alpha-linolenic acid
Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
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Introduction
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with alpha-linolenic acid?
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
PubChem Associated disorders and diseases
What pathways are associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with alpha-linolenic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with alpha-linolenic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with alpha-linolenic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Blondeau N et al. | Alpha-linolenic acid: an omega-3 fatty acid with neuroprotective properties-ready for use in the stroke clinic? | 2015 | Biomed Res Int | pmid:25789320 |
| Liu GJ et al. | Targeted Lipidomics Studies Reveal that Linolenic Acid Promotes Cotton Fiber Elongation by Activating Phosphatidylinositol and Phosphatidylinositol Monophosphate Biosynthesis. | 2015 | Mol Plant | pmid:25731673 |
| Veshkini A et al. | Effect of Linolenic acid during in vitro maturation of ovine oocytes: embryonic developmental potential and mRNA abundances of genes involved in apoptosis. | 2015 | J. Assist. Reprod. Genet. | pmid:25715790 |
| Bellaloui N and Mengistu A | Effects of boron nutrition and water stress on nitrogen fixation, seed δ15N and δ13C dynamics, and seed composition in soybean cultivars differing in maturities. | 2015 | ScientificWorldJournal | pmid:25667936 |
| Wu A et al. | Curcumin boosts DHA in the brain: Implications for the prevention of anxiety disorders. | 2015 | Biochim. Biophys. Acta | pmid:25550171 |
| Kaka A et al. | α-Linolenic acid supplementation in BioXcell® extender can improve the quality of post-cooling and frozen-thawed bovine sperm. | 2015 | Anim. Reprod. Sci. | pmid:25544152 |
| Fu X et al. | Regulation of formation of volatile compounds of tea (Camellia sinensis) leaves by single light wavelength. | 2015 | Sci Rep | pmid:26567525 |
| Cespedes E et al. | Adipose tissue n-3 fatty acids and metabolic syndrome. | 2015 | Eur J Clin Nutr | pmid:25097001 |
| Chen S et al. | Profiling of volatile compounds and associated gene expression and enzyme activity during fruit development in two cucumber cultivars. | 2015 | PLoS ONE | pmid:25799542 |
| Yan S et al. | Autoxidated linolenic acid inhibits aflatoxin biosynthesis in Aspergillus flavus via oxylipin species. | 2015 | Fungal Genet. Biol. | pmid:25498164 |
| Hernandez LR et al. | Effect of plant growth regulators on fatty acids composition in Jatropha curcas L. callus culture. | 2015 | J Oleo Sci | pmid:25757437 |
| Clouard C et al. | Dietary linoleic and α-linolenic acids affect anxiety-related responses and exploratory activity in growing pigs. | 2015 | J. Nutr. | pmid:25644359 |
| Hsieh JC et al. | High-Oleic Ready-to-Use Therapeutic Food Maintains Docosahexaenoic Acid Status in Severe Malnutrition. | 2015 | J. Pediatr. Gastroenterol. Nutr. | pmid:25633498 |
| Amminger GP et al. | Predictors of treatment response in young people at ultra-high risk for psychosis who received long-chain omega-3 fatty acids. | 2015 | Transl Psychiatry | pmid:25585167 |
| Running CA and Mattes RD | Humans are more sensitive to the taste of linoleic and α-linolenic than oleic acid. | 2015 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:25540234 |
| Conde-Sieira M et al. | Hypothalamic fatty acid sensing in Senegalese sole (Solea senegalensis): response to long-chain saturated, monounsaturated, and polyunsaturated (n-3) fatty acids. | 2015 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:26468264 |
| Jung SW et al. | Mechanism of antibacterial activity of liposomal linolenic acid against Helicobacter pylori. | 2015 | PLoS ONE | pmid:25793403 |
| Piermartiri T et al. | α-Linolenic Acid, A Nutraceutical with Pleiotropic Properties That Targets Endogenous Neuroprotective Pathways to Protect against Organophosphate Nerve Agent-Induced Neuropathology. | 2015 | Molecules | pmid:26569216 |
| Wright AM et al. | Effect of forage type with or without corn supplementation on animal performance, beef fatty acid composition, and palatability. | 2015 | J. Anim. Sci. | pmid:26523597 |
| Shi H et al. | Molecular mechanism of substrate specificity for delta 6 desaturase from Mortierella alpina and Micromonas pusilla. | 2015 | J. Lipid Res. | pmid:26486975 |
| Dodington DW et al. | Higher Intakes of Fruits and Vegetables, β-Carotene, Vitamin C, α-Tocopherol, EPA, and DHA Are Positively Associated with Periodontal Healing after Nonsurgical Periodontal Therapy in Nonsmokers but Not in Smokers. | 2015 | J. Nutr. | pmid:26423734 |
| Dal Bello B et al. | Healthy yogurt fortified with n-3 fatty acids from vegetable sources. | 2015 | J. Dairy Sci. | pmid:26409962 |
| Liao K et al. | Dietary Olive and Perilla Oils Affect Liver Mitochondrial DNA Methylation in Large Yellow Croakers. | 2015 | J. Nutr. | pmid:26400965 |
| Kim KR et al. | Selective Production of 9R-Hydroxy-10E,12Z,15Z-Octadecatrienoic Acid from α-Linolenic Acid in Perilla Seed Oil Hydrolyzate by a Lipoxygenase from Nostoc Sp. SAG 25.82. | 2015 | PLoS ONE | pmid:26379279 |
| Bobiński R and Mikulska M | The ins and outs of maternal-fetal fatty acid metabolism. | 2015 | Acta Biochim. Pol. | pmid:26345097 |
| Mansara PP et al. | Differential Ratios of Omega Fatty Acids (AA/EPA+DHA) Modulate Growth, Lipid Peroxidation and Expression of Tumor Regulatory MARBPs in Breast Cancer Cell Lines MCF7 and MDA-MB-231. | 2015 | PLoS ONE | pmid:26325577 |
| Imran M et al. | Impact of extrusion processing conditions on lipid peroxidation and storage stability of full-fat flaxseed meal. | 2015 | Lipids Health Dis | pmid:26286266 |
| Salazar MO et al. | A thin-layer chromatography autographic method for the detection of inhibitors of the Salmonella PhoP-PhoQ regulatory system. | 2014 Mar-Apr | Phytochem Anal | pmid:24185747 |
| Thamphiwatana S et al. | In vivo treatment of Helicobacter pylori infection with liposomal linolenic acid reduces colonization and ameliorates inflammation. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25422427 |
| Alvarado-Gilis CA et al. | Effects of feeding diets rich in α-linolenic acid and copper on performance, carcass characteristics, and fatty acid profiles of feedlot heifers. | 2014 | J. Anim. Sci. | pmid:25414107 |
| Petrogianni M et al. | Additional benefit in CVD risk indices derived from the consumption of fortified milk when combined with a lifestyle intervention. | 2014 | Public Health Nutr | pmid:23249766 |
| Liu J and Ma DW | The role of n-3 polyunsaturated fatty acids in the prevention and treatment of breast cancer. | 2014 | Nutrients | pmid:25412153 |
| Eastwood L et al. | Changing the omega-6 to omega-3 fatty acid ratio in sow diets alters serum, colostrum, and milk fatty acid profiles, but has minimal impact on reproductive performance. | 2014 | J. Anim. Sci. | pmid:25403193 |
| Fleming JA and Kris-Etherton PM | The evidence for α-linolenic acid and cardiovascular disease benefits: Comparisons with eicosapentaenoic acid and docosahexaenoic acid. | 2014 | Adv Nutr | pmid:25398754 |
| Białek A et al. | [Conjugated linolenic acids (CLnA, super CLA)--natural sources and biological activity]. | 2014 | Postepy Hig Med Dosw (Online) | pmid:25380206 |
| Ponnampalam EN et al. | Health beneficial long chain omega-3 fatty acid levels in Australian lamb managed under extensive finishing systems. | 2014 | Meat Sci. | pmid:23643471 |
| Aliferis KA et al. | A metabolic profiling strategy for the dissection of plant defense against fungal pathogens. | 2014 | PLoS ONE | pmid:25369450 |
| Lagarde M et al. | Structure-function relationships of non-cyclic dioxygenase products from polyunsaturated fatty acids: poxytrins as a class of bioactive derivatives. | 2014 | Biochimie | pmid:25223888 |
| De Mel D and Suphioglu C | Fishy business: effect of omega-3 fatty acids on zinc transporters and free zinc availability in human neuronal cells. | 2014 | Nutrients | pmid:25195602 |
| Fretts AM et al. | Plasma phospholipid and dietary α-linolenic acid, mortality, CHD and stroke: the Cardiovascular Health Study. | 2014 | Br. J. Nutr. | pmid:25159901 |
| Villar-Tajadura MA et al. | Production of conjugated linoleic and conjugated α-linolenic acid in a reconstituted skim milk-based medium by bifidobacterial strains isolated from human breast milk. | 2014 | Biomed Res Int | pmid:25110689 |
| Hoogeveen EK et al. | Effect of omega-3 fatty acids on kidney function after myocardial infarction: the Alpha Omega Trial. | 2014 | Clin J Am Soc Nephrol | pmid:25104273 |
| Hwang E et al. | Coriander leaf extract exerts antioxidant activity and protects against UVB-induced photoaging of skin by regulation of procollagen type I and MMP-1 expression. | 2014 | J Med Food | pmid:25019675 |
| dos Santos AL et al. | Dietary fat composition and cardiac events in patients with type 2 diabetes. | 2014 | Atherosclerosis | pmid:25014032 |
| Caligiuri SP et al. | The HYPERFlax trial for determining the anti-HYPERtensive effects of dietary flaxseed in newly diagnosed stage 1 hypertensive patients: study protocol for a randomized, double-blinded, controlled clinical trial. | 2014 | Trials | pmid:24938224 |
| Baumgartner J et al. | Providing male rats deficient in iron and n-3 fatty acids with iron and alpha-linolenic acid alone affects brain serotonin and cognition differently from combined provision. | 2014 | Lipids Health Dis | pmid:24928171 |
| Tian E et al. | Detection and molecular characterization of two FAD3 genes controlling linolenic acid content and development of allele-specific markers in yellow mustard (Sinapis alba). | 2014 | PLoS ONE | pmid:24823372 |
| Zhu G et al. | Enhanced production of docosahexaenoic acid in mammalian cells. | 2014 | PLoS ONE | pmid:24788769 |
| Enos RT et al. | Reducing the dietary omega-6:omega-3 utilizing α-linolenic acid; not a sufficient therapy for attenuating high-fat-diet-induced obesity development nor related detrimental metabolic and adipose tissue inflammatory outcomes. | 2014 | PLoS ONE | pmid:24733548 |
| Papanikolaou Y et al. | U.S. adults are not meeting recommended levels for fish and omega-3 fatty acid intake: results of an analysis using observational data from NHANES 2003-2008. | 2014 | Nutr J | pmid:24694001 |
| Burns-Whitmore B et al. | Effects of supplementing n-3 fatty acid enriched eggs and walnuts on cardiovascular disease risk markers in healthy free-living lacto-ovo-vegetarians: a randomized, crossover, free-living intervention study. | 2014 | Nutr J | pmid:24673793 |
| Jung JY et al. | Effect of dietary supplementation with omega-3 fatty acid and gamma-linolenic acid on acne vulgaris: a randomised, double-blind, controlled trial. | 2014 | Acta Derm. Venereol. | pmid:24553997 |
| Belayachi L et al. | Retama monosperma n-hexane extract induces cell cycle arrest and extrinsic pathway-dependent apoptosis in Jurkat cells. | 2014 | BMC Complement Altern Med | pmid:24460687 |
| Djoussé L et al. | Repeated versus single measurement of plasma omega-3 fatty acids and risk of heart failure. | 2014 | Eur J Nutr | pmid:24395612 |
| Eisinger K et al. | Lipidomic analysis of the liver from high-fat diet induced obese mice identifies changes in multiple lipid classes. | 2014 | Exp. Mol. Pathol. | pmid:24830603 |
| Qin G et al. | Evolution of the aroma volatiles of pear fruits supplemented with fatty acid metabolic precursors. | 2014 | Molecules | pmid:25474290 |
| Ebrahimi M et al. | Effects of oils rich in linoleic and α-linolenic acids on fatty acid profile and gene expression in goat meat. | 2014 | Nutrients | pmid:25255382 |
| Ladeira MM et al. | Fatty acid profile, color and lipid oxidation of meat from young bulls fed ground soybean or rumen protected fat with or without monensin. | 2014 | Meat Sci. | pmid:24018278 |
| Marklund M et al. | A dietary biomarker approach captures compliance and cardiometabolic effects of a healthy Nordic diet in individuals with metabolic syndrome. | 2014 | J. Nutr. | pmid:25080537 |
| Purushothaman D et al. | Flaxseed oil supplementation alters the expression of inflammatory-related genes in dogs. | 2014 | Genet. Mol. Res. | pmid:25078588 |
| Domenichiello AF et al. | Whole body synthesis rates of DHA from α-linolenic acid are greater than brain DHA accretion and uptake rates in adult rats. | 2014 | J. Lipid Res. | pmid:24212299 |
| Hellstrand S et al. | Genetic variation in FADS1 has little effect on the association between dietary PUFA intake and cardiovascular disease. | 2014 | J. Nutr. | pmid:25008580 |
| Aki T et al. | Regulation of polyunsaturated fatty acid biosynthesis by seaweed fucoxanthin and its metabolite in cultured hepatocytes. | 2014 | Lipids | pmid:24174374 |
| Lane K et al. | Bioavailability and potential uses of vegetarian sources of omega-3 fatty acids: a review of the literature. | 2014 | Crit Rev Food Sci Nutr | pmid:24261532 |
| Carbonera F et al. | Effect of dietary replacement of sunflower oil with perilla oil on the absolute fatty acid composition in Nile tilapia (GIFT). | 2014 | Food Chem | pmid:24262550 |
| Herchi W et al. | Flaxseed hull: Chemical composition and antioxidant activity during development. | 2014 | J Oleo Sci | pmid:24919478 |
| Morris JB et al. | Flavonol content, oil%, and fatty acid composition variability in seeds of Teramnus labialis and T. uncinatus accessions with nutraceutical potential. | 2014 | J Diet Suppl | pmid:25054688 |
| Mariutto M et al. | Reprogramming of fatty acid and oxylipin synthesis in rhizobacteria-induced systemic resistance in tomato. | 2014 | Plant Mol. Biol. | pmid:24146221 |
| Matravadia S et al. | Both linoleic and α-linolenic acid prevent insulin resistance but have divergent impacts on skeletal muscle mitochondrial bioenergetics in obese Zucker rats. | 2014 | Am. J. Physiol. Endocrinol. Metab. | pmid:24844257 |
| Shimada TL et al. | Leaf oil body functions as a subcellular factory for the production of a phytoalexin in Arabidopsis. | 2014 | Plant Physiol. | pmid:24214535 |
| Singer SD et al. | Development and characterization of low α-linolenic acid Brassica oleracea lines bearing a novel mutation in a 'class a' FATTY ACID DESATURASE 3 gene. | 2014 | BMC Genet. | pmid:25167929 |
| Able JA et al. | Omega-3 fatty acid deficient male rats exhibit abnormal behavioral activation in the forced swim test following chronic fluoxetine treatment: association with altered 5-HT1A and alpha2A adrenergic receptor expression. | 2014 | J Psychiatr Res | pmid:24360505 |
| Choi JI et al. | Development of microalga Scenedesmus dimorphus mutant with higher lipid content by radiation breeding. | 2014 | Bioprocess Biosyst Eng | pmid:24871276 |
| Zhang T et al. | High-fat diet from perilla oil induces insulin resistance despite lower serum lipids and increases hepatic fatty acid oxidation in rats. | 2014 | Lipids Health Dis | pmid:24422660 |
| MartÃnez-RamÃrez HR et al. | Whole-body retention of α-linolenic acid and its apparent conversion to other n-3 PUFA in growing pigs are reduced with the duration of feeding α-linolenic acid. | 2014 | Br. J. Nutr. | pmid:24438755 |
| Saliba L et al. | Effect of feeding linseed oil in diets differing in forage to concentrate ratio: 1. Production performance and milk fat content of biohydrogenation intermediates of α-linolenic acid. | 2014 | J. Dairy Res. | pmid:24433586 |
| Dai XW et al. | Erythrocyte membrane n-3 fatty acid levels and carotid atherosclerosis in Chinese men and women. | 2014 | Atherosclerosis | pmid:24401220 |
| MartÃnez-RamÃrez HR et al. | Retention of n-3 polyunsaturated fatty acids in trimmed loin and belly is independent of timing of feeding ground flaxseed to growing-finishing female pigs. | 2014 | J. Anim. Sci. | pmid:24305874 |
| Gong Z et al. | G protein-coupled receptor 120 signaling regulates ghrelin secretion in vivo and in vitro. | 2014 | Am. J. Physiol. Endocrinol. Metab. | pmid:24222669 |
| Sánchez-Reyes OB et al. | Free fatty acids and protein kinase C activation induce GPR120 (free fatty acid receptor 4) phosphorylation. | 2014 | Eur. J. Pharmacol. | pmid:24239485 |
| Berasategi I et al. | Healthy reduced-fat Bologna sausages enriched in ALA and DHA and stabilized with Melissa officinalis extract. | 2014 | Meat Sci. | pmid:24334039 |
| Sengupta A and Ghosh M | Effect of sterol esters on lipid composition and antioxidant status of erythrocyte membrane of hypercholesterolemic rats. | 2014 | J Oleo Sci | pmid:24770475 |
| Yuan X et al. | Accumulation of eicosapolyenoic acids enhances sensitivity to abscisic acid and mitigates the effects of drought in transgenic Arabidopsis thaliana. | 2014 | J. Exp. Bot. | pmid:24609499 |
| Berasategi I et al. | Reduced-fat bologna sausages with improved lipid fraction. | 2014 | J. Sci. Food Agric. | pmid:24105447 |
| Vedtofte MS et al. | Association between the intake of α-linolenic acid and the risk of CHD. | 2014 | Br. J. Nutr. | pmid:24964401 |
| Petzinger C et al. | Conversion of α-linolenic acid to long-chain omega-3 fatty acid derivatives and alterations of HDL density subfractions and plasma lipids with dietary polyunsaturated fatty acids in Monk parrots (Myiopsitta monachus). | 2014 | J Anim Physiol Anim Nutr (Berl) | pmid:23600588 |
| Sugasini D et al. | Lymphatic transport of α-linolenic acid and its conversion to long chain n-3 fatty acids in rats fed microemulsions of linseed oil. | 2014 | Lipids | pmid:24338560 |
| O'Callaghan N et al. | Telomere shortening in elderly individuals with mild cognitive impairment may be attenuated with ω-3 fatty acid supplementation: a randomized controlled pilot study. | 2014 | Nutrition | pmid:24342530 |
| Caligiuri SP et al. | Flaxseed consumption reduces blood pressure in patients with hypertension by altering circulating oxylipins via an α-linolenic acid-induced inhibition of soluble epoxide hydrolase. | 2014 | Hypertension | pmid:24777981 |
| Dal Bosco A et al. | Effect of dietary alfalfa on the fatty acid composition and indexes of lipid metabolism of rabbit meat. | 2014 | Meat Sci. | pmid:24036258 |
| Javadi N et al. | GC-MS-based metabolite profiling of Cosmos caudatus leaves possessing alpha-glucosidase inhibitory activity. | 2014 | J. Food Sci. | pmid:24888400 |
| Wennman A et al. | Kinetic investigation of the rate-limiting step of manganese- and iron-lipoxygenases. | 2014 | Arch. Biochem. Biophys. | pmid:24857825 |
| Liang CH et al. | Synthesis of doxorubicin α-linolenic acid conjugate and evaluation of its antitumor activity. | 2014 | Mol. Pharm. | pmid:24720787 |
| Yang Q et al. | Anti-thrombotic effects of α-linolenic acid isolated from Zanthoxylum bungeanum Maxim seeds. | 2014 | BMC Complement Altern Med | pmid:25252789 |
| Khodadoust S et al. | Identification and determination of the fatty acid composition of Quercus brantii growing in southwestern Iran by GC-MS. | 2014 | Nat. Prod. Res. | pmid:24499169 |
| Wu MH et al. | A novel sodium N-fatty acyl amino acid surfactant using silkworm pupae as stock material. | 2014 | Sci Rep | pmid:24651079 |
| Reiner WB et al. | Fatty acids in mountain gorilla diets: implications for primate nutrition and health. | 2014 | Am. J. Primatol. | pmid:24243235 |
| Shen J et al. | A 13-lipoxygenase, TomloxC, is essential for synthesis of C5 flavour volatiles in tomato. | 2014 | J. Exp. Bot. | pmid:24453226 |
| Canetti L et al. | Linoleic and alpha linolenic acids ameliorate streptozotocin-induced diabetes in mice. | 2014 | Arch. Physiol. Biochem. | pmid:24320056 |
| Ambrozova JV et al. | Influence of extractive solvents on lipid and fatty acids content of edible freshwater algal and seaweed products, the green Microalga Chlorella kessleri and the Cyanobacterium Spirulina platensis. | 2014 | Molecules | pmid:24566307 |