alpha-linolenic acid

Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.

Cross Reference

Introduction

To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with alpha-linolenic acid?

alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Hyperlipidemias D006949 73 associated lipids
Hyperlipidemia, Familial Combined D006950 9 associated lipids
Hypersensitivity D006967 22 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Hypertension D006973 115 associated lipids
Inflammation D007249 119 associated lipids
Insect Bites and Stings D007299 4 associated lipids
Per page 10 20 50 100 | Total 104

PubChem Associated disorders and diseases

What pathways are associated with alpha-linolenic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with alpha-linolenic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with alpha-linolenic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with alpha-linolenic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with alpha-linolenic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with alpha-linolenic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with alpha-linolenic acid

Download all related citations
Per page 10 20 50 100 | Total 2471
Authors Title Published Journal PubMed Link
Sugasini D and Lokesh BR Uptake of α-linolenic acid and its conversion to long chain omega-3 fatty acids in rats fed microemulsions of linseed oil. 2012 Lipids pmid:23104428
Jung DM et al. Chemical properties and oxidative stability of perilla oils obtained from roasted perilla seeds as affected by extraction methods. 2012 J. Food Sci. pmid:23106331
Pereira H et al. Polyunsaturated Fatty acids of marine macroalgae: potential for nutritional and pharmaceutical applications. 2012 Mar Drugs pmid:23118712
Botsoglou E et al. Effect of supplementation of the laying hen diet with olive leaves (Olea europea L.) on lipid oxidation and fatty acid profile of α-linolenic acid enriched eggs during storage. 2012 Br. Poult. Sci. pmid:23130586
Zhao T et al. Impact of roasting on the chemical composition and oxidative stability of perilla oil. 2012 J. Food Sci. pmid:23140339
Barrett E et al. Bifidobacterium breve with α-linolenic acid and linoleic acid alters fatty acid metabolism in the maternal separation model of irritable bowel syndrome. 2012 PLoS ONE pmid:23185248
Fang XL et al. Roles of α-linolenic acid on IGF-I secretion and GH/IGF system gene expression in porcine primary hepatocytes. 2012 Mol. Biol. Rep. pmid:23053988
He ML et al. Triticale dried distillers' grain increases alpha-linolenic acid in subcutaneous fat of beef cattle fed oilseeds. 2012 Lipids pmid:23054550
Msika O et al. NGF blocks polyunsaturated fatty acids biosynthesis in n-3 fatty acid-supplemented PC12 cells. 2012 Biochim. Biophys. Acta pmid:22564256
Garcia CV et al. Characterisation of bound volatile compounds of a low flavour kiwifruit species: Actinidia eriantha. 2012 Food Chem pmid:23107675
Beck JJ et al. Generation of the volatile spiroketals conophthorin and chalcogran by fungal spores on polyunsaturated fatty acids common to almonds and pistachios. 2012 J. Agric. Food Chem. pmid:23153034
Moodley R et al. Elemental composition and fatty acid profile of the edible fruits of Amatungula (Carissa macrocarpa) and impact of soil quality on chemical characteristics. 2012 Anal. Chim. Acta pmid:22632042
Lakshmanan V et al. Metabolomic analysis of patient plasma yields evidence of plant-like α-linolenic acid metabolism in Plasmodium falciparum. 2012 J. Infect. Dis. pmid:22566569
Saha SS et al. Synergistic effect of conjugated linolenic acid isomers against induced oxidative stress, inflammation and erythrocyte membrane disintegrity in rat model. 2012 Biochim. Biophys. Acta pmid:22967758
Shimpukade B et al. Discovery of a potent and selective GPR120 agonist. 2012 J. Med. Chem. pmid:22519963
Shinohara N et al. Jacaric acid, a linolenic acid isomer with a conjugated triene system, has a strong antitumor effect in vitro and in vivo. 2012 Biochim. Biophys. Acta pmid:22521763
Kim N and Choe E Singlet oxygen-related photooxidative stability and antioxidant changes of diacylglycerol-rich oil derived from mixture of olive and perilla oil. 2012 J. Food Sci. pmid:23057833
Georgiadi A et al. Detailed transcriptomics analysis of the effect of dietary fatty acids on gene expression in the heart. 2012 Physiol. Genomics pmid:22274564
Jackson MD et al. Associations of whole-blood fatty acids and dietary intakes with prostate cancer in Jamaica. 2012 Cancer Causes Control pmid:21984307
de Batlle J et al. Association between Ω3 and Ω6 fatty acid intakes and serum inflammatory markers in COPD. 2012 J. Nutr. Biochem. pmid:21889886
He ML et al. Feeding flaxseed in grass hay and barley silage diets to beef cows increases alpha-linolenic acid and its biohydrogenation intermediates in subcutaneous fat. 2012 J. Anim. Sci. pmid:22274861
Sun T et al. Meat fatty acid and cholesterol level of free-range broilers fed on grasshoppers on alpine rangeland in the Tibetan Plateau. 2012 J. Sci. Food Agric. pmid:22318921
Deckelbaum RJ and Torrejon C The omega-3 fatty acid nutritional landscape: health benefits and sources. 2012 J. Nutr. pmid:22323763
Larsen MK et al. Fatty acid, tocopherol and carotenoid content in herbage and milk affected by sward composition and season of grazing. 2012 J. Sci. Food Agric. pmid:22337263
Angulo J et al. Nutritional evaluation of fruit and vegetable waste as feedstuff for diets of lactating Holstein cows. 2012 J. Environ. Manage. pmid:21784573
Pirat C et al. Targeting peroxisome proliferator-activated receptors (PPARs): development of modulators. 2012 J. Med. Chem. pmid:22260081
Huang T et al. Effect of n-3 polyunsaturated fatty acid on gene expression of the critical enzymes involved in homocysteine metabolism. 2012 Nutr J pmid:22260268
Gaquerel E et al. Nicotiana attenuata α-DIOXYGENASE1 through its production of 2-hydroxylinolenic acid is required for intact plant defense expression against attack from Manduca sexta larvae. 2012 New Phytol. pmid:22937952
Hughes BH et al. Oxidative stability and consumer acceptance of fish oil fortified nutrition bars. 2012 J. Food Sci. pmid:22957916
Aliani M et al. Effect of flax addition on the flavor profile and acceptability of bagels. 2012 J. Food Sci. pmid:22260132
Lerch S et al. Rapeseed or linseed in grass-based diets: effects on conjugated linoleic and conjugated linolenic acid isomers in milk fat from Holstein cows over 2 consecutive lactations. 2012 J. Dairy Sci. pmid:22999291
Wilk JB et al. Plasma and dietary omega-3 fatty acids, fish intake, and heart failure risk in the Physicians' Health Study. 2012 Am. J. Clin. Nutr. pmid:22952185
Janssen S et al. Sensing of fatty acids for octanoylation of ghrelin involves a gustatory G-protein. 2012 PLoS ONE pmid:22768248
Reinders I et al. Association of serum n-3 polyunsaturated fatty acids with C-reactive protein in men. 2012 Eur J Clin Nutr pmid:22113248
Shen J et al. Effect of essential fatty acids on glucose-induced cytotoxicity to retinal vascular endothelial cells. 2012 Lipids Health Dis pmid:22781401
Kuhns EH et al. A lepidopteran aminoacylase (L-ACY-1) in Heliothis virescens (Lepidoptera: Noctuidae) gut lumen hydrolyzes fatty acid-amino acid conjugates, elicitors of plant defense. 2012 Insect Biochem. Mol. Biol. pmid:22056272
Mitra K et al. Studies of reaction variables for lipase-catalyzed production of alpha-linolenic acid enriched structured lipid and oxidative stability with antioxidants. 2012 J. Food Sci. pmid:22122200
Couëdelo L et al. The fraction of α-linolenic acid present in the sn-2 position of structured triacylglycerols decreases in lymph chylomicrons and plasma triacylglycerols during the course of lipid absorption in rats. 2012 J. Nutr. pmid:22131546
Nwaru BI et al. Maternal intake of fatty acids during pregnancy and allergies in the offspring. 2012 Br. J. Nutr. pmid:22067943
Pham AT et al. Combinations of mutant FAD2 and FAD3 genes to produce high oleic acid and low linolenic acid soybean oil. 2012 Theor. Appl. Genet. pmid:22476873
Rosa DD et al. Fish oil improves the lipid profile and reduces inflammatory cytokines in Wistar rats with precancerous colon lesions. 2012 Nutr Cancer pmid:22483364
Karppi J et al. Serum β-carotene in relation to risk of prostate cancer: the Kuopio Ischaemic Heart Disease Risk Factor study. 2012 Nutr Cancer pmid:22420939
Pal M and Ghosh M Prophylactic effect of α-linolenic acid and α-eleostearic acid against MeHg induced oxidative stress, DNA damage and structural changes in RBC membrane. 2012 Food Chem. Toxicol. pmid:22683484
Zhang G et al. Erythrocyte n-3 fatty acids and metabolic syndrome in middle-aged and older Chinese. 2012 J. Clin. Endocrinol. Metab. pmid:22456621
Kowalska A et al. Impact of diets with different proportions of linseed and sunflower oils on the growth, liver histology, immunological and chemical blood parameters, and proximate composition of pikeperch Sander lucioperca (L.). 2012 Fish Physiol. Biochem. pmid:21656178
Ishida Y et al. Validation of thermally assisted hydrolysis and methylation-gas chromatography using a vertical microfurnace pyrolyzer for the compositional analysis of Fatty Acid components in microalgae. 2012 J. Agric. Food Chem. pmid:22458968
Mirmiran P et al. Association between interaction and ratio of ω-3 and ω-6 polyunsaturated fatty acid and the metabolic syndrome in adults. 2012 Nutrition pmid:22459553
Maqbool A et al. Relation between dietary fat intake type and serum fatty acid status in children with cystic fibrosis. 2012 J. Pediatr. Gastroenterol. Nutr. pmid:22699835
Du Q et al. Dairy fat blends high in α-linolenic acid are superior to n-3 fatty-acid-enriched palm oil blends for increasing DHA levels in the brains of young rats. 2012 J. Nutr. Biochem. pmid:22445803
Miyake Y et al. Dietary meat and fat intake and prevalence of rhinoconjunctivitis in pregnant Japanese women: baseline data from the Kyushu Okinawa Maternal and Child Health Study. 2012 Nutr J pmid:22449171
Nakamura YK et al. Modulation of oxidative stress by γ-glutamylcysteine (GGC) and conjugated linoleic acid (CLA) isomer mixture in human umbilical vein endothelial cells. 2012 Food Chem. Toxicol. pmid:22490668
Zhang LH et al. [Effects of alpha-linolenic acid on inflammation and oxidative stress in the diabetic rats]. 2012 Zhongguo Ying Yong Sheng Li Xue Za Zhi pmid:22493899
Fatima T et al. Fatty acid composition of developing sea buckthorn (Hippophae rhamnoides L.) berry and the transcriptome of the mature seed. 2012 PLoS ONE pmid:22558083
Luo ZM et al. A new norisoprenoid and other compounds from Fuzhuan brick tea. 2012 Molecules pmid:22430120
Ibrahim A et al. Dietary α-linolenic acid-rich formula reduces adhesion molecules in rats with experimental colitis. 2012 Nutrition pmid:22261574
Zhang H et al. A mechanism underlying the effects of polyunsaturated fatty acids on breast cancer. 2012 Int. J. Mol. Med. pmid:22692672
Marei WF et al. Differential effects of linoleic and alpha-linolenic fatty acids on spatial and temporal mitochondrial distribution and activity in bovine oocytes. 2012 Reprod. Fertil. Dev. pmid:22697118
Kronberg SL et al. Treatment of flaxseed to reduce biohydrogenation of α-linolenic acid by ruminal microbes in sheep and cattle, and increase n-3 fatty acid concentrations in red meat. 2012 J. Anim. Sci. pmid:22696616
Passos PP et al. Dopaminergic cell populations of the rat substantia nigra are differentially affected by essential fatty acid dietary restriction over two generations. 2012 J. Chem. Neuroanat. pmid:22687395
Longvah T et al. Eri silkworm: a source of edible oil with a high content of α-linolenic acid and of significant nutritional value. 2012 J. Sci. Food Agric. pmid:22290445
de Freitas JM et al. Influence of cellular fatty acid composition on the response of Saccharomyces cerevisiae to hydrostatic pressure stress. 2012 FEMS Yeast Res. pmid:22846157
Monteiro J et al. Menhaden oil, but not safflower or soybean oil, aids in restoring the polyunsaturated fatty acid profile in the novel delta-6-desaturase null mouse. 2012 Lipids Health Dis pmid:22642787
Nam KH and Yoshihara T Interactions among LOX metabolites regulate temperature-mediated flower bud formation in morning glory (Pharbitis nil). 2012 J. Plant Physiol. pmid:22902207
Evans SJ et al. Association of plasma ω-3 and ω-6 lipids with burden of disease measures in bipolar subjects. 2012 J Psychiatr Res pmid:22884424
Castro LF et al. Functional desaturase Fads1 (Δ5) and Fads2 (Δ6) orthologues evolved before the origin of jawed vertebrates. 2012 PLoS ONE pmid:22384110
Pan H et al. Alpha-linolenic acid is a potent neuroprotective agent against soman-induced neuropathology. 2012 Neurotoxicology pmid:22884490
Huan M et al. In vivo anti-tumor activity of a new doxorubicin conjugate via α-linolenic acid. 2012 Biosci. Biotechnol. Biochem. pmid:22878199
Zhang G et al. [Effects of fatty acids on proliferation and differentiation of myoblast]. 2012 Wei Sheng Yan Jiu pmid:23424861
Santos FS et al. Status of cis and trans fatty acids in Brazilian adolescent mothers and their newborns. 2012 J Pediatr Adolesc Gynecol pmid:22840939
Dhobale MV et al. Reduced levels of placental long chain polyunsaturated fatty acids in preterm deliveries. 2011 Sep-Oct Prostaglandins Leukot. Essent. Fatty Acids pmid:21816593
Jiang MH et al. Comparative GC/MS analysis of essential oils extracted by 3 methods from the bud of Citrus aurantium L. var. amara Engl. 2011 Nov-Dec J. Food Sci. pmid:22416680
Kim Y and Ilich JZ Implications of dietary α-linolenic acid in bone health. 2011 Nov-Dec Nutrition pmid:21726979
Qu WX et al. Analysis of fatty acids in A. szechenyianum Gay. by microwave-assisted extraction and gas chromatography-mass spectrometry. 2011 May-Jun Phytochem Anal pmid:20848395
Gao F et al. Liver conversion of docosahexaenoic and arachidonic acids from their 18-carbon precursors in rats on a DHA-free but α-LNA-containing n-3 PUFA adequate diet. 2011 Jul-Aug Biochim. Biophys. Acta pmid:21651989
Trimarco B et al. [The Alpha Omega study]. 2011 Jul-Aug G Ital Cardiol (Rome) pmid:21779112
Zhang Y et al. α-Linolenic acid prevents endoplasmic reticulum stress-mediated apoptosis of stearic acid lipotoxicity on primary rat hepatocytes. 2011 Lipids Health Dis pmid:21592363
Maqbool A et al. The skinny on tuna fat: health implications. 2011 Public Health Nutr pmid:21324226
Popescu FD et al. Effects of season and reproductive state on lipid intake and fatty acid composition of gastrointestinal tract contents in the European hare. 2011 J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. pmid:21328065
Lee MJ et al. The effects of hempseed meal intake and linoleic acid on Drosophila models of neurodegenerative diseases and hypercholesterolemia. 2011 Mol. Cells pmid:21331775
Banik M et al. Transcript profiling and gene characterization of three fatty acid desaturase genes in high, moderate, and low linolenic acid genotypes of flax (Linum usitatissimum L.) and their role in linolenic acid accumulation. 2011 Genome pmid:21627464
Letona AZ et al. CLA-enriched diet containing t10,c12-CLA alters bile acid homeostasis and increases the risk of cholelithiasis in mice. 2011 J. Nutr. pmid:21628634
Saha SS and Ghosh M Antioxidant effect of vegetable oils containing conjugated linolenic acid isomers against induced tissue lipid peroxidation and inflammation in rat model. 2011 Chem. Biol. Interact. pmid:21382362
Antruejo A et al. Omega-3 enriched egg production: the effect of α -linolenic ω -3 fatty acid sources on laying hen performance and yolk lipid content and fatty acid composition. 2011 Br. Poult. Sci. pmid:22221241
Park MH et al. Effects of roasting conditions on the physicochemical properties and volatile distribution in perilla oils (Perilla frutescens var. japonica). 2011 J. Food Sci. pmid:21623788
Huang F et al. EPA inhibits the inhibitor of κBα (IκBα)/NF-κB/muscle RING finger 1 pathway in C2C12 myotubes in a PPARγ-dependent manner. 2011 Br. J. Nutr. pmid:20955633
Metwal N et al. Influence of debittered, defatted fenugreek seed powder and flaxseed powder on the rheological characteristics of dough and quality of cookies. 2011 Int J Food Sci Nutr pmid:21250900
Myhrstad MC et al. Effect of the fat composition of a single high-fat meal on inflammatory markers in healthy young women. 2011 Br. J. Nutr. pmid:21736782
Egert S and Stehle P Impact of n-3 fatty acids on endothelial function: results from human interventions studies. 2011 Curr Opin Clin Nutr Metab Care pmid:21252652
Brinkman MT et al. Intake of α-linolenic acid and other fatty acids in relation to the risk of bladder cancer: results from the New Hampshire case-control study. 2011 Br. J. Nutr. pmid:21736846
Gopinath B et al. Consumption of long-chain n-3 PUFA, α-linolenic acid and fish is associated with the prevalence of chronic kidney disease. 2011 Br. J. Nutr. pmid:21255476
Arshad A et al. Potential applications of fish oils rich in n-3 fatty acids in the palliative treatment of advanced pancreatic cancer. 2011 Br. J. Nutr. pmid:21745426
Hayirli A et al. Peripartum responses of dairy cows to prepartal feeding level and dietary fatty acid source. 2011 J. Dairy Sci. pmid:21257060
Poudyal H et al. Omega-3 fatty acids and metabolic syndrome: effects and emerging mechanisms of action. 2011 Prog. Lipid Res. pmid:21762726
Zhang Y et al. Effect of α-linolenic acid on endoplasmic reticulum stress-mediated apoptosis of palmitic acid lipotoxicity in primary rat hepatocytes. 2011 Lipids Health Dis pmid:21787405
Gibson RA et al. Conversion of linoleic acid and alpha-linolenic acid to long-chain polyunsaturated fatty acids (LCPUFAs), with a focus on pregnancy, lactation and the first 2 years of life. 2011 Matern Child Nutr pmid:21366864
Lauritzen L and Carlson SE Maternal fatty acid status during pregnancy and lactation and relation to newborn and infant status. 2011 Matern Child Nutr pmid:21366866
Brenna JT Animal studies of the functional consequences of suboptimal polyunsaturated fatty acid status during pregnancy, lactation and early post-natal life. 2011 Matern Child Nutr pmid:21366867
Briend A et al. Fatty acid status in early life in low-income countries--overview of the situation, policy and research priorities. 2011 Matern Child Nutr pmid:21366873
Salem N and Kuratko CN Lack of evidence for increased α-linolenic acid metabolism in vegetarians. 2011 Am. J. Clin. Nutr. pmid:21430120
Carrillo C et al. Oleic acid versus linoleic and α-linolenic acid. different effects on Ca2+ signaling in rat thymocytes. 2011 Cell. Physiol. Biochem. pmid:21471726