| MeSH term | MeSH ID | Detail |
|---|---|---|
| Bronchial Spasm | D001986 | 18 associated lipids |
| Carcinoma, Ductal, Breast | D018270 | 19 associated lipids |
| Pregnancy Complications | D011248 | 19 associated lipids |
| Dermatitis, Atopic | D003876 | 19 associated lipids |
| Tuberculosis | D014376 | 20 associated lipids |
| Prostatic Hyperplasia | D011470 | 20 associated lipids |
| Diabetic Angiopathies | D003925 | 20 associated lipids |
| Myocardial Infarction | D009203 | 21 associated lipids |
| Hypersensitivity | D006967 | 22 associated lipids |
| Malaria, Falciparum | D016778 | 22 associated lipids |
alpha-linolenic acid
Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
Cross Reference
Introduction
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with alpha-linolenic acid?
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
PubChem Associated disorders and diseases
What pathways are associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with alpha-linolenic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with alpha-linolenic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with alpha-linolenic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with alpha-linolenic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Shomonov-Wagner L et al. | Alpha linolenic acid in maternal diet halts the lipid disarray due to saturated fatty acids in the liver of mice offspring at weaning. | 2015 | Lipids Health Dis | pmid:25889505 |
| Reza JZ et al. | Modulation peroxisome proliferators activated receptor alpha (PPAR alpha) and acyl coenzyme A: cholesterol acyltransferase1 (ACAT1) gene expression by fatty acids in foam cell. | 2009 | Lipids Health Dis | pmid:19725980 |
| Baumgartner J et al. | Providing male rats deficient in iron and n-3 fatty acids with iron and alpha-linolenic acid alone affects brain serotonin and cognition differently from combined provision. | 2014 | Lipids Health Dis | pmid:24928171 |
| Høstmark AT and Haug A | The inverse association between relative abundances of oleic acid and arachidonic acid is related to alpha -linolenic acid. | 2014 | Lipids Health Dis | pmid:24885640 |
| Zhang Y et al. | α-Linolenic acid prevents endoplasmic reticulum stress-mediated apoptosis of stearic acid lipotoxicity on primary rat hepatocytes. | 2011 | Lipids Health Dis | pmid:21592363 |
| Grindel A et al. | Cheek cell fatty acids reflect n-3 PUFA in blood fractions during linseed oil supplementation: a controlled human intervention study. | 2013 | Lipids Health Dis | pmid:24229084 |
| Dai J et al. | Effects of polyunsaturated fatty acids on the growth of gastric cancer cells in vitro. | 2013 | Lipids Health Dis | pmid:23663688 |
| Arm JP et al. | Impact of botanical oils on polyunsaturated fatty acid metabolism and leukotriene generation in mild asthmatics. | 2013 | Lipids Health Dis | pmid:24088297 |
| Mirabi P et al. | The role of fatty acids on ICSI outcomes: a prospective cohort study. | 2017 | Lipids Health Dis | pmid:28109274 |
| Zhang T et al. | High-fat diet from perilla oil induces insulin resistance despite lower serum lipids and increases hepatic fatty acid oxidation in rats. | 2014 | Lipids Health Dis | pmid:24422660 |
| Svensson J et al. | Postprandial lipid responses to an alpha-linolenic acid-rich oil, olive oil and butter in women: a randomized crossover trial. | 2011 | Lipids Health Dis | pmid:21711508 |
| Shen J et al. | Effect of essential fatty acids on glucose-induced cytotoxicity to retinal vascular endothelial cells. | 2012 | Lipids Health Dis | pmid:22781401 |
| Zhang Y et al. | Effect of α-linolenic acid on endoplasmic reticulum stress-mediated apoptosis of palmitic acid lipotoxicity in primary rat hepatocytes. | 2011 | Lipids Health Dis | pmid:21787405 |
| Muralikumar S et al. | Probing the intermolecular interactions of PPARγ-LBD with polyunsaturated fatty acids and their anti-inflammatory metabolites to infer most potential binding moieties. | 2017 | Lipids Health Dis | pmid:28109294 |
| Zhao N et al. | α-Linolenic acid increases the G0/G1 switch gene 2 mRNA expression in peripheral blood mononuclear cells from obese patients: a pilot study. | 2016 | Lipids Health Dis | pmid:26912161 |
| Monteiro J et al. | Menhaden oil, but not safflower or soybean oil, aids in restoring the polyunsaturated fatty acid profile in the novel delta-6-desaturase null mouse. | 2012 | Lipids Health Dis | pmid:22642787 |
| Deng Q et al. | Single frequency intake of α-linolenic acid rich phytosterol esters attenuates atherosclerosis risk factors in hamsters fed a high fat diet. | 2016 | Lipids Health Dis | pmid:26843021 |
| Imran M et al. | Impact of extrusion processing conditions on lipid peroxidation and storage stability of full-fat flaxseed meal. | 2015 | Lipids Health Dis | pmid:26286266 |
| Mason JK et al. | α-linolenic acid and docosahexaenoic acid, alone and combined with trastuzumab, reduce HER2-overexpressing breast cancer cell growth but differentially regulate HER2 signaling pathways. | 2015 | Lipids Health Dis | pmid:26282560 |
| Berger A and German JB | Phospholipid fatty acid composition of various mouse tissues after feeding alpha-linolenate (18:3n-3) or eicosatrienoate (20:3n-3). | 1990 | Lipids | pmid:1977067 |
| Karapanagiotidis IT et al. | Replacement of dietary fish oils by alpha-linolenic acid-rich oils lowers omega 3 content in tilapia flesh. | 2007 | Lipids | pmid:17473942 |
| Wien M et al. | Decreasing the linoleic acid to alpha-linolenic acid diet ratio increases eicosapentaenoic acid in erythrocytes in adults. | 2010 | Lipids | pmid:20496049 |
| Hamberg M | Biosynthesis of new divinyl ether oxylipins in Ranunculus plants. | 2002 | Lipids | pmid:12030324 |
| Ishihara K et al. | Comparison of the effects of dietary alpha-linolenic, stearidonic, and eicosapentaenoic acids on production of inflammatory mediators in mice. | 2002 | Lipids | pmid:12056590 |
| Ackman RG | alpha-Linolenic acid in human adipose tissue. | 1994 | Lipids | pmid:7916440 |
| Stamey Lanier J et al. | Mammary uptake of fatty acids supplied by intravenous triacylglycerol infusion to lactating dairy cows. | 2013 | Lipids | pmid:23504269 |
| Coakley M et al. | Inhibitory effect of conjugated alpha-linolenic acid from bifidobacteria of intestinal origin on SW480 cancer cells. | 2009 | Lipids | pmid:19048324 |
| Fritsche KL and Johnston PV | Modulation of eicosanoid production and cell-mediated cytotoxicity by dietary alpha-linolenic acid in BALB/c mice. | 1989 | Lipids | pmid:2569149 |
| Guesnet P et al. | Modifying the n-3 fatty acid content of the maternal diet to determine the requirements of the fetal and suckling rat. | 1997 | Lipids | pmid:9168459 |
| Sugasini D and Lokesh BR | Uptake of α-linolenic acid and its conversion to long chain omega-3 fatty acids in rats fed microemulsions of linseed oil. | 2012 | Lipids | pmid:23104428 |
| Garg ML et al. | Dietary saturated fat level alters the competition between alpha-linolenic and linoleic acid. | 1989 | Lipids | pmid:2569150 |
| Zainal Z et al. | Modification of palm oil for anti-inflammatory nutraceutical properties. | 2009 | Lipids | pmid:19449050 |
| Sioen I et al. | Effect of ALA-enriched food supply on cardiovascular risk factors in males. | 2009 | Lipids | pmid:19452183 |
| DiRienzo MA et al. | Effect of substitution of low linolenic acid soybean oil for hydrogenated soybean oil on fatty acid intake. | 2006 | Lipids | pmid:17707981 |
| Dinh TK et al. | Effect of age and alpha-linolenic acid deficiency on delta 6 desaturase activity and liver lipids in rats. | 1993 | Lipids | pmid:8102769 |
| Javouhey-Donzel A et al. | Rat vitamin E status and heart lipid peroxidation: effect of dietary alpha-linolenic acid and marine n-3 fatty acids. | 1993 | Lipids | pmid:8102771 |
| Astiz M et al. | Exogenous arachidonate restores the dimethoate-induced inhibition of steroidogenesis in rat interstitial cells. | 2012 | Lipids | pmid:22476691 |
| Hamberg M | A pathway for biosynthesis of divinyl ether fatty acids in green leaves. | 1998 | Lipids | pmid:9870900 |
| Chang HH et al. | Dietary perilla oil inhibits proinflammatory cytokine production in the bronchoalveolar lavage fluid of ovalbumin-challenged mice. | 2008 | Lipids | pmid:18386091 |
| Gavino VC et al. | Kinetic analysis of the selectivity of acylcarnitine synthesis in rat mitochondria. | 2003 | Lipids | pmid:12848298 |
| DiRienzo MA et al. | Effect of substitution of high stearic low linolenic acid soybean oil for hydrogenated soybean oil on fatty acid intake. | 2008 | Lipids | pmid:18365266 |
| Kim Y et al. | Synergism of α-linolenic acid, conjugated linoleic acid and calcium in decreasing adipocyte and increasing osteoblast cell growth. | 2013 | Lipids | pmid:23757205 |
| Taha AY et al. | Markedly raised intake of saturated and monounsaturated fatty acids in rats on a high-fat ketogenic diet does not inhibit carbon recycling of 13C-alpha-linolenate. | 2006 | Lipids | pmid:17180881 |
| He ML et al. | Triticale dried distillers' grain increases alpha-linolenic acid in subcutaneous fat of beef cattle fed oilseeds. | 2012 | Lipids | pmid:23054550 |
| Igarashi M and Miyazawa T | Preparation and fractionation of conjugated trienes from alpha-linolenic acid and their growth-inhibitory effects on human tumor cells and fibroblasts. | 2005 | Lipids | pmid:15825836 |
| Delton-Vandenbroucke I et al. | A role for cerebral and retinal endothelial cells in the supply of docosahexaenoic acid to the brain and the retina? | 1999 | Lipids | pmid:10419115 |
| Vermunt SH et al. | Effects of age and dietary n-3 fatty acids on the metabolism of [13C]-alpha-linolenic acid. | 1999 | Lipids | pmid:10419119 |
| Turpeinen AM et al. | A high linoleic acid diet increases oxidative stress in vivo and affects nitric oxide metabolism in humans. | 1999 | Lipids | pmid:10419181 |
| Su HM et al. | Dietary 18:3n-3 and 22:6n-3 as sources of 22:6n-3 accretion in neonatal baboon brain and associated organs. | 1999 | Lipids | pmid:10419199 |
| Torstensen BE and Stubhaug I | Beta-oxidation of 18:3n-3 in Atlantic salmon (Salmo salar L.) hepatocytes treated with different fatty acids. | 2004 | Lipids | pmid:15134142 |
| Abedin L et al. | The effects of dietary alpha-linolenic acid compared with docosahexaenoic acid on brain, retina, liver, and heart in the guinea pig. | 1999 | Lipids | pmid:10380119 |
| Delmonte P et al. | Synthesis, isolation, and GC analysis of all the 6,8- to 13,15-cis/trans conjugated linoleic acid isomers. | 2004 | Lipids | pmid:15134147 |
| Aki T et al. | Regulation of polyunsaturated fatty acid biosynthesis by seaweed fucoxanthin and its metabolite in cultured hepatocytes. | 2014 | Lipids | pmid:24174374 |
| Hennessy AA et al. | The production of conjugated α-linolenic, γ-linolenic and stearidonic acids by strains of bifidobacteria and propionibacteria. | 2012 | Lipids | pmid:22160449 |
| Chardigny JM et al. | Identification of novel trans isomers of 20:5n-3 in liver lipids of rats fed a heated oil. | 1996 | Lipids | pmid:8835404 |
| Wall R et al. | Impact of administered bifidobacterium on murine host fatty acid composition. | 2010 | Lipids | pmid:20405232 |
| Hagve TA et al. | Desaturation and chain elongation of essential fatty acids in isolated liver cells from rat and rainbow trout. | 1986 | Lipids | pmid:2871473 |
| Jernerén F et al. | Linolenate 9R-dioxygenase and allene oxide synthase activities of Lasiodiplodia theobromae. | 2012 | Lipids | pmid:22048860 |
| Trattner S et al. | Sesamin supplementation increases white muscle docosahexaenoic acid (DHA) levels in rainbow trout (Oncorhynchus mykiss) fed high alpha-linolenic acid (ALA) containing vegetable oil: metabolic actions. | 2008 | Lipids | pmid:18781351 |
| Trattner S et al. | Sesamin increases alpha-linolenic acid conversion to docosahexaenoic acid in atlantic salmon (Salmo salar L.) hepatocytes: role of altered gene expression. | 2008 | Lipids | pmid:18784949 |
| Ghafoorunissa A et al. | Effects of dietary alpha-linolenic acid from blended oils on biochemical indices of coronary heart disease in Indians. | 2002 | Lipids | pmid:12558058 |
| Waters KM and Ntambi JM | Polyunsaturated fatty acids inhibit hepatic stearoyl-CoA desaturase-1 gene in diabetic mice. | 1996 | Lipids | pmid:8729090 |
| Cleland LG et al. | Paradoxical effect of n-3-containing vegetable oils on long-chain n-3 fatty acids in rat heart. | 2005 | Lipids | pmid:16382570 |
| Emken EA et al. | Effect of dietary docosahexaenoic acid on desaturation and uptake in vivo of isotope-labeled oleic, linoleic, and linolenic acids by male subjects. | 1999 | Lipids | pmid:10529088 |
| Sinclair AJ et al. | What is the role of alpha-linolenic acid for mammals? | 2002 | Lipids | pmid:12617463 |
| Wolff RL | Are trans isomers of alpha-linolenic acid of nutritional significance for certain populations? | 2002 | Lipids | pmid:12617467 |
| Talahalli RR et al. | Lower efficacy in the utilization of dietary ALA as compared to preformed EPA + DHA on long chain n-3 PUFA levels in rats. | 2010 | Lipids | pmid:20734237 |
| Katrangi W et al. | Interactions of linoleic and alpha-linolenic acids in the development of fatty acid alterations in cystic fibrosis. | 2013 | Lipids | pmid:23440519 |
| Anding RH and Hwang DH | Effects of dietary linolenate on the fatty acid composition of brain lipids in rats. | 1986 | Lipids | pmid:2879208 |
| Tang AB et al. | Preferential reduction in adipose tissue alpha-linolenic acid (18:3 omega 3) during very low calorie dieting despite supplementation with 18:3 omega 3. | 1993 | Lipids | pmid:7904040 |
| Acar N et al. | FA composition of plasma, red blood cell, and liver phospholipids of newborn piglets fed trans isomers of alpha-linolenic acid. | 2002 | Lipids | pmid:12458619 |
| Harauma A et al. | Repletion of n-3 fatty acid deficient dams with alpha-linolenic acid: effects on fetal brain and liver fatty acid composition. | 2010 | Lipids | pmid:20625936 |
| Li Y et al. | Impact of dietary n-3 FA deficiency on rat bone tissue FA composition. | 2003 | Lipids | pmid:12934680 |
| Nakamura T | Red pigment-forming substances from autoxidized linolenate: identification of prostaglandin-like substances. | 1985 | Lipids | pmid:2859511 |
| Grandgirard A et al. | Incorporation of trans long-chain n-3 polyunsaturated fatty acids in rat brain structures and retina. | 1994 | Lipids | pmid:7909911 |
| Barceló-Coblijn G et al. | Dietary alpha-linolenic acid increases brain but not heart and liver docosahexaenoic acid levels. | 2005 | Lipids | pmid:16296397 |
| McCullough RS et al. | The alpha linolenic acid content of flaxseed is associated with an induction of adipose leptin expression. | 2011 | Lipids | pmid:22031167 |
| Tsuzuki T et al. | Oxidation rate of conjugated linoleic acid and conjugated linolenic acid is slowed by triacylglycerol esterification and alpha-tocopherol. | 2004 | Lipids | pmid:15506243 |
| Miranda J et al. | cis-9,trans-11,cis-15 and cis-9,trans-13,cis-15 CLNA mixture activates PPARα in HEK293 and reduces triacylglycerols in 3T3-L1 cells. | 2011 | Lipids | pmid:21984112 |
| Magrum LJ and Johnston PV | Modulation of prostaglandin synthesis in rat peritoneal macrophages with omega-3 fatty acids. | 1983 | Lipids | pmid:6312240 |
| Vaysse-Boué C et al. | Moderate dietary intake of myristic and alpha-linolenic acids increases lecithin-cholesterol acyltransferase activity in humans. | 2007 | Lipids | pmid:17564735 |
| Hansen HS and Jensen B | Urinary prostaglandin E2 and vasopressin excretion in essential fatty acid-deficient rats: effect of linolenic acid supplementation. | 1983 | Lipids | pmid:6318006 |
| Poumès-Ballihaut C et al. | Comparative bioavailability of dietary alpha-linolenic and docosahexaenoic acids in the growing rat. | 2001 | Lipids | pmid:11592729 |
| Astorg PO and Chevalier J | Polyunsaturated fatty acids in tissues of rats fed trielaidin and high or low levels of linolenic acid. | 1987 | Lipids | pmid:2897610 |
| Gibson RA et al. | Randomized trials with polyunsaturated fatty acid interventions in preterm and term infants: functional and clinical outcomes. | 2001 | Lipids | pmid:11724459 |
| Sugasini D et al. | Lymphatic transport of α-linolenic acid and its conversion to long chain n-3 fatty acids in rats fed microemulsions of linseed oil. | 2014 | Lipids | pmid:24338560 |
| Weisinger HS et al. | Dietary manipulation of long-chain polyunsaturated fatty acids in the retina and brain of guinea pigs. | 1995 | Lipids | pmid:7637569 |
| Vermunt SH et al. | Effects of dietary alpha-linolenic acid on the conversion and oxidation of 13C-alpha-linolenic acid. | 2000 | Lipids | pmid:10757543 |
| Arbuckle LD and Innis SM | Docosahexaenoic acid in developing brain and retina of piglets fed high or low alpha-linolenate formula with and without fish oil. | 1992 | Lipids | pmid:1349717 |
| Kurvinen JP et al. | The effect of low alpha-linolenic acid diet on glycerophospholipid molecular species in guinea pig brain. | 2000 | Lipids | pmid:11026621 |
| Hennessy AA et al. | The health promoting properties of the conjugated isomers of α-linolenic acid. | 2011 | Lipids | pmid:21161605 |
| Levant B et al. | Differential effects of modulation of docosahexaenoic acid content during development in specific regions of rat brain. | 2006 | Lipids | pmid:16933785 |
| Hoffman DR and Uauy R | Essentiality of dietary omega 3 fatty acids for premature infants: plasma and red blood cell fatty acid composition. | 1992 | Lipids | pmid:1362792 |
| Alessandri JM et al. | Estradiol favors the formation of eicosapentaenoic acid (20:5n-3) and n-3 docosapentaenoic acid (22:5n-3) from alpha-linolenic acid (18:3n-3) in SH-SY5Y neuroblastoma cells. | 2008 | Lipids | pmid:17912567 |
| Watkins SM et al. | Unique phospholipid metabolism in mouse heart in response to dietary docosahexaenoic or alpha-linolenic acids. | 2001 | Lipids | pmid:11337979 |
| Kronberg SL et al. | Flaxseed treatments to reduce biohydrogenation of alpha-linolenic acid by rumen microbes in cattle. | 2007 | Lipids | pmid:17985170 |
| Sugiyama K et al. | Correlation of suppressed linoleic acid metabolism with the hypocholesterolemic action of eritadenine in rats. | 1997 | Lipids | pmid:9270978 |
| Fu Z and Sinclair AJ | Increased alpha-linolenic acid intake increases tissue alpha-linolenic acid content and apparent oxidation with little effect on tissue docosahexaenoic acid in the guinea pig. | 2000 | Lipids | pmid:10858024 |
| Okuyama H et al. | Dietary lipids impacts on healthy ageing. | 2007 | Lipids | pmid:17546469 |
| Goré J et al. | Linoleic acid uptake by isolated enterocytes: influence of alpha-linolenic acid on absorption. | 1994 | Lipids | pmid:7861937 |