| MeSH term | MeSH ID | Detail |
|---|---|---|
| Metabolism, Inborn Errors | D008661 | 46 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Myocardial Infarction | D009203 | 21 associated lipids |
| Adrenoleukodystrophy | D000326 | 29 associated lipids |
| Urinary Bladder Neoplasms | D001749 | 7 associated lipids |
| Prostatic Hyperplasia | D011470 | 20 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
alpha-linolenic acid
Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
Cross Reference
Introduction
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with alpha-linolenic acid?
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
PubChem Associated disorders and diseases
What pathways are associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with alpha-linolenic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with alpha-linolenic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with alpha-linolenic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Shirasaka N et al. | Microbial synthesis of trans isomer of eicosapentaenoic acid (EPA) from the chemically synthesized trans isomer of linolenic acid by a delta12 desaturase-defective mutant of Mortierella alpina 1S-4. | 2003 | Biosci. Biotechnol. Biochem. | pmid:12834302 |
| Laoteng K et al. | A Mucor rouxii mutant with high accumulation of an unusual trans-linoleic acid (9c,12t-C18:2). | 2003 | FEMS Microbiol. Lett. | pmid:12829281 |
| Qian SY et al. | Identification of spin trapped carbon-centered radicals in soybean lipoxygenase-dependent peroxidations of omega-3 polyunsaturated fatty acids by LC/ESR, LC/MS, and tandem MS. | 2003 | Free Radic. Biol. Med. | pmid:12826254 |
| Rallidis LS et al. | Dietary alpha-linolenic acid decreases C-reactive protein, serum amyloid A and interleukin-6 in dyslipidaemic patients. | 2003 | Atherosclerosis | pmid:12818406 |
| Erkkilä AT et al. | n-3 Fatty acids and 5-y risks of death and cardiovascular disease events in patients with coronary artery disease. | 2003 | Am. J. Clin. Nutr. | pmid:12816772 |
| Park WS et al. | Torilin from Torilis japonica, as a new inhibitor of testosterone 5 alpha-reductase. | 2003 | Planta Med. | pmid:12802730 |
| Rodriguez A et al. | Preterm infant formula supplementation with alpha linolenic acid and docosahexaenoic acid. | 2003 | Eur J Clin Nutr | pmid:12792656 |
| Kim H et al. | Suppression of fatty acid synthase by dietary polyunsaturated fatty acids is mediated by fat itself, not by peroxidative mechanism. | 2003 | J. Biochem. Mol. Biol. | pmid:12787479 |
| Barceló-Coblijn G et al. | Gene expression and molecular composition of phospholipids in rat brain in relation to dietary n-6 to n-3 fatty acid ratio. | 2003 | Biochim. Biophys. Acta | pmid:12782153 |
| Ward AT et al. | Fresh forage and solin supplementation on conjugated linoleic acid levels in plasma and milk. | 2003 | J. Dairy Sci. | pmid:12778585 |
| Dai CC et al. | [Comparative studies on the fatty acids contained in four species of medicinal plants from family Euphorbiaceae and their endophytic fungi]. | 2001 | Zhongguo Zhong Yao Za Zhi | pmid:12776425 |
| Buckner JS and Hagen MM | Triacylglycerol and phospholipid fatty acids of the silverleaf whitefly: composition and biosynthesis. | 2003 | Arch. Insect Biochem. Physiol. | pmid:12761874 |
| Gorinstein S et al. | Comparison of the contents of the main biochemical compounds and the antioxidant activity of some Spanish olive oils as determined by four different radical scavenging tests. | 2003 | J. Nutr. Biochem. | pmid:12742543 |
| Mashek DG and Grummer RR | Short communication: Net uptake of nonesterified long chain fatty acids by the perfused caudate lobe of the caprine liver. | 2003 | J. Dairy Sci. | pmid:12741546 |
| Babu US et al. | Impact of high flaxseed diet on mitogen-induced proliferation, IL-2 production, cell subsets and fatty acid composition of spleen cells from pregnant and F1 generation Sprague-Dawley rats. | 2003 | Food Chem. Toxicol. | pmid:12738196 |
| Wiesenfeld PW et al. | Flaxseed increased alpha-linolenic and eicosapentaenoic acid and decreased arachidonic acid in serum and tissues of rat dams and offspring. | 2003 | Food Chem. Toxicol. | pmid:12738189 |
| Pratt DA et al. | Theoretical calculations of carbon-oxygen bond dissociation enthalpies of peroxyl radicals formed in the autoxidation of lipids. | 2003 | J. Am. Chem. Soc. | pmid:12733921 |
| Steer P et al. | Vitamin C, diclophenac, and L-arginine protect endothelium-dependent vasodilation against elevated circulating fatty acid levels in humans. | 2003 | Atherosclerosis | pmid:12732388 |
| Inagaki K et al. | Evidence of isozymes for delta6 fatty acid desaturase in rat hepatocytes. | 2003 | Biosci. Biotechnol. Biochem. | pmid:12729021 |
| Wallace FA et al. | Comparison of the effects of linseed oil and different doses of fish oil on mononuclear cell function in healthy human subjects. | 2003 | Br. J. Nutr. | pmid:12720588 |
| Kew S et al. | Lack of effect of foods enriched with plant- or marine-derived n-3 fatty acids on human immune function. | 2003 | Am. J. Clin. Nutr. | pmid:12716684 |
| James MJ et al. | Metabolism of stearidonic acid in human subjects: comparison with the metabolism of other n-3 fatty acids. | 2003 | Am. J. Clin. Nutr. | pmid:12716664 |
| Steer P et al. | Endothelial vasodilatory function is related to the proportions of saturated fatty acids and alpha-linolenic acid in young men, but not in women. | 2003 | Eur. J. Clin. Invest. | pmid:12713452 |
| Gueck T et al. | Effects of essential fatty acids on mediators of mast cells in culture. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12711248 |
| Ichihara K and Suda Y | Lipid biosynthesis in developing perilla seeds. | 2003 | Phytochemistry | pmid:12711134 |
| AbuGhazaleh AA et al. | Milk conjugated linoleic acid response to fish oil supplementation of diets differing in fatty acid profiles. | 2003 | J. Dairy Sci. | pmid:12703631 |
| Eynard AR | Potential of essential fatty acids as natural therapeutic products for human tumors. | 2003 | Nutrition | pmid:12679177 |
| Bakshi A et al. | Gamma-linolenic acid therapy of human gliomas. | 2003 | Nutrition | pmid:12679162 |
| Baylin A et al. | Adipose tissue alpha-linolenic acid and nonfatal acute myocardial infarction in Costa Rica. | 2003 | Circulation | pmid:12668490 |
| Djoussé L et al. | Dietary linolenic acid and carotid atherosclerosis: the National Heart, Lung, and Blood Institute Family Heart Study. | 2003 | Am. J. Clin. Nutr. | pmid:12663278 |
| Finnegan YE et al. | Plant- and marine-derived n-3 polyunsaturated fatty acids have differential effects on fasting and postprandial blood lipid concentrations and on the susceptibility of LDL to oxidative modification in moderately hyperlipidemic subjects. | 2003 | Am. J. Clin. Nutr. | pmid:12663273 |
| Acar N et al. | Modification of the dopaminergic neurotransmitters in striatum, frontal cortex and hippocampus of rats fed for 21 months with trans isomers of alpha-linolenic acid. | 2003 | Neurosci. Res. | pmid:12657450 |
| Tanaka A and Nishizaki T | The newly synthesized linoleic acid derivative FR236924 induces a long-lasting facilitation of hippocampal neurotransmission by targeting nicotinic acetylcholine receptors. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12643906 |
| Adlof RO and List GR | Synthesis and analysis of symmetrical and nonsymmetrical disaturated/monounsaturated triacylglycerols. | 2003 | J. Agric. Food Chem. | pmid:12643679 |
| Itoh Y et al. | Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40. | 2003 | Nature | pmid:12629551 |
| Suresh Y and Das UN | Long-chain polyunsaturated fatty acids and chemically induced diabetes mellitus. Effect of omega-3 fatty acids. | 2003 | Nutrition | pmid:12620523 |
| Wolff RL | Are trans isomers of alpha-linolenic acid of nutritional significance for certain populations? | 2002 | Lipids | pmid:12617467 |
| Sinclair AJ et al. | What is the role of alpha-linolenic acid for mammals? | 2002 | Lipids | pmid:12617463 |
| Pawlosky RJ et al. | Effects of beef- and fish-based diets on the kinetics of n-3 fatty acid metabolism in human subjects. | 2003 | Am. J. Clin. Nutr. | pmid:12600844 |
| Yang X et al. | [Effects of silkworm pupa oil on serum lipids level and platelet function in rats]. | 2002 | Wei Sheng Yan Jiu | pmid:12600031 |
| Araseki M et al. | Oxidative stability of polyunsaturated fatty acid in phosphatidylcholine liposomes. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12596850 |
| Kurowska EM et al. | Bioavailability of omega-3 essential fatty acids from perilla seed oil. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12591004 |
| Tsydendambaev VD and Vereshchagin AG | Changes in triacylglycerol composition during ripening of sea buckthorn (Hippophaë rhamnoides L.) seeds. | 2003 | J. Agric. Food Chem. | pmid:12590468 |
| Chen J et al. | Dietary flaxseed inhibits human breast cancer growth and metastasis and downregulates expression of insulin-like growth factor and epidermal growth factor receptor. | 2002 | Nutr Cancer | pmid:12588699 |
| Bazinet RP et al. | Whole-body beta-oxidation of 18:2omega6 and 18:3omega3 in the pig varies markedly with weaning strategy and dietary 18:3omega3. | 2003 | J. Lipid Res. | pmid:12576513 |
| von Schacky C | The role of omega-3 fatty acids in cardiovascular disease. | 2003 | Curr Atheroscler Rep | pmid:12573200 |
| Tan X et al. | [Supercritical-CO2 fluid extraction of fatty oils from Perilla frutescens seeds and pharmacological study]. | 1999 | Zhong Yao Cai | pmid:12571915 |
| Saito M and Kubo K | Relationship between tissue lipid peroxidation and peroxidizability index after alpha-linolenic, eicosapentaenoic, or docosahexaenoic acid intake in rats. | 2003 | Br. J. Nutr. | pmid:12568661 |
| Castelli F et al. | Biomimesis of linolenic acid transport through model lipidic membranes by differential scanning calorimetry. | 2003 | J. Agric. Food Chem. | pmid:12568537 |
| Ascherio A | Epidemiologic studies on dietary fats and coronary heart disease. | 2002 | Am. J. Med. | pmid:12566133 |
| Kotarsky K et al. | A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12565875 |
| Ghafoorunissa A et al. | Effects of dietary alpha-linolenic acid from blended oils on biochemical indices of coronary heart disease in Indians. | 2002 | Lipids | pmid:12558058 |
| Suzuki M et al. | Endogenous alpha-ketol linolenic acid levels in short day-induced cotyledons are closely related to flower induction in Pharbitis nil. | 2003 | Plant Cell Physiol. | pmid:12552145 |
| Vos E and Cunnane SC | Alpha-linolenic acid, linoleic acid, coronary artery disease, and overall mortality. | 2003 | Am. J. Clin. Nutr. | pmid:12540417 |
| Innis SM and Elias SL | Intakes of essential n-6 and n-3 polyunsaturated fatty acids among pregnant Canadian women. | 2003 | Am. J. Clin. Nutr. | pmid:12540410 |
| Lemaitre RN et al. | n-3 Polyunsaturated fatty acids, fatal ischemic heart disease, and nonfatal myocardial infarction in older adults: the Cardiovascular Health Study. | 2003 | Am. J. Clin. Nutr. | pmid:12540389 |
| Scorolli L et al. | [Photodynamic therapy for age related macular degeneration with and without antioxidants]. | 2002 | Can. J. Ophthalmol. | pmid:12518724 |
| Takemura N et al. | Dietary, but not topical, alpha-linolenic acid suppresses UVB-induced skin injury in hairless mice when compared with linoleic acids. | 2002 | Photochem. Photobiol. | pmid:12511046 |
| Liu YC and Wu SN | Block of erg current by linoleoylamide, a sleep-inducing agent, in pituitary GH3 cells. | 2003 | Eur. J. Pharmacol. | pmid:12498905 |
| Briscoe CP et al. | The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids. | 2003 | J. Biol. Chem. | pmid:12496284 |
| López-López A et al. | Fatty acid and sn-2 fatty acid composition in human milk from Granada (Spain) and in infant formulas. | 2002 | Eur J Clin Nutr | pmid:12494309 |
| Maillard V et al. | Interaction of dietary beta-carotene and alpha-linolenic acid: effect on promotion of experimental mammary tumours. | 2002 | IARC Sci. Publ. | pmid:12484221 |
| Fisher AJ et al. | The biochemical origin of pentenol emissions from wounded leaves. | 2003 | Phytochemistry | pmid:12482451 |
| Simopoulos AP | Omega-3 fatty acids in inflammation and autoimmune diseases. | 2002 | J Am Coll Nutr | pmid:12480795 |
| Acar N et al. | FA composition of plasma, red blood cell, and liver phospholipids of newborn piglets fed trans isomers of alpha-linolenic acid. | 2002 | Lipids | pmid:12458619 |
| Lanzmann-Petithory D et al. | Primary prevention of cardiovascular diseases by alpha-linolenic acid. | 2002 | Am. J. Clin. Nutr. | pmid:12450919 |
| Kris-Etherton PM et al. | Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. | 2002 | Circulation | pmid:12438303 |
| Sanderson P et al. | UK Food Standards Agency alpha-linolenic acid workshop report. | 2002 | Br. J. Nutr. | pmid:12425738 |
| Bowen RA and Clandinin MT | Dietary low linolenic acid compared with docosahexaenoic acid alter synaptic plasma membrane phospholipid fatty acid composition and sodium-potassium ATPase kinetics in developing rats. | 2002 | J. Neurochem. | pmid:12421348 |
| Kratz M et al. | The impact of dietary fat composition on serum leptin concentrations in healthy nonobese men and women. | 2002 | J. Clin. Endocrinol. Metab. | pmid:12414865 |
| Decsi T et al. | Polyunsaturated fatty acids in plasma and erythrocyte membrane lipids of diabetic children. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12401433 |
| Petkova-Andonova M et al. | CYP92B1, A cytochrome P450, expressed in petunia flower buds, that catalyzes monooxidation of long-chain fatty acids. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12400678 |
| Nishimura K et al. | Regulation of apoptosis through arachidonate cascade in mammalian cells. | 2002 Jul-Dec | Appl. Biochem. Biotechnol. | pmid:12396127 |
| Acar N et al. | Modification of the monoaminergic neurotransmitters in frontal cortex and hippocampus by dietary trans alpha-linolenic acid in piglets. | 2002 | Neurosci. Lett. | pmid:12383930 |
| Karvonen HM et al. | Effect of alpha-linolenic acid-rich Camelina sativa oil on serum fatty acid composition and serum lipids in hypercholesterolemic subjects. | 2002 | Metab. Clin. Exp. | pmid:12370843 |
| Acar N et al. | Long-term intake of trans (n-3) polyunsaturated fatty acids reduces the b-wave amplitude of electroretinograms in rats. | 2002 | J. Nutr. | pmid:12368410 |
| Murase T et al. | Dietary alpha-linolenic acid-rich diacylglycerols reduce body weight gain accompanying the stimulation of intestinal beta-oxidation and related gene expressions in C57BL/KsJ-db/db mice. | 2002 | J. Nutr. | pmid:12368389 |
| Parmentier HK et al. | Different sources of dietary n-6 polyunsaturated fatty acids and their effects on antibody responses in chickens. | 2002 | Br. Poult. Sci. | pmid:12365510 |
| Korotkova M et al. | Leptin levels in rat offspring are modified by the ratio of linoleic to alpha-linolenic acid in the maternal diet. | 2002 | J. Lipid Res. | pmid:12364559 |
| Mashek DG et al. | Metabolic fate of long-chain unsaturated fatty acids and their effects on palmitic acid metabolism and gluconeogenesis in bovine hepatocytes. | 2002 | J. Dairy Sci. | pmid:12362461 |
| Renaud S and Lanzmann-Petithory D | Dietary fats and coronary heart disease pathogenesis. | 2002 | Curr Atheroscler Rep | pmid:12361488 |
| Itoh A et al. | Identification of a jasmonate-regulated allene oxide synthase that metabolizes 9-hydroperoxides of linoleic and linolenic acids. | 2002 | J. Biol. Chem. | pmid:12351632 |
| Renaud SC and Lanzmann-Petithory D | The beneficial effect of alpha-linolenic acid in coronary artery disease is not questionable. | 2002 | Am. J. Clin. Nutr. | pmid:12324307 |
| Baylin A et al. | Adipose tissue biomarkers of fatty acid intake. | 2002 | Am. J. Clin. Nutr. | pmid:12324287 |
| Burdge GC and Wootton SA | Conversion of alpha-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women. | 2002 | Br. J. Nutr. | pmid:12323090 |
| Burdge GC et al. | Eicosapentaenoic and docosapentaenoic acids are the principal products of alpha-linolenic acid metabolism in young men*. | 2002 | Br. J. Nutr. | pmid:12323085 |
| Blank C et al. | Optimizing DHA levels in piglets by lowering the linoleic acid to alpha-linolenic acid ratio. | 2002 | J. Lipid Res. | pmid:12235186 |
| Itoh S et al. | Synthesis of the (17R)- and (17S)-isomers of volicitin, an elicitor of plant volatiles contained in the oral secretion of the beet armyworm. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12224650 |
| Weiler HA and Fitzpatrick-Wong SC | Modulation of essential (n-6):(n-3) fatty acid ratios alters fatty acid status but not bone mass in piglets. | 2002 | J. Nutr. | pmid:12221227 |
| Göbel C et al. | Oxylipin profiling in pathogen-infected potato leaves. | 2002 | Biochim. Biophys. Acta | pmid:12213493 |
| Kaup MT et al. | A role for diacylglycerol acyltransferase during leaf senescence. | 2002 | Plant Physiol. | pmid:12177474 |
| Kreider RB et al. | Effects of conjugated linoleic acid supplementation during resistance training on body composition, bone density, strength, and selected hematological markers. | 2002 | J Strength Cond Res | pmid:12173945 |
| Pratt VC et al. | Alterations in lymphocyte function and relation to phospholipid composition after burn injury in humans. | 2002 | Crit. Care Med. | pmid:12163788 |
| Ghebremeskel K et al. | Liver triacylglycerols and free fatty acids in streptozotocin-induced diabetic rats have atypical n-6 and n-3 pattern. | 2002 | Comp. Biochem. Physiol. C Toxicol. Pharmacol. | pmid:12161168 |
| Akakabe Y et al. | Enantioselective formation of (R)-9-HPODE and (R)-9-HPOTrE in marine green alga Ulva conglobata. | 2002 | Bioorg. Med. Chem. | pmid:12150862 |
| Jeffrey BG et al. | n-3 fatty acid deficiency alters recovery of the rod photoresponse in rhesus monkeys. | 2002 | Invest. Ophthalmol. Vis. Sci. | pmid:12147619 |
| Hansen RA et al. | Effects of dietary flaxseed oil supplementation on equine plasma fatty acid concentrations and whole blood platelet aggregation. | 2002 Jul-Aug | J. Vet. Intern. Med. | pmid:12141309 |
| Schreck U et al. | Intraindividual comparison of two different skin care conceptions in patients undergoing radiotherapy of the head-and-neck region. Creme or powder? | 2002 | Strahlenther Onkol | pmid:12122788 |
| Blée E | Impact of phyto-oxylipins in plant defense. | 2002 | Trends Plant Sci. | pmid:12119169 |
| Shinohara R et al. | Evaluation of antilipid peroxidative action of propolis ethanol extract. | 2002 | Phytother Res | pmid:12112290 |