alpha-linolenic acid

Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.

Cross Reference

Introduction

To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with alpha-linolenic acid?

alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid

MeSH term MeSH ID Detail
Metabolism, Inborn Errors D008661 46 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Thrombosis D013927 49 associated lipids
Myocardial Infarction D009203 21 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Urinary Bladder Neoplasms D001749 7 associated lipids
Prostatic Hyperplasia D011470 20 associated lipids
Arteriosclerosis D001161 86 associated lipids
Neuroblastoma D009447 66 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Per page 10 20 50 100 | Total 104

PubChem Associated disorders and diseases

What pathways are associated with alpha-linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with alpha-linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with alpha-linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with alpha-linolenic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with alpha-linolenic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with alpha-linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with alpha-linolenic acid

Download all related citations
Per page 10 20 50 100 | Total 2471
Authors Title Published Journal PubMed Link
Wong WT et al. Relative contribution of individual oxidized components in ox-LDL to inhibition on endothelium-dependent relaxation in rat aorta. 2011 Nutr Metab Cardiovasc Dis pmid:20005687
Scheim DE Cytotoxicity of unsaturated fatty acids in fresh human tumor explants: concentration thresholds and implications for clinical efficacy. 2009 Lipids Health Dis pmid:20003514
Fedorova I et al. Deficit in prepulse inhibition in mice caused by dietary n-3 fatty acid deficiency. 2009 Behav. Neurosci. pmid:20001105
Niewitetzki O et al. A new near-infrared reflectance spectroscopy method for high-throughput analysis of oleic acid and linolenic acid content of single seeds in oilseed rape (Brassica napus L.). 2010 J. Agric. Food Chem. pmid:19961144
Zhu H et al. Dietary fish oil n-3 polyunsaturated fatty acids and alpha-linolenic acid differently affect brain accretion of docosahexaenoic acid and expression of desaturases and sterol regulatory element-binding protein 1 in mice. 2010 J. Nutr. Biochem. pmid:19954955
Cherif A et al. Phytosterols, unsaturated fatty acid composition and accumulation in the almond kernel during harvesting period: importance for development regulation. 2009 C. R. Biol. pmid:19931844
Carayol M et al. Prospective studies of dietary alpha-linolenic acid intake and prostate cancer risk: a meta-analysis. 2010 Cancer Causes Control pmid:19921446
Kishino S et al. Microbial production of conjugated gamma-linolenic acid from gamma-linolenic acid by Lactobacillus plantarum AKU 1009a. 2010 J. Appl. Microbiol. pmid:19919619
Ander BP et al. Distribution of omega-3 fatty acids in tissues of rabbits fed a flaxseed-supplemented diet. 2010 Metab. Clin. Exp. pmid:19913851
Patwardhan AM et al. Activation of TRPV1 in the spinal cord by oxidized linoleic acid metabolites contributes to inflammatory hyperalgesia. 2009 Proc. Natl. Acad. Sci. U.S.A. pmid:19843694
van Rensburg SJ et al. Changes in erythrocyte membrane fatty acids during a clinical trial of eicosapentaenoic acid (EPA) supplementation in schizophrenia. 2009 Metab Brain Dis pmid:19826937
Wan ZX et al. Lipid content and fatty acids composition of mature human milk in rural North China. 2010 Br. J. Nutr. pmid:19825220
Whent M et al. Effect of genotype, environment, and their interaction on chemical composition and antioxidant properties of low-linolenic soybeans grown in Maryland. 2009 J. Agric. Food Chem. pmid:19817459
Nishimura K et al. Effects of siRNAs targeting the spacer sequence of plant RNAi vectors on the specificity and efficiency of RNAi. 2009 J. Biosci. Bioeng. pmid:19804870
Bourre JM et al. Nutritional fatty acids control. Composition and function of cerebral membranes. 1990 Bibl Nutr Dieta pmid:1980414
Shimizu T and Tomioka H [Novel type of antimicrobial mechanism in host macrophages against mycobacterial infections]. 2009 Nihon Hansenbyo Gakkai Zasshi pmid:19803380
Habermann N et al. Effects of fatty acids on metabolism and cell growth of human colon cell lines of different transformation state. 2009 Sep-Oct Biofactors pmid:19798733
Fritsche KL and Johnston PV Effect of dietary alpha-linolenic acid on growth, metastasis, fatty acid profile and prostaglandin production of two murine mammary adenocarcinomas. 1990 J. Nutr. pmid:1979807
Henry MM et al. Effect of dietary alpha-linolenic acid on equine monocyte procoagulant activity and eicosanoid synthesis. 1990 Circ. Shock pmid:1979759
Kunz HH et al. The ABC transporter PXA1 and peroxisomal beta-oxidation are vital for metabolism in mature leaves of Arabidopsis during extended darkness. 2009 Plant Cell pmid:19794119
Matsunaga H et al. Omega-3 polyunsaturated fatty acids ameliorate the severity of ileitis in the senescence accelerated mice (SAM)P1/Yit mice model. 2009 Clin. Exp. Immunol. pmid:19793338
Uauy R Are omega-3 fatty acids required for normal eye and brain development in the human? 1990 J. Pediatr. Gastroenterol. Nutr. pmid:1978859
Clemente TE and Cahoon EB Soybean oil: genetic approaches for modification of functionality and total content. 2009 Plant Physiol. pmid:19783644
Even P et al. Postprandial effects of a lipid-rich meal in the rat are modulated by the degree of unsaturation of 18C fatty acids. 2010 Metab. Clin. Exp. pmid:19775712
Oxholm A et al. Abnormal essential fatty acid metabolism in Darier's disease. 1990 Arch Dermatol pmid:1977367
Berger A and German JB Phospholipid fatty acid composition of various mouse tissues after feeding alpha-linolenate (18:3n-3) or eicosatrienoate (20:3n-3). 1990 Lipids pmid:1977067
Katsoulieris E et al. alpha-Linolenic acid protects renal cells against palmitic acid lipotoxicity via inhibition of endoplasmic reticulum stress. 2009 Eur. J. Pharmacol. pmid:19765573
Nakashima Y et al. Effect of plant- and fish-oil derived n-3 polyunsaturated fatty acids on counteraction of n-3 fatty acid shortage in adult rats fed a lard diet. 2009 J. Nutr. Sci. Vitaminol. pmid:19763036
Palladino RA et al. Fatty acid intake and milk fatty acid composition of Holstein dairy cows under different grazing strategies: herbage mass and daily herbage allowance. 2009 J. Dairy Sci. pmid:19762839
Brickner AE et al. Effects of abomasal lipid infusion on liver triglyceride accumulation and adipose lipolysis during fatty liver induction in dairy cows. 2009 J. Dairy Sci. pmid:19762812
Galli C and Calder PC Effects of fat and fatty acid intake on inflammatory and immune responses: a critical review. 2009 Ann. Nutr. Metab. pmid:19752539
Brenna JT and Lapillonne A Background paper on fat and fatty acid requirements during pregnancy and lactation. 2009 Ann. Nutr. Metab. pmid:19752538
Chapkin RS and Carmichael SL Effect of dietary blackcurrant seed oil on mouse macrophage subclasses of choline and ethanolamine glycerophospholipids. 1990 J. Nutr. pmid:1974284
He K Fish, long-chain omega-3 polyunsaturated fatty acids and prevention of cardiovascular disease--eat fish or take fish oil supplement? 2009 Sep-Oct Prog Cardiovasc Dis pmid:19732603
Reza JZ et al. Modulation peroxisome proliferators activated receptor alpha (PPAR alpha) and acyl coenzyme A: cholesterol acyltransferase1 (ACAT1) gene expression by fatty acids in foam cell. 2009 Lipids Health Dis pmid:19725980
Park KS et al. Inhibitory mechanism of omega-3 fatty acids in pancreatic inflammation and apoptosis. 2009 Ann. N. Y. Acad. Sci. pmid:19723085
Yu JH et al. Effects of omega-3 fatty acids on apoptosis of human gastric epithelial cells exposed to silica-immobilized glucose oxidase. 2009 Ann. N. Y. Acad. Sci. pmid:19723076
Kim JY et al. Growth-inhibitory and proapoptotic effects of alpha-linolenic acid on estrogen-positive breast cancer cells. 2009 Ann. N. Y. Acad. Sci. pmid:19723055
Padilla MN et al. Functional characterization of two 13-lipoxygenase genes from olive fruit in relation to the biosynthesis of volatile compounds of virgin olive oil. 2009 J. Agric. Food Chem. pmid:19722522
Kestin M et al. n-3 fatty acids of marine origin lower systolic blood pressure and triglycerides but raise LDL cholesterol compared with n-3 and n-6 fatty acids from plants. 1990 Am. J. Clin. Nutr. pmid:1971991
Hunter JE n-3 fatty acids from vegetable oils. 1990 Am. J. Clin. Nutr. pmid:1970702
Ruiz-López N et al. The synthesis and accumulation of stearidonic acid in transgenic plants: a novel source of 'heart-healthy' omega-3 fatty acids. 2009 Plant Biotechnol. J. pmid:19702757
Li M et al. Solid phase extraction and enrichment of essential fatty acid methyl esters from soy-derived biodiesel by novel pi-complexing sorbents. 2009 Bioresour. Technol. pmid:19692237
Barden AE et al. Flaxseed oil supplementation increases plasma F1-phytoprostanes in healthy men. 2009 J. Nutr. pmid:19675101
Sertznig P et al. Cross-talk between vitamin D receptor (VDR)- and peroxisome proliferator-activated receptor (PPAR)-signaling in melanoma cells. 2009 Anticancer Res. pmid:19667161
Safarinejad MR et al. Relationship of omega-3 and omega-6 fatty acids with semen characteristics, and anti-oxidant status of seminal plasma: a comparison between fertile and infertile men. 2010 Clin Nutr pmid:19666200
Ishikawa C et al. Efficient incorporation of free oxygen into volicitin in Spodoptera litura common cutworm larvae. 2009 Biosci. Biotechnol. Biochem. pmid:19661708
Coates W and Ayerza R Chia (Salvia hispanica L.) seed as an n-3 fatty acid source for finishing pigs: effects on fatty acid composition and fat stability of the meat and internal fat, growth performance, and meat sensory characteristics. 2009 J. Anim. Sci. pmid:19648503
Sartorelli DS et al. Dietary omega-3 fatty acid and omega-3: omega-6 fatty acid ratio predict improvement in glucose disturbances in Japanese Brazilians. 2010 Nutrition pmid:19647413
Blondeau N et al. Subchronic alpha-linolenic acid treatment enhances brain plasticity and exerts an antidepressant effect: a versatile potential therapy for stroke. 2009 Neuropsychopharmacology pmid:19641487
Nieman DC et al. Chia seed does not promote weight loss or alter disease risk factors in overweight adults. 2009 Nutr Res pmid:19628108
Poudel-Tandukar K et al. Dietary intakes of alpha-linolenic and linoleic acids are inversely associated with serum C-reactive protein levels among Japanese men. 2009 Nutr Res pmid:19628101
Rossi M et al. Growth, lipid accumulation, and fatty acid composition in obligate psychrophilic, facultative psychrophilic, and mesophilic yeasts. 2009 FEMS Microbiol. Ecol. pmid:19624740
Barceló-Coblijn G and Murphy EJ Alpha-linolenic acid and its conversion to longer chain n-3 fatty acids: benefits for human health and a role in maintaining tissue n-3 fatty acid levels. 2009 Prog. Lipid Res. pmid:19619583
Fincham JR et al. Fatty acid metabolism and deposition in subcutaneous adipose tissue of pasture- and feedlot-finished cattle. 2009 J. Anim. Sci. pmid:19617512
Morise A et al. Hepatic lipid metabolism response to dietary fatty acids is differently modulated by PPARalpha in male and female mice. 2009 Eur J Nutr pmid:19588182
Marei WF et al. The effect of linolenic Acid on bovine oocyte maturation and development. 2009 Biol. Reprod. pmid:19587335
Patenaude A et al. Bioavailability of alpha-linolenic acid from flaxseed diets as a function of the age of the subject. 2009 Eur J Clin Nutr pmid:19584895
Extier A et al. Differential effects of steroids on the synthesis of polyunsaturated fatty acids by human neuroblastoma cells. 2009 Neurochem. Int. pmid:19576517
Peng CC et al. Aqua-culture improved buckwheat sprouts with more abundant precious nutrients and hypolipidemic activity. 2009 Int J Food Sci Nutr pmid:19568972
Prasad K Flaxseed and cardiovascular health. 2009 J. Cardiovasc. Pharmacol. pmid:19568181
Gómez-Cortés P et al. Characterization of cis-9 trans-11 trans-15 C18:3 in milk fat by GC and covalent adduct chemical ionization tandem MS. 2009 J. Lipid Res. pmid:19542528
Rapoport SI and Igarashi M Can the rat liver maintain normal brain DHA metabolism in the absence of dietary DHA? 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19540098
Kris-Etherton PM et al. Dietary reference intakes for DHA and EPA. 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19525100
Ruiz-Rodriguez A et al. Recent trends in the advanced analysis of bioactive fatty acids. 2010 J Pharm Biomed Anal pmid:19525080
Sanders TA DHA status of vegetarians. 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19500961
Ogawa A et al. Dietary alpha-linolenic acid inhibits angiotensin-converting enzyme activity and mRNA expression levels in the aorta of spontaneously hypertensive rats. 2009 J Oleo Sci pmid:19491530
Duda MK et al. omega-3 polyunsaturated fatty acid supplementation for the treatment of heart failure: mechanisms and clinical potential. 2009 Cardiovasc. Res. pmid:19474179
Devore EE et al. Dietary intake of fish and omega-3 fatty acids in relation to long-term dementia risk. 2009 Am. J. Clin. Nutr. pmid:19474131
DeFilippis AP et al. Effect of baseline plasma fatty acids on eicosapentaenoic acid levels in individuals supplemented with alpha-linolenic acid. 2009 Int J Food Sci Nutr pmid:19468954
Sioen I et al. Effect of ALA-enriched food supply on cardiovascular risk factors in males. 2009 Lipids pmid:19452183
Zainal Z et al. Modification of palm oil for anti-inflammatory nutraceutical properties. 2009 Lipids pmid:19449050
Yavin E et al. Delayed cell migration in the developing rat brain following maternal omega 3 alpha linolenic acid dietary deficiency. 2009 Neuroscience pmid:19447164
Piccione G et al. Daily pattern of some fatty acids in the athletic horse. 2009 J Anim Physiol Anim Nutr (Berl) pmid:19386003
Umezawa M et al. Effect of dietary unsaturated fatty acids on senile amyloidosis in senescence-accelerated mice. 2009 J. Gerontol. A Biol. Sci. Med. Sci. pmid:19377016
Yang L et al. Oxidative stability of conjugated linolenic acids. 2009 J. Agric. Food Chem. pmid:19368396
Indo Y et al. Functional expression of a humanized gene for an omega-3 fatty acid desaturase from scarlet flax in transfected bovine adipocytes and bovine embryos cloned from the cells. 2009 Biochim. Biophys. Acta pmid:19367764
Ogawa A et al. Effect of dietary alpha-linolenic acid on vascular reactivity in aorta of spontaneously hypertensive rats. 2009 J Oleo Sci pmid:19367077
Raz R et al. The influence of short-chain essential fatty acids on children with attention-deficit/hyperactivity disorder: a double-blind placebo-controlled study. 2009 J Child Adolesc Psychopharmacol pmid:19364294
pmid:19349968
Tooker JF and De Moraes CM A gall-inducing caterpillar species increases essential fatty acid content of its host plant without concomitant increases in phytohormone levels. 2009 Mol. Plant Microbe Interact. pmid:19348573
Venegas-Calerón M et al. Effect of the ferredoxin electron donor on sunflower (Helianthus annuus) desaturases. 2009 Plant Physiol. Biochem. pmid:19342250
Huan ML et al. Conjugation with alpha-linolenic acid improves cancer cell uptake and cytotoxicity of doxorubicin. 2009 Bioorg. Med. Chem. Lett. pmid:19329312
Sekine S et al. Alpha-linolenic acid-rich flaxseed oil ingestion increases plasma adiponectin level in rats. 2008 Jul-Sep Int J Vitam Nutr Res pmid:19326346
Simon JA et al. The relation of alpha-linolenic acid to the risk of prostate cancer: a systematic review and meta-analysis. 2009 Am. J. Clin. Nutr. pmid:19321563
Kishino S et al. Metabolic diversity in biohydrogenation of polyunsaturated fatty acids by lactic acid bacteria involving conjugated fatty acid production. 2009 Appl. Microbiol. Biotechnol. pmid:19319523
Hejazi L et al. Discrimination among geometrical isomers of alpha-linolenic acid methyl ester using low energy electron ionization mass spectrometry. 2009 J. Am. Soc. Mass Spectrom. pmid:19318230
Lemaitre RN et al. Red blood cell membrane alpha-linolenic acid and the risk of sudden cardiac arrest. 2009 Metab. Clin. Exp. pmid:19303975
Liu J et al. Ganoderic acid DM: anti-androgenic osteoclastogenesis inhibitor. 2009 Bioorg. Med. Chem. Lett. pmid:19289282
Chang HH et al. Dietary perilla oil lowers serum lipids and ovalbumin-specific IgG1, but increases total IgE levels in ovalbumin-challenged mice. 2009 Food Chem. Toxicol. pmid:19271319
Brenna JT et al. alpha-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans. 2009 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:19269799
Egert S et al. Dietary alpha-linolenic acid, EPA, and DHA have differential effects on LDL fatty acid composition but similar effects on serum lipid profiles in normolipidemic humans. 2009 J. Nutr. pmid:19261730
Ishitsuka Y et al. Effects of bolus injection of soybean-based fat emulsion and fatty acids on pulmonary gas exchange function. 2009 Biol. Pharm. Bull. pmid:19252304
Van Elswyk ME and Kuratko C Achieving adequate DHA in maternal and infant diets. 2009 J Am Diet Assoc pmid:19248850
Yazawa H et al. Production of polyunsaturated fatty acids in yeast Saccharomyces cerevisiae and its relation to alkaline pH tolerance. 2009 Yeast pmid:19243079
Bommareddy A et al. Effects of dietary flaxseed on intestinal tumorigenesis in Apc(Min) mouse. 2009 Nutr Cancer pmid:19235044
Cornish SM and Chilibeck PD Alpha-linolenic acid supplementation and resistance training in older adults. 2009 Appl Physiol Nutr Metab pmid:19234585
Küpper FC et al. Free Fatty Acids and Methyl Jasmonate Trigger Defense Reactions in Laminaria digitata. 2009 Plant Cell Physiol. pmid:19213737
Schwartz J et al. Modification of dietary polyunsaturated fatty acids via complementary food enhances n-3 long-chain polyunsaturated fatty acid synthesis in healthy infants: a double blinded randomised controlled trial. 2009 Arch. Dis. Child. pmid:19193660
Wu D et al. Determination of alpha-linolenic acid and linoleic acid in edible oils using near-infrared spectroscopy improved by wavelet transform and uninformative variable elimination. 2009 Anal. Chim. Acta pmid:19185115