Alpha-linolenic acid is a lipid of Fatty Acyls (FA) class. Alpha-linolenic acid is associated with abnormalities such as Coronary heart disease, abnormal fragmented structure, Arterial thrombosis and Subarachnoid Hemorrhage. The involved functions are known as Anabolism, Signal, Transcription, Genetic, Saturated and Regulation. Alpha-linolenic acid often locates in Blood, Body tissue, Plasma membrane, Hepatic and peroxisome. The associated genes with alpha-linolenic acid are FATE1 gene, volicitin, CYP2U1 gene, CYP1A2 gene and CYP2J2 gene. The related lipids are Fatty Acids, Dietary Fatty Acid, stearidonic acid and Fatty Acids, Nonesterified.
To understand associated biological information of alpha-linolenic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
alpha-linolenic acid is suspected in Coronary heart disease, Arterial thrombosis, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with alpha-linolenic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Leitzmann MF et al. | Dietary intake of n-3 and n-6 fatty acids and the risk of prostate cancer. | 2004 | Am. J. Clin. Nutr. | pmid:15213050 |
Waylan AT et al. | Effect of flax supplementation and growth promotants on lipoprotein lipase and glycogenin messenger RNA concentrations in finishing cattle. | 2004 | J. Anim. Sci. | pmid:15217016 |
Bemelmans WJ et al. | Increased alpha-linolenic acid intake lowers C-reactive protein, but has no effect on markers of atherosclerosis. | 2004 | Eur J Clin Nutr | pmid:15220952 |
Hemmings SJ et al. | The effects of dietary flaxseed on the Fischer 344 rat: II. Liver gamma-glutamyltranspeptidase activity. | 2004 Jul-Aug | Cell Biochem. Funct. | pmid:15248182 |
Bauer JE et al. | Maternal diet alpha-linolenic acid during gestation and lactation does not increase docosahexaenoic acid in canine milk. | 2004 | J. Nutr. | pmid:15284396 |
Kajikawa M et al. | Isolation and characterization of delta(6)-desaturase, an ELO-like enzyme and delta(5)-desaturase from the liverwort Marchantia polymorpha and production of arachidonic and eicosapentaenoic acids in the methylotrophic yeast Pichia pastoris. | 2004 | Plant Mol. Biol. | pmid:15284491 |
Pari L and Venkateswaran S | Protective role of Phaseolus vulgaris on changes in the fatty acid composition in experimental diabetes. | 2004 | J Med Food | pmid:15298769 |
Kim HK et al. | Suppression of hepatic fatty acid synthase by feeding alpha-linolenic acid rich perilla oil lowers plasma triacylglycerol level in rats. | 2004 | J. Nutr. Biochem. | pmid:15302084 |
Zhao A et al. | Polyunsaturated fatty acids are FXR ligands and differentially regulate expression of FXR targets. | 2004 | DNA Cell Biol. | pmid:15307955 |
Bazinet RP et al. | Dietary 18:3omega3 influences immune function and the tissue fatty acid response to antigens and adjuvant. | 2004 | Immunol. Lett. | pmid:15325802 |
de Lorgeril M and Salen P | Alpha-linolenic acid and coronary heart disease. | 2004 | Nutr Metab Cardiovasc Dis | pmid:15330276 |
Kuklev DV and Smith WL | Synthesis of four isomers of parinaric acid. | 2004 | Chem. Phys. Lipids | pmid:15351273 |
Morise A et al. | Dose effect of alpha-linolenic acid on PUFA conversion, bioavailability, and storage in the hamster. | 2004 | Lipids | pmid:15357020 |
Caballero MJ et al. | Histological alterations in the liver of sea bream, Sparus aurata L., caused by short- or long-term feeding with vegetable oils. Recovery of normal morphology after feeding fish oil as the sole lipid source. | 2004 | J. Fish Dis. | pmid:15357712 |
Raes K et al. | Effect of diet and dietary fatty acids on the transformation and incorporation of C18 fatty acids in double-muscled Belgian Blue young bulls. | 2004 | J. Agric. Food Chem. | pmid:15366860 |
López-Alarcón M et al. | Breastfeeding protects against the anorectic response to infection in infants: possible role of DHA. | 2004 | Adv. Exp. Med. Biol. | pmid:15384603 |
pmid:15428914 | ||||
Lee JH et al. | Feeding encapsulated ground full-fat soybeans to increase polyunsaturated fat concentrations and effects on flavor volatiles in fresh lamb. | 2004 | J. Anim. Sci. | pmid:15446490 |
Dobson G et al. | Comparison of fatty acid and polar lipid contents of tubers from two potato species, Solanum tuberosum and Solanum phureja. | 2004 | J. Agric. Food Chem. | pmid:15453705 |
Simopoulos AP | Omega-3 fatty acids and antioxidants in edible wild plants. | 2004 | Biol. Res. | pmid:15455656 |
De Lorgeril M and Salen P | Use and misuse of dietary fatty acids for the prevention and treatment of coronary heart disease. | 2004 May-Jun | Reprod. Nutr. Dev. | pmid:15460167 |
Javadi M et al. | The effect of six different C18 fatty acids on body fat and energy metabolism in mice. | 2004 | Br. J. Nutr. | pmid:15469642 |
Le Jossic-Corcos C et al. | Hepatic farnesyl diphosphate synthase expression is suppressed by polyunsaturated fatty acids. | 2005 | Biochem. J. | pmid:15473864 |
Tsuzuki T et al. | Oxidation rate of conjugated linoleic acid and conjugated linolenic acid is slowed by triacylglycerol esterification and alpha-tocopherol. | 2004 | Lipids | pmid:15506243 |
Ristić-Medić D et al. | [Alpha-linolenic acid and cardiovascular diseases]. | 2003 | Med. Pregl. | pmid:15510909 |
Zhao G et al. | Dietary alpha-linolenic acid reduces inflammatory and lipid cardiovascular risk factors in hypercholesterolemic men and women. | 2004 | J. Nutr. | pmid:15514264 |
Zhou D et al. | Vitamin A deficiency reduces liver and colon docosahexaenoic acid levels in rats fed high linoleic and low alpha-linolenic acid diet. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15519497 |
Paschos GK et al. | Background diet influences the anti-inflammatory effect of alpha-linolenic acid in dyslipidaemic subjects. | 2004 | Br. J. Nutr. | pmid:15522134 |
Lefkowitz W et al. | Where does the developing brain obtain its docosahexaenoic acid? Relative contributions of dietary alpha-linolenic acid, docosahexaenoic acid, and body stores in the developing rat. | 2005 | Pediatr. Res. | pmid:15531740 |
Hastings N et al. | Molecular cloning and functional characterization of fatty acyl desaturase and elongase cDNAs involved in the production of eicosapentaenoic and docosahexaenoic acids from alpha-linolenic acid in Atlantic salmon (Salmo salar). | 2004 Sep-Oct | Mar. Biotechnol. | pmid:15549653 |
Manav M et al. | Omega-3 fatty acids and selenium as coronary heart disease risk modifying factors in Asian Indian and Chinese males. | 2004 Nov-Dec | Nutrition | pmid:15561485 |
Giamarellos-Bourboulis EJ et al. | n-6 polyunsaturated fatty acids enhance the activities of ceftazidime and amikacin in experimental sepsis caused by multidrug-resistant Pseudomonas aeruginosa. | 2004 | Antimicrob. Agents Chemother. | pmid:15561848 |
Ander BP et al. | Dietary flaxseed protects against ventricular fibrillation induced by ischemia-reperfusion in normal and hypercholesterolemic Rabbits. | 2004 | J. Nutr. | pmid:15570021 |
de Lorgeril M and Salen P | alpha-linolenic acid, coronary heart disease, and prostate cancer. | 2004 | J. Nutr. | pmid:15570041 |
Hussein N et al. | Long-chain conversion of [13C]linoleic acid and alpha-linolenic acid in response to marked changes in their dietary intake in men. | 2005 | J. Lipid Res. | pmid:15576848 |
Actis AB et al. | Fatty acid profile of human saliva: a possible indicator of dietary fat intake. | 2005 | Arch. Oral Biol. | pmid:15598411 |
Wang YW et al. | Maternal dietary ratio of linoleic acid to alpha-linolenic acid affects the passive immunity of hatching chicks. | 2004 | Poult. Sci. | pmid:15615018 |
Sun L et al. | Inhibition of osteoporosis due to restricted food intake by the fish oils DHA and EPA and perilla oil in the rat. | 2004 | Biosci. Biotechnol. Biochem. | pmid:15618634 |
Hirasawa A et al. | Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. | 2005 | Nat. Med. | pmid:15619630 |
Mozaffarian D et al. | Interplay between different polyunsaturated fatty acids and risk of coronary heart disease in men. | 2005 | Circulation | pmid:15630029 |
Nguyen LQ et al. | Feeding of spinach or sweet-potato leaves and growth performance of growing pigs kept on smallholder farms in Central Vietnam. | 2004 | Trop Anim Health Prod | pmid:15643817 |
Milne GL et al. | The cyclopentenone (A2/J2) isoprostanes--unique, highly reactive products of arachidonate peroxidation. | 2005 Jan-Feb | Antioxid. Redox Signal. | pmid:15650409 |
Loor JJ et al. | Relationship among trans and conjugated fatty acids and bovine milk fat yield due to dietary concentrate and linseed oil. | 2005 | J. Dairy Sci. | pmid:15653539 |
Schmidely P et al. | Influence of extruded soybeans with or without bicarbonate on milk performance and fatty acid composition of goat milk. | 2005 | J. Dairy Sci. | pmid:15653542 |
Liu CG et al. | Linolenic acid-modified chitosan for formation of self-assembled nanoparticles. | 2005 | J. Agric. Food Chem. | pmid:15656685 |
Fokkema MR et al. | Short-term carnitine supplementation does not augment LCPomega3 status of vegans and lacto-ovo-vegetarians. | 2005 | J Am Coll Nutr | pmid:15670986 |
Paschos GK et al. | Apolipoprotein E genotype in dyslipidemic patients and response of blood lipids and inflammatory markers to alpha-linolenic Acid. | 2005 Jan-Feb | Angiology | pmid:15678256 |
Yoshinaga N et al. | In vitro biosynthesis of volicitin in Spodoptera litura. | 2005 | Insect Biochem. Mol. Biol. | pmid:15681227 |
Carrillo-DomÃnguez S et al. | Cholesterol and n-3 and n-6 fatty acid content in eggs from laying hens fed with red crab meal (Pleuroncodes planipes). | 2005 | Poult. Sci. | pmid:15685957 |
Parry J et al. | Fatty acid composition and antioxidant properties of cold-pressed marionberry, boysenberry, red raspberry, and blueberry seed oils. | 2005 | J. Agric. Food Chem. | pmid:15686403 |