al. Desaturation and chain elongation of essential fatty acids in isolated liver cells from rat and rainbow trout. 1986 Lipids pmid:2871473
Dyerberg J Linolenate-derived polyunsaturated fatty acids and prevention of atherosclerosis. 1986 Nutr. Rev. pmid:2872640
Cholesterol metabolism and omega-3 polyenes in fish oils. 1986 Nutr. Rev. pmid:2872641
Meadows J et al. Uric acid protects membranes and linolenic acid from ozone-induced oxidation. 1986 Biochem. Biophys. Res. Commun. pmid:2872893
Adam O et al. Effect of alpha-linolenic acid in the human diet on linoleic acid metabolism and prostaglandin biosynthesis. 1986 J. Lipid Res. pmid:2873197
Takahashi K et al. Polyethylene glycol-modified hemin having peroxidase activity in organic solvents. 1986 Biochem. Biophys. Res. Commun. pmid:2874801
Berry EM and Hirsch J Does dietary linolenic acid influence blood pressure? 1986 Am. J. Clin. Nutr. pmid:2875645
Nouvelot A et al. Hepatic metabolism of dietary alpha-linolenic acid in suckling rats, and its possible importance in polyunsaturated fatty acid uptake by the brain. 1986 Ann. Nutr. Metab. pmid:2875687
Nakamoto S et al. Lipid peroxidation and cytotoxicity of Ehrlich ascites tumor cells by ferric nitrilotriacetate. 1986 Biochim. Biophys. Acta pmid:2876731
Acosta PB and Stepnick-Gropper S Problems related to diet management of maternal phenylketonuria. 1986 J. Inherit. Metab. Dis. pmid:2877116
Guesnet P et al. Dietary alpha-linolenic acid deficiency in the rat. I. Effects on reproduction and postnatal growth. 1986 Reprod Nutr Dev pmid:2877477
Nutrition classics. Lipids, June 1979 Volume 14, No. 6: Reproduction and survival of rainbow trout (Salmo gairdneri) fed linolenic acid as the only source of essential fatty acids. By T.C. Yu, R.O. Sinnhuber, and J.D. Hendricks. 1986 Nutr. Rev. pmid:2878402
Zöllner N Dietary linolenic acid in man--an overview. 1986 Prog. Lipid Res. pmid:2892211
Leikin AI and Brenner RR Regulation of linoleic acid delta 6-desaturation by a cytosolic lipoprotein-like fraction in isolated rat liver microsomes. 1986 Biochim. Biophys. Acta pmid:2869785
Carlson SE et al. High fat diets varying in ratios of polyunsaturated to saturated fatty acid and linoleic to linolenic acid: a comparison of rat neural and red cell membrane phospholipids. 1986 J. Nutr. pmid:2871142
Leat WM et al. Retinal function in rats and guinea-pigs reared on diets low in essential fatty acids and supplemented with linoleic or linolenic acids. 1986 Ann. Nutr. Metab. pmid:2872851
Jenkins KJ and Kramer JK Influence of low linoleic and linolenic acids in milk replacer on calf performance and lipids in blood plasma, heart, and liver. 1986 J. Dairy Sci. pmid:2873158
Morson LA and Clandinin MT Diets varying in linoleic and linolenic acid content alter liver plasma membrane lipid composition and glucagon-stimulated adenylate cyclase activity. 1986 J. Nutr. pmid:2879899
Siegel I et al. Inhibition of sperm motility and agglutination of sperm cells by free fatty acids in whole semen. 1986 Fertil. Steril. pmid:2868925
Tabachnick M and Korcek L Effect of long-chain fatty acids on the binding of thyroxine and triiodothyronine to human thyroxine-binding globulin. 1986 Biochim. Biophys. Acta pmid:2869786